Journal
ANALYTICAL CHEMISTRY
Volume 83, Issue 6, Pages 2371-2377Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac200032k
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Funding
- Ontario Ministry of Research Innovation
- Natural Sciences and Engineering Research Council of Canada
- Canadian Water Network
- Canada Research Chairs Program
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Pre-equilibrium solid-phase microextraction (PE-SPME) has attracted considerable research attention due to shorter sampling times and better temporal resolution than afforded by equilibrium SPME (E-SPME). However, the calibration of PE-SPME is often time-consuming and requires deuterated calibrants, which if available, are often expensive. To address these challenges, we propose a simple but versatile kinetic calibration method, in which nonisotopic (label-free) compounds of interest can supplant the use of deuterated analogues, and the need to determine partitioning coefficients inherent to earlier procedures has been eliminated. Using this approach, both free and total concentrations of analytes can be simultaneously measured within complex sample systems with high accuracy and precision. This A calibration method was validated against established E-SPME and solid-phase extraction techniques through the measurement of selected pharmaceuticals in progressively complex matrixes including inorganic buffers, fish blood, and municipal wastewater effluents. This calibration approach may significantly improve time and cost-effectiveness, while improving the application of the SPME approach within highly dynamic systems.
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