Article
Chemistry, Physical
Kewei Zhu, Sibo Cheng, Nina Kovalchuk, Mark Simmons, Yi-Ke Guo, Omar K. Matar, Rossella Arcucci
Summary: In this study, the use of deep learning generative models is proposed to predict drop coalescence in chemical engineering. By training the predictive models with generated synthetic data, the lack of training data and label imbalance problem can be overcome. A novel generative model called DSCVAE is developed for labelled tabular data, which is capable of generating consistent and realistic samples compared to the standard CVAE. By enhancing random forest and gradient boosting classifiers on synthetic data and evaluating their performances based on real experimental data, numerical results show a considerable improvement in prediction accuracy, with DSCVAE outperforming the standard CVAE. This research provides valuable insights into handling imbalanced data for classification problems, particularly in chemical engineering.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Bo Wang, Yan-Fang Wang, Zi Wang, Zhong-Yu Hou
Summary: A microfluidics-based tripolar system was developed for extracting ionic current in the gas sensing process, compatible with gas chromatography (GC) systems. The system, fabricated with microelectromechanical systems technology, showed higher signal quality than discharge current for ethanol sensing. An analytical model was proposed to explain the ion extraction behavior.
Article
Engineering, Chemical
Ziwei Liu, Xiyang Liu, Shaokun Jiang, Chunying Zhu, Youguang Ma, Taotao Fu
Summary: This study investigated the application of Y step emulsification technology in microfluidic devices, focusing on the influences of microdevice structures and fluid physical properties on droplet generation. Important factors affecting emulsion flux were identified, and a prediction equation for droplet size was proposed based on inertial and viscous forces of the dispersed phase.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Biochemical Research Methods
Laura Froute, Kelly M. Guan, Wenbing Yun, Sylvia J. Y. Lewis, Benjamin D. Stripe, Xiaolin Yang, Alexandre Lapene, Anthony R. Kovscek, Patrice Creux
Summary: Characterizing the microscopic details of mudstones and shales is crucial for understanding their storage and transport properties. However, current methods struggle to accurately probe multiple scales and measure properties at the finest resolution under in situ conditions. The study introduces micro X-ray fluorescence (μXRF) as a high-performance imaging technique that can offer insights into various shale properties. By designing and implementing a porosity mapping protocol, the study demonstrates the potential advantages of μXRF for microfluidic applications.
Article
Chemistry, Analytical
Maryam Aghaseyedi, Alireza Salehi, Shayan Valijam, Mostafa Shooshtari
Summary: A study was conducted to investigate the effects of microchannel geometry on the performance of microfluidic-based gas sensors. The simulated models showed that a serpentine microchannel had higher selectivity and response compared to a simple channel. Increasing the length and reducing the height of the channel also improved selectivity.
Article
Acoustics
Hanlin Wang, Fan Yuan, Zhihua Xie, Chao Sun, Fangda Wu, Roman Mikhaylov, Minghong Shen, Jian Yang, You Zhou, Dongfang Liang, Xianfang Sun, Zhenlin Wu, Zhiyong Yang, Xin Yang
Summary: Acoustofluidic techniques are widely used for manipulating nano- and micro-particles in microfluidics. This work developed and modeled two hybrid acoustofluidic devices, a double surface acoustic wave (SAW) transducer and a PZT-SAW transducer. The numerical study showed that these devices achieved higher acoustic pressure and particle velocities in the microchannel, and the amplitude and distribution pattern of the pressure can be controlled. The particle trajectories demonstrated that both SAW-SAW and PZT-SAW configurations generated significantly higher acoustic pressure and particle velocity. This study provides new insights for designing acoustofluidic devices with multiple SAW transducers to efficiently manipulate micro- and nano-particles.
Article
Chemistry, Analytical
Yutaka Kazoe, Yusuke Shimizu, Kyojiro Morikawa, Yasushi Terui, Takashi Irie, Takehiko Kitamori
Summary: This study presents a method for shooting picoliter droplets in a controlled direction using microscale gas-phase laminar flows applied to a mass spectrometry interface. A microfluidic device with a branched and stepped hydrophobic microchannel was fabricated to achieve high-efficiency sample transport to a single quadrupole mass spectrometer. By understanding and utilizing capillary force and drag force, a design guideline was established for efficient droplet shooting.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Ali Amini, Rosanne M. Guijt, Thomas Themelis, Jelle De Vos, Sebastiaan Eeltink
Summary: DLP 3D printing is an efficient additive manufacturing method for fabricating analytical microdevices. It utilizes a digital micromirror device to direct light and polymerize a liquid resin layer by layer. Advances in vat and lift design, projector technology, and resin composition enable the accurate fabrication of microchannel structures as small as 18 x 20 μm. This review presents the latest advances in DLP 3D printing technology, including instrument set-up and resin formulation, and highlights key efforts in fabricating microdevices for emerging (bio-)analytical chemistry applications such as colorimetric assays, extraction, and separation.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Automation & Control Systems
Heba Mansour, Emad A. Soliman, Ahmed M. Fath El-Bab, Ahmed L. Abdel-Mawgood
Summary: This study investigated the feasibility of using laser ablation to fabricate epoxy resin-based microfluidic chips. The chemical and thermal properties of the epoxy resin were characterized, and migration tests were performed. The results showed that CO2 laser microfabrication is a quick and cost-effective method for producing high-quality microchannels.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2022)
Article
Robotics
Pengyun Li, Xiaoming Liu, Dan Liu, Xiaoqing Tang, Masaru Kojima, Qiang Huang, Tatsuo Arai
Summary: This study presents an automated 8-DOF alignment system assisted by computer vision for the alignment and bonding of PDMS multi-layer microfluidic devices. Experimental results show high alignment accuracy and short bonding time, indicating great potential for development.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Chemistry, Analytical
Hangrui Liu, James A. Piper, Ming Li
Summary: This study proposes a rapid, simple, and inexpensive method for spatially patterning wettability in microfluidic devices to continuously generate monodisperse DEs and successfully generate gelatin microgels. The biological capability of the generated DEs in encapsulating and supporting the growth of yeast cells is demonstrated through flow cytometric screening.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Pauline Duc, Michel Vignes, Gerald Hugon, Audrey Sebban, Gilles Carnac, Eugene Malyshev, Benoit Charlot, Florence Rage
Summary: The study combines microfluidics, soft lithography, and custom microelectrodes array technology to create hNMJs on specific pattern of electrodes, stimulating pre-synaptic axons and recording post-synaptic muscle activity. This platform allows for mature and functional in vitro modeling of hNMJs, demonstrating that electrical activation of MNs can trigger recordable extracellular muscle action potentials.
Article
Engineering, Chemical
Jia Zhang, Wenhua Xu, Fengying Xu, Wangwang Lu, Liuyun Hu, Jianlin Zhou, Chen Zhang, Zhuo Jiang
Summary: Droplet microfluidics using 3D printing technology to fabricate microfluidic devices show great potential in food emulsion processing, enabling efficient generation of single emulsions and double emulsions with stability and high quality.
JOURNAL OF FOOD ENGINEERING
(2021)
Review
Nanoscience & Nanotechnology
S. Ramya, S. Praveen Kumar, G. Dinesh Ram, D. Lingaraja
Summary: This article discusses the importance of inertial-based spiral microfluidic separation devices in medical settings, as well as the influence of cross-sectional geometries of spiral channels on separation performance. The study emphasizes the significance of cross-sectional geometry in optimizing microfluidic design for cell manipulation and separation.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Chemistry, Analytical
Terak Hornik, James Kempa, Jeffrey Catterlin, Emil Kartalov
Summary: 3D printing is expected to make significant advances in fields such as artificial muscles, prosthetics, biomedical diagnostics, biofuel cells, flexible electronics, and military logistics. However, before this can happen, the basic problem of removing sacrificial material from embedded microchannels needs to be solved. The presented technique demonstrates consistent performance in clearing sacrificial material from 3D-printed microfluidics, making it an important tool in realizing the potential of 3D printing in microfluidics and its wide range of applications.
Review
Chemistry, Analytical
Shin-Ichi Ohira, Kei Toda
Article
Chemistry, Analytical
Willy Cahya Nugraha, Haruka Nagai, Shin-Ichi Ohira, Kei Toda
ANALYTICAL SCIENCES
(2020)
Article
Chemistry, Analytical
Shin-Ichi Ohira, Tomomi Sakaki, Ryoma Miyachi, Aoi Otsubo, Asami Umemoto, Yoshihide Kuwahara, Kei Toda
Article
Chemistry, Analytical
Yumi Sugo, Ryoma Miyachi, Yo-hei Maruyama, Shin-Ichi Ohira, Masanobu Mori, Noriko S. Ishioka, Kei Toda
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Kodai Abe, Koki Shimohira, Yusuke Miki, Yasuo Hirose, Shin-Ichi Ohira, Kei Toda
Article
Biology
Kylie Owen, Kentaro Saeki, Joseph D. Warren, Alessandro Bocconcelli, David N. Wiley, Shin-Ichi Ohira, Annette Bombosch, Kei Toda, Daniel P. Zitterbart
Summary: Finding prey is essential to marine predators' survival, and natural DMS concentrations are spatially correlated to zooplankton biomass. Agent simulations demonstrate that tracking fine-scale gradients of DMS leads zooplankton predators to areas with higher prey biomass efficiently.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Analytical
Shin-Ichi Ohira, Yuka Sato, Kazuki Horiuchi, Charles Phillip Shelor, Kei Toda
Summary: A fast response potentiometric flow-through pH sensor was used for organic acid determination with ammonia permeation device for baseline pH adjustment. By titrating the introduced organic acids, the pH response could be used for theoretical calculation of analyte concentrations. Real sample analysis showed good agreement between the present system and conventional BTB method.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yumi Sugo, Ryoma Miyachi, Syohei Obata, Yo-hei Maruyama, Hinako Manabe, Masanobu Mori, Noriko S. Ishioka, Kei Toda, Shin-Ichi Ohira
Summary: Short-lived radioactive metals are important tracers in clinical diagnosis, and can be effectively separated using selective complex formation and cation-exchange adsorption. This method allows for rapid and efficient separation of radioactive metals from target metals, using a principle opposite to that of typical solid-phase extraction.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kentaro Saeki, Kazuya Ikari, Hiroyuki Yokoi, Shin-Ichi Ohira, Hiroshi Okochi, Kei Toda
Summary: Diamines, including Dap and Put, are essential organic bases for plants and are emitted into the atmosphere. Analysis shows that amide derivatives of Dap and Put are found in higher concentrations in the atmosphere than their source diamine. These aminoamides are likely produced after the release of Dap and Put into the atmosphere. The concentrations of biogenic diamines and aminoamides vary throughout the day, with lower concentrations during sunny conditions, indicating photochemical decomposition. They readily bond with water vapor and sulfuric acid in the atmosphere and may play a role in the formation of particles and organic aerosols in the forest atmosphere.
ACS EARTH AND SPACE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yusuke Okazaki, Shigeyuki Hoshi, Toshimasa Kato, Takeo Fukui, Kei Toda, Shin-Ichi Ohira
Summary: This study investigates the electrodialytic enrichment of metal cations for monitoring ultra-pure water quality. A newly designed enrichment device is used to transfer metal ions to an acidic solution, improving the sensitivity of ICP-MS analysis. The use of dynamic gravimetric method for preparing standards avoids contamination from volumetric flasks.
Article
Chemistry, Multidisciplinary
Yumi Sugo, Shin-Ichi Ohira, Hinako Manabe, Yo-hei Maruyama, Naoaki Yamazaki, Ryoma Miyachi, Kei Toda, Noriko S. Ishioka, Masanobu Mori
Summary: A highly efficient separation method was developed to recover Cu-64 from the target material generated by proton beam irradiation. The method utilizes a flow electrolysis cell and chemical reaction separation technique to achieve separation and recovery of ultratrace radioisotopes.
Article
Chemistry, Multidisciplinary
Md Aminul Hague, Kei Toda, Shin-Ichi Ohire
Summary: This study presents a general purpose electrodialysis approach to produce highly pure ILs with a purity of greater than 99%. This method offers advantages over conventional methods by avoiding the use of hazardous solvents, eliminating purification processes, and preventing the generation of side products. Moreover, this membrane-based technology allows for the easy generation of various mixed ILs.
Article
Chemistry, Analytical
Maria Shichijo, Kazumasa Okamoto, Toru Takahashi, Miharu Nomura, Shin-ichi Ohira, Hitoshi Mizuguchi, Hideji Tanaka, Masaki Takeuchi
Summary: This paper proposes a feedback standard addition method coupled flow injection analysis, FB-SAM/FIA, for the rapid and accurate determination of trace interest in seawater samples. This approach significantly improves the sample throughput compared to the manual standard addition method. The FB-SAM/FIA technique successfully applied to the determination of NO2- in natural seawater samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Kunio Sakakibara, Misaki Taira, Kanako Nagatomi, Genki Kuriyama, Shin-Ichi Ohira, Kei Toda
Summary: In this study, an automated sampler/preconcentrator was developed to monitor variations in ortho- and para-NPs over time in the gas and particle phases separately. The study found that NPs were mostly present in the gas phase and concentrations increased at night. Additionally, 2-nitro-o-cresol was detected for the first time as one of the major NPs in winter.
ENVIRONMENTAL SCIENCE-ATMOSPHERES
(2022)
Article
Chemistry, Analytical
Misaki Taira, Kunio Sakakibara, Kentaro Saeki, Shin-Ichi Ohira, Kei Toda
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2020)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)