Research Advances on Pathways of Nickel-Induced Apoptosis

Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells

(2015) Maqusood Ahamed et al.   CHEMOSPHERE

An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy

(2015) Noboru Iwasaki et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The neuroprotective effects of taurine against nickel by reducing oxidative stress and maintaining mitochondrial function in cortical neurons

(2015) Shangcheng Xu et al.   NEUROSCIENCE LETTERS

NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells

(2015) Wei-Xia Duan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dietary NiCl2 causes G2/M cell cycle arrest in the broiler’s kidney

(2015) Hongrui Guo et al.   Oncotarget

NHE9 induces chemoradiotherapy resistance in esophageal squamous cell carcinoma by upregulating the Src/Akt/β-catenin pathway and Bcl-2 expression

(2015) Junying Chen et al.   Oncotarget

Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens

(2015) Shuang Yin et al.   Oncotarget

New dimension in therapeutic targeting of BCL-2 family proteins

(2015) Samaher Besbes et al.   Oncotarget

Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-κB pathway and reduction of anti-inflammatory mediator expression in the kidney

(2015) Hongrui Guo et al.   Oncotarget

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

(2015) Andrew R. Lavik et al.   Oncotarget

Effect of Dietary Nickel Chloride on Splenic Immune Function in Broilers

(2014) Jianying Huang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

NiCl2-Down-Regulated Antioxidant Enzyme mRNA Expression Causes Oxidative Damage in the Broiler’s Kidney

(2014) Hongrui Guo et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Downregulation of TLR4 and 7 mRNA Expression Levels in Broiler’s Spleen Caused by Diets Supplemented with Nickel Chloride

(2014) Jianying Huang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Inhibitive Effects of Nickel Chloride (NiCl2) on Thymocytes

(2014) Kun Tang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation

(2014) Anton Kichev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of thermal stress and nickel exposure on biomarkers responses in Mytilus galloprovincialis (Lam)

(2014) Hajer Attig et al.   MARINE ENVIRONMENTAL RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Apoptosis Signalling Kinase-1 (ASK-1) Does Not Prevent the Development of Neuropathy in Streptozotocin-Induced Diabetic Mice

(2014) Victoria L. Newton et al.   PLoS One

New directions in ER stress-induced cell death

(2013) Susan E. Logue et al.   APOPTOSIS

Nickel-induced oxidative stress and apoptosis in Carassius auratus liver by JNK pathway

(2013) Gui-Hong Zheng et al.   AQUATIC TOXICOLOGY

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dietary Nickel Chloride Restrains the Development of Small Intestine in Broilers

(2013) Bangyuan Wu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Reactive Oxygen Species-Mediated DNA Damage and Apoptosis in Human Skin Epidermal Cells After Exposure to Nickel Nanoparticles

(2013) Saud Alarifi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2)

(2013) Maqusood Ahamed et al.   CHEMOSPHERE

Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers

(2013) Bangyuan Wu et al.   FOOD AND CHEMICAL TOXICOLOGY

Nickel Induces Interleukin-1β Secretion via the NLRP3–ASC–Caspase-1 Pathway

(2013) Xiujin Li et al.   INFLAMMATION

Sesamin Protects Mouse Liver against Nickel-Induced Oxidative DNA Damage and Apoptosis by the PI3K-Akt Pathway

(2013) Chan-Min Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reproductive toxicology of nickel – Review

(2013) Zsolt Forgacs et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Oxidative DNA damage may not mediate Ni-induced genotoxicity in marine mussels: Assessment of genotoxic biomarkers and transcriptional responses of key stress genes

(2013) Lorna J. Dallas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1

(2013) Sanjivan Gautam et al.   PLoS One

Cellular Mechanisms Controlling Caspase Activation and Function

(2013) A. B. Parrish et al.   Cold Spring Harbor Perspectives in Biology

Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

(2013) Bangyuan Wu et al.   International Journal of Environmental Research and Public Health

The Association between Splenocyte Apoptosis and Alterations of Bax, Bcl-2 and Caspase-3 mRNA Expression, and Oxidative Stress Induced by Dietary Nickel Chloride in Broilers

(2013) Jianying Huang et al.   International Journal of Environmental Research and Public Health

Tissue specificity in nickel uptake and induction of oxidative stress in kidney and spleen of goldfish Carassius auratus, exposed to waterborne nickel

(2012) Olga I. Kubrak et al.   AQUATIC TOXICOLOGY

Oxidative stress in apoptosis and cancer: an update

(2012) José M. Matés et al.   ARCHIVES OF TOXICOLOGY

Nickel induces apoptosis in human neutrophils

(2012) Marisa Freitas et al.   BIOMETALS

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Nickel oxide nanoparticles induce cytotoxicity, oxidative stress and apoptosis in cultured human cells that is abrogated by the dietary antioxidant curcumin

(2012) Maqsood A. Siddiqui et al.   FOOD AND CHEMICAL TOXICOLOGY

Nickel species: Analysis and toxic effects

(2012) Dirk Schaumlöffel   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Upregulating Noxa by ER Stress, Celastrol Exerts Synergistic Anti-Cancer Activity in Combination with ABT-737 in Human Hepatocellular Carcinoma Cells

(2012) Hong Zhu et al.   PLoS One

Acute oral toxicity of nickel compounds

(2012) Rayetta G. Henderson et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hepatic toxicity of nickel chloride in mice

(2012) Khalid H. Gathwan et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway

(2012) Yi-Fen Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Body Piercing

(2011) Jaimee Holbrook et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Molecular targets of oxidative stress

(2011) Simon V. Avery   BIOCHEMICAL JOURNAL

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats

(2011) K. Amudha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Differential biochemical response of rat kidney towards low and high doses of NiCl2as revealed by NMR spectroscopy

(2011) Ritu Tyagi et al.   JOURNAL OF APPLIED TOXICOLOGY

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

(2011) Michael J. Jurczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Role of Bcl-2 family proteins and caspases in the regulation of apoptosis

(2011) Mohammad Shamsul Ola et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Allicin induces apoptosis in EL-4 cellsin vitroby activation of expression of caspase-3 and -12 and up-regulation of the ratio of Bax/Bcl-2

(2011) Ziren Wang et al.   NATURAL PRODUCT RESEARCH

Aquatic Birnavirus-Induced ER Stress-Mediated Death Signaling Contribute to Downregulation of Bcl-2 Family Proteins in Salmon Embryo Cells

(2011) Hui Ling Huang et al.   PLoS One

Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling

(2011) Zengguang Xu et al.   TOXICOLOGY

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Elucidating the mechanisms of nickel compound uptake: A review of particulate and nano-nickel endocytosis and toxicity

(2011) Alexandra Muñoz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells

(2011) Eshan Patel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxic response of nickel nanoparticles in human lung epithelial A549 cells

(2011) Maqusood Ahamed   TOXICOLOGY IN VITRO

Protective effects of grape seed procyanidin extract against nickel sulfate-induced apoptosis and oxidative stress in rat testes

(2011) Li Su et al.   TOXICOLOGY MECHANISMS AND METHODS

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptogenic factors released from mitochondria

(2010) David L. Vaux   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

(2010) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Reactive Oxygen Species-Activated Akt/ASK1/p38 Signaling Pathway in Nickel Compound-Induced Apoptosis in BEAS 2B Cells

(2010) Jingju Pan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MicroRNA regulation of core apoptosis pathways in cancer

(2010) Raquel T. Lima et al.   EUROPEAN JOURNAL OF CANCER

Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel

(2010) Serena Bonin et al.   EXPERIMENTAL DERMATOLOGY

Regulation of the Apaf-1-caspase-9 apoptosome

(2010) S. B. Bratton et al.   JOURNAL OF CELL SCIENCE

Nickel accumulation and its effect on biomass, protein content and antioxidative enzymes in roots and leaves of watercress (Nasturtium officinale R. Br.)

(2010) Fatih Duman et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Nickel(II)-Induced Oxidative Stress, Apoptosis, G2/M Arrest, and Genotoxicity in Normal Rat Kidney Cells

(2010) Chang-Yu Chen et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Nickel induced structural and functional alterations in mouse Leydig cells in vitro

(2010) Jiřina Zemanová Kročková et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Carcinogenicity assessment of water-soluble nickel compounds

(2009) Julie E. Goodman et al.   CRITICAL REVIEWS IN TOXICOLOGY

Oxidative damage effects in the copepod Tigriopus japonicus Mori experimentally exposed to nickel

(2009) Minghua Wang et al.   ECOTOXICOLOGY

Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

(2009) Lingai Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin

(2009) Masae Furuhata et al.   EXPERIMENTAL CELL RESEARCH

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity

(2009) Annamaria Buschini et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors

(2009) Camillo Porta et al.   JOURNAL OF UROLOGY

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway

(2009) Jinshun Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

(2008) Detmar Beyersmann et al.   ARCHIVES OF TOXICOLOGY

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Apoptotic signaling by c-MYC

(2008) B Hoffman et al.   ONCOGENE

Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway

(2008) Qin Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium

(2007) Konstantin Salnikow et al.   CHEMICAL RESEARCH IN TOXICOLOGY