Article
Biochemical Research Methods
Sabine Szunerits, Hannes Doerfler, Quentin Pagneux, John Daniel, Shekhar Wadekar, Eloise Woitrain, Dennis Ladage, David Montaigne, Rabah Boukherroub
Summary: Since the outbreak of the SARS-CoV-2 pandemic, the analysis of exhaled breath has gained attention as a non-invasive diagnostic approach. Mass spectrometry has been recognized as a powerful tool for clinical diagnostics, but its use is limited in the clinical setting. Recent developments focus on online sampling using portable and wearable devices, such as face masks, which have the potential to enable fast and non-invasive diagnosis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jing-Wen Xu, Yan-Yan Song
Summary: Volatile organic compounds (VOCs) in exhaled breath can be used as disease markers for early cancer diagnosis, and surface-enhanced Raman scattering (SERS) can be applied for detecting these markers. However, the challenges of low detection sensitivity and high misdiagnosis rate in the detection of disease markers in exhaled breath using SERS have impeded its application. In a recent study, a Cu-doped p-n heterojunction semiconductor with spongy-like structure was used as a SERS substrate, and combined with Raman barcodes, it successfully detected multiple biomarkers in human exhaled breath simultaneously for diagnosis of lung cancer with high sensitivity, providing a new strategy for early cancer diagnosis.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Health Care Sciences & Services
Dian Kesumapramudya Nurputra, Ahmad Kusumaatmadja, Mohamad Saifudin Hakim, Shidiq Nur Hidayat, Trisna Julian, Budi Sumanto, Yodi Mahendradhata, Antonia Morita Iswari Saktiawati, Hutomo Suryo Wasisto, Kuwat Triyana
Summary: The RT-qPCR method is widely used for detecting SARS-CoV-2, but clinicians prefer to diagnose COVID-19 by combining clinical signs and symptoms, laboratory tests, imaging, and multivariable clinical prediction models. Researchers report the development of a low cost, noninvasive method using a portable electronic nose (GeNose C19) to rapidly screen for COVID-19.
NPJ DIGITAL MEDICINE
(2022)
Article
Chemistry, Analytical
Hao He, Maofeng Cao, Xiaxia Yue, Mengxi Xu, Lei Wang, Bin Ren
Summary: A collaborative low-rank matrix approximation method was developed for fast hyperspectral Raman imaging and TERS imaging, demonstrating high signal-to-noise ratio and improved performance in signal extraction. The method significantly reduces noise, accelerates data acquisition, and provides a promising tool for fast TERS and conventional Raman imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Sagnik Das, Preeti Lata Mahapatra, Partha Pratim Mondal, Tanushri Das, Mrinal Pal, Debdulal Saha
Summary: This study presented a highly sensitive and stable cobalt chromite thick film-based trace acetone sensor with quick response and recovery times, showing great potential for diabetes detection. The sensor exhibited a high p-type response to acetone vapor, good resolution between different concentrations, and fast response and recovery times. It also showed stability and repeatability in measurements.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Analytical
Xiaoping Zhang, Xiang Ren, Yuan Zhong, Konstantin Chingin, Huanwen Chen
Summary: The study detected ketones in exhaled breath using mass spectrometry and developed a fast, sensitive, noninvasive method for ketone analysis. Results showed higher levels of acetone in the breath of smokers compared to non-smokers.
Article
Biophysics
Lichao Liu, Teng Fei, Xin Guan, Hongran Zhao, Tong Zhang
Summary: The incorporation of organic acids into crosslinked hydrogels enhances the detection performance of NH3 in high humidity environments, resulting in sensors with excellent selectivity and stability towards NH3 under high humidity conditions.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Analytical
Tutku Beduk, Ceren Durmus, Simge Balaban Hanoglu, Duygu Beduk, Khaled Nabil Salama, Tuncay Goksel, Kutsal Turhan, Suna Timur
Summary: Health care monitoring is a vast field of research with great potential to solve many problems in human life. Non-invasive health monitoring has become essential for early diagnosis of various diseases. Current breath analyzing systems offer a cost-effective, sensitive platform for straightforward analysis, but face challenges in terms of practicality, on-site ability, and accessibility.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Energy & Fuels
Liu Chuanhai, Chen Ran, Zhang Baoyong, Wu Qiang, Zhang Qiang, Gao Xia, Wu Qiong
Summary: The accurate determination of coal mine gas separation product characteristics is essential for gas separation applications. Gas hydrates synthesized from gases with different compositions were analyzed using in situ Raman spectroscopy. The study found that the crystal structure of the mixed-gas hydrate is stable in the presence of 75% CO2 compared to 70% CO2, with large cages being predominantly occupied by guest molecules while small cages are not easily occupied.
FRONTIERS IN ENERGY RESEARCH
(2021)
Article
Spectroscopy
Johannes Glockler, Boris Mizaikoff, Lorena Diaz de Leon-Martinez
Summary: The COVID-19 pandemic poses a global challenge, especially with the emergence of long-COVID. Various measures, including case counting, variant assessment, drug treatments, mask usage, social distancing, vaccination, rehabilitation, and mass screening, are crucial in mitigating the pandemic's impact. This study focuses on gas-phase infrared spectroscopy as a proof-of-concept for detecting COVID-19 patients' breath biomarkers. The analysis demonstrates the potential of this method in providing faster and cheaper screening and follow-up for infected individuals.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Asheesh Kumar, Hari Prakash Veluswamy, Sanat Kumar, Rajnish Kumar, Praveen Linga
Summary: Clathrate hydrate-based sustainable technologies, such as solidified natural gas (SNG) technology, show great potential for storing natural gas. Experiments on mixed hydrates in a seawater environment reveal the promotional effect of seawater on hydrate formation and suggest the economic feasibility of using natural seawater to enhance SNG technology.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Nanoscience & Nanotechnology
Hang Yuan, Linna Guo, Qianqian Su, Xianlong Su, Yue Wen, Tao Wang, Pengyuan Yang, Ming Xu, Fuyou Li
Summary: Porphyria is a genetic disease that results in excessive accumulation of porphyrins in the body, causing photosensitivity and liver damage. There is an urgent need for efficient and fast detection methods, and a molecular afterglow reporter-based sensing scheme shows great clinical potential for quantitative detection of porphyrins in whole blood.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Spectroscopy
Abdu Saeed, Fouad Abolaban
Summary: The study irradiated 20 rats with fast neutrons, finding that low-dose fast neutrons can cause tiny changes in the structure of hemoglobin, including alterations in sulfur-hydrogen bonds and the oxidation state of iron atoms. UV-Vis spectroscopy revealed that the irradiated rats might be more susceptive to oxidation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Dingyi Feng, Hongrong Zheng, Hao Sun, Jinze Li, Jiawei Xi, Li Deng, Yasong Guo, Biqiang Jiang, Jianlin Zhao
Summary: A fiber-optic humidity sensor based on excessively tilted fiber grating (Ex-TFG) wrapped with tin dioxide (SnO2)/ polyvinyl alcohol (PVA) hybrid nanofibers is presented. The humidity rise causes changes in refractive index and geometry size, resulting in changes in the transmitted spectrum of the Ex-TFG. The wrapped grating shows significantly improved humidity sensitivity compared to pure PVA film coated ones.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Sang Hun Kim, Young Kook Moon, Jong-Heun Lee, Yun Chan Kang, Seong-Yong Jeong
Summary: A chemiresistive-type gas sensor for detecting exhaled hydrogen has been developed, showing excellent selectivity, high response speed, and low detection limit. The sensor holds great potential for disease diagnosis.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Biochemistry & Molecular Biology
Christian Domes, Timea Frosch, Juergen Popp, Torsten Frosch
Article
Chemistry, Analytical
Andreas Knebl, Robert Domes, Sebastian Wolf, Christian Domes, Juergen Popp, Torsten Frosch
ANALYTICAL CHEMISTRY
(2020)
Article
Ecology
Karin Potthast, Stefanie Meyer, Alexander Tischer, Gerd Gleixner, Anne Sieburg, Torsten Frosch, Beate Michalzik
Summary: This study investigates the impact of insect herbivory on nutrient cycling in a grassland ecosystem under nutrient-poor soil conditions. Results show that herbivory leads to a reduction in aboveground grass biomass and increased dissolved carbon and nitrogen in throughfall solutions. Additionally, nitrogen from insect feces is rapidly translocated to the belowground system, facilitating root uptake and reducing nitrogen losses.
Article
Biochemical Research Methods
Annika Blohm, Swatantar Kumar, Andreas Knebl, Martina Herrmann, Kirsten Kuesel, Jurgen Popp, Torsten Frosch
Summary: This study aimed to investigate substrate preferences for two mixotrophic denitrifying bacterial strains, Acidovorax delafieldii and Hydrogenophaga taeniospiralis, under heterotrophic, autotrophic, or mixotrophic conditions. The results demonstrated that Acidovorax delafieldii preferentially performed heterotrophic denitrification in the mixotrophic sub-experiments, while Hydrogenophaga taeniospiralis preferred autotrophic denitrification in the mixotrophic incubation. Advanced Raman multi-gas analysis proved useful in studying substrate use and electron donor preferences in denitrification based on comprehensive quantification of complex microbial gas exchange processes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Andreas Knebl, Christian Domes, Robert Domes, Sebastian Wolf, Juergen Popp, Torsten Frosch
Summary: Power-to-gas is a heavily discussed option for storing surplus electricity from renewable sources by feeding generated hydrogen into the gas grid. Frequent monitoring of gas is necessary to ensure safety and stable operation. Raman gas spectroscopy is favored for future point-of-use monitoring, offering comprehensive analysis of fuel gas components.
ANALYTICAL CHEMISTRY
(2021)
Correction
Chemistry, Analytical
Andreas Knebl, Robert Domes, Di Yan, Juergen Popp, Susan Trumbore, Torsten Frosch
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Analytical
Andreas Knebl, Christian Domes, Robert Domes, Sebastian Wolf, Juergen Popp, Torsten Frosch
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Dana Cialla-May, Christoph Krafft, Petra Roesch, Tanja Deckert-Gaudig, Torsten Frosch, Izabella J. Jahn, Susanne Pahlow, Clara Stiebing, Tobias Meyer-Zedler, Thomas Bocklitz, Iwan Schie, Volker Deckert, Juergen Popp
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Liangling Wang, Wei Zheng, Francesco Vitale, Xiangzhou Zhang, Xiuling Li, Yanchen Ji, Zhen Liu, Omid Ghaebi, Christian T. Plass, Robert Domes, Torsten Frosch, Giancarlo Soavi, Elke Wendler, Yuhai Zhang, Carsten Ronning
Summary: Alloyed lead-free double perovskites exhibit intense photoluminescence, environmental friendliness, and long-term device operation. The strong electron-phonon coupling plays a crucial role in the formation of self-trapped excitons in lead-free double perovskites. Understanding the strong coupling between longitudinal-optical phonons and electrons is of paramount importance for the design of future optoelectronic devices.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Sebastian Wolf, Robert Domes, Andreas Merian, Christian Domes, Torsten Frosch
Summary: Raman spectroscopy provides high chemical selectivity, revealing small differences in weak interactions and molecular structure changes. By integrating diffractive optical elements, lens arrays, and fiber bundles, parallelized and highly sensitive Raman difference spectroscopy can be achieved in a microtiter-array setup. This setup enables the investigation of subtle changes in biochemically important molecular interactions and the monitoring of highly parallelized chemical reactions.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sebastian Wolf, Juergen Popp, Torsten Frosch
Summary: High-throughput screening requires efficient spectral imaging techniques, but current designs lack the ability to measure hyperspectral images or microscopy setups. This study presents a novel setup for parallelized hyperspectral Raman spectroscopy that allows simultaneous acquisition of 64 high-resolution Raman spectra from a multi-well plate. This setup offers a time-saving solution for high-throughput screening applications and allows real-time chemical comparison between different micro-well spots.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Robert Domes, Torsten Frosch
Summary: Deep ultraviolet resonance Raman experiments were conducted to investigate the antimalarial drug FQ. The drug's behavior in different pH environments and membrane polarities was simulated using buffered aqueous solutions. Density functional theory calculations were performed to analyze the drug's microspeciation and shifts in Raman signals. The study found that FQ exists in different forms in polar and nonpolar environments and determined the limit of detection at different pH values.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Christian Domes, Juergen Popp, Stefan Hagel, Mathias W. Pletz, Torsten Frosch
Summary: Therapeutic drug monitoring (TDM) is important in clinical practice, and pharmacokinetics plays a decisive role in determining the effective antibiotic concentration during treatment. This study investigates the potential use of deep UV resonance Raman spectroscopy (DUV-RRS) in simulating the pharmacokinetics of levofloxacin under different administration forms. The results show the potential of DUV-RRS in combination with PLS regression as a promising supportive method for TDM.
Review
Nanoscience & Nanotechnology
Timea Frosch, Andreas Knebl, Torsten Frosch