Structural Implications of β-Cardiac Myosin Heavy Chain Mutations in Human Disease

Familial Hypertrophic Cardiomyopathy: Unequal Expression of Mutant and Wildtype Myosin in Individual Myocytes as Trigger for Functional Impairment of the Heart?

(2015) Judith Montag et al.   BIOPHYSICAL JOURNAL

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

(2013) E. Rosalie Witjas-Paalberends et al.   CARDIOVASCULAR RESEARCH

Cardiomyopathy Mutations in the Tail of β-Cardiac Myosin Modify the Coiled-coil Structure and Affect Integration into Thick Filaments in Muscle Sarcomeres in Adult Cardiomyocytes

(2013) Marcin Wolny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Coiled coils and SAH domains in cytoskeletal molecular motors

(2012) Michelle Peckham   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Hypertrophic Cardiomyopathy in 2012

(2012) Carolyn Y. Ho   CIRCULATION

A new mutational mechanism for hypertrophic cardiomyopathy

(2012) Laura Pezzoli et al.   GENE

Mutations in MYH7 cause Multi-minicore Disease (MmD) with variable cardiac involvement

(2012) T. Cullup et al.   NEUROMUSCULAR DISORDERS

Prenatal ultrasound diagnosis ofMYH7non-compaction cardiomyopathy

(2012) Y. M. Hoedemaekers et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy

(2011) Snigdha Tripathi et al.   BASIC RESEARCH IN CARDIOLOGY

Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins

(2011) Zenon Grabarek   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting

(2011) J. Lossie et al.   CARDIOVASCULAR RESEARCH

Cardiac and skeletal muscle expression of mutant β-myosin heavy chains, degree of functional impairment and phenotypic heterogeneity in hypertrophic cardiomyopathy

(2011) Marina Di Domenico et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of Pathogenic Proline Mutations on Myosin Assembly

(2011) Massimo Buvoli et al.   JOURNAL OF MOLECULAR BIOLOGY

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Ebstein’s anomaly may be caused by mutations in the sarcomere protein gene MYH7

(2011) K. van Engelen et al.   Netherlands Heart Journal

Research Priorities in Hypertrophic Cardiomyopathy

(2010) Thomas Force et al.   CIRCULATION

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry

(2010) M. J. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in the β-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype

(2009) Thomas Z. Armel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estimate of the abundance of cardiomyopathic mutations in the β-myosin gene

(2009) Micah Hamady et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes

(2009) Thomas Z. Armel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mutations in the  -myosin rod cause myosin storage myopathy via multiple mechanisms

(2009) T. Z. Armel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

(2008) W. Glenn L. Kerrick et al.   FASEB JOURNAL

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Defective regulation of contractile function in muscle fibres carrying an E41K β-tropomyosin mutation

(2008) Julien Ochala et al.   JOURNAL OF PHYSIOLOGY-LONDON

The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils

(2008) Alexandra Belus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fifty years of coiled-coils and α-helical bundles: A close relationship between sequence and structure

(2008) David A.D. Parry et al.   JOURNAL OF STRUCTURAL BIOLOGY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics Assessment of β-Myosin Mutations Reveals Myosin's High Sensitivity to Mutations

(2008) Massimo Buvoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE