Article
Biochemistry & Molecular Biology
Dipali Goyal, Sean W. Limesand, Ravi Goyal
Summary: A stem cell-like population is found in fetal carotid arteries, and the survival of these cells depends on the B-Raf kinase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wen Ling, Sarah K. Johnson, Syed J. Mehdi, Daisy Alapat, Michael Bauer, Maurizio Zangari, Carolina Schinke, Sharmilan Thanendrarajan, Frits van Rhee, Shmuel Yaccoby
Summary: In multiple myeloma, the expression of the receptor EDNRA gradually increases with disease progression, with high-risk patients having higher expression than low-risk patients. These findings suggest that EDNRA could serve as a useful biomarker for disease progression and disrupted bone marrow vasculature. The detached EDNRA-expressing cells indicate increased angiogenesis.
Review
Immunology
Dominique Farge, Severine Loisel, Pauline Lansiaux, Karin Tarte
Summary: Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by vasculopathy, dysregulation of immune responses, and progressive fibrosis. Mesenchymal stromal cells (MSC) have shown promise as a potential stem cell therapy for SSc, with studies demonstrating proangiogenic, immuno-suppressive, and anti-fibrotic properties. Preclinical studies in animal models and early clinical trials in humans have reported positive results in reducing fibrosis in SSc patients.
AUTOIMMUNITY REVIEWS
(2021)
Review
Cell & Tissue Engineering
Jiehan Cui, Lu Jin, Meng Ding, Jingjing He, Lin Yang, Shaoxin Cui, Xiaoping Wang, Jun Ma, Aijing Liu
Summary: This systematic review and meta-analysis found that mesenchymal stem cell (MSC) therapy can improve the degree of skin fibrosis, lung function, and mouth opening, and relieve finger ulcers and pain in patients with systemic sclerosis (SSc) without severe adverse events.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Rheumatology
Yasushi Kawaguchi, Masataka Kuwana
Summary: In patients with systemic sclerosis (SSc), vascular manifestations precede skin and organ fibrosis. There is increasing evidence demonstrating a pathogenic link between early vascular injury and subsequent development of tissue fibrosis.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Engineering, Biomedical
Min Nie, Bin Kong, Guopu Chen, Ying Xie, Yuanjin Zhao, Lingyun Sun
Summary: The novel MSCs-laden injectable self-healing hydrogel developed for SSc treatment shows promising results in promoting MSCs proliferation, increasing cellular half-life, promoting angiopoiesis, and inhibiting fibrosis in disease model mice.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Kishor K. Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H. Adams
Summary: Bone stroma plays a crucial role in regulating osteogenesis and hematopoiesis, as well as fracture healing and disease processes. BMSCs from different bone regions, such as metaphysis and diaphysis, exhibit distinct characteristics and functions. The fate of BMSCs is controlled by signaling pathways involving PDGFR beta and transcription factor Jun-B, contributing to bone development and our understanding of BMSC lineage relationships and differentiation.
Article
Cell Biology
Francesca Pagani, Elisa Tratta, Patrizia Dell'Era, Manuela Cominelli, Pietro Luigi Poliani
Summary: EBF1 plays a significant role in cell fate commitment and is crucial for the expression and function of peri-endothelial cells in vessels. The study found that EBF1 is highly expressed in peri-endothelial cells, which represent bona fide pericytes and are confirmed in human placenta-derived pericytes and human brain vascular pericytes.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: MSCs are multipotent stem cells that can enhance tissue repair and regeneration by regulating immune cell function, promoting new blood vessel formation, and modulating phenotype and function of immune cells. This review article summarizes the current knowledge about the molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Qi Zhou, Min Yuan, Weiwen Qiu, Wenfeng Cao, Renshi Xu
Summary: The study assessed the quality of preclinical evidence for MSCs therapy of ALS, determined the effect size of MSCs treatment, and identified clinical parameters associated with differences in MSCs effects. The results showed that MSCs transplantation was beneficial for neurobehavioral improvement in ALS animal models, with animal gender and immunosuppressive drug CSA having a close correlation with disease progression deceleration effect size.
NEUROLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yan Zhang, Yanli Yang, Xiang Gao, Wenqin Gao, Liyun Zhang
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by skin thickening and fibrosis. The pathogenesis involves microvascular injury, inflammation, and fibroblast activation. Mesenchymal stem cells (MSCs) and their secreted exosomes are potential treatment options due to their immunomodulatory, antifibrotic, and pro-angiogenic effects. This review aims to summarize the latest research progress on MSCs and exosomes in SSc, providing novel ideas for its treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Renan Fava Marson, Andrea Pereira Regner, Lindolfo da Silva Meirelles
Summary: Cultured mesenchymal stromal cells have great potential in clinical trials, but their therapeutic benefits have not been fully realized. This review explores the possibility that activated subpopulations of perivascular and/or adventitial cells may behave as MSCs in tissue injury, contributing to the resolution of tissue injury by promoting the development of regenerative macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Solmaz Khalighfard, Vahid Khori, Ali Mohammad Alizadeh, Gelareh Vahabzadeh, Mahboubeh Tajaldini, Sima Sedighi, Zohreh Nozarian, Hamid Khodayari, Saeed Khodayari, Fatemeh Ganji, Ziba Veisi Malekshahi, Tahereh Mirmajidi
Summary: A low dose of atorvastatin (2 mg/kg) significantly increased the levels of proteins related to cell angiogenesis and proliferation, improving the function of MSCs and their differentiation into tissue angiogenesis.effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yoshitaka Iso, Sayaka Usui, Hiroshi Suzuki
Summary: The aim of this study was to investigate the pro-angiogenic potential of skeletal muscle mesenchymal stem/stromal cells (mMSCs). The results showed that PDGFR-alpha positive mMSCs secreted VEGF and hepatocyte growth factor, inducing endothelial tube formation and promoting capillary growth. Epo stimulation enhanced phosphorylation and cellular proliferation in mMSCs, leading to improved perfusion recovery and capillary growth in the ischemic limbs.
Article
Cell & Tissue Engineering
Chi Zhang, Yinuo Lin, Ke Zhang, Luyang Meng, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu
Summary: The study found that GDF11 can enhance the therapeutic effects of stem cells for ischemic diseases by increasing stem cell viability, mobility, and angiogenic paracrine functions.
STEM CELL RESEARCH & THERAPY
(2021)
Letter
Rheumatology
Piero Ruscitti, Giorgio Sesti, Paola Cipriani, Roberto Gerli, Roberto Giacomelli
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ilenia Di Cola, Federico Bruno, Onorina Berardicurti, Riccardo Monti, Alessandro Conforti, Alessandra Di Sibio, Viktoriya Pavlych, Carlo Masciocchi, Antonio Barile, Paola Cipriani, Piero Ruscitti
Summary: This study aimed to describe multivisceral involvement in adult-onset Still's disease (AOSD) and identify imaging-based differences in patients with and without macrophage activation syndrome (MAS). Patients with MAS had higher ferritin and systemic score values, as well as a higher prevalence of lung disease, hepatomegaly, splenomegaly, abdominal effusions, and lymph node enlargement. These manifestations correlated significantly with the systemic score, highlighting their prognostic value. Due to study limitations, further research is needed to confirm these findings and fully understand their implications.
CLINICAL RHEUMATOLOGY
(2021)
Review
Immunology
Cesare Tripolino, Jacopo Ciaffi, Valentina Pucino, Piero Ruscitti, Nina van Leeuwen, Claudio Borghi, Roberto Giacomelli, Riccardo Meliconi, Francesco Ursini
Summary: Inflammatory arthritis is burdened by an increased risk of metabolic disorders, which might have a bidirectional cause-effect relationship. Insulin signaling plays a crucial role in immune response and arthritis, while inflammatory mediators can affect insulin signaling.
FRONTIERS IN IMMUNOLOGY
(2021)
Meeting Abstract
Rheumatology
L. La Barbera, M. Lo Pizzo, D. Di Liberto, C. Schinocca, P. Ruscitti, R. Giacomelli, F. Dieli, F. Ciccia, G. Guggino
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
P. Ruscitti, A. Barile, O. Berardicurti, S. Iafrate, P. Di Benedetto, A. Vitale, F. Caso, L. Costa, F. Bruno, F. Ursini, L. Navarini, F. Sensini, R. Scarpa, B. Frediani, L. Cantarini, C. Masciocchi, R. Giacomelli, P. Cipriani
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Medicine, General & Internal
Cesare Tripolino, Jacopo Ciaffi, Piero Ruscitti, Roberto Giacomelli, Riccardo Meliconi, Francesco Ursini
Summary: Psoriatic arthritis (PsA) is the articular component of systemic psoriatic disease and is associated with various metabolic abnormalities. Uric acid, as the final product of purine metabolism, may be elevated in PsA patients and affect the clinical manifestations and inflammation levels.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Antonio Vitale, Laura Obici, Marco Cattalini, Giuseppe Lopalco, Giampaolo Merlini, Nicola Ricco, Alessandra Soriano, Francesco La Torre, Elena Verrecchia, Antonella Insalaco, Lorenzo Dagna, Masen Abdel Jaber, Davide Montin, Giacomo Emmi, Luisa Ciarcia, Sara Barneschi, Paola Parronchi, Piero Ruscitti, Maria Cristina Maggio, Ombretta Viapiana, Jurgen Sota, Carla Gaggiano, Roberto Giacomelli, Ludovico Luca Sicignano, Raffaele Manna, Alessandra Renieri, Caterina Lo Rizzo, Bruno Frediani, Donato Rigante, Luca Cantarini
Summary: Biotechnological therapies are highly effective in controlling clinical and laboratory TRAPS manifestations. Patients with a relapsing-remitting disease course and a lower frequency of flares at the start of treatment are more likely to achieve a complete response to biologic agents.
FRONTIERS IN MEDICINE
(2021)
Letter
Rheumatology
Francesco Ursini, Piero Ruscitti, Vincenzo Raimondo, Rossella De Angelis, Fabio Cacciapaglia, Erika Pigatto, Domenico Olivo, Ilenia Di Cola, Felice Galluccio, Francesca Francioso, Rosario Foti, Antonio Tavoni, Salvatore D'Angelo, Corrado Campochiaro, Francesca Motta, Maria De Santis, Silvia Bilia, Caterina Bruno, Giacomo De Luca, Marcella Visentini, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Martina D'Onghia, Giovanna Cuomo, Enrico Fusaro, Lorenzo Dagna, Serena Guiducci, Riccardo Meliconi, Florenzo Iannone, Annamaria Iagnocco, Roberto Giacomelli, Clodoveo Ferri
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Piero Ruscitti, Ilenia Di Cola, Onorina Berardicurti, Alessandro Conforti, Daniela Iacono, Ilenia Pantano, Gelsomina Rozza, Silvia Rossi, Stefano De Ludovico, Silvia Balduzzi, Antonio Vitale, Francesco Caso, Luisa Costa, Marcella Prete, Luca Navarini, Fabiola Atzeni, Giuliana Guggino, Federico Perosa, Luca Cantarini, Bruno Frediani, Carlomaurizio Montecucco, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani
Summary: This study found that smoking may affect the prognosis of adult-onset Still's disease (AOSD) patients, with smokers more likely to experience pericarditis, pleuritis, abdominal pain, and complications like macrophage activation syndrome (MAS) and parenchymal lung disease, leading to a poorer prognosis.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Giuseppe Lopalco, Vincenzo Venerito, Antonio Brucato, Giacomo Emmi, Roberto Giacomelli, Alberto Cauli, Matteo Piga, Paola Parronchi, Mariangela Nivuori, Danilo Malandrino, Piero Ruscitti, Gianfranco Vitiello, Claudia Fabiani, Luca Cantarini, Florenzo Iannone
Summary: Anakinra appears to be a safe and effective therapeutic option for patients refractory to traditional anti-inflammatory treatments in polyserositis, showing significant efficacy in reducing recurrences and corticosteroid use.
Article
Chemistry, Medicinal
Piero Ruscitti, Vasiliki Liakouli, Noemi Panzera, Adriano Angelucci, Onorina Berardicurti, Elena Di Nino, Luca Navarini, Marta Vomero, Francesco Ursini, Daniele Mauro, Vincenza Dolo, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani
Summary: This study found that the expression of markers of myofibroblast differentiation in the synovial tissue of rheumatoid arthritis patients was significantly higher than in healthy controls, and that TGF-beta and IL-6 stimulation promoted the expression of these markers; tofacitinib may have a role in reducing the expression of these markers.
Article
Biochemistry & Molecular Biology
Luca Navarini, Marta Vomero, Stefano Di Donato, Damiano Currado, Onorina Berardicurti, Annalisa Marino, Pietro Bearzi, Alice Biaggi, Matteo Ferrito, Piero Ruscitti, Marina Fava, Alessandro Leuti, Paola Cipriani, Mauro Maccarrone, Roberto Giacomelli
Summary: This study found that 2-AG modulates the production of type 2 interferon in CD4+ T lymphocytes from SLE patients through CB2 activation.
Article
Immunology
Elvira Favoino, Ettore Grapsi, Giovanna Barbuti, Vasiliki Liakouli, Piero Ruscitti, Caterina Foti, Roberto Giacomelli, Federico Perosa
Summary: This study evaluated whether anti-centromeric protein A (CENP-A) antibodies cross-react with mitochondrial antigens. The results showed that antibodies with a specific mitochondrial antigen (PDC-E2) cross-reacted with anti-centromere antibodies (Ap1-17). This finding is important for investigating the pathogenic significance of these antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Rheumatology
E. Favoino, G. Catacchio, A. Mininni, P. Ruscitti, V. Riccieri, V. Liakouli, A. Corrado, L. Navarini, F. Ciccia, P. Cipriani, F. P. Cantatore, G. Valesini, R. Giacomelli, F. Perosa
Summary: Anti-p4.2 antibodies can identify a subset of systemic sclerosis (SSc) patients at a high risk of developing pulmonary vascular disease (PVD), even in the absence of pulmonary fibrosis (PF).
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Review
Rheumatology
R. Giacomelli, J. Sota, P. Ruscitti, C. Campochiaro, S. Colafrancesco, L. Dagna, D. Iacono, F. Iannone, G. Lopalco, P. Sfriso, L. Cantarini
Summary: Literature reviews suggest that anakinra is effective in treating patients with AOSD, leading to complete remission and reducing the need for corticosteroids. The treatment has a largely favorable safety profile and can spare patients from long-term corticosteroid side effects.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)