Article
Biochemistry & Molecular Biology
Evelin Csepanyi, Alexandra Gyongyosi, Istvan Lekli, Arpad Tosaki, Istvan Bak
Summary: This study suggests that beta-carotene may become pro-oxidant under severe oxidative conditions, potentially enhanced by the presence of iron. The use of an iron-chelator can reverse the pro-oxidant effects of beta-carotene and reduce cardiac injury caused by ischemia/reperfusion.
Article
Cell Biology
Qun Chen, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky
Summary: Aging-induced endoplasmic reticulum (ER) stress impairs mitochondrial function, which can be improved by attenuating ER stress or inhibiting calpain 1 (CPN1). These interventions can decrease cardiac injury during ischemia-reperfusion in aged hearts.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Marie V. Hjortbak, Nichlas R. Jespersen, Rebekka V. Jensen, Thomas R. Lassen, Johanne Hjort, Jonas A. Povlsen, Nicolaj B. Stottrup, Jakob Hansen, Derek J. Hausenloy, Hans Erik Botker
Summary: The study showed that mild hypothermia combined with IPC has an additive effect on reducing ischemia-reperfusion injury, while the combination of mild hypothermia and RIC did not provide additional cardioprotection. Mild hypothermia appeared to have an anti-ischemic effect during the ischemic period, while IPC and RIC targeted reperfusion injury.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yunchao Pan, Yuan Wang, Wenyan Shi, Yun Liu, Song Cao, Tian Yu
Summary: Diazoxide post-conditioning has been shown to alleviate myocardial ischemia/reperfusion injury, potentially by increasing the expression of protective proteins such as NDUFV1, NDUFS1, OGDH, and ATP synthase alpha subunit, while decreasing the expression of another isoform of ATP synthase alpha subunit. These differentially expressed proteins could be potential targets for the treatment of cardiac I/R injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Gang Cheng, Li-huan Li
Summary: The results of this study demonstrate that sevoflurane post-conditioning and delayed sevoflurane post-conditioning protect isolated rat hearts from ischemia-reperfusion injury. This protective effect is associated with the phosphorylation levels of Akt and GSK-3 beta.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoyu Xiao, Dezhao Liu, Sufang Chen, Xiang Li, Mian Ge, Wenqi Huang
Summary: Sevoflurane preconditioning can reduce liver ischemia reperfusion injury by activating the HGF/Met-mediated autophagy pathway, highlighting the crucial role of autophagy in this protective effect.
CELLULAR SIGNALLING
(2021)
Article
Cell & Tissue Engineering
Jinting Yang, Lihui Tang, Fengjiang Zhang, Tingting Yang, Ting Lu, Kai Sun, Na Sun, Jinxuan Ren, Min Yan
Summary: Sevoflurane preconditioning can enhance MSCs to attenuate myocardial I/R injury through TRPC6-induced angiogenesis. It also promotes angiogenesis and anti-inflammatory effects of HUVECs, as well as improves left ventricle systolic function and reduces infarction and inflammation in mice subjected to I/R insult.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Keshav Jayaraman, Meizi Liu, Gregory J. Zipfel, Umeshkumar Athiraman
Summary: Studies have shown that pre-treatment with sevoflurane or desflurane can alleviate large artery vasospasm and neurologic deficits caused by SAH. Further research is needed to confirm and understand the mechanisms of these protective effects in both preclinical and clinical settings, considering the frequent clinical use and safety profile of these anesthetics.
Article
Pharmacology & Pharmacy
Houyou Yu, Xin Hong, Lihua Liu, Yangpeng Wu, Xuemei Xie, Guoxiang Fang, Shaomin Zhi
Summary: Cordycepin protects diabetic hearts from MI/R injury by promoting mitochondrial fusion and Mfn2 expression. The study also demonstrated that the AMPK/Mfn2-dependent mitochondrial fusion mechanism contributes to the cardioprotective role of cordycepin.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Shujun Shang, Fengqiang Sun, Yulin Zhu, Jingui Yu, Lingzhi Yu, Wei Shao, Zhijuan Wang, Xuecai Yi
Summary: This study aimed to investigate the influence of sevoflurane on the NLRP3 pathways in rats with cerebral ischemia/reperfusion (I/R) injury. The results indicated that sevoflurane could alleviate brain damage caused by cerebral I/R by inhibiting the ROS-NLRP3 pathway.
NEUROSCIENCE LETTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Felix Braczko, Nilgun Gedik, Merlin Stroetges, Gerd Heusch, Petra Kleinbongard
Summary: The study investigated the impact of T3 on infarct size and its underlying signal transduction, finding that T3 reduces infarct size during reperfusion by activating the RISK pathway.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Physiology
Veronika Farkasova, Lucia Kindernay, Miroslav Ferko, Tomas Rajtik, Adrian Szobi, Tatiana Ravingerova
Summary: Remote ischemic preconditioning (RIPC) has age-dependent cardioprotective effects in spontaneously hypertensive (SHR) rats, mediated by the activation of the Reperfusion Injury Salvage Kinase (RISK) pathway. RIPC effectively reduced infarction and arrhythmias in three and five months-old rats, but not in eight months-old rats. These beneficial effects were associated with increased RISK activity and decreased apoptotic signaling only in the younger animals.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Janet Olayemi Sangodele, Zephaniah Inuwa, Bashir Lawal, Grace Adebayo-Gege, Bamidele Joseph Okoli, Fanyana Mtunzi
Summary: This study demonstrated that the protective treatment of Proxeed Plus (PP) significantly increased antioxidative defense capacities and sex hormone levels, while reducing oxidative stress and apoptotic markers in rats with testicular ischemia/reperfusion (I/R) injury. PP also ameliorated histological changes, increased spermatogenetic activity, and decreased testicular inducible nitric oxide synthase (iNOS) expressions, suggesting its potential as a promising therapeutic approach for preventing testicular damage from I/R injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)