Journal
ANALYTICAL CHEMISTRY
Volume 81, Issue 1, Pages 80-86Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac802348r
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Funding
- NSF [0546165]
- NIH [GM079613, C06-RR-016489]
- University of Missouri Research Board
- University of Missouri Research Council
- NATIONAL CENTER FOR RESEARCH RESOURCES [K23RR016489] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079613] Funding Source: NIH RePORTER
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Nanopores are increasingly utilized as tools for single-molecule detection in biotechnology. Many nanopores are fabricated through procedures that require special materials, expensive facilities and experienced operators, which limit their usefulness on a wider scale. We have developed a simple method of fabricating a robust, low-noise nanopore by externally penetrating a nanocavity enclosed in the terminal of a capillary pipet. The nanocavity was shown to have a pore size on the scale of a single molecule, verified by translocation of molecules of known sizes, including double-stranded DNA (2 nm), gold nanoparticles (10 nm), and ring-shaped cyclodextrin (1.5 nm). ne small pore size allows entrapment of a single cyclodextrin molecule. The glass nanopore with a trapped cyclodextrin proves useful in single-molecule discrimination of chiral enantiomers.
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