Article
Materials Science, Multidisciplinary
H. Ogawa, T. Shibuya, Y. Moriai, D. Satoh, E. Terasawa, S. Maru, M. Tanaka, R. Kuroda
Summary: The dependence of ablation rate on laser fluence was measured in femtosecond laser processing of polydimethylsiloxane. It was found that the slope of ablation rate changed in three different regimes. Analysis of the laser-irradiated area using Raman and photoluminescence spectroscopy revealed the influence of chemical structural changes on the slope. The study showed that both photochemical and photothermal processes contribute to the change in slope in the middle fluence regime.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Food Science & Technology
Charlotte Vinther Schmidt, Lorenz Plankensteiner, Mathias Porsmose Clausen, Anders Runge Walhter, Jacob Judas Kain Kirkensgaard, Karsten Olsen, Ole G. Mouritsen
Summary: The study focused on sous vide cooking of squid mantles at various temperatures and times, analyzing the macroscopic textural properties, collagen content, and structural changes. Collagen was found to be the major protein responsible for cooking loss and both collagen and actin significant for mechanical textural changes. Lower temperature cooking resulted in decreased cooking loss with minimal changes in most textural parameters. Further investigation into optimized cooking conditions is recommended, potentially enhancing the gastronomic use of squid mantles as a nutritious protein resource.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Instruments & Instrumentation
Aurelien Canizares, Frederic Foucher, Mickael Baque, Jean-Pierre de Vera, Thierry Sauvage, Olivier Wendling, Aurelien Bellamy, Paul Sigot, Thomas Georgelin, Patrick Simon, Frances Westall
Summary: Organic molecules are a key focus in the search for extraterrestrial life. This study investigates the effects of proton irradiation on polymers and proposes improvements for future in situ characterization.
APPLIED SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Julian Hniopek, Carolin Mueller, Thomas Bocklitz, Michael Schmitt, Benjamin Dietzek, Juergen Popp
Summary: This study presents, for the first time, a systematic investigation on the use of 2D correlation analysis in the field of femtosecond transient absorption spectroscopy. The results demonstrate that TA-2DCOS is a model-free approach that can effectively analyze excited state kinetics in fs-TA data sets, offering potential as an alternative method to traditional approaches.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Spectroscopy
Martyna Krainska, Aleksandra Weselucha-Birczynska
Summary: An analysis of FT-Raman spectra of quinidine aqueous solutions with varying pH was conducted using the 2D correlation method. The results showed that the pH change of the solution influenced the protonation process of quinidine, which was confirmed by changes in characteristic peaks. The importance of remodeling and the methoxy group in the process of double protonation was also revealed, providing further insights into the compound's changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Microbiology
Dmitry Malyshev, Imogen Anne Jones, Matthew McKracken, Rasmus Oberg, Glenn M. Harper, Lovleen Tina Joshi, Magnus Andersson
Summary: This study uses TEM imaging and Raman spectroscopy to analyze changes in the physiology of C. difficile spores in response to sodium hypochlorite. Certain strains of C. difficile show high resistance to hypochlorite treatment, and the exposed spores exhibit changes in biochemical composition and structure. These findings have implications for designing effective disinfection protocols and Raman-based detection methods.
Article
Materials Science, Ceramics
Jiangjiang Mao, Kunjie Yang, Xu Chen, Shikun Zhu, Guoqiang Zhang, Fan Yang, Xiaoyang Zhang, Kemian Qin, Tieshan Wang, Haibo Peng
Summary: The study on borosilicate glass irradiated with gamma rays found that the irradiation had an impact on the surface structure, which was influenced by the glass composition. Therefore, the effects of gamma irradiation on vitrification properties need to be paid more attention to.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Saman Ghazvini, Saji Uthaman, Lilly Synan, Eugene C. Lin, Soumik Sarkar, Mark K. Santillan, Donna A. Santillan, Rizia Bardhan
Summary: Raman spectroscopy combined with machine learning enables early prediction of preeclampsia in the 1st trimester with >82% accuracy. Statistically significant metabolites were identified in different trimesters, and their association with clinical factors was also revealed. These findings highlight the potential of Raman spectroscopy as a powerful tool for early diagnosis and prognosis of preeclampsia.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Analytical
Tanveer Ahmed Shaik, Joao L. Lagarto, Enrico Baria, Melis Goktas, Patrick Igoche Onoja, Kerstin G. Blank, Francesco S. Pavone, Juergen Popp, Christoph Krafft, Riccardo Cicchi
Summary: The study demonstrates the potential of nondestructive optical imaging techniques such as SHG, RS, and FLIM in monitoring collagen degradation and assessing mechanical properties in tissues. These techniques can provide label-free monitoring of collagen degradation and rough evaluation of mechanical properties in a nondestructive manner.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
K. S. Almugren, S. F. Abdul Sani, Irzwan Affendy Sulong, S. N. Mat Nawi, A. S. Siti Shafiqah, D. A. Bradley
Summary: This study investigates the use of black carbon charcoal as passive radiation dosimetry, exploring Raman spectroscopy and photoluminescence analysis in graphite charcoal, as well as characterizing the crystal structure using X-ray diffractometry. The findings provide a low-cost yet highly effective system for studying radiation-induced changes in carbon and have potential applications in radiotherapy.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Irina V. Antonova, Konstantin A. Kokh, Nadezhda A. Nebogatikova, Evgenii A. Suprun, Vladimir A. Golyashov, Oleg E. Tereshchenko
Summary: This study investigates the growth of Bi2Se3 films on printed graphene using vapor deposition. By using 2D-printed graphene and the capillary effect conditions, it is possible to form continuous films with a thickness of 8 nm or more and larger crystallites. The properties of the films grown on printed graphene are similar to those grown on CVD graphene. Additionally, heterostructures with high carrier mobility and transparent electrodes can be formed if the printed graphene contains residual organic additives.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Spectroscopy
Anna Kolodziej, Aleksandra Weselucha-Birczynska, Elzbieta Dlugon, Malgorzata Swietek, Maciej Gubernat, Lukasz Skalniak, Marta Blazewicz
Summary: This research investigated the biological potential of two types of polymer nanocomposites and studied the interaction between cells and materials using techniques such as cell proliferation, fluorescence microscopy, Raman spectroscopy, and two-dimensional correlation spectroscopy. The results showed that these nanocomposites have good biological activity and can identify the complexity of cellular response.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Physics, Applied
Tara Pena, Aditya Dey, Shoieb A. Chowdhury, Ahmad Azizimanesh, Wenhui Hou, Arfan Sewaket, Carla Watson, Hesam Askari, Stephen M. Wu
Summary: We demonstrate controllable manipulation of a moire superlattice interference pattern in twisted bilayer graphene through the use of designable device-level heterostrain. By depositing stressed thin films onto the graphene samples, we can control the magnitude and directionality of heterostrain. Raman spectroscopy and simulations confirm the breaking of C-3 rotational symmetry and tunable periodicity in the moire superlattices under uniaxial or biaxial strain.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xin Chen, Malte Kohring, M'hamed Assebban, Bartlomiej Tywoniuk, Cian Bartlam, Narine Moses Badlyan, Janina Maultzsch, Georg S. Duesberg, Heiko B. Weber, Kathrin C. Knirsch, Andreas Hirsch
Summary: The study presents an efficient method to pattern 2D MoS2 into delicate ribbon patterns with a minimum feature size of 2 micrometers, combining electron beam lithography with surface covalent functionalization. The patterned monolayer MoS2 domain consists of a well-defined heterophase homojunction and alternately distributed surface characteristics, showing great potential for further exploration in MoS2 based devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
N. M. Yitzhak, O. Girshevitz, A. Haran, A. Butenko, M. Kaveh, I. Shlimak
Summary: Raman spectra of monolayer graphene samples were measured, and it was found that the positions of Raman lines are redshifted in free-standing samples, which is caused by irradiation with protons or helium ions. This redshift is attributed to an electronic mechanism for changing the graphene structure, depending on the charge and velocity of the incident ions.
APPLIED SURFACE SCIENCE
(2022)
Article
Respiratory System
Pouline M. P. van Oort, Tamara M. Nijsen, Iain R. White, Hugo H. Knobel, Timothy Felton, Nicholas Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas, Pedro R. Povoa, Ignacio Martin-Loeches, Hans Weda, Royston Goodacre, Marcus J. Schultz, Paul M. Dark, Stephen J. Fowler, Lieuwe D. Bos
Summary: The study found that exhaled breath analysis can effectively distinguish patients suspected of ventilator-associated lower respiratory tract infections, with high sensitivity and negative predictive value.
Article
Endocrinology & Metabolism
Ivayla Roberts, Marina Wright Muelas, Joseph M. Taylor, Andrew S. Davison, Yun Xu, Justine M. Grixti, Nigel Gotts, Anatolii Sorokin, Royston Goodacre, Douglas B. Kell
Summary: This study utilizes untargeted metabolomics analysis to evaluate 120 samples of COVID-19 patients and predict the severity and outcome of the infection. The study identifies a group of metabolites with relevant biological functions, such as deoxycytidine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) that can predict disease severity and outcome.
Article
Immunology
Waqar M. Ahmed, Dominic Fenn, Iain R. White, Breanna Dixon, Tamara M. E. Nijsen, Hugo H. Knobel, Paul Brinkman, Pouline M. P. Van Oort, Marcus J. Schultz, Paul Dark, Royston Goodacre, Timothy Felton, Lieuwe D. J. Bos, Stephen J. Fowler
Summary: Microbial volatiles were detected in the exhaled breath of mechanically ventilated patients with bacterial lung infection. Concentration of isovaleric acid and isovaleraldehyde were higher in patients with Staphylococcus aureus. Indole was higher in patients with bacteria known to metabolize tryptophan.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Sahand Shams, Cassio Lima, Yun Xu, Shwan Ahmed, Royston Goodacre, Howbeer Muhamadali
Summary: The rise and extensive spread of antimicrobial resistance (AMR) has become a global concern and threat to the environment and human health. Traditional AMR identification methods are time-consuming or expensive, and thus culture-independent and single-cell technologies are needed for rapid detection and identification of antimicrobial-resistant bacteria. In this study, a non-destructive phenotyping method using optical photothermal infrared (O-PTIR) spectroscopy was employed for the first time to detect AMR in Uropathogenic Escherichia coli (UPEC) at both single-cell and population levels.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Analytical
Georgios Theodoridis, Helen Gika, Daniel Raftery, Royston Goodacre, Robert S. Plumb, Ian D. Wilson
Summary: Metabolite identification is a major challenge in contemporary metabolomics research, particularly in liquid chromatography-mass spectrometry technology. This article categorizes the errors into two types: biologically implausible identities and identities that do not match the chromatographic and physicochemical properties of the proposed molecule. It discusses the issue, presents examples, and proposes measures for improvement.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Sarir Sarmad, Mark R. Viant, Warwick B. Dunn, Royston Goodacre, Ian D. Wilson, Katie E. Chappell, Julian L. Griffin, Valerie B. O'Donnell, Brendon Naicker, Matthew R. Lewis, Toru Suzuki
Summary: In this Perspective, the authors propose a four-tiered framework to evaluate the reliability of targeted metabolomics analyses. They discuss the need for community-accepted, harmonized guidelines and summarize the regulatory guidance provided by various authorities. The framework includes levels for discovery, screening, qualification, and validation.
Article
Multidisciplinary Sciences
Ashton G. Theakstone, Paul M. Brennan, Michael D. Jenkinson, Royston Goodacre, Matthew J. Baker
Summary: Discrimination between brain cancer and non-cancer patients was achieved using serum-based ATR-FTIR spectroscopy with a sensitivity of 92.8% and specificity of 91.5%. Further research stratified between different brain tumor types with a sensitivity of 90.1% and specificity of 86.3%. The study highlighted the importance of high molecular weight components in discriminating between cancer and non-cancer cases and different tumor types.
Editorial Material
Multidisciplinary Sciences
Asaph Aharoni, Royston Goodacre, Alisdair R. Fernie
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Spectroscopy
Douglas Carvalho Caixeta, Cassio Lima, Yun Xu, Marco Guevara-Vega, Foued Salmen Espindola, Royston Goodacre, Denise Maria Zezell, Robinson Sabino-Silva
Summary: This study used ATR-FTIR spectroscopy to evaluate the differences in urinary components among non-diabetic, diabetic, and diabetic insulin-treated rats. ATR-FTIR combined with univariate and multivariate chemometric analyses provides an innovative, non-invasive, and sustainable approach to diabetes surveillance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Howbeer Muhamadali, Catherine L. Winder, Warwick B. Dunn, Royston Goodacre
Summary: Metabolomics is a powerful research tool that can measure hundreds to thousands of metabolites. This review discusses the use of GC-MS and LC-MS in discovery-based metabolomics research, defines metabolomics workflows, and highlights considerations for generating robust and reproducible data. It emphasizes the routine application of metabolomics across various biological species and systems, including the study of microbial interactions and their impact on human health. The review also discusses the challenges and potential applications of metabolomics in synthetic biology and gut microbial interactions with the human host.
BIOCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Antonio Valle, Maria Elena de la Calle, Howbeer Muhamadali, Katherine A. Hollywood, Yun Xu, Jonathan R. Lloyd, Royston Goodacre, Domingo Cantero, Jorge Bolivar
Summary: Metabolic engineering can enhance the production of hydrogen and ethanol by modifying Escherichia coli. Metabolomics platforms can identify metabolic bottlenecks, and various strategies can increase hydrogen production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Paul I. C. Richardson, Adam Burke, Nigel Gotts, Royston Goodacre
Summary: Electronic cigarettes have gained popularity as an alternative to traditional cigarettes. This study introduces a complementary technology based on Raman spectroscopy and chemometrics to detect and quantify the PG:VG ratio and nicotine content of e-cigarette liquids. Results showed accurate quantification of PG:VG ratio and nicotine content for most commercial samples, without the need for accurate knowledge of flavonoid composition. The limitations of Raman spectroscopy are discussed, along with potential solutions.
Article
Chemistry, Analytical
Najla AlMasoud, Taghrid S. Alomar, Yun Xu, Cassio Lima, Royston Goodacre
Summary: Paracetamol (acetaminophen) is commonly used as an OTC drug for mild pain, headache, cold and flu. However, it is also used for suicide attempts in young adults, making rapid detection of overdose crucial to limit liver damage. In this study, a surface-enhanced Raman scattering (SERS) methodology was developed to accurately quantify paracetamol and its metabolites in water and artificial urine.
Article
Polymer Science
Liam J. Dodd, Cassio Lima, David Costa-Milan, Alex R. Neale, Benedict Saunders, Bowen Zhang, Andrei Sarua, Royston Goodacre, Laurence J. Hardwick, Martin Kuball, Tom Hasell
Summary: Inverse vulcanised polymers have been studied due to their easy and cheap synthesis from elemental sulfur, resulting in a wide range of valuable properties. However, the high sulfur content makes the polymers difficult to analyze. This study presents the use of Raman spectroscopy to better understand the structure and properties of these polymers. It was found that Raman spectroscopy can provide key information about the elemental sulfur content, homogeneity, reactions, and proportions of different sulfur ranks in the polymer.
Meeting Abstract
Ophthalmology
Neeru Amrita Vallabh, Cassio Lima, Hannah Levis, Hussameddin Muntasser, Stephen Kaye, Royston Goodacre
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
