GPCR: G protein complexes—the fundamental signaling assembly

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

Detecting single photons: A supramolecular matter?

(2012) Lorenzo Cangiano et al.   FEBS LETTERS

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the agonist-bound neurotensin receptor

(2012) Jim F. White et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

(2012) D. El Moustaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Dynamics of Activation for the Pentameric Complex of Dimeric G Protein-Coupled Receptor and Heterotrimeric G Protein

(2012) Tivadar Orban et al.   STRUCTURE

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin

(2012) Martha E. Sommer et al.   Nature Communications

Rod photoreceptor temporal properties in retinitis pigmentosa

(2011) Yuquan Wen et al.   EXPERIMENTAL EYE RESEARCH

G Protein Activation by Serotonin Type 4 Receptor Dimers

(2011) Lucie P. Pellissier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization

(2011) Beata Jastrzebska et al.   JOURNAL OF STRUCTURAL BIOLOGY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

(2011) N. Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin

(2011) A. V. Struts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Role of Aggregation in Rhodopsin Signal Transduction

(2010) Marilisa Neri et al.   BIOCHEMISTRY

Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells

(2010) Tomohiro Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation

(2010) A. Rivero-Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Nanoscale organization of β 2 -adrenergic receptor-Venus fusion protein domains on the surface of mammalian cells

(2009) Dusan Vobornik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors

(2009) Graeme Milligan   CURRENT OPINION IN PHARMACOLOGY

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

Pirenzepine Promotes the Dimerization of Muscarinic M1 Receptors through a Three-step Binding Process

(2009) Brigitte Ilien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Network-level analysis of light adaptation in rod cells under normal and altered conditions

(2009) Daniele Dell’Orco et al.   Molecular BioSystems

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Rescue of β1-Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones

(2009) Hiroyuki Kobayashi et al.   TRAFFIC

Mesoscopic Monte Carlo Simulations of Stochastic Encounters between Photoactivated Rhodopsin and Transducin in Disc Membranes

(2008) Daniele Dell'Orco et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Inherent Chirality Dominates the Visible/Near-Ultraviolet CD Spectrum of Rhodopsin

(2008) Gennaro Pescitelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

GPCR monomers and oligomers: it takes all kinds

(2008) Vsevolod V. Gurevich et al.   TRENDS IN NEUROSCIENCES

How and why do GPCRs dimerize?

(2008) Vsevolod V. Gurevich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES