Article
Materials Science, Multidisciplinary
Jiuchuan Guo, Shuqin Chen, Jinhong Guo, Xing Ma
Summary: Lateral flow immunoassays (LFIAs) have rapidly developed and widely used in point-of-care-testing, offering advantages such as low cost, easy operation, and short time-consumption. To improve sensitivity, novel nanomaterials have been utilized as labels in LFIAs to generate various signals for quantitative or semi-quantitative detection.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Thomas Strober, Segolene Tubau, Etienne Girard, Herve Legay, George Goussetis, Mauro Ettorre
Summary: This article presents a parallel-plate lens beam-former for satellite communications, which achieves beam steering through a mechanical feed system and is optimized using geometrical optics technique for continuous beam-steering capability over a large range. The proposed concept is validated by an all-metal prototype of a 20.5 lambda lens, showing good performance.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2021)
Article
Optics
Jing Wang, Xiaokun Wang, Lirong Peng, Jincheng Wang, Zhongkai Liu, Lingzhong Li, Mengxue Cai, Bin Liu, Wenhan Li, Xuejun Zhang
Summary: A non-null testing method utilizing Shack-Hartmann wavefront sensor is proposed to measure freeform surfaces, which improves measurement accuracy and dynamic range. A mathematical model and algorithm are developed to calculate the corresponding relationship between sampling points and spots, and experimental results demonstrate the feasibility and measurement capabilities of the method.
Article
Optics
Jing Wang, Xiaokun Wang, Lirong Peng, Jincheng Wang, Zhongkai Liu, Lingzhong Li, Mengxue Cai, Bin Liu, Wenhan Li, Xuejun Zhang
Summary: A non-null testing method utilizing a Shack-Hartmann wavefront sensor is proposed for measuring freeform surfaces. By establishing a mathematical model and algorithm, the dynamic range and measurement accuracy can be improved. Experimental results demonstrate the feasibility and measurement capabilities of this method.
Article
Engineering, Biomedical
Natalie Guirguis, Antoine-Xavier Bertrand, Christopher F. Rose, Simon Matoori
Summary: Bilirubin, first detected in blood in 1847, is widely used as a biomarker for liver disease. However, the current gold standard colorimetric test for bilirubin has limitations and lacks a bedside option, leading to delays in clinical decisions. To bridge this care gap, bioengineered point-of-care bilirubin assays are being developed. This Perspective critically discusses these recently developed assays and evaluates their potential for translation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Geography, Physical
Vivien Zahs, Lukas Winiwarter, Katharina Anders, Jack G. Williams, Martin Rutzinger, Bernhard Hoefle
Summary: A correspondence-driven plane-based M3C2 approach is proposed for quantifying small-magnitude 3D topographic change of rough surfaces. This method reduces uncertainties and is applicable to natural scenes in photogrammetric or laser scanning point clouds.
ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
(2022)
Review
Chemistry, Analytical
Yanawut Manmana, Takuya Kubo, Koji Otsuka
Summary: Point-of-care testing devices are essential for improving human life in both developing and developed countries. Specific biomolecules related to particular diseases are important targets for POC testing. Advances in new technologies have enabled researchers to develop POC devices in various platforms and designs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Tinglei Ma, Suyue Ren, Yixiang Wang, Haihan Yu, Lin Li, Xu Li, Luqing Zhang, Jinghua Yu, Yan Zhang
Summary: In recent years, point-of-care testing (POCT) technology has shifted from laboratory determination to practical applications. This article highlights the latest advances and principal issues in the design and fabrication of paper-based bipolar electrode electrochemiluminescence (BPE-ECL) sensors widely used in the POCT field. It discusses the attractive physical and chemical properties of cellulose paper, approaches to enhance paper functionality, and the materials used for fabricating paper-based BPE-ECL sensors. The article also introduces methods to enhance BPE-ECL signal and improve detection accuracy, as well as the application of paper-based BPE-ECL sensors in various fields.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Qiangqiang Fu, Tao Qi, Ze Wu, Yongjian He, Shujuan Guan, Shihua Luo, Qi Zhang, Wenfeng Luo, Wei Xiao, Bo Situ, Lei Zheng
Summary: This study presents a portable and affordable smartphone-based Hb analyzer for quick anemia testing, especially suitable for high-risk patients in areas with limited medical resources.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Multidisciplinary
Giulia Moro, Chiara Dalle Fratte, Nicola Normanno, Federico Polo, Stefano Cinti
Summary: Point-of-care (PoC) testing is revolutionizing healthcare by improving patient care and reaching remote areas. In the field of cancer management, the development of PoC devices for rapid detection of cancer markers, particularly focusing on stable blood-based markers like microRNAs, is urgently needed. This article highlights the potential impact of detecting circulating microRNAs on cancer management and emphasizes the importance of PoC testing devices, especially for low-income countries. It also discusses the challenges in promoting the technological transfer and clinical use of these tools, providing readers with a comprehensive overview of opportunities and limitations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Psychiatry
Matthew Atkins, Philip McGuire, Bhirundra Balgobin, Neville Desouza, David Taylor
Summary: This study investigated the utility of a finger prick method for full blood counts (FBC) in clozapine patients. The results showed that the point of care testing (POCT) finger prick method provided comparable results to the standard laboratory venous method. The availability of an accurate capillary monitoring method may improve clozapine uptake and adherence.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Junfeng Cui, Guanghui Wang, Changliang Zou, Zhaojun Wang
Summary: Large parallel data sets, collected from multiple sources over time, consist of paired measurements of responses and covariates. A residual-aggregated testing (RAT) method is proposed to identify the data sources where the regression relationship of each data set has shifted. The proposed method incorporates the dependence structure among different data sets and is more robust than the conventional Benjamini-Hochberg method. Under mild conditions, the asymptotic validity for false discovery proportion and FDR control is established. Extensive numerical results confirm the effectiveness and robustness of the proposed method.
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2023)
Review
Chemistry, Multidisciplinary
Zhaowei Zhang, Peng Ma, Rajib Ahmed, Jie Wang, Demir Akin, Fernando Soto, Bi-Feng Liu, Peiwu Li, Utkan Demirci
Summary: The passage highlights the global threats caused by human acute respiratory virus infections and the importance of new technologies in addressing the inadequacies of traditional detection methods. It emphasizes the key elements in clinical sample testing and the significance of sensitivity, specificity, and speed in detecting respiratory viruses.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Nicholas X. Williams, Brittani Carroll, Steven G. Noyce, Hansel Alex Hobbie, Daniel Y. Joh, Joseph G. Rogers, Aaron D. Franklin
Summary: A handheld point-of-care test (POCT) was developed to measure blood coagulation time using low-cost printed sensors, providing a rapid and accurate way to test coagulation time anywhere. The system exhibited good stability and reliability, with consistent measurements for both chicken and human blood under different conditions.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Public, Environmental & Occupational Health
Lucy Hocking, Jenny George, Eeva K. Broberg, Marc J. Struelens, Katrin C. Leitmeyer, Advait Deshpande, Sarah Parkinson, Joe Francombe, Katherine Morley, Helena de Carvalho Gomes
Summary: Although point of care testing (POCT) for infectious diseases is commonly available in all EU/EEA countries, its potential to support public health functions such as disease surveillance and reporting is underutilized. While POCT has the potential to improve clinical care by providing faster diagnoses and more appropriate use of antimicrobials, further research is needed to fully realize its benefits in wider public health functions.
FRONTIERS IN PUBLIC HEALTH
(2021)
