Advancing the Drug Discovery and Development Process

Academic-Industrial Partnerships in Drug Discovery and Development

(2014) K. C. Nicolaou   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Epigenetics in Drug Discovery

(2014) Antonello Mai   ChemMedChem

Follow your lead

(2014) Brian K Shoichet   Nature Chemical Biology

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

(2014) Pietro Ciceri et al.   Nature Chemical Biology

2013 FDA drug approvals

(2014) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Drug Discovery: A Modern Decathlon

(2013) Stefan Laufer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Translational paradigms in pharmacology and drug discovery

(2013) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis

(2013) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

Industrial natural product chemistry for drug discovery and development

(2013) Armin Bauer et al.   NATURAL PRODUCT REPORTS

Bringing together the academic drug discovery community

(2013) Barbara S. Slusher et al.   NATURE REVIEWS DRUG DISCOVERY

Tough Times for Medicinal Chemists: Are We to Blame?

(2013) Takashi Tsukamoto   ACS Medicinal Chemistry Letters

Editorial: Drug Discovery …︁ The Third in the Band!

(2012) Herbert Waldmann   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Future of Medicinal Chemistry

(2012) Torsten Hoffmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Emergence of the Structure of the Molecule and the Art of Its Synthesis

(2012) K. C. Nicolaou   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Challenges for Academic Drug Discovery

(2012) William L. Jorgensen   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

(2012) K. C. Nicolaou et al.   CHEMICAL SOCIETY REVIEWS

Mechanistic systems modeling to guide drug discovery and development

(2012) Brian J. Schmidt et al.   DRUG DISCOVERY TODAY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities

(2012) Michele De Palma et al.   Molecular Oncology

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

A medicinal chemistry perspective on melting point: matched molecular pair analysis of the effects of simple descriptors on the melting point of drug-like compounds

(2012) Sabine Schultes et al.   MedChemComm

Editorial: The Importance of Chemistry for the Future of the Pharma Industry

(2011) Hanno Wild et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

(2011) Christopher E. Keefer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Blueprint for Advancing Genetics-Based Cancer Therapy

(2011) William R. Sellers   CELL

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Matched Molecular Pairs as a Medicinal Chemistry Tool

(2011) Ed Griffen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

(2011) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimum information about a bioactive entity (MIABE)

(2011) Sandra Orchard et al.   NATURE REVIEWS DRUG DISCOVERY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Organic synthesis toward small-molecule probes and drugs

(2011) S. L. Schreiber   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Opening Up to Precompetitive Collaboration

(2010) J. S. Altshuler et al.   Science Translational Medicine

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

(2009) Thomas Ryckmans et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Congenital neutropenia

(2009) C. Klein   Hematology-American Society of Hematology Education Program

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS