Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 14, Pages 5107-5110Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9007223
Keywords
-
Categories
Funding
- NIH-NIGMS [GM071650]
- NIH [5T32GM008597-12]
- Camille and Henry Dreyfus Foundation
- GlaxoSmithKline
- Eli Lilly
- Amgen
- 3M
Ask authors/readers for more resources
A four-step synthesis of cis-3,5-disubstituted morpholines from enantiomerically pure amino alcohols is described. The key step in the synthesis is a Pd-catalyzed carboamination reaction between a substituted ethanolamine derivative and an aryl or alkenyl bromide. The morpholine products are generated as single stereoisomers in moderate to good yield. This strategy also provides access to fused bicyclic morpholines as well as 2,3- and 2,5-disubstituted products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available