Article
Chemistry, Analytical
Liang Fu, Guangsheng Huang, Yaobo Hu, Fusheng Pan
Summary: A new strategy using ICP-MS/MS was proposed for the determination of metal impurities in Mg(TFSI)(2) electrolytes. N2O was employed as the reaction gas and mass shift methods were used to achieve high sensitivities and low LODs. The method showed high accuracy and precision, as demonstrated by spike recovery experiments and comparative analyses with SF-ICP-MS.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yanbei Zhu
Summary: Nitrous oxide (N2O) was investigated as a reaction gas for the determination of rare earth elements (REEs) by inductively coupled plasma-tandem quadrupole mass spectrometry (ICP-QMS/QMS). The use of N2O as the reaction gas improved the yields of (MO+)-M-m-O-16 for Eu and Yb, resulting in improved sensitivities for measurement of Eu and Yb. The use of N2O as the reaction gas also helped suppress Ba-related spectral interferences with the measurement of Eu. The method was validated by determining REEs in certified reference materials.
FRONTIERS IN CHEMISTRY
(2022)
Article
Spectroscopy
Liang Fu, Hualin Xie, Jianhua Huang, Xianhua Chen, Lin Chen
Summary: An analytical method utilizing reaction gas mixtures for ICP-MS/MS was developed to eliminate spectral interferences and detect metal impurity elements in LiPF6 with high sensitivity. The method successfully eliminated interferences, with detection limits ranging from 0.30 to 63.8 ng L-1, and showed good accuracy and precision compared to SF-ICP-MS analysis.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Liang Fu, Guangsheng Huang, Yaobo Hu, Xianhua Chen, Jingfeng Wang, Fusheng Pan
Summary: A new strategy using N2O as a reaction gas for the simultaneous determination of nonmetallic impurity elements in high-purity magnesium alloys by ICP-MS/MS was proposed. Through O-atom and N-atom transfer reactions, spectral interferences were eliminated and higher sensitivity and lower LODs were achieved compared to other reaction modes. The accuracy of the method was evaluated and it showed consistent results with SF-ICP-MS. This study provides a systematic method for precise quantification of impurity elements and can be applied to other fields.
ANALYTICAL CHEMISTRY
(2023)
Review
Spectroscopy
Yanbei Zhu, Tomoko Ariga, Kazumi Nakano, Yasuyuki Shikamori
Summary: The review highlights the trends and advances in inductively coupled plasma tandem quadrupole mass spectrometry technology from January 2018 to July 2021, covering various research fields and capabilities such as elemental concentration determination and isotope analysis. The use of different reaction gases has been explored to improve analytical capabilities.
ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Liang Fu, Hualin Xie, Jianhua Huang, Xianhua Chen, Lin Chen
Summary: This study introduces a novel strategy for determining ultra-trace Ti in human serum using ICP-MS/MS, successfully eliminating interference and achieving high sensitivity. The proposed method was evaluated for accuracy and reliability through spike recovery experiments and comparative analysis, confirming its effectiveness for accurate determination of ultra-trace Ti in serum samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Spectroscopy
Zhang Hao-yu, Fu Biao, Wang Jiao, Ma Xiao-ling, Luo Guang-qian, Yao Hong
Summary: Coal ash is an important alternative source of rare earth elements (REEs). However, there is currently no standard method for determining REEs in coal ash. This study proposed a new efficient and accurate method using graphite digestion-ICP-MS/MS. The method demonstrated low cost, simple operation, and high efficiency.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2023)
Article
Spectroscopy
Yanbei Zhu, Kazumi Nakano, Yasuyuki Shikamori, Akihide Itoh
Summary: Rare earth elements (REEs) in natural water samples were measured using ICP-MS/MS with oxygen as the reaction gas, achieving low detection limits and confirming the effectiveness and accuracy of the method through optimization of operating conditions. The results of REEs in multiple river and lake water samples were evaluated by normalization to the concentrations of REEs in post Archean Australian shale (PAAS).
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Spectroscopy
Arijeet Mitra, Indra Sekhar Sen, Christoph Walkner, Thomas C. Meisel
Summary: This study proposes a method for measuring PGE and Re mass fractions in road dust and rock samples with complex matrices, utilizing matrix removal, high pressure-high temperature digestion, isotope dilution calibration, cation exchange resin separation, and ICP-MS/MS measurements. Validation results show that the method provides accurate measurements with intermediate precision for PGE and Re mass fractions in environmental samples with complex matrices.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Eduardo Bolea-Fernandez, Ana Rua-Ibarz, Martin Resano, Frank Vanhaecke
Summary: The use of chemical resolution in ICP-MS is becoming popular, leading to a reevaluation of internal standard selection. This study found that chemical resolution significantly affects short-term signal stability and can impact signal intensities differently between mass-shifted and on-mass measurements.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2021)
Article
Environmental Sciences
Cindy Ka Y. Law, Kankana Kundu, Luiza Bonin, Lorena Penacoba-Antona, Eduardo Bolea-Fernandez, Frank Vanhaecke, Korneel Rabaey, Abraham Esteve-Nunez, Bart De Gusseme, Nico Boon
Summary: In this study, biogenic palladium nanoparticles were used for the reductive transformation and/or dehalogenation of persistent micropollutants. The size of the nanoparticles and their catalytic activity could be controlled by adjusting the H-2 flow rate. The results showed that the nanoparticles with larger sizes exhibited higher catalytic activity and more efficient removal of micropollutants.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Analytical
Ryoga Maeda, Thibaut Van Acker, Frank Vanhaecke, Akira Yamaguchi, Vinciane Debaille, Phillippe Claeys, Steven Goderis
Summary: This study applied the fast elemental mapping technique LA-ICP-TOF-MS to analyze chondritic meteorite samples. The technique allows for the visualization of element distribution maps at sub-micrometer spatial resolution and semi-quantitative analysis of major and trace elements. The accuracy and precision of this method were compared to conventional spot analysis methods, and good agreement was found. However, there are limitations to LA-ICP-TOF-MS mapping, such as limited ablated yield when using a small laser spot size and lower sensitivity compared to LA-ICP-SF-MS.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Multidisciplinary
Antonio Bazo, Maite Aramendia, Flavio V. Nakadi, Martin Resano
Summary: This paper proposes a novel approach using internal standards and bandpass mode in single particle ICP-MS for the characterization of Au nanoparticles in complex matrices. The method was validated for different matrices and the sensitivity of the nanoparticles was affected by matrix effects. Two methods, particle size method and dynamic mass flow method, were used to determine the transport efficiency and achieve accurate results. The use of bandpass mode provided flexibility in tuning the sensitivity for each nanoparticle type to ensure accurate characterization.
Article
Biology
Kasper Hobin, Marta Costas-Rodriguez, Elien Van Wonterghem, Roosmarijn E. Vandenbroucke, Frank Vanhaecke
Summary: Alzheimer's disease is associated with protein aggregations and altered copper metabolism. Two ICP-MS analysis techniques were used to determine the copper concentration and isotope ratio in blood plasma and brain regions of Alzheimer's mice. The concentration of copper in blood plasma was significantly altered in response to age and Alzheimer's-related effects, while the isotope ratio was affected by Alzheimer's disease only. Both the brain stem and cerebellum showed changes in copper concentration and isotope ratio. The determination of copper concentration and isotope ratio is relevant for understanding the role of copper in aging and Alzheimer's disease.
Article
Nanoscience & Nanotechnology
Helena Braet, Peter-Paul Fransen, Remco Marien, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Christian Vanhove, Stefan van der Vegte, Elke Gasthuys, An Vermeulen, Patricia Y. W. Dankers, Stefaan C. De Smedt, Katrien Remaut
Summary: This study aimed to improve the treatment of peritoneal metastasis from ovarian cancer by evaluating a nanoparticle-loaded, pH-switchable supramolecular polymer hydrogel as a controlled release drug delivery system. The research demonstrated that acidifying the nebulized hydrogel solution with carbon dioxide stimulated in situ gelation, prolonging the retention of the hydrogel in the peritoneal cavity. In vitro experiments showed that the drug was gradually released from the hydrogel and maintained cytotoxicity for 10 days. Furthermore, aerosolization of the hydrogel delayed tumor progression and significantly increased overall survival time in a xenograft model of peritoneal metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jari Leemans, Dobromil Respekta, Jing Bai, Simone Braeuer, Frank Vanhaecke, Zeger Hens
Summary: This study demonstrates a one-size-one-batch synthetic protocol for colloidal InAs quantum dots (QDs) with adjustable sizes by adjusting temperature profiles. By accelerating temperature transition and reducing synthesis concentration, larger QDs can be obtained.
Article
Biochemistry & Molecular Biology
Kaj Vaughan Sullivan, Yasmina Assantuh, Rosa Grigoryan, Marta Costas-Rodriguez, Eduardo Bolea-Fernandez, Bruno Lapauw, Steven Van Laecke, Frank Vanhaecke
Summary: Hypomagnesemia, a condition often found in type 1 diabetes mellitus (T1DM) patients, has become less prevalent due to improved treatment. However, a recent study found that disruptions to magnesium homeostasis still persist in T1DM patients. This study aimed to investigate the temporal variability in serum magnesium isotopic composition before and after insulin injection or meal consumption. The results showed a significant difference in serum magnesium isotopic composition between T1DM patients and controls, but no significant difference was observed before and after insulin injection/meal consumption. This suggests that the timing of the most recent meal may not affect serum magnesium isotopic composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geochemistry & Geophysics
Lidia Pittarello, Ludovic Ferriere, Stepan M. Chernonozhkin, Frank Vanhaecke, Steven Goderis
Summary: This study investigates the petrographic and geochemical characteristics of Diogenites meteorite, focusing on an anomalous vesiculated layer. The research reveals that the vesiculated layer shows distinct features and may have originated from in situ melting induced by a large impact event.
METEORITICS & PLANETARY SCIENCE
(2023)
Article
Geochemistry & Geophysics
Ryoga Maeda, Steven Goderis, Akira Yamaguchi, Thibaut Van Acker, Frank Vanhaecke, Vinciane Debaille, Phillippe Claeys
Summary: The chemical effects of terrestrial alteration were studied on a set of H chondrites, focusing on lithophile trace elements. It was found that rare earth elements, thorium, and uranium accumulate in cracks observed in weathered meteorite specimens. These features are interpreted to have been caused by terrestrial weathering following chemical leaching. However, the overall effects on the bulk chemical composition remain limited.
METEORITICS & PLANETARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lyndsey Hendriks, Robert Bruenjes, Sara Taskula, Jovana Kocic, Bodo Hattendorf, Garret Bland, Gregory Lowry, Eduardo Bolea-Fernandez, Frank Vanhaecke, Jingjing Wang, Mohammed Baalousha, Marcus von der Au, Bjoern Meermann, Timothy Ronald Holbrook, Stephan Wagner, Stasia Harycki, Alexander Gundlach-Graham, Frank von der Kammer
Summary: This study conducted an interlaboratory comparison to evaluate and validate the SOP for sp-ICP-TOFMS. Two Pt NP suspensions were characterized and showed good agreement among participating labs in terms of particle mass. However, the particle number concentration results were more scattered. The study also discussed the potential for particle density determination and assessed the precision and trueness of isotope ratio determinations.
Article
Biochemistry & Molecular Biology
Kaj Sullivan, Rebekah E. T. Moore, Frank Vanhaecke
Summary: The application of high-precision isotopic analysis in biomedicine has revealed the alteration of stable isotopic compositions of essential mineral elements in relation to metal dysregulation, which is fundamental to the pathogenesis of cancers and other diseases. This article summarizes the available evidence regarding physiological and lifestyle factors that may or may not influence the variations in essential mineral element isotopic compositions in human subjects. Factors such as sex, menopausal status, age, diet, supplementation, genetic variation, and obesity have been shown to influence the isotopic composition of at least one essential mineral element in the human body.
Article
Chemistry, Analytical
Thibaut Van Acker, Ana Rua-Ibarz, Frank Vanhaecke, Eduardo Bolea-Fernandez
Summary: In this study, laser ablation was investigated as a method for introducing microplastic particles into an inductively coupled plasma for monitoring using a mass spectrometer. Different types and sizes of microplastic particles were successfully introduced intact. The laser energy density did not affect particle sampling, and better performance was observed with a smaller laser beam diameter and a higher repetition rate. The C-13(+) signal intensity showed a linear correlation with the absolute carbon mass, and the linear range could be extended by using helium. Laser ablation generated narrower signal distributions compared to the traditional solution-based approach and was successful for analyzing mixed suspensions and sampling microplastic particles from filters.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Dominika Berdecka, Manon Minsart, Tao Lu, Deep Punj, Riet De Rycke, Mina Nikolic, Eduardo Bolea-Fernandez, Frank Vanhaecke, Ranhua Xiong, Stefaan C. De Smedt, Peter Dubruel, Winnok H. De Vos, Kevin Braeckmans
Summary: Cell therapies often require modification of cells with external substances to enhance their therapeutic effectiveness. The study investigates the potential of using PEN photoporation to deliver macromolecules into unstimulated T cells. The results show that PEN treatment has minimal impact on T cell proliferation and activation, making it a promising and safe delivery strategy for genetic modification of minimally differentiated T cells.
APPLIED MATERIALS TODAY
(2023)
Article
Materials Science, Multidisciplinary
Omar Martinez-Mora, Luis F. Leon-Fernandez, Milica Velimirovic, Frank Vanhaecke, Kristof Tirez, Jan Fransaer, Xochitl Dominguez-Benetton
Summary: The development of high-performance electrocatalysts is crucial for improving the performance and commercial viability of direct methanol fuel cells (DMFCs). This study utilized the gas-diffusion electrocrystallization process (GDEx) to synthesize platinum nanoclusters (NCs) stabilized by polyvinylpyrrolidone (PVP). The electrocatalytic activity of the Pt NCs for methanol oxidation was successfully evaluated, with PVP-stabilized GDEx-made Pt NCs demonstrating superior performance due to their porous structure and high effective surface area.
MATERIALS ADVANCES
(2023)
