Lymphatic vessels: new targets for the treatment of inflammatory diseases

Transgenic Overexpression of Interleukin-1β Induces Persistent Lymphangiogenesis But Not Angiogenesis in Mouse Airways

(2013) Peter Baluk et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease

(2012) Andre Okanobo et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration

(2012) Inho Choi et al.   ANGIOGENESIS

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

(2012) Tara Karnezis et al.   CANCER CELL

9-Cis Retinoic Acid Promotes Lymphangiogenesis and Enhances Lymphatic Vessel Regeneration

(2012) Inho Choi et al.   CIRCULATION

The CXCL12-CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

(2012) W. Zhuo et al.   CLINICAL CANCER RESEARCH

The expression of podoplanin and classic cadherins in the mouse brain

(2012) Chiaki Kaji et al.   JOURNAL OF ANATOMY

Expansion of Cortical and Medullary Sinuses Restrains Lymph Node Hypertrophy during Prolonged Inflammation

(2012) K. W. Tan et al.   JOURNAL OF IMMUNOLOGY

Inflammation-Driven Dermal Lymphangiogenesis in Atopic Dermatitis is Associated with CD11b+ Macrophage Recruitment and VEGF-C Up-regulation in the IL-4-Transgenic Mouse Model

(2012) VIVIAN Y. SHI et al.   MICROCIRCULATION

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

(2012) M. M. P. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Lymphangiogenesis With Implantation of Adipose‐Derived Regenerative Cells

(2012) Yuuki Shimizu et al.   Journal of the American Heart Association

Lymphatic endothelial cells - key players in regulation of tolerance and immunity

(2012) Eric F. Tewalt et al.   Frontiers in Immunology

Inflammation-Induced Lymph Node Lymphangiogenesis Is Reversible

(2011) Viviane Mumprecht et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of Inflammatory Corneal Lymphangiogenesis by Application of Topical Corticosteroids

(2011) Deniz Hos   ARCHIVES OF OPHTHALMOLOGY

Roles of Prostaglandin E 2 –EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation

(2011) Kanako Hosono et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice

(2011) Quan Zhou et al.   ARTHRITIS AND RHEUMATISM

A novel pro-lymphangiogenic function for Th17/IL-17

(2011) S. K. Chauhan et al.   BLOOD

An important role of lymphatic vessel activation in limiting acute inflammation

(2011) R. Huggenberger et al.   BLOOD

Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner

(2011) B. Vigl et al.   BLOOD

Glucocorticoids Suppress Corneal Lymphangiogenesis

(2011) Maria M Steele et al.   CORNEA

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Molecular mechanisms of lymphangiogenesis in development and cancer

(2011) Imke Albrecht et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma

(2011) Satoru Shinriki et al.   JOURNAL OF PATHOLOGY

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema

(2011) Shinya Kashiwagi et al.   LABORATORY INVESTIGATION

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Interaction of tumor cells and lymphatic vessels in cancer progression

(2011) A Alitalo et al.   ONCOGENE

Regulation of T Cell Priming by Lymphoid Stroma

(2011) Omar Khan et al.   PLoS One

Steroid-Resistant Lymphatic Remodeling in Chronically Inflamed Mouse Airways

(2010) Li-Chin Yao et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging roles of lymphatics in inflammatory bowel disease

(2010) J. Steven Alexander et al.   Annals of the New York Academy of Sciences

Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells

(2010) Xi Chen et al.   CANCER SCIENCE

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

(2010) Tie Zheng Hou et al.   FEBS LETTERS

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease

(2010) G Jurisic et al.   GENES AND IMMUNITY

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

(2010) Reto Huggenberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor

(2010) S. Fiorentini et al.   JOURNAL OF GENERAL VIROLOGY

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development

(2010) Daniela Marino et al.   JOURNAL OF VASCULAR RESEARCH

Differential Cytokine Responses in Human and Mouse Lymphatic Endothelial Cells to Cytokines in Vitro

(2010) G.V. Chaitanya et al.   Lymphatic Research and Biology

Role of CD11b + Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm

(2009) Kyung Eun Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis

(2009) Ruolin Guo et al.   ARTHRITIS AND RHEUMATISM

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution

(2009) R. P. Kataru et al.   BLOOD

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF- B and Prox1

(2009) M. J. Flister et al.   BLOOD

Endothelial Nitric Oxide Synthase Mediates Lymphangiogenesis and Lymphatic Metastasis

(2009) J. Lahdenranta et al.   CANCER RESEARCH

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

(2009) S. Vetrano et al.   GUT

Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal

(2009) Masahiro Yamashita et al.   HUMAN PATHOLOGY

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

(2009) S. Podgrabinska et al.   JOURNAL OF IMMUNOLOGY

Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells

(2008) Nikolaus Wick et al.   AMERICAN JOURNAL OF PATHOLOGY

Markers for Microscopic Imaging of Lymphangiogenesis and Angiogenesis

(2008) Peter Baluk et al.   Annals of the New York Academy of Sciences

Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints

(2008) K Polzer et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-κB activation

(2008) Kosuke Watari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages

(2008) S. Kang et al.   BLOOD

A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis

(2008) S. Clasper et al.   CANCER RESEARCH

Activation of the VEGFR-3 Pathway by VEGF-C Attenuates UVB-Induced Edema Formation and Skin Inflammation by Promoting Lymphangiogenesis

(2008) Kentaro Kajiya et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase α1β1-impact on inflammation

(2007) Kentaro Kajiya et al.   FASEB JOURNAL