Conformational Analysis of Misfolded Protein Aggregation by FRET and Live-Cell Imaging Techniques

Redox sensor proteins for highly sensitive direct imaging of intracellular redox state

(2015) Kazunori Sugiura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

(2015) Edward Avezov et al.   BMC BIOLOGY

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Control of systemic proteostasis by the nervous system

(2015) Pablo Mardones et al.   TRENDS IN CELL BIOLOGY

How the Nucleus Copes with Proteotoxic Stress

(2014) Yoko Shibata et al.   CURRENT BIOLOGY

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

(2014) P. van Oosten-Hawle et al.   GENES & DEVELOPMENT

Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1

(2014) Akira Kitamura et al.   GENES TO CELLS

Dimerization, Oligomerization, and Aggregation of Human Amyotrophic Lateral Sclerosis Copper/Zinc Superoxide Dismutase 1 Protein Mutant Forms in Live Cells

(2014) Jiho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of Polyglutamine-containing Fibrils from Time-resolved Fluorescence Decay

(2014) Christoph Röthlein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative In Vivo Fluorescence Cross-Correlation Analyses Highlight the Importance of Competitive Effects in the Regulation of Protein-Protein Interactions

(2014) W. Sadaie et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease

(2014) Reiko Inagi et al.   Nature Reviews Nephrology

Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative Diseases

(2014) Chen Zheng et al.   Neurodegenerative Diseases

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

(2014) Satoshi Tsunoda et al.   eLife

The 1.6 Å resolution structure of a FRET-optimized Cerulean fluorescent protein

(2013) Jennifer L. Watkins et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Determination of dissociation constant of the NFκB p50/p65 heterodimer using fluorescence cross-correlation spectroscopy in the living cell

(2013) Manisha Tiwari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The interaction of Hsp104 with yeast prion Sup35 as analyzed by fluorescence cross-correlation spectroscopy

(2013) Shohei Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prefoldin Protects Neuronal Cells from Polyglutamine Toxicity by Preventing Aggregation Formation

(2013) Erika Tashiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

(2013) Claudia Simões-Pires et al.   Molecular Neurodegeneration

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Long-Distance Integration of Nuclear ERK Signaling Triggered by Activation of a Few Dendritic Spines

(2013) S. Zhai et al.   SCIENCE

Ligand binding and aggregation of pathogenic SOD1

(2013) Gareth S.A. Wright et al.   Nature Communications

Red fluorescent proteins: chromophore formation and cellular applications

(2012) Atsushi Miyawaki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone

(2012) Magdalena Bartoszewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Orange Fluorescent Protein with a Large Stokes Shift for Single-Excitation Multicolor FCCS and FRET Imaging

(2012) Daria M. Shcherbakova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimum set of mutations needed to optimize cyan fluorescent proteins for live cell imaging

(2012) Marie Erard et al.   Molecular BioSystems

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

(2012) S. J. Weisberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

Amyloid Structure: Conformational Diversity and Consequences

(2011) Brandon H. Toyama et al.   Annual Review of Biochemistry

Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress

(2011) Leena Latonen   BIOESSAYS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus

(2010) Akira Kitamura et al.   FEBS Journal

A Novel Fluorescent Sensor Protein for Visualization of Redox States in the Cytoplasm and in Peroxisomes

(2010) T. Yano et al.   MOLECULAR AND CELLULAR BIOLOGY

Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis

(2010) Derrick Sek Tong Ong et al.   Nature Chemical Biology

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

(2010) K. A. Geiler-Samerotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative study of synthetic Hox transcription factor-DNA interactions in live cells

(2010) V. Vukojevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions, protein homeostasis, and phenotypic diversity

(2010) Randal Halfmann et al.   TRENDS IN CELL BIOLOGY

Quantitative Comparison of Different Fluorescent Protein Couples for Fast FRET-FLIM Acquisition

(2009) Sergi Padilla-Parra et al.   BIOPHYSICAL JOURNAL

Binding Modes of Thioflavin-T to the Single-Layer β-Sheet of the Peptide Self-Assembly Mimics

(2009) Chun Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

An ultramarine fluorescent protein with increased photostability and pH insensitivity

(2009) Wataru Tomosugi et al.   NATURE METHODS

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE