Review
Oncology
Yitian Li, Jing Zhang, Huihui Zhou, Zhen Du
Summary: This review discusses the promising anticancer effects of naturally occurring phytochemicals and their derivatives in anaplastic thyroid cancer. These phytochemicals show potential in inhibiting cell growth, inducing apoptosis, promoting cell cycle arrest, and suppressing angiogenesis. They can also serve as adjuvants to enhance the anticancer effects of other drugs. However, drug resistance is still a challenge in some cases. This research enriches our understanding of the anticancer effects of phytochemicals and offers alternative therapies to prevent drug resistance in anaplastic thyroid cancer.
Article
Nutrition & Dietetics
Nagisa Mori, Neil Murphy, Norie Sawada, David Achaintre, Taiki Yamaji, Augustin Scalbert, Motoki Iwasaki, Manami Inoue, Marc J. Gunter, Shoichiro Tsugane
Summary: This study measured the plasma concentrations of 35 polyphenols and assessed their associations with colon cancer risk. The results showed that certain polyphenols in coffee were inversely associated with colon cancer risk, although these associations were not significant after adjustment for multiple comparisons.
CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Cord Naujokat, Dwight L. McKee
Summary: Cancer stem cells (CSCs) possess resistance mechanisms to current cancer therapies and pathways for survival. Certain phytochemicals can interfere with these pathways and eliminate CSCs, offering a potential novel therapeutic strategy against cancer.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Celestino Santos-Buelga, Susana Gonzalez-Manzano, Ana M. Gonzalez-Paramas
Summary: While moderate red wine drinking is believed to be beneficial for health, alcohol consumption may have serious consequences. The Mediterranean diet includes not only wine, but also olive oil, fruits, grains, and vegetables, which are also healthy choices.
Review
Genetics & Heredity
Ke-Xue Li, Miao-Jin Ji, Hai-Jian Sun
Summary: Phytochemicals, including resveratrol, have emerged as alternative therapies with therapeutic effects on various pathologies, including diabetic kidney disease. Resveratrol has been found to have a broad spectrum of health benefits, particularly in ameliorating chronic or acute kidney injury in the renal system. Further research is needed to overcome limitations, such as poor bioavailability, and improve the efficacy of resveratrol in diabetic nephropathy therapy.
Article
Education, Scientific Disciplines
Sabna Kotta
Summary: The study developed a nanoemulsion of resveratrol for the treatment of colorectal cancer, with promising results showing its cytotoxic effect on colon cancer cells and non-toxicity to non-tumor cells, indicating its potential for colorectal cancer management.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Article
Anatomy & Morphology
Ayse Cakir Gundogdu, Rumeysa Ozyurt
Summary: Epithelial sodium channels (ENaCs) play important roles in cancer progression, including proliferation, migration, invasion, and apoptosis. Inhibition of ENaCs may have therapeutic potential in cancer treatment. Resveratrol, a natural polyphenol, activates AMP-activated protein kinase (AMPK) and reduces ENaC abundance in cell membrane. However, the effects of resveratrol on ENaCs in cancer cells are unknown. This study investigated the effects of resveratrol on ENaCs in human colon cancer cells and found that resveratrol activates AMPK, inhibits ENaCs, decreases cell viability, and increases apoptosis. These findings suggest that ENaC inhibition through AMPK activation may contribute to the anti-cancer effects of resveratrol.
Review
Biochemistry & Molecular Biology
Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei
Summary: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive alcohol consumption. Despite advances in the early diagnosis and treatment of breast cancer, it remains a leading cause of cancer-related death in women worldwide. Phytochemicals, such as resveratrol, have shown promise in preventing and treating breast cancer. While resveratrol can affect various signaling pathways in vitro, its efficacy in animal models of breast cancer has been disappointing.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Nabil A. Alhakamy, Shadab Md
Summary: Phytochemicals, particularly resveratrol, formulated into nanoemulsions through ultrasonication show promising potential for the treatment of neurodegenerative disorders. The nanoemulsion formulation demonstrated superior in vitro release and permeation properties, as well as high brain targeting efficacy in rat intranasal administration. Incorporation of resveratrol into nanoemulsions could be a promising alternative for managing Alzheimer's disease.
Review
Chemistry, Medicinal
Ravi Gor, Ilangovan Ramachandran, Satish Ramalingam
Summary: Endocrine cancer refers to the uncontrolled growth of cells in the hormone-producing glands. With the increasing incidence of pancreatic and thyroid cancers, the study of cancer stem cells has become more important. Finding natural phytochemicals that target cancer stem cells can improve the prognosis and life expectancy of cancer patients.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Helena Moreira, Anna Szyjka, Justyna Grzesik, Katarzyna Pelc, Magdalena Zuk, Anna Kulma, Fathi Emhemmed, Christian D. Muller, Kazimierz Gasiorowski, Ewa Barg
Summary: The recovery rate in patients with metastatic colorectal cancer is low due to drug resistance and the presence of colorectal cancer stem cells (CSCs). Phytochemicals like -celastrol and resveratrol have shown promise in colon cancer therapy due to their low toxicity and ability to interact with various biological targets. This study investigates the anticancer mechanisms of these compounds against metastatic colon cancer cells and their capacity to eradicate CSCs.
Article
Biochemistry & Molecular Biology
Xiaoying Qin, Honghong Luo, Yixuan Deng, Xintong Yao, Jie Zhang, Baicheng He
Summary: Resveratrol, a natural compound, exhibits anti-cancer activity against colon cancer cells by activating the Hippo/YAP signaling pathway and disrupting the interaction between YAP and TEAD, leading to inhibition of cell proliferation and induction of apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ting-Ann Lin, Wei-Sheng Lin, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hisung Pan
Summary: The study demonstrates that OXY inhibits human colon cancer cell migration by regulating both EMT and miRNAs, suggesting its potential anti-metastatic properties in CRC.
Article
Pharmacology & Pharmacy
Apeksha Saraf, Nidhi Dubey, Nitin Dubey, Mayank Sharma
Summary: Globally, cancer is a major cause of death with colon cancer being a significant contributor. Current cancer treatments have side effects, leading to exploration of natural compounds like DADS. DADS from garlic has shown anticancer activity against colon cancer, but its poor water solubility limits its clinical use.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Kai Wang, De-Zhi Hou, Yi-Ming Ouyang, Ping Ling
Summary: This study aimed to evaluate the effects of resveratrol in combination with paclitaxel on apoptosis and its underlying mechanisms in the Caco-2 colon cancer cell line. The results showed that resveratrol significantly enhanced the cytotoxic effects of paclitaxel, increased the expression levels of g-H2AX protein, and promoted apoptosis induction by increasing reactive oxygen species (ROS) levels, inducing oxidative DNA damage, and decreasing cellular antioxidant defense. Therefore, the combination of resveratrol and paclitaxel can enhance cellular cytotoxicity and induce potent apoptosis in cancer cell lines.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Kui-Jin Kim, Jihye Lee, Yeonhwa Park, Seong-Ho Lee
BIOMOLECULES & THERAPEUTICS
(2015)
Article
Biochemistry & Molecular Biology
Hong Jun Shao, Zhiyuan Lou, Jin Boo Jeong, Kui Jin Kim, Jihye Lee, Seong-Ho Lee
BIOMOLECULES & THERAPEUTICS
(2015)
Article
Agriculture, Multidisciplinary
Jihye Lee, Jee-Young Imm, Seong-Ho Lee
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Jihye Lee, Yiren Yue, Yeonhwa Park, Seong-Ho Lee
JOURNAL OF MEDICINAL FOOD
(2017)
Article
Biochemistry & Molecular Biology
Taekyu Ha, Jihye Lee, Zhiyuan Lou, Bok-Soon Lee, Chul-Ho Kim, Seong-Ho Lee
MOLECULAR CARCINOGENESIS
(2019)
Article
Chemistry, Medicinal
Jihye Lee, Byungwhi Kong, Seong-Ho Lee
JOURNAL OF MEDICINAL FOOD
(2020)
Review
Immunology
Hee-Seop Lee, Jihye Lee, Dmitriy Smolensky, Seong-Ho Lee
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Seong-Ho Lee, Hee-Seop Lee, Jihye Lee, Darshika Amarakoon, Zhiyuan Lou, Leela E. Noronha, Thomas J. Herald, Ramasamy Perumal, Dmitriy Smolensky
Summary: High-phenolic sorghum bran extracts have been found to inhibit proliferation and induce apoptosis in colorectal cancer cell lines. They can repress NF-kappa B and PI3K/AKT pathways while activating AMPK and autophagy, which significantly suppress tumor formation in colorectal cancer mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jihye Lee, Zhong Liu, Ying Gai Tusing, Chao Li, Erik Westin, Wei Li, Rui Zhao
Summary: iPSCs derived from B lymphocytes of two AD patients homozygous for the APOE e3 allele express pluripotency markers, possess the ability to differentiate into all three embryonic layers, and have normal karyotypes, making them valuable in vitro models for studying AD and evaluating new treatments.
STEM CELL RESEARCH
(2021)
Article
Physiology
Kyuwon Lee, Hyeonju Yu, Stephanie Shouse, Byungwhi Kong, Jihye Lee, Seong-Ho Lee, Kwang Suk Ko
Summary: The study revealed that deficiency of liver-specific Phb1 resulted in abnormal gene expression related to lipid metabolism and liver diseases in liver tissues, potentially causing liver injuries and enhanced immune responses.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Xin Wang, Jihye Lee, Changqing Xie
Summary: Some cancers have a higher relapse rate due to the presence of cancer stem cells (CSCs) that display stem-like characteristics and contribute to tumor growth, metastasis, and poor prognosis. Autophagy is a mechanism that helps CSCs maintain their stemness and resistance to therapy. However, recent studies have also suggested that autophagy can have anti-tumor effects. This review summarizes the current literature on the role of autophagy in CSC maintenance and suggests that regulation of autophagy could be targeted in future cancer therapies.
Article
Cell & Tissue Engineering
Jing Bian, Jianyang Fu, Xin Wang, Jihye Lee, Gagandeep Brar, Freddy E. Escorcia, Maggie Cam, Changqing Xie
Summary: In this study, the immunogenicity of malignant cells in human intrahepatic cholangiocarcinoma (iCCA) was investigated using single-cell transcriptomic data. The results showed significant heterogeneity in stemness/differentiation states among malignant cells. High stemness malignant cells exhibited lower expression levels of major histocompatibility complex II molecules and significant expression of certain cytokine members, suggesting immune evasion and communication with surrounding immune cells.
STEM CELLS INTERNATIONAL
(2022)
Article
Oncology
Jihye L. Golino, Xin Wang, Jing Bian, Benjamin Ruf, Michael Kelly, Baktiar O. Karim, Maggie C. Cam, Changqing Xie
Summary: In this study, the researchers found that verteporfin, an inhibitor of the YAP1 pathway, reduces tumorigenesis and tumor growth in a murine model of cholangiocarcinoma by altering the immune cell profile and decreasing the stem-like properties of malignant cells.
Review
Cell Biology
Jihye L. L. Golino, Xin Wang, Hoyoung M. M. Maeng, Changqing Xie
Summary: The prognosis of cholangiocarcinoma is poor due to the heterogeneity of its tumor ecosystem, which affects tumorigenesis, therapeutic resistance, and clinical outcomes. Recent advancements in single-cell RNA sequencing (scRNA-seq) have provided a detailed understanding of the heterogeneity of various cell components in the tumor ecosystem, including stromal and malignant cells, as well as infiltrating immune cells. This review examines tumor heterogeneity, the interaction between different cellular components, discusses current limitations, and proposes future directions and clinical applications.
Article
Cell & Tissue Engineering
Xin Wang, Jihye L. Golino, Nga Voong Hawk, Changqing Xie
Summary: Cholangiocarcinoma is a aggressive liver cancer with limited treatment options. Cancer stem cells (CSCs) are believed to be responsible for cancer initiation, metastasis, and relapse. However, studying these cells is challenging due to their elusive nature and differences in identification among different types of cancer. The interaction between CSCs and immune cells, such as macrophages, in the tumor microenvironment is still largely unknown.
STEM CELL REVIEWS AND REPORTS
(2023)