Journal
ANALYTICAL CHEMISTRY
Volume 85, Issue 20, Pages 9522-9527Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac401169c
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Funding
- U.S. National Science Foundation [CMMI 0749028]
- NSF Career Award ECCS [07-47178]
- U.S. Department of Energy [DE-FG02-08ER64568]
- NBRPC [2011CB935704]
- NNSFC [20975060]
- National Basic Research Program of China [2011CB935704]
- National Natural Science Foundation of China [21235004]
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Efficient near-infrared detection of specific DNA with single nucleotide polymorphism selectivity is important for diagnostics and biomedical research. Herein, we report the use of gallium arsenide (GaAs) as a sensing platform for probing DNA immobilization and targeting DNA hybridization, resulting in similar to 8-fold enhanced GaAs photoluminescence (PL) at similar to 875 run. The new signal amplification strategy, further coupled with the plasmonic effect of Au nanoparticles, is capable of detecting DNA molecules with a detection limit of 0.8 pM and selectivity against single base mismatches. Such an ultrasensitive near-infrared sensor can find a wide range of biochemical and biomedical applications.
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