Polyketide construction via hydrohydroxyalkylation and related alcohol C–H functionalizations: reinventing the chemistry of carbonyl addition

Protecting-Group-Free Diastereoselective CC Coupling of 1,3-Glycols and Allyl Acetate through Site-Selective Primary Alcohol Dehydrogenation

(2013) Anne-Marie R. Dechert-Schmitt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries, or Premetalated Carbon Nucleophiles

(2013) Andrew R. Waldeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of (+)-trans-Aerangis Lactone

(2013) Aejin Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Modular Total Synthesis of Rhizopodin: A Highly Potent G-Actin Dimerizing Macrolide

(2013) Manuel Kretschmer  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of 6-Deoxyerythronolide B via C–C Bond-Forming Transfer Hydrogenation

(2013) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Trienomycins A and F via C–C Bond-Forming Hydrogenation and Transfer Hydrogenation

(2013) David J. Del Valle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of the Butyrolactone and the Oxazoline/Furan Fragment of Leupyrrin A1

(2013) Thomas Debnar et al.   ORGANIC LETTERS

Stereoselective synthesis of the C1–C8 subunit of peloruside A

(2013) Sadagopan Raghavan et al.   TETRAHEDRON

Enantioselective synthesis of (+)-aspercyclide A

(2013) Jimmy J.P. Sejberg et al.   TETRAHEDRON LETTERS

Efficient, divergent synthesis of cryptophycin unit A analogues

(2012) Kyle L. Bolduc et al.   CHEMICAL COMMUNICATIONS

Concise Synthesis of the Macrocyclic Core of Rhizopodin by a Heck Macrocyclization Strategy

(2012) Michael Dieckmann et al.   JOURNAL OF ORGANIC CHEMISTRY

Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs

(2012) Yu Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral-Anion-Dependent Inversion of Diastereo- and Enantioselectivity in Carbonyl Crotylation via Ruthenium-Catalyzed Butadiene Hydrohydroxyalkylation

(2012) Emma L. McInturff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives

(2012) Haruhiko Fuwa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Synthesis of the Macrolactone Core of (+)-Neopeltolide

(2012) Sadagopan Raghavan et al.   ORGANIC LETTERS

Iridium-Catalyzed Allylation of Chiral β-Stereogenic Alcohols: Bypassing Discrete Formation of Epimerizable Aldehydes

(2012) Daniel C. Schmitt et al.   ORGANIC LETTERS

Cyclopropane Compatibility with Oxidative Carbocation Formation: Total Synthesis of Clavosolide A

(2012) GuangRong Peh et al.   ORGANIC LETTERS

Formation of C–C bonds via ruthenium-catalyzed transfer hydrogenation

(2012) Joseph Moran et al.   PURE AND APPLIED CHEMISTRY

Enantioselective C-H Crotylation of Primary Alcohols via Hydrohydroxyalkylation of Butadiene

(2012) J. R. Zbieg et al.   SCIENCE

A Catalytic Approach to the Synthesis of (+)-Fluvastatin Analogue

(2011) Ae-Jin Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

(2011) Miguel Yus et al.   CHEMICAL REVIEWS

Mechanism and Origins of Regio- and Enantioselectivities in RhI-Catalyzed Hydrogenative Couplings of 1,3-Diynes and Activated Carbonyl Partners: Intervention of a Cumulene Intermediate

(2011) Peng Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Formal Total Synthesis of Cyanolide A

(2011) Srihari Pabbaraja et al.   JOURNAL OF ORGANIC CHEMISTRY

A Formal Synthesis of (−)-Cyanolide A Featuring a Stereoselective Mukaiyama Aldol Reaction and Oxocarbenium Reduction

(2011) Robert J. Sharpe et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Brønsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Ester Surrogates

(2011) Haruhiko Fuwa et al.   JOURNAL OF ORGANIC CHEMISTRY

Enhanced anti-Diastereo- and Enantioselectivity in Alcohol-Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst

(2011) Xin Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of the Cyanolide A Aglycon

(2011) Michael R. Gesinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 9

(2011) Paul A. Wender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Generation of Acyclic Polypropionate StereopolyadsviaDouble Diastereo- and Enantioselective Iridium-Catalyzed Crotylation of 1,3-Diols: Beyond Stepwise Carbonyl Addition in Polyketide Construction

(2011) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 7viaC–C Bond-Forming Hydrogenation

(2011) Yu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereo- and Enantioselective Ruthenium-Catalyzed Hydrohydroxyalkylation of 2-Silyl-butadienes: Carbonylsyn-Crotylation from the Alcohol Oxidation Level

(2011) Jason R. Zbieg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs

(2011) Shuangyi Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans

(2011) Haruhiko Fuwa et al.   ORGANIC LETTERS

Stereocontrolled Synthesis of the C8–C22 Fragment of Rhizopodin

(2011) Manuel Kretschmer et al.   ORGANIC LETTERS

Concise Formal Synthesis of (+)-Neopeltolide

(2011) Zhen Yang et al.   ORGANIC LETTERS

Unlocking Hydrogenation for C–C Bond Formation: A Brief Overview of Enantioselective Methods

(2011) Abbas Hassan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Molluscicidal Agent Cyanolide A Macrolactone fromd-(−)-Pantolactone

(2010) Atul K. Hajare et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Roxaticin via C−C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 1

(2010) Gary E. Keck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of cyanolide A

(2010) Zhen Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of Cyanolide A and Confirmation of Its Absolute Configuration

(2010) Hyoungsu Kim et al.   ORGANIC LETTERS

Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

(2010) Haruhiko Fuwa et al.   ORGANIC LETTERS

A novel strategy towards the atorvastatin lactone

(2010) Pramod Sawant et al.   TETRAHEDRON

1,n-Glycols as Dialdehyde Equivalents in Iridium-Catalyzed Enantioselective Carbonyl Allylation and Iterative Two-Directional Assembly of 1,3-Polyols

(2009) Yu Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiency

(2009) Soo Bong Han et al.   CHEMICAL COMMUNICATIONS

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor

(2009) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

anti-Diastereo- and Enantioselective Carbonyl Crotylation from the Alcohol or Aldehyde Oxidation Level Employing a Cyclometallated Iridium Catalyst: α-Methyl Allyl Acetate as a Surrogate to Preformed Crotylmetal Reagents

(2009) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis and study of 6-deoxyerythronolide B by late-stage C–H oxidation

(2009) Erik M. Stang et al.   Nature Chemistry

Elongation of 1,3-Polyols via Iterative Catalyst-Directed Carbonyl Allylation from the Alcohol Oxidation Level

(2009) Abbas Hassan et al.   ORGANIC LETTERS

Concise Synthesis of the Bryostatin A-Ring via Consecutive C−C Bond Forming Transfer Hydrogenations

(2009) Yu Lu et al.   ORGANIC LETTERS

An Efficient Formal Synthesis of (−)-Clavosolide A Featuring a “Mismatched” Stereoselective Oxocarbenium Reduction

(2009) Jesse D. Carrick et al.   ORGANIC LETTERS

De novo asymmetric syntheses of (+)-goniothalamin, (+)-goniothalamin oxide, and 7,8-bis-epi-goniothalamin using asymmetric allylations

(2009) Philip Harsh et al.   TETRAHEDRON

The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug

(2008) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level Using Allyl Acetate as an Allyl Metal Surrogate

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level via Transfer Hydrogenative Coupling of Allyl Acetate: Departure from Chirally Modified Allyl Metal Reagents in Carbonyl Addition

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

(2008) Barry M. Trost et al.   NATURE

Total synthesis of clavosolide A

(2008) Tushar Kanti Chakraborty et al.   TETRAHEDRON