Article
Infectious Diseases
Fabian Udden, Elisabeth Runow, Hans-Christian Slotved, Kurt Fuursted, Jonas Ahl, Kristian Riesbeck
Summary: This study investigated the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages following the transition from PCV10 to PCV13. The results showed that 17% of isolates were covered by PCV13, with serotypes 3 and 19A being the most common. Nonvaccine serotypes such as 11A, 23B, 15A, and 35F were also identified, with certain serotypes showing multidrug resistance or penicillin nonsusceptibility.
JOURNAL OF INFECTION
(2021)
Article
Infectious Diseases
Zhiyong Lyu, Jing Li, Jinghui Zhen, Wei Shi, Qingying Meng, Wei Zhou, Jingyun An, Kaihu Yao, Fang Dong
Summary: This study revealed that Streptococcus pneumoniae is one of the most commonly detected bacteria in pediatric clinical samples, especially in children under 5 years old. Penicillin remains the first-choice drug for treating non-meningitis pneumococcal infections, while erythromycin should not be involved in the treatment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Bekele Sharew, Feleke Moges, Gizachew Yismaw, Wondwossen Abebe, Surafal Fentaw, Didrik Vestrheim, Belay Tessema
Summary: This study aimed to assess the antimicrobial resistance profiles and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected of pneumococcal infections in Ethiopia. Most isolates were susceptible to ceftriaxone and cefotaxime, but resistance to commonly used antibiotics including penicillin was observed, indicating the need for periodic monitoring to select appropriate empirical treatments for better management of pneumococcal infection.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Infectious Diseases
Sara de Miguel, Marta Perez-Abeledo, Belen Ramos, Luis Garcia, Araceli Arce, Rodrigo Martinez-Arce, Jose Yuste, Juan Carlos Sanz
Summary: The use of pneumococcal conjugate vaccines has impacted the epidemiology and distribution of Streptococcus pneumoniae serotypes causing Invasive Pneumococcal Disease (IPD). This study analyzed the evolution of antimicrobial susceptibility to penicillin (PEN) in IPD strains isolated in Madrid, Spain, from 2007 to 2021. The results showed the emergence of non-PCV13 pneumococcal strains with different resistance patterns, including the worrisome event of serotype 11A becoming resistant to penicillin.
Article
Microbiology
Natasa Opavski, Milos Jovicevic, Jovana Kabic, Dusan Kekic, Zorica Vasiljevic, Tanja Tosic, Deana Medic, Suzana Laban, Lazar Ranin, Ina Gajic
Summary: This study characterizes invasive isolates of Streptococcus pneumoniae in Serbia before the introduction of PCVs. The findings indicate high levels of penicillin and macrolides resistance, as well as worrisome rates of multidrug- and extensive-drug resistance. The study also shows a high degree of genetic diversity, providing a basis for further investigation of changes in serotypes and genotypes after the routine introduction of PCVs.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Kristin Andrejko, Buddhika Ratnasiri, Joseph A. Lewnard
Summary: This study reviewed the antimicrobial susceptibility of pneumococcal serotypes among children globally. The results showed geographical and temporal variation in nonsusceptibility, which was associated with biological characteristics of the serotypes. The implementation of PCVs led to an increase in nonsusceptibility among non-PCV serotypes.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Korrie Salsabila, Wisiva Tofriska Paramaiswari, Hafsah Amalia, Akhmad Ruyani, Wisnu Tafroji, Yayah Winarti, Miftahuddin Majid Khoeri, Dodi Safari
Summary: This study investigated the nasopharyngeal carriage rate, serotype distribution, and antibiotic susceptibility of Streptococcus pneumoniae in children under five years of age in South Kalimantan, Indonesia. The results showed that multidrug-resistant S. pneumoniae vaccine type strains were dominated by serotype 19F. Implementing a pneumococcal conjugate vaccine program in Indonesia may reduce the circulation of multidrug-resistant strains in the community in the future.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Immunology
Yu-Te Tsai, Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Hung-Jen Tang, Chun-Yu Lin, Yen-Hsu Chen, Po-Ren Hsueh
Summary: The study suggests that empirical treatment with ceftriaxone monotherapy for pneumococcal meningitis should be carefully monitored due to its high non-susceptibility rate. However, the high susceptibility rates of most isolates to other antibiotics such as penicillin, carbapenems, respiratory quinolones, vancomycin, and linezolid indicate their potential in treating pneumococcal diseases in Taiwan.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Chih-Ho Chen, Rajendra Prasad Janapatla, Lin-Hui Su, Hsin-Chieh Li, Kuang-Che Kuo, Chun-Chih Chien, Chang-Chun Hsiao, Cheng-Hsun Chiu
Summary: The multi-center clinical microbiological study in Taiwan aimed to evaluate the impact of childhood PCV13 immunization on pneumococcal disease, and the magnitude of serotype replacement in invasive and non-invasive pneumococcal disease among all age groups. The study found that childhood PCV13 immunization exerted an indirect protection to vaccine serotype clinically defined non-bacteremic pneumococcal pneumonia among adults, especially those between 50 and 64 years of age. Emerging non-PCV13 serotypes mainly caused non-invasive mucosal disease among children.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela
Summary: The virulence factor PspA plays a critical role in the aggregation and protection of Streptococcus pneumoniae during colonization, while lactoferrin counters this effect. PspA forms protein complexes with mGAPDH and lactoferrin on the surface of the bacteria, and changes in the levels of these proteins may have important implications on the colonization, survival on fomites, and transmission of S. pneumoniae.
Article
Infectious Diseases
Javier Eduardo Fernandez, Vincent Perreten, Sybille Schwendener
Summary: The study revealed novel macrolide resistance determinants in a strain of Macrococcus canis from a dog with an ear infection, which were functional in conferring resistance to clinically important macrolides when expressed in Staphylococcus aureus. These resistance genes were associated with mobile genetic elements, indicating the potential for further dissemination of macrolide resistance in bacterial populations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Satoshi Ide, Masahiro Ishikane, Kensuke Aoyagi, Akane Ono, Yusuke Asai, Shinya Tsuzuki, Yoshiki Kusama, Yoshiaki Gu, Eiichi Kodama, Norio Ohmagari
Summary: Macrolide usage in Japan exceeds that in Europe and the United States. This study aimed to evaluate the prescription patterns of macrolides and the diseases for which they were prescribed in Japan. Data from January 2013 to December 2018 were analyzed, and it was found that approximately 30% of oral antimicrobial prescriptions were for macrolides, with clarithromycin being the most commonly prescribed. Acute diseases such as common cold accounted for most prescriptions, while chronic diseases included allergic and dermatological conditions. These findings highlight the importance of appropriate macrolide use and the need for further research and interventions.
Article
Microbiology
Menglan Zhou, Ziran Wang, Li Zhang, Timothy Kudinha, Haoran An, Chenyun Qian, Bin Jiang, Yao Wang, Yingchun Xu, Zhengyin Liu, Hong Zhang, Jingren Zhang
Summary: This multicenter study investigated the serotype and sequence type (ST) distribution, antimicrobial susceptibility, and virulence of Streptococcus pneumoniae strains causing invasive pneumococcal diseases (IPDs) in China. The study found that different serotypes of strains had different levels of virulence and antibiotic resistance rates.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Adriano P. Araujo, Maria Leonor S. Oliveira, Eliane N. Miyaji
Summary: Streptococcus pneumoniae colonizes the human nasopharynx asymptomatically, but can cause various diseases. This study demonstrates the important role of PspA and PspC in nasopharyngeal colonization, although their significance may vary between different strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Leigh M. Howard, Xiang Huang, Wencong Chen, Yuhan Liu, Kathryn M. Edwards, Marie R. Griffin, Yuwei Zhu, Jorge E. Vidal, Keith P. Klugman, Ana I. Gil, Nicole R. Soper, Isaac P. Thomsen, Katherine Gould, Jason Hinds, Claudio F. Lanata, Carlos G. Grijalva
Summary: We investigated the association between nasopharyngeal pneumococcal co-colonization and pneumococcal density in young Peruvian children. Pneumococcal co-colonization was common but not associated with increased pneumococcal density.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Hematology
Elizabeth M. Todd, Julie Y. Zhou, Taylor P. Szasz, Lauren E. Deady, June A. D'Angelo, Matthew D. Cheung, Alfred H. J. Kim, Sharon Celeste Morley
Article
Biochemistry & Molecular Biology
Julie Y. Zhou, Taylor P. Szasz, Phillip J. Stewart-Hutchinson, Janardan Sivapalan, Elizabeth M. Todd, Lauren E. Deady, John A. Cooper, Michael D. Onken, S. Celeste Morley
MOLECULAR IMMUNOLOGY
(2016)
Article
Immunology
Michelle McFarland, Taylor P. Szasz, Julie Y. Zhou, Kara Motley, Janardan S. Sivapalan, Megan Isaacson-Schmid, Elizabeth M. Todd, Patrick G. Hogan, Stephanie A. Fritz, Carey-Ann D. Burnham, Steen Hoffmann, Sharon Celeste Morley
Review
Immunology
Julie Y. Zhou, Douglas M. Oswald, Kelsey D. Oliva, Lori S. C. Kreisman, Brian A. Cobb
TRENDS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Mark B. Jones, Carlos A. Alvarez, Jenny L. Johnson, Julie Y. Zhou, Nathan Morris, Brian A. Cobb
Article
Biochemistry & Molecular Biology
Douglas M. Oswald, Julie Y. Zhou, Mark B. Jones, Brian A. Cobb
GLYCOCONJUGATE JOURNAL
(2020)
Review
Immunology
Julie Y. Zhou, Brian A. Cobb
Summary: Glycans play essential roles in the immune system, participating in various immunological processes and impacting inflammatory, autoimmune, and cancer disease states.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Biology
Julie Y. Zhou, Carlos A. Alvarez, Brian A. Cobb
Summary: Cells integrate concurrent signaling initiated by different cytokines to produce specific responses, and the combinatorial effects of different cytokines can lead to distinct biological outcomes, understanding this signaling pathway is crucial for addressing diseases.
Article
Cell Biology
Leandre M. Glendenning, Julie Y. Zhou, Kalob M. Reynero, Brian A. Cobb
Summary: The degree of alpha 2,6-linked sialylation on IgG glycans is associated with inflammatory conditions. IgG has divergent pathways for glycosylation and trafficking, with poor sialylation and high core fucosylation in cell culture. In contrast, cell surface glycoproteins on IgG-producing cells show high sialylation and low fucosylation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Microbiology
Shanshan Zhang, Yi Han, Whitman Schofield, Michael Nicosia, Paul E. Karell, Kevin P. Newhall, Julie Y. Zhou, Ryan J. Musich, Siyi Pan, Anna Valujskikh, Naseer Sangwan, Mohammed Dwidar, Qiuhe Lu, Thaddeus S. Stappenbeck
Summary: This study found that the prebiotic pectin oligosaccharide (pec-oligo) stimulated high levels of IgA production in the small intestine in a T cell-dependent manner. Surprisingly, the increased IgA levels persisted even after cessation of pec-oligo treatment, and microbiome transmission was sufficient to maintain high IgA levels. Notably, the specific bacterial taxa associated with pec-oligo did not align with the IgA-coated microbes, suggesting a role for ethanol-resistant microbes in driving the IgA-high phenotype.
CELL HOST & MICROBE
(2023)
Article
Biochemistry & Molecular Biology
Douglas M. Oswald, Sylvain D. Lehoux, Julie Y. Zhou, Leandre M. Glendenning, Richard D. Cummings, Brian A. Cobb
Summary: The glycosylation of IgG is important for its function, but the mechanisms and factors involved are not well understood. This study suggests that alpha 2,6-sialylation of IgG occurs after release from B cells and is not dependent on plasma-localized ST6Gal1 activity.
Article
Biochemistry & Molecular Biology
Julie Y. Zhou, David Zhou, Kevin Telfer, Kalob Reynero, Mark B. Jones, John Hambor, Brian A. Cobb
Summary: The immunodominant capsular carbohydrate, Polysaccharide A (PSA), from Bacteroides fragilis, can activate suppressive CD4(+) T cells and promote an alternatively activated M2 macrophage phenotype. PSA also upregulates the T cell activation marker CD86 on dendritic cells. These findings suggest that the immune response induced by PSA involves both T cell stimulation by dendritic cells and anti-inflammatory polarization of macrophages.
