Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry

Focused Pseudostatic Hydrazone Libraries Screened by Mass Spectrometry Binding Assay: Optimizing Affinities toward γ-Aminobutyric Acid Transporter 1

(2013) Miriam Sindelar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry

(2013) Jianwei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors

(2012) Marina Demetriades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4′,5′-f][1,3]diazepines

(2012) Atul Kondaskar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

From dynamic combinatorial ‘hit’ to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy

(2012) Leslie O. Ofori et al.   NUCLEIC ACIDS RESEARCH

Structure-based drug design to augment hit discovery

(2011) Subha Kalyaanamoorthy et al.   DRUG DISCOVERY TODAY

STD-NMR: application to transient interactions between biomolecules—a quantitative approach

(2011) Jesus Angulo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A Small Nonrule of 3 Compatible Fragment Library Provides High Hit Rate of Endothiapepsin Crystal Structures with Various Fragment Chemotypes

(2011) Helene Köster et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Strecker Synthesis of α-Arylglycines

(2011) Yolanda Pérez-Fuertes et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

(2010) Venugopal T. Bhat et al.   Nature Chemistry

Direct STD NMR Identification of β-Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System

(2009) Rémi Caraballo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated Carbohydrates as Lectin Ligands: Versatile Sensors in19F-Detected Saturation Transfer Difference NMR Spectroscopy

(2009) Tammo Diercks et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovering Potent Small Molecule Inhibitors of Cyclophilin A Using de Novo Drug Design Approach

(2009) Shuaishuai Ni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Towards an Integrated Description of Hydrogen Bonding and Dehydration: Decreasing False Positives in Virtual Screening with the HYDE Scoring Function

(2008) Ingo Reulecke et al.   ChemMedChem

The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction

(2008) Leighton Coates et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic combinatorial chemistry: on the road to fulfilling the promise

(2007) Sylvain Ladame   ORGANIC & BIOMOLECULAR CHEMISTRY