Journal
ANALYTICAL CHEMISTRY
Volume 84, Issue 6, Pages 3003-3009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac300257q
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Funding
- National Institutes of Health [NIDDK 1R21DK082990]
- Research Corporation for Scientific Advancement
- American Heart Association
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Heterogeneous conductance of individual pores on a porous membrane was studied with a four-electrode scanning ion conductance microscope (SICM). Application of a potential difference across the membrane resulted in migration of ions through nanopores, where subsequent conductance changes were measured by a nanopipet positioned above the nanopore as a change in pipet current. Current responses of single-pore membranes and individual pores within a multipore membrane were examined and demonstrated variations in ion current rectification (ICR) ratios due to the small differences in pore geometries.
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