Article
Polymer Science
Antonio David Abreu-Rejon, Wilberth Antonio Herrera-Kao, Alejandro May-Pat, Alejandro Avila-Ortega, Nayeli Rodriguez-Fuentes, Jorge Alonso Uribe-Calderon, Jose Manuel Cervantes-Uc
Summary: This study evaluated the effects of different molecular weights and grafting densities of polyethylene glycol (PEG) on the surface properties of polyurethane (PU) and the viability of osteoblasts and fibroblasts. The results showed that grafting PEG onto PU increased hydrophilicity and surface energy, and improved osteoblast viability. However, fibroblast viability only increased at certain combinations of PEG parameters, indicating an optimal level. PEG grafting also promoted a more spread cell morphology but induced apoptotic-like behavior at higher molecular weights and concentrations. The study suggests that the surface energy of PU substrates can be controlled by adjusting PEG parameters, but optimal levels should be determined to promote cell viability without inducing apoptosis.
Article
Nanoscience & Nanotechnology
Yanqing Zhao, Zheng Li, Jiutong Ma, Qiong Jia
Summary: The novel smart responsive material MNP-SP exhibits fast magnetic response, high sensitivity, and good reusability, making it suitable for the enrichment and identification of phosphopeptides. The capture and release of phosphopeptides can be easily adjusted by changing external light and the pH of the solution.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Chemical
Eris Sinoimeri, Anne-Claire Pescheux, Ismael Guillotte, Jerome Cognard, Lenka Svecova, Isabelle Billard
Summary: In this study, the behavior of eight metal ions (Co(II), Cr(III), Cr(VI), Cu(II), Fe(III), Mn(II), Mo(VI), and Ni(II)) in the PEG-400/Na2SO4/H2O system was investigated. It was found that six of these ions (Co(II), Cr(III), Cu(II), Fe(III), Mn(II), and Ni(II)) tend to be excluded from the upper PEG-rich phase as the PEG amount is increased, while the two oxoanions Cr(VI) and Mo(VI) accumulate in the upper PEG-rich phase.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Kai Cheng, Jie Zhou, Yujie Zhao, Yu Chen, Lan Ming, Da Huang, Rui Yang, Zhenyu Lin, Daozhen Chen
Summary: A CD44-targeting polymeric micelle Emo@CD44p-PM with pH responsiveness and targeting ability against breast cancer cells has been synthesized, showing enhanced cellular internalization and anti-tumor effects.
Article
Chemistry, Physical
Zhenyu Zhang, Juan Liu, Ting Li, Zhikai Fu, Jinshui Mao, Xiaocheng Li, Sili Ren
Summary: The recycling of Nd(III) and Dy(III) from waste NdFeB magnets is crucial for the sustainable development of the rare-earth elements (REEs) industry. The conventional solvent extraction (SX) method faces challenges in efficiently separating Nd(III) and Dy(III) due to the properties of water. In this study, a novel non-aqueous solvent extraction (NASX) system based on the neutral extractant P350 was developed, showing high extraction efficiency and separation factor for Nd(III) and Dy(III). By replacing most of the water in the aqueous phase with low-dielectric-constant polar molecular organic solvents (PMOSs), the influence of water on the extraction process was reduced. The results demonstrate that the developed P350-PEG 200 extraction system-based separation process is a promising and cost-effective alternative for the efficient recycling of Nd(III) and Dy(III) from end-of-life NdFeB magnets.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Sikhumbuzo Charles Kunene, Kuen-Song Lin, Meng-Tzu Weng, Maria Janina Carrera Espinoza, You-Sheng Lin, Yi-Ting Lin
Summary: In this study, pH-sensitive nanocluster platforms were constructed using reduced graphene oxide (RGO), encapsulated with the anticancer drug doxorubicin (DOX), and surface-modified with polyethylene glycol (PEG) for enhanced tumor accumulation and homologous targeting ability. The nanoclusters demonstrated biocompatibility and nontoxicity towards HepG2 cell line, and the DOX-loaded formulation exhibited a significant therapeutic effect. The designed RGONP-DOX-PEG-CM showed the highest antitumor effect and induced necrotic and apoptotic areas in cancer cells.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Mahmoud Baranei, Ramezan Ali Taheri, Mahtab Tirgar, Ardeshir Saeidi, Fatemeh Oroojalian, Lokman Uzun, Azadeh Asefnejad, Frederik R. Wurm, Vahabodin Goodarzi
Summary: This study introduced a new, stable plasma, pH-sensitive niosomal formulation of green tea extract (GTE) with excellent bioavailability and cytotoxic effect against cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Elaheh Ranjbar, Hassan Namazi
Summary: In this study, a biocompatible pH-sensitive system was designed for targeted anticancer drug delivery using a nano-composition of layered double hydroxide@hydroxyapatite-doxorubicin coated magnetic Fe3O4-polyethylene glycol. The nanocomposites showed controlled drug release behavior and high cytotoxicity, making them a promising candidate for targeted drug delivery.
Article
Multidisciplinary Sciences
Mingzhang Maple Wang, Caitlin N. Wappelhorst, Erika L. Jensen, Ying-Chih Thomas Chi, Jason C. Rouse, Qin Zou
Summary: This study investigates the lipid composition at the surface of mRNA-LNPs using high-field nuclear magnetic resonance spectroscopy. The results identify the presence of PEG chains and partial ionizable lipids on the surface of intact LNPs, and reveal the brush-like conformation of PEG on the surface of mRNA-LNPs. In addition, a diffusion NMR strategy is implemented for routine testing of drug formulations, providing a global view of the mRNA-LNP surface structure for enhanced product knowledge.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Friederike Eilts, Marleen Steger, Keven Lothert, Michael W. Wolff
Summary: This study investigated the application of latex particles in steric exclusion chromatography and found that aggregation and pore blockage were limitations in the process. The kinetics of aggregation rather than the size of aggregates influenced the recovery. Additionally, it was found that functionalized polystyrene particles had limitations in representing biological nanoparticles.
Article
Nanoscience & Nanotechnology
Zhihuan Zhao, Yao Wang, Haoyang Jiang, Jixian Liu, Linjun Huang, Yanna Zhang, Yanqi Wang, Laurence A. Belfiore, Jianguo Tang
Summary: Inorganic/polymer hybrid hydrogels with stable luminescence, especially those coordinated with RE (Eu3+) complex, exhibit excellent mechanical properties and long luminescence lifetime, showing great potential in soft material applications.
SCIENCE OF ADVANCED MATERIALS
(2021)
Article
Chemistry, Physical
Min Ji Son, Taelin Kim, Sang-Wha Lee
Summary: Fluorescent mesoporous silica nanoparticles were synthesized as a nanocarrier for the efficient delivery of Die molecules. The release rate of Die was pH-responsive, with the PEG-coated nanoparticles showing the most pronounced difference between pH 4.5 and pH 7.4. The double-layer-coated nanoparticles exhibited significantly delayed release rates compared to the coating-free and single-layer-coated analogs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Energy & Fuels
Wonmi Lee, Gyunho Park, Yongchai Kwon
Summary: A redox flow battery using zinc chloride and Tiron as the redox couple has been introduced, showing high cell voltage and efficiencies but with a high capacity fading rate. The addition of polyethylene glycol improves the battery performance, resulting in higher efficiencies and a lower capacity loss rate.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Polymer Science
Duoduo Wang, Yuqi Bao, Yaxin Tan, Lijie Liu, Qiaorong Ye, Chensi Zeng, Ni Tan
Summary: A pH/GSH double-sensitive sorafenib stealth imprinting material, S-SMIP, was successfully prepared by UV-initiated surface imprinted polymerization. It showed good adsorption capacity and selectivity. S-SMIP could greatly improve solubility of sorafenib and had a pH/GSH dual-sensitive response performance. Compared to the non-stealth imprinted material, S-SMIP had a better long-cycle effect on the release of sorafenib.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Shivam Saretia, Makafui Y. Folikumah, Yue Liu, Rainhard Machatschek
Summary: Injectable hydrogels are important for tissue regeneration, but understanding their behavior in vivo is challenging. Ultrathin films can provide insights into formation and degradation at material-liquid interfaces and can be used as bioresponsive coatings.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Tomoko Haraga, Kazuki Ouchi, Yoshiyuki Sato, Hitoshi Hoshino, Rei Tanaka, Takashi Fujihara, Hideki Kurokawa, Masami Shibukawa, Ken-ichiro Ishimori, Yutaka Kameo, Shingo Saito
ANALYTICA CHIMICA ACTA
(2018)
Article
Chemistry, Analytical
Fouzia Akter, Shingo Saito, Yuiko Tasaki-Handa, Masami Shibukawa
ANALYTICAL SCIENCES
(2018)
Article
Chemistry, Multidisciplinary
Masami Shibukawa, Masaru Yanagisawa, Ryota Morinaga, Tomomi Shimasaki, Shingo Saito, Shao-ting Wang, Yu-qi Feng
Article
Chemistry, Physical
Keisuke Nakamura, Ryusuke Ubukata, Hisashi Mizuno, Shingo Saito, Masami Shibukawa
JOURNAL OF PHYSICAL CHEMISTRY C
(2018)
Article
Medicine, Research & Experimental
Koji Wakui, Toru Yoshitomi, Akane Yamaguchi, Maho Tsuchida, Shingo Saito, Masami Shibukawa, Hitoshi Furusho, Keitaro Yoshimoto
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Biochemistry & Molecular Biology
Leona R. Sirkisoon, Honest C. Makamba, Shingo Saito, Christa L. Colyer
Article
Multidisciplinary Sciences
Junko Ishikawa, Akinori Maeshima, Allyson Mellinger, Anne Durand, Marie-Line Bourbon, Daichi Higo, Christa L. Colyer, Masami Shibukawa, Soufian Ouchane, Shingo Saito
SCIENTIFIC REPORTS
(2019)
Article
Engineering, Environmental
Kazuki Marumo, Atsumasa Matsumoto, Sumika Nakano, Masami Shibukawa, Takumi Saito, Tomoko Haraga, Shingo Saito
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Biochemical Research Methods
Tomoko Haraga, Hiroto Tsujimura, Saori Miyauchi, Takuya Kamimura, Masami Shibukawa, Shingo Saito
Article
Chemistry, Multidisciplinary
Shingo Saito, Toshiki Sakamoto, Naoki Tanaka, Ryo Watanabe, Takuya Kamimura, Kazuki Ota, Kathryn R. Riley, Keitaro Yoshimoto, Yuiko Tasaki-Handa, Masami Shibukawa
Summary: The study introduced a novel single-round selection method for aptamers, demonstrating successful and highly reproducible aptamer selection for thrombin. Selection rules based on dissociation equilibria and kinetics were devised to obtain families of analogous sequences that bind thrombin with high affinity. Additionally, a novel fluorescent molecular recognition sensor for thrombin with nanomolar detection limits was discovered through data mining and sub-library creation.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Engineering, Environmental
Sumika Nakano, Kazuki Marumo, Rintaro Kazami, Takumi Saito, Tomoko Haraga, Yuiko Tasaki-Handa, Shingo Saito
Summary: Humic acid has the ability to complex with metal ions to form supramolecular assemblies, but determining the distribution and stoichiometry between small HA unit molecules and metal ions is challenging. The study investigated the changes in size distributions of HAs induced by Cu2+ and Tb3+ ions, with results suggesting that the supramolecular behaviors differ depending on the source of the HA and are related to the abundance of sulfur atoms.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Masami Shibukawa, Hiroki Okutsu, Shingo Saito
Summary: The volumes, composition, and structural properties of the bulk liquid phase and the interfacial liquid layer in octadecyl-bonded silica columns equilibrated with binary mixed solvents were studied using liquid chromatography. The behavior of solute compounds with weak retention can be explained by the partition between the bulk liquid phase and the interfacial solvation liquid layer. The results obtained by liquid chromatography are consistent with molecular dynamics simulation results.
Article
Chemistry, Inorganic & Nuclear
Kazuhito Yamagata, Kazuki Ouchi, Kazuki Marumo, Yuiko Tasaki-Handa, Tomoko Haraga, Shingo Saito
Summary: We discovered a Np(V)O2+ complex that exhibits unprecedented kinetic inertness in aqueous solution, with a reaction rate one million times slower than the widely accepted neptunyl complexes. By using polyacrylamide gel electrophoresis (PAGE), we found an inert NpO2+ complex with a fluorescent 1,10-phenanthroline-2,9-dicarboxylate derivative through kinetic selection from a small chemical library. The autoreduction from Np(VI)O22+ to Np(V)O2+ through complexation was observed. The remarkably low spontaneous dissociation rate constant of 8 x 10-6 s-1 (with a half-life of 23 hours) was determined using PAGE. Selective detection of Np(V)O2+ was achieved in PAGE with a detection limit of 68 pmol dm-3 (17 fg). This system was successfully applied to simulate radioactive waste samples. Our findings provide insights into actinide chemistry and offer possibilities for developing a novel separation system for real radioactive material samples.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shingo Saito, Junko Ishikawa, Moe Ono, Yuiko Tasaki-Handa, Masami Shibukawa
Summary: This paper presents a novel method, called HAC-2D urea PAGE, for analyzing Fe3+-bound transferrin species in biological samples. The method dissociates Fe3+ ions bound to the protein and determines their concentration using PAGE with a fluorescent probe. The distribution of Fe-bound transferrin species in a standard human serum sample was successfully determined, and the concentration of free Fe3+ in the serum was estimated.
ANALYTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yuiko Tasaki-Handa, Maho Yoshikawa, Shingo Saito, Masami Shibukawa
NEW JOURNAL OF CHEMISTRY
(2019)