Article
Medicine, General & Internal
Jaime Altcheh, Mabel V. Carosella, Ana Ceballos, Ulises D'Andrea, Sandra M. Jofre, Carolina Marotta, Domingo Mugeri, Liliana Sabbaj, Adriana Soto, Constant Josse, Francois Montestruc, Lynne V. McFarland
Summary: This study compared the efficacy and safety of two probiotics for pediatric acute diarrhea. The results showed that Saccharomyces boulardii CNCM I-745 demonstrated better efficacy than a four-strain mixture of Bacillus clausii for reducing the duration of diarrhea.
Article
Medicine, General & Internal
Yuchong Zhao, Yilei Yang, Aruna, Jun Xiao, Jun Song, Tizheng Huang, Shuyu Li, Jiguang Kou, Lu Huang, Dexiong Ji, Si Xiong, Wang Peng, Sanping Xu, Bin Cheng
Summary: The combination of S. boulardii and quadruple therapy for H. pylori eradication significantly reduces the incidence and duration of diarrhea, but did not have a significant impact on the eradication rate.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Maria Lucianny Lima Barbosa, Mariana Oliveira Albano, Conceicao da Silva Martins, Cirle Alcantara Warren, Gerly Anne de Castro Brito
Summary: Clostridioides difficile infection (CDI) is a common cause of healthcare-associated diarrhea, especially in older adults. Probiotics, as live microorganisms, have been studied for their potential protective benefits against CDI. This review found that there is no consensus among studies, but three out of seven evaluated studies suggested that probiotics could reduce the incidence of hospital-onset CDI in older adults. More research is needed to understand the effectiveness of probiotics in preventing CDI in hospitalized older adults receiving antibiotics.
FRONTIERS IN MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
M. R. S. Ribeiro, D. R. Oliveira, M. V. Caliari, D. C. Cara Machado, M. E. R. Andrade, V. N. Cardoso, F. dos Santos Martins, J. R. Nicoli, M. A. Gomes
Summary: This study evaluated the effect of treatment with the probiotic Saccharomyces boulardii with or without metronidazole in experimental giardiasis, finding a significant reduction in parasitic load and protection against intestinal mucosal damage and oxidative stress. The results suggest the potential use of S. boulardii as an alternative treatment for giardiasis, especially in cases of resistance or intolerance to conventional treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Ibrahim Ethem Cakcak, Yusuf Emre Aytin, Sezin Sayin, Ahmet Kucukarda, Ali Gokyer, Ivo Gokmen, Erkan Ozcan, Selcuk Korkmaz, Ebru Tastekin, Irfan Cicin
Summary: In this study, the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model were investigated. The results showed that the group treated with Saccharomyces boulardii had better outcomes in terms of diarrhea and weight loss, as well as lower histopathological changes compared to the control group.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Immunology
Erick Manuel Toro Monjaraz, Karen Rubi Ignorosa Arellano, Alejandro Loredo Mayer, Berenice Palacios-Gonzalez, Roberto Cervantes Bustamante, Jaime Alfonso Ramirez Mayans
Summary: Acute diarrhea is associated with norovirus and Campylobacter jejuni in Mexican children. Treatment with Saccharomyces boulardii CNCM I-745 can facilitate gut microbiota restoration and improve alpha diversity in children with acute diarrhea.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
Qicheng Lu, Junli Niu, Yanyan Wu, Wenju Zhang
Summary: This study found that supplementation with live Saccharomyces cerevisiae var. boulardii improved the growth performance of dairy calves, increased serum immunoglobulin concentrations, and modulated the rectal microbiota.
Review
Microbiology
Natasza M. R. Hain-Saunders, Daniel R. Knight, Mieghan Bruce, Thomas V. Riley
Summary: Clostridioides difficile poses a significant health risk to both humans and animals, especially in equine populations. Current understanding of equine C. difficile infection is inadequate, highlighting the need for a holistic One Health approach to address this complex issue.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Pediatrics
Di Hu, Ying Wang, Suyan Yang, Huijuan Zhang
Summary: This study evaluated the therapeutic effect of Saccharomyces boulardii supplementation on jaundice in premature infants undergoing phototherapy. The results showed that premature infants receiving S. boulardii supplementation had shorter duration of jaundice resolution and phototherapy, lower total serum bilirubin levels, and improved bowel movements. The conclusion is that S. boulardii in combination with phototherapy has a good therapeutic effect in the treatment of jaundice in premature infants.
JORNAL DE PEDIATRIA
(2023)
Article
Critical Care Medicine
Scott Mayer, Colin Bonhag, Patrick Jenkins, Brendon Cornett, Paula Watts, Dmitriy Scherbak
Summary: This retrospective observational cohort study found that the administration of probiotics to ICU patients with central venous catheters is associated with a substantial rate of probiotic-associated bloodstream infections, leading to increased mortality. Powder formulations of probiotics have a higher rate of infection compared to nonpowder formulations.
CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Jiawei Zhang, Su Wan, Qingqing Gui
Summary: The study showed that both Bifidobacterium triple viable and Saccharomyces boulardii were more effective in treating childhood diarrhea compared to conventional treatment. Bifidobacterium triple viable exhibited a more significant treatment effect, proving to be safe and able to shorten the duration of the disease, with clinical relevance.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Food Science & Technology
Mengjian Liu, WuJun Liu, WenJu Zhang, Jun Yao, Xucheng Mo
Summary: The study aimed to determine the optimal ultrasound-assisted extraction parameters of Saccharomyces boulardii yeast wall polysaccharides (BYWP) and investigate its effects on early-weaned lambs. Results showed that supplementing BYWP in the diet of early-weaned lambs could improve growth performance, intestinal morphology, immune response, and microbial flora balance, while reducing the incidence of diarrhea.
FOOD SCIENCE & NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Jingpeng Yang, Lingtong Meng, Yanan Li, He Huang
Summary: This article discusses the vital role of probiotics in the food and nutraceutical fields, as well as their potential effects in regulating gut inflammation and the nutritional environment. The coadministration of probiotics with antibiotics is explored as a preventive measure for intestinal infections caused by Clostridioides difficile. The article emphasizes the need for further research on specific probiotic strains, the order and timing of coadministration, and the development of next-generation probiotics for a more effective bacteria-drug combination model.
Review
Biochemistry & Molecular Biology
Jingpeng Yang, Lingtong Meng, Yanan Li, He Huang
Summary: Probiotics play a vital role in the food and nutraceutical fields. The combination of probiotics and antibiotics has been used in clinical nutrition to prevent intestinal infections, but the mechanism behind this model is not yet clear. Further research is needed on the selection of probiotic strains and the time interval of coadministration.
Article
Dentistry, Oral Surgery & Medicine
Hongye Lu, Lu He, Dongsiqi Jin, Yunxuan Zhu, Huanxin Meng
Summary: Periodontitis treatment with SRP and adjunctive antibiotics led to significant clinical improvement and reduced microbial diversity within 6 months. The use of antibiotics also showed potential benefits for systemic inflammation and glucose levels.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Pediatrics
Dilek Yilmaz Ciftdogan, Yildiz Ekemen Keles, Adem Karbuz, Benhur Sirvan Cetin, Sefika Elmas Bozdemir, Eda Kepenekli Kadayifci, Ozge Metin Akcan, Arife Ozer, Tugba Erat, Murat Sutcu, Ayse Buyukcam, Nursen Belet, Emine Hafize Erdeniz, Nazan Dalgic Karabulut, Selda Hancerli Torun, Selim Oncel, Zerrin Orbak, Ozden Turel, Zeynep Gokce Gayretli Aydin, Omer Kilic, Aysun Yahsi, Ahu Kara Aksay, Zeynep Ergenc, Mey Talip Petmezci, Mehmet Burhan Oflaz, Remzi Sarikaya, Gulcin Otar Yener, Seval Ozen, Doruk Gul, Gazi Arslan, Soner Sertan Kara, Demet Demirkol, Pinar Yazici Ozkaya, Yilmaz Yozgat, Celal Varan, Manolya Kara, Gul Arga, Nurhayat Yakut, Ahmet Osman Kilic, Ozlem Cakici, Mehmet Kucuk, Ozge Kaba, Hatice Karaoglu Asrak, Burcu Bursal Duramaz, Tahir Dalkiran, Ayse Berna Anil, Mehmet Turgut, Bulent Karapinar, Ayper Somer, Ferhan Elmali, Ener Cagri Dinleyici, Ergin Ciftci, Ates Kara
Summary: This study describes the clinical features, laboratory characteristics, and outcomes of children diagnosed with MIS-C in 25 different hospitals in Turkey. The study found that MIS-C has a broad clinical spectrum and most patients were previously healthy. Prompt diagnosis and treatment are essential for the management of MIS-C.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Immunology
Yu-Lung Lau, Ting Fan Leung, Benhur Sirvan Cetin, Ener Cagri Dinleyici, Li-Min Huang, Scott A. Halperin, Chien-Chou Hsiao, Bruce Tapiero, Mary Tipton, James D. Campbell, Leentje Moerman, Michael Povey, Dan Bi, Tina Singh
Summary: This study evaluated the reactogenicity and safety of a liquid PCV-free HRV vaccine. The results showed that the occurrence of general adverse events was comparable between infants who received the liquid PCV-free HRV vaccine and those who received the lyophilized HRV vaccine. Irritability/fussiness was the most frequently reported adverse event. The incidence of unsolicited adverse events and serious adverse events was also similar between the two groups.
Article
Pharmacology & Pharmacy
Kaan Aslan, Omer Kilic, Eylem Kiral, Gurkan Bozan, Ozcan Bor, Ener cagri Dinleyici
Summary: By reviewing the use of tigecycline in paediatric patients, it was found that tigecycline may be a safe and effective option for the treatment of resistant infections in children.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Infectious Diseases
Merve Iseri Nepesov, Omer Kilic, Ener Cagri Dinleyici
Summary: Meningitis caused by resistant microorganisms after neurosurgical intervention is difficult to treat, and intraventricular colistin has been recommended as a potential solution. This report shows a successful case of treating ventriculoperitoneal shunt-related meningitis caused by extended spectrum β-lactamase-producing Klebsiella pneumoniae using intraventricular colistin.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Gastroenterology & Hepatology
Hania Szajewska, Roberto Berni Canani, Magnus Domellof, Alfredo Guarino, Iva Hojsak, Flavia Indrio, Andrea Lo Vecchio, Walter A. Mihatsch, Alexis Mosca, Rok Orel, Silvia Salvatore, Raanan Shamir, Chris H. P. van den Akker, Johannes B. van Goudoever, Yvan Vandenplas, Zvi Weizman
Summary: The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. Specific probiotic strains are recommended for the treatment of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. However, further studies are needed to confirm the effects and determine the type, dose, and timing of probiotics, and the use of probiotics without documented health benefits should be discouraged.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Pediatrics
Sevgen Tanir Basaranoglu, Ayse Karaaslan, Enes Sali, Ergin Ciftci, Zeynep Gokce Gayretli Aydin, Bilge Aldemir Kocabas, Cemil Kaya, Semra Sen Bayturan, Soner Sertan Kara, Dilek Yilmaz Ciftdogan, Ummuhan Cay, Hacer Gundogdu Akturk, Melda Celik, Halil Ozdemir, Ayper Somer, Tijen Diri, Ahmet Sami Yazar, Murat Sutcu, Hasan Tezer, Eda Karadag Oncel, Manolya Kara, Solmaz Celebi, Aslinur Ozkaya Parlakay, Sabahat Karakaslilar, Emin Sami Arisoy, Gonul Tanir, Tugce Tural Kara, Ilker Devrim, Tugba Erat, Kubra Aykac, Ozge Kaba, Sirin Guven, Edanur Yesil, Ayse Tekin Yilmaz, Sevgi Yasar Durmus, Ilknur Caglar, Fatih Gunay, Metehan Ozen, Ener Cagri Dinleyici, Ates Kara
Summary: This study assessed the epidemiological data of pediatric patients with antibiotic-associated diarrhea in our region. The results showed that the prevalence of antibiotic-associated diarrhea was 10.4% for amoxicillin-clavulanate and 14.4% for cephalosporins. The occurrence of antibiotic-associated diarrhea differed significantly according to geographical regions in Turkey, particularly higher in The Eastern Anatolia and Southeastern Anatolia. This study provides epidemiological data and geographical differences for pediatric antibiotic-associated diarrhea.
Letter
Immunology
Mahmut Can Kizil, Yalcin Kara, Gurkan Bozan, Surhan Arda, Gul Durmaz, Omer Kilic, Ener Cagri Dinleyici
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Yalcin Kara, Mahmut Can Kizil, Mehmet Ozgur Arslanoglu, Ebru Kacmaz, Nidai Dalokay, Ezgi Pala, Eylem Kiral, Gurkan Bozan, Tercan Us, Omer Kilic, Ener Cagri Dinleyici
Summary: During the COVID-19 pandemic, pediatric cases of human bocavirus (HBoV) infection presented with severe respiratory symptoms, including common cold, acute otitis media, asthma exacerbations, and bronchiolitis pneumonia, and some cases required pediatric intensive care unit stay. A retrospective study evaluated the clinical characteristics of 54 children diagnosed with HBoV respiratory infections, revealing that cough, fever, and respiratory distress were the most prevalent symptoms, and a significant proportion of children required intensive care.
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Meltem Dinleyici, Jana Barbieur, Ener Cagri Dinleyici, Yvan Vandenplas
Summary: Human milk oligosaccharides (HMOs) are important components in human milk, varying greatly between mothers. HMOs improve gut health, protect against infection, and promote cognitive development. Supplementing formula with HMOs is safe and beneficial for microbiota composition and infection prevention, but the clinical benefits compared to non-human oligosaccharides are not known. More research is needed to understand the factors influencing HMO composition and their functions.
Article
Medicine, General & Internal
Gurkan Bozan, Vicente Perez-Brocal, Kaan Aslan, Eylem Kiral, Esra Sevketoglu, Mutlu Uysal Yazici, Ebru Azapagasi, Tanil Kendirli, Serhat Emeksiz, Oguz Dursun, Dincer Yildizdas, Ayse Berna Anil, Nihal Akcay, Hasan Serdar Kihtir, Merve Havan, Nazan Ulgen Tekerek, Faruk Ekinci, Omer Kilic, Andres Moya, Ener Cagri Dinleyici
Summary: The composition of microbiota in the intestines and nasopharynx of children with invasive meningococcal disease (IMD) was found to be different from that of healthy children. The infection itself or other care interventions led to changes in the microbiota composition. Understanding the interaction of microbiota with pathogens, such as N. meningitidis, could help us understand the dynamics of the disease.
Article
Pediatrics
Ayben Leblebici, Gurkan Bozan, Asli Kavaz Tufan, Eylem Kiral, Ebru Kacmaz, Ener Cagri Dinleyici
Summary: AKI in PICUs is a crucial factor affecting mortality in critically ill pediatric patients. This study compared the AKIN and pRIFLE AKI classifications and PICU scoring modalities, finding a significant correlation between AKI and PRISM III, PELOD-2, and pSOFA scores. However, there were no significant differences in the stages of kidney injury according to the AKIN criteria. Identifying the risk factors for AKI and planning antimicrobial regimens based on PICU admission could decrease mortality rates.
Article
Gastroenterology & Hepatology
Gonca Kilic Yildirim, Meltem Dinleyici, Yvan Vandenplas, Ener Cagri Dinleyici
Summary: This study is the first to demonstrate that the use of a multispecies synbiotic is associated with changes in intestinal microbiota composition and a decrease in BMI in children and adolescents with obesity.
Article
Microbiology
Gurkan Bozan, Yalcin Kara, Eylem Kiral, Mahmut Can Kizil, Ebru Kacmaz, Tercan Us, Gul Durmaz, Omer Kilic, Ener Cagri Dinleyici
Summary: This study evaluated the use of a rapid molecular diagnostic pneumonia panel in children with lower respiratory tract infections. The results showed that this approach has advantages in diagnosing pneumonia and guiding antibiotic therapy, as it provides results more quickly and enables the identification of resistance profiles.
Article
Microbiology
Pinar Yildiz, Melisa Sahin Tekin, Mucahit Kaya, Ener Cagri Dinleyici
Summary: The prevalence of Neisseria meningitidis carriage and serogroup distribution among older adults in Turkiye was assessed. The study found that 13.9% of participants carried Nm, with MenY being the most common serogroup. Only MenY was detected in patients over 75 years of age. Adequate surveillance and carriage studies can inform vaccination strategies for older adults.
Article
Pediatrics
Dilek Yilmaz, Gulnihan Ustundag, Ayse Buyukcam, Enes Sali, Umit Celik, Gulhadiye Avcu, Nursen Belet, Esra Cakmak Taskin, Sevliya Ocal Demir, Ahmet Ziya Birbilen, Omer Kilic, Ozge Metin Akcan, Ayse Tekin Yilmaz, Bilge Aldemir Kocabas, Nevin Hatipoglu, Adem Karbuz, Deniz Cakir, Murat Sutcu, Fatma Deniz Aygun, Taylan Celik, Semra Bayturan Sen, Nazan Dalgic, Zuhal Umit, Soner Sertan Kara, Eda Karadag Oncel, Ahmet Bolat, Merve Kilic Cil, Caner Turan, Ayse Cakil Guzin, Sevgi Topal, Gulser Esen Besli, Gizem Dogan, Sabiha Sahin, Fatih Akin, Yasar Bildirici, Gulperi Timurtas Dayar, Emine Ergul Sari, Didem Kizmaz Isancli, Manolya Kara, Pinar Onal, Hakan Aylac, Duygu Luleci, Belma Yasar, Elif Dede, Aykut Caglar, Sevgi Akova, Elif Afat Turgut, Pinar Yazici Ozkaya, Tugba Kandemir Gulmez, Emel Ulusoy, Muhterem Duyu, Yalcin Kara, Huseyin Celiktas, Onur Tekeli, Fatma Caglar, Doruk Gul, Sinem Oral Cebeci, Fatih Battal, Alkan Bal, Emre Aygun, Metin Uysalol, Gazi Arslan, Ayberk Ozkavakli, Mahmut Can Kizil, Abdullah Yazar, Fatih Aygun, Ayper Somer, Necdet Kuyucu, Ener Cagri Dinleyici, Ates Kara
Summary: This is a multi-center point prevalence study on children diagnosed with coronavirus disease 2019 (COVID-19). The study included inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 12 cities and 24 centers in Turkey on February 2nd, 2022. Among 8605 patients in participating centers on that day, 706 (8.2%) had COVID-19. The study found that fever, cough, and fatigue were the most common symptoms of COVID-19 in children, and asthma, neurologic disorders, and obesity were the most common underlying chronic diseases. The vaccination rate for COVID-19 was 12.5%.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
