Article
Chemistry, Analytical
Bahareh Feyzi-barnaji, Rassoul Dinarvand, Hamid Salehzadeh, Elham Arkan, Abdollah Salimi, Fatemeh Nili, Ali Mohammadi
Summary: A novel and sensitive electrochemical biosensor has been developed for the detection of anti-p53 autoantibody in human sera. The sensor, based on a nanocomposite support platform, demonstrated successful antibody detection by immobilizing p53 antigen and utilizing HRP and H2O2 in an indirect immunoassay. The biosensor showed promising stability, selectivity, and reproducibility, making it a potential platform for the development of other electrochemical biosensors.
Article
Engineering, Environmental
Elena Brinas, Viviana Jehova Gonzalez, Maria Antonia Herrero, Mohammed Zougagh, Angel Rios, Ester Vazquez
Summary: A simple, reproducible, and sensitive method using surface-enhanced Raman spectroscopy (SERS) was developed for the detection of graphene oxide (GO) in water samples at low concentrations. The practical limit of quantification achieved with this method was 0.1 ng mL(-1), which is lower than the predicted concentrations for graphene in effluent water. This optimized procedure has been successfully applied to the determination of ultratraces of GO in water samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Physical
Sara Fiori, Deepak Dagur, Michele Capra, Andrea Picone, Alberto Brambilla, Piero Torelli, Giancarlo Panaccione, Giovanni Vinai
Summary: In the past decade, reducing the dimensionality of materials to few atomic layers has allowed the exploration of new physical properties and functionalities absent in two dimensions. Interfaces and interlayers have been found to play a crucial role in this regime. This study investigates the influence of interfaces and interlayers on the electronic properties and structural quality of ultrathin Cr2O3 films on Pt(1 1 1) in the presence of a multidomain graphene intralayer. The results show that the ultrathin Cr2O3 films are slightly affected by the interfacial epitaxial quality from an electronic point of view, making them potential candidates for graphene-integrated heterostructures.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Michele Melchionna, Miriam Moro, Simone Adorinni, Lucia Nasi, Sara Colussi, Lorenzo Poggini, Silvia Marchesan, Giovanni Valenti, Francesco Paolucci, Maurizio Prato, Paolo Fornasiero
Summary: Integrating graphene oxide (GO) into nanostructured Bi2O3 electrocatalysts for CO2 reduction (CO2RR) improves performance toward formic acid production, with different structures potentially resulting in varied electrocatalytic behavior.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Polymer Science
Eyob N. N. Tarekegn, Mastooreh Seyedi, Igor Luzinov, William R. R. Harrell
Summary: In this study, we fabricated and characterized organic thin-film transistors (OTFTs) based on poly(3-hexylthiophene-2, 5-diyl) (P3HT) containing an interfacial layer made from virgin Graphene Oxide (GO). The performance of the OTFTs was noticeably improved by modifying the interfaces with the GO deposition.
Article
Materials Science, Multidisciplinary
Seemesh Bhaskar, Sai Sathish Ramamurthy
Summary: The integration of high refractive index dielectric TiCN nanocubes and plasmonic Ag nanofilms, with or without a graphene oxide nanolayer, resulted in significantly enhanced surface plasmon-coupled emission (SPCE) with sharp directionality and polarization. The obtained fluorescence enhancements showed excellent correlation with luminosity values obtained using smartphone-based SPCE platform, indicating potential for sensing applications and exploration of novel nanomaterials with 2-dimensional plasmonic materials.
Article
Chemistry, Analytical
Jing Su, Liqiang Zhang, Luogen Lai, Wufu Zhu, Chong Hu
Summary: A hemin-graphene nanocomposite-based aptasensor was developed for ultrasensitive colorimetric detection of leukemia cells. The biosensor has high sensitivity and can detect a minimal number of leukemia cells.
Article
Materials Science, Multidisciplinary
Aayush Rai, Seemesh Bhaskar, Kalathur Mohan Ganesh, Sai Sathish Ramamurthy
Summary: In this study, silver nanoparticle assemblies incorporating graphene oxide were synthesized using adiabatic cooling methodology. The plasmonic properties of the hybrid structures were investigated, showing over 900-fold surface plasmon-coupled emission enhancement. This research has the potential for applications in sensing and luminosity analysis in resource-limited settings.
Article
Multidisciplinary Sciences
Mingmao Wu, Hongya Geng, Yajie Hu, Hongyun Ma, Ce Yang, Hongwu Chen, Yeye Wen, Huhu Cheng, Chun Li, Feng Liu, Lan Jiang, Liangti Qu
Summary: This paper presents a laser-engraving strategy for producing graphene meta-aerogels with unusual characters. By reinforcing the graphene walls with nanofiber networks and using laser engraving, the macro-configurations of the graphene meta-aerogels can be arbitrarily regulated, resulting in highly elastic, robust, and stiff materials with large reversible elongation, light specific weight, and a wide range of Poisson's ratio.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Yusaku Nakabeppu, Jun-ichi Kira
Summary: This study aimed to investigate the impact of serum anti-oligodendrocyte antibodies on the clinical features of MS patients and validate whether these antibodies could serve as biomarkers for CNS tissue damage in MS patients. Results showed that anti-oligodendrocyte antibodies were positive in PPMS and SPMS patients, while absent in RRMS, NMOSD, OIND patients, and healthy controls.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemical Research Methods
Yukihiro Tanimura, Yoko Hiroaki, Masahiro Mori, Yoshinori Fujiyoshi
Summary: In this study, a live cell-based method for simultaneous detection of multiple autoantibodies was established. This method improves the efficiency of evaluating serum samples by using fluorescent proteins and fluorochromes.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
David Tebbe, Marc Schuette, Kenji Watanabe, Takashi Taniguchi, Christoph Stampfer, Bernd Beschoten, Lutz Waldecker
Summary: The environment plays a role in screening Coulomb interactions in two-dimensional semiconductors, which can be used for material property manipulation and sensing applications. In this study, we investigate the tuning of band gap and exciton binding energy in two-dimensional semiconductor WS2 by external dielectric screening. By embedding WS2 in van der Waals heterostructures with graphene and hBN spacers of varying thickness, we experimentally determine the energies as a function of distance and charge carrier density. We find that the modification to the band gap and exciton binding energy can be described by a one-over-distance dependence, with a significant effect even at several nanometers distance.
NPJ 2D MATERIALS AND APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Josef Jampilek, Katarina Kralova
Summary: Climate change and environmental contamination caused by human activities have a growing negative impact on human life. Developing technologies and sophisticated materials, such as graphene-based nanomaterials, could help overcome these negative effects. Graphene-based nanomaterials have promising applications in various fields including medicine and agriculture, but their potential negative effects on living organisms should be carefully considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Electrochemistry
Subburayan Kalaiselvi, Deivasigamani Ranjith Kumar, Mahmudul Hasan, Jayadevan Santhanalakshmi, Devaraj Manoj, Mohammad Khalid, Jae-Jin Shim
Summary: In this study, a robust electrode platform was developed for the sensitive detection of hydrogen peroxide (H2O2) in human serum. The modified electrode exhibited high sensitivity and a wide linear range of H2O2 concentrations. It was successfully applied to analyze H2O2 in real human serum samples.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Michael Lopez Mujica, Yuanyuan Zhang, Fabiana Gutierrez, Fethi Bedioui, Gustavo Rivas
Summary: An impedimetric genosensor was developed for quantifying microRNA-21, allowing label-free, nonamplified, simple, and fast biosensing in human blood serum, urine, and saliva samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Mohamed Sharafeldin, Felix Fleschhut, Timothy James, Jason J. Davis
Summary: The emergence of protein biomarkers promises a revolution in healthcare, shifting the focus from disease management to earlier intervention. This study introduces a convenient method for protein tagging prior to target capture, allowing for easy quantification of biomarkers. When translated to an automated microfluidic platform, the method enables rapid and accurate quantification of markers, showing good correlation with standard immunoassays. The platform is simple, versatile, highly sensitive, and does not require secondary labeling/binding or amplification.
ANALYTICAL CHEMISTRY
(2022)
Article
Mathematics, Applied
E. Guerrero Fernandez, M. J. Castro Diaz, M. Dumbser, T. Morales de Luna
Summary: In this paper, a novel numerical discretization method is proposed for simulating a variable pressure multilayer shallow water model. The method is capable of simulating density driven gravity currents in a shallow water framework and maintains high accuracy even in the presence of strong gradients or discontinuities.
JOURNAL OF SCIENTIFIC COMPUTING
(2022)
Article
Chemistry, Physical
Shunzhi Wang, Sangmin Lee, Jingshan S. Du, Benjamin E. Partridge, Ho Fung Cheng, Wenjie Zhou, Vinayak P. Dravid, Byeongdu Lee, Sharon C. Glotzer, Chad A. Mirkin
Summary: This study presents a method to generate complex, low-symmetry colloidal crystals using programmable atom equivalents and mobile electron equivalents. The spatial distribution of the electron equivalents breaks the symmetry of the atom equivalents, resulting in well-defined coordination geometries and three new low-symmetry crystalline phases.
Review
Nanoscience & Nanotechnology
Cheng Jiang, Ying Fu, Guozhen Liu, Bowen Shu, Jason Davis, George K. Tofaris
Summary: Extracellular vesicles (EVs) play a crucial role in molecular trafficking, intercellular transport, and protein egress. They can be detected in bodily fluids and offer opportunities for biomarker discovery. Multiplexing platforms can achieve breakthroughs in analytical power, throughput, and consistency.
NANO-MICRO LETTERS
(2022)
Article
Materials Science, Biomaterials
Connor M. Ellis, Juan Pellico, Liam A. J. Young, Jack Miller, Jason J. Davis
Summary: By adjusting the Dy3+ loading density within a mesoporous silica architecture, the dominant Curie effect can be effectively tuned to optimize T-2 contrast at high magnetic fields up to 11.7 T, enhancing image sensitivity in MRI scans.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Mohamed Sharafeldin, Jason J. Davis
Summary: The development of diagnostic devices relies on the immobilization of biomolecules to generate quantifiable signals. The selectivity and sensitivity of biosensors depend on the interfacial properties, which can be analyzed using characterization techniques.
ANALYTICA CHIMICA ACTA
(2022)
Article
Computer Science, Interdisciplinary Applications
Ernesto Pimentel-Garcia, Manuel J. Castro, Christophe Chalons, Tomas Morales de Luna, Carlos Pares
Summary: This paper presents a new strategy for the numerical approximation of discontinuous solutions in non-conservative hyperbolic systems, with a second-order extension. The method captures isolated shocks accurately and maintains the well-balanced property. Numerical tests are conducted to validate the effectiveness of the proposed method.
JOURNAL OF COMPUTATIONAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Daisy Marshall, Joshua Lehr
Summary: The early detection of anti-asparaginase biomarker is important for timely modification of asparaginase chemotherapy and avoiding complications. A novel electrochemical biosensing interface was prepared for rapid detection of anti-asparaginase in the picomolar range. The coimmobilization of ferrocene and asparaginase facilitated transduction through attenuation of the surface-bound ferrocene redox couple, with a limit of detection of 0.8 pM.
Article
Chemistry, Analytical
Mohamed Sharafeldin, Shijun Yan, Cheng Jiang, George K. Tofaris, Jason J. Davis
Summary: We present a scalable, fast, and low-cost method for extracting cargo proteins from exosome subpopulations using an alternating (AC) magnetic field to facilitate the mixing of antibody-coated magnetic beads (MBs) with serum samples. By applying this method, we were able to achieve high capture efficiencies of >70% from <50 μL of neat serum in just 30 minutes. This approach, when combined with array-based assaying and a standard duplex electrochemical sandwich ELISA, enabled the detection of sub pg/mL levels of α-synuclein content with excellent precision and a sample-to-answer time of approximately 75 minutes. The high performance and semi-automation of this method hold promise for low-cost Parkinson's disease diagnostics and exosomal biomarker analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shaoyu Kang, Mohamed Sharafeldin, Sophie C. Patrick, Xuanxiao Chen, Jason J. Davis
Summary: We present a simple method for quantifying target proteins by monitoring the redox capacitance of a conductive polymer interface. This method allows real-time analysis of both association and dissociation regimes and can detect target proteins at picomolar levels within 15 seconds. This proof-of-principle methodology is expected to be widely applicable in quantifying other clinically relevant targets.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Krzysztof M. Bak, Sophie C. Patrick, Xiaoxiong Li, Paul D. Beer, Jason J. Davis
Summary: Mimicking Nature's polymeric protein architectures, designing hosts with binding cavities screened from bulk solvent is a promising approach to achieving anion recognition in competitive media. The authors present a synthetically tractable approach by directly incorporating potent supramolecular anion-receptive motifs into a polymeric scaffold. The polymeric hosts consistently outperform their monomeric analogues, with large halide binding enhancements observed in aqueous-organic solvent mixtures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Daohe Yuan, Connor M. Ellis, Ferenc E. Mozes, Jason J. Davis
Summary: High T-1 MRI switches can be obtained using pH-responsive polymer-coated paramagnetic mesoporous silica nanoparticles. The strong peripheral hydration capping at the mesopores enhances water mobility, leading to greatly enhanced outer sphere contributions to contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Yi Wang, Jack Howley, Erica N. N. Faria, Chen Huang, Sadie Carter-Searjeant, Simon Fairclough, Angus Kirkland, Jason J. J. Davis, Falak Naz, Muhammad Tariq Sajjad, Jose M. M. Goicoechea, Mark Green
Summary: We present a new synthetic method to prepare high-quality InP-based quantum dots (QDs) with tuneable emission, by using a solid, air- and moisture-tolerant primary phosphine as a group-V precursor. This method offers a significantly simpler synthetic pathway compared to the current state-of-the-art precursors used in phosphide quantum dot synthesis, which are volatile, dangerous, and sensitive to air, such as P(Si(CH3)(3))(3).
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Sharafeldin, Robert Hein, Jason J. Davis
Summary: We present a novel electrochemical protein quantitation method that involves shotgun biotin tagging of proteins before interfacial immunocapture and polymeric enzyme tagging. The highly amplified faradaic signals produced by a novel ferrocene-tyramine adduct allow for the detection of protein markers at attomolar levels and across a dynamic range of 5 orders of magnitude. This work supports the ultrasensitive detection of protein markers in a single antibody immunoassay format.
CHEMICAL COMMUNICATIONS
(2022)
