Article
Immunology
Ignacio Salamanca de la Cueva, Barbara Pahud, Li-Min Huang, Michael Leonardi, Jose Garcia-Sicilia, Javier Cespedes, Arturo Abdelnour, Tsuyoshi Tamura, Haruo Kuroki, Nan-Chang Chiu, Miia Virta, Satu Kokko, Michael Horn, Falko Panzer, Jong-Hyun Kim, Lee Jin, Leentje Moerman, Christophe Debacq, Jose Parra, Ana Ugarte, Dan Bi
Summary: The immunogenicity of PCV-free HRV was comparable to HRV when administered to infants according to a 2-dose series, and consistency was demonstrated across different lots of PCV-free HRV. Adverse events incidence was similar following vaccination with PCV-free HRV or HRV.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Remon Abu-Elyazeed, Nicola P. Klein, Leentje Moerman, Michael Povey, Anthony Pruitt, Shelly Senders, Peter Silas, Dan Bi
Summary: This study conducted in the United States showed that the liquid PCV-free HRV and lyophilized HRV had similar immunogenicity and safety profiles. There were no differences in immune responses to routine vaccine antigens between the two groups.
Article
Veterinary Sciences
Jeonggyo Lim, Myongha Jin, Injoong Yoon, Han Sang Yoo
Summary: This study evaluated the efficacy of two new bivalent vaccines of PCV2 and MHP in SPF pigs and found that both vaccines effectively protected pigs against PCV2d infection.
JOURNAL OF VETERINARY SCIENCE
(2022)
Review
Immunology
Hemanta Kumar Maity, Kartik Samanta, Rajib Deb, Vivek Kumar Gupta
Summary: Porcine circovirus (PCV), belonging to Circoviridae family, poses significant economic risk to global swine industry. PCV2, with nine genotypes (a-i), especially PCV2d, has emerged as the predominant genotype worldwide. PCV2 is commonly found in both domestic pigs and wild boars, sporadically in non-porcine animals. The virus spreads among swine populations through horizontal and vertical transmission. Despite available vaccines, genotypic shifts maintain PCV2 as a significant pathogen. This review aims to provide updated understanding of biology, genetic variation, distribution, and preventive strategies of porcine circoviruses and associated diseases in swine.
Review
Infectious Diseases
Stella Pranoto, Hsing-Chieh Wu, Chun-Yen Chu
Summary: Porcine circovirus (PCV) is composed of four distinct species, with PCV2 causing significant economic losses in the swine industry. PCV3 has been circulating prior to its discovery and is suspected to have a similar impact to PCV2. However, PCV2 vaccines are inadequate in protecting against PCV3 due to their low amino acid identity. Swift measures, including vaccine development, are necessary to control PCV3 and address the challenges faced in this field.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Infectious Diseases
Salma Al Bahrani, Ali Albarrak, Othman Ali Alghamdi, Mesfer Abdullah Alghamdi, Fatimah H. Hakami, Asmaa K. Al Abaadi, Sausan A. Alkhrashi, Mansour Y. Alghamdi, Meshael M. Almershad, Mansour Moklif Alenazi, Mohamed Hany El Gezery, Arulanantham Zechariah Jebakumar, Jaffar A. Al-Tawfiq
Summary: This study evaluated the safety and reactogenicity of the ChAdOx1-S vaccine after the first dose in 1592 adults, finding that males were more likely to experience adverse reactions such as fever, skin rash, and pain at the injection site. The study also showed no breakthrough infections of the ChAdOx1-S vaccine during the observation period.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Ning Li, Jing Liu, Jiali Qi, Feng Hao, Lei Xu, Kangkang Guo
Summary: The study reveals the genetic diversity of PCV2 in China, showing that PCV2b was initially dominant but shifted to PCV2d from 2009. This suggests a potential transition from PCV2b to PCV2d in 2009, similar to global patterns. Additionally, novel PCV2 strains were identified, highlighting the rich genetic diversity of PCV2 in China from 2000 to 2019.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Flavia Guarneri, Enrico Tommaso Tresoldi, Giuseppe Sarli, Maria Beatrice Boniotti, Davide Lelli, Ilaria Barbieri, Barbara Bacci, Giulia D'Annunzio, Massimo Amadori
Summary: PCV2 vaccines' protection against PCV2b virus post immunization, with pigs showing specific IFN-gamma response in blood being protected against viremia. However, neutralizing and ELISA antibody titers do not show obvious correlation with protection, with some pigs developing higher antibody responses post immunization.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Wan Li, Mingkai Lei, Zhuofei Li, Huimin Li, Zheng Liu, Qigai He, Rui Luo
Summary: In this paper, a bivalent vaccine against PEDV and PoRV was developed and shown to be effective in preventing infections and improving piglet survival rates.
Article
Veterinary Sciences
Pichanun Wongchanapai, Panuwat Yamsakul, Jirapat Arunorat, Thunyamas Guntawang, Tidaratt Sittisak, Saralee Srivorakul, Kornravee Photichai, Roongroje Thanawongnuwech, Manakorn Sukmak, Kidsadagon Pringproa
Summary: Porcine circovirus-associated disease (PCVAD) is one of the most important viral infectious diseases in pigs. This study demonstrated that vaccinating pigs with the chimeric PCV1-2a or PCV1-2a-2b vaccines can effectively enhance immune response against PCV2d infection and reduce viral load.
VETERINARY SCIENCES
(2023)
Article
Microbiology
Payuda Hansoongnern, Nantawan Phecharat, Ketkaew Wasanasuk, Wantanee Tommeurd, Penpitcha Chankeeree, Chalermpol Lekcharoensuk, Ploypailin Semkum, Sunan Pinitkiatisakul, Porntippa Lekcharoensuk
Summary: In this study, a recombinant plasmid carrying CpG ODN was designed and constructed to incorporate CpG ODN into porcine circovirus type 2 (PCV2) virus-like particles (VLPs) for enhancing the immunogenicity of the vaccine. The CpG ODN-loaded VLPs significantly increased PCV2-specific neutralizing antibodies and interferon gamma (IFN-gamma) expression in immunized mice compared to VLPs alone.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Lanjeong Ju, Su-Hwa You, Min-A Lee, Usharani Jayaramaiah, Young-Ju Jeong, Hyang-Sim Lee, Bang-Hun Hyun, Nakhyung Lee, Seok-Jin Kang
Summary: In this study, a PCV2d vaccine candidate was selected and its protective efficacy against PCV2d isolate was evaluated. The results showed that the vaccine effectively reduced the copy number of PCV2d in blood and tissues, demonstrating protective efficacy against the currently prevalent PCV2d.
Article
Immunology
Barbara Poulsen Nautrup, Ilse Van Vlaenderen, Martha A. Mellencamp
Summary: This meta-analysis compared the effectiveness of a chimeric vaccine against porcine circovirus type 2 (PCV2) containing genotypes PCV2a+b (Fostera((R)) Gold PCV MH [FOS-G]) with commonly used vaccines derived from genotype PCV2a. The analysis considered parameters including average daily gain (ADG), mortality, and market classification. The results showed that in the US setting, there were no significant differences in ADG, mortality, and market classification between FOS-G and its competitor. However, in a Korean study, pigs vaccinated with FOS-G had higher ADG compared to those vaccinated with POR.
Article
Immunology
Lanjeong Ju, Usharani Jayaramaiah, Min-A Lee, Young-Ju Jeong, Su-Hwa You, Hyang-Sim Lee, Bang-Hun Hyun, Nakhyung Lee, Seok-Jin Kang
Summary: This study evaluated the efficacy of a VLP vaccine against PCV2d in a farm environment. The results showed that vaccinated piglets had lower viremia levels and higher body weight gain compared to the control group after natural infection.
Article
Immunology
Nguyen Minh Hai, Nguyen Dang Dung, Dinh Cong Pho, Vu Tung Son, Vu Ngoc Hoan, Phan Tan Dan, Bui Dang The Anh, La Huong Giang, Pham Ngoc Hung
Summary: The study in Vietnam evaluated the immunogenicity, safety, and reactogenicity of ROTAVAC (R) in 360 healthy infants. The vaccine regimen demonstrated an immunological response with clinically acceptable safety profile, with only minor adverse events recorded.
Article
Allergy
Lingyi Wang, Qing Xiong, Nawannaporn Saelim, Lin Wang, Wenyan Nong, Angel Tsz-Yau Wan, Mai Shi, Xiaoyu Liu, Qin Cao, Jerome Ho Lam Hui, Nitat Sookrung, Ting-Fan Leung, Anchalee Tungtrongchitr, Stephen Kwok Wing Tsui
Summary: The study successfully characterized the allergen profile of the American cockroach at the molecular level, identifying seven novel allergen groups and one isoallergen. The research also revealed the possibility of cross-reaction with closely related species.
Article
Gastroenterology & Hepatology
Hania Szajewska, Roberto Berni Canani, Magnus Domellof, Alfredo Guarino, Iva Hojsak, Flavia Indrio, Andrea Lo Vecchio, Walter A. Mihatsch, Alexis Mosca, Rok Orel, Silvia Salvatore, Raanan Shamir, Chris H. P. van den Akker, Johannes B. van Goudoever, Yvan Vandenplas, Zvi Weizman
Summary: The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. Specific probiotic strains are recommended for the treatment of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. However, further studies are needed to confirm the effects and determine the type, dose, and timing of probiotics, and the use of probiotics without documented health benefits should be discouraged.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Respiratory System
Danilo Buonsenso, Antoni Noguera-Julian, Rossana Moroni, Angel Hernandez-Bartolome, Nora Fritschi, Laura Lancella, Laura Cursi, Aleix Soler-Garcia, Renate Krueger, Cornelia Feiterna-Sperling, Michela Sali, Andrea Lo Vecchio, Sara Scarano, Alicia Hernanz Lobo, Maria Espiau, Antonio Soriano-Arandes, Benhur Sirvan Cetin, Folke Brinkmann, Iveta Ozere, Fernando Baquero-Artigao, Maria Tsolia, Milheiro Tiago Silva, Matilde Bustillo-Alonso, Andrea Martin Nalda, Margherita Mancini, Anna Starshinova, Nicole Ritz, Svetlana Velizarova, Laura Ferreras-Antolin, Florian Goetzinger, Olga Bilogortseva, Vira Chechenyeva, Marc Tebruegge, Begona Santiago-Garcia
Summary: The latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Tests performed worse in children with CNS and miliary TB, as well as in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.
Article
Pediatrics
Sevgen Tanir Basaranoglu, Ayse Karaaslan, Enes Sali, Ergin Ciftci, Zeynep Gokce Gayretli Aydin, Bilge Aldemir Kocabas, Cemil Kaya, Semra Sen Bayturan, Soner Sertan Kara, Dilek Yilmaz Ciftdogan, Ummuhan Cay, Hacer Gundogdu Akturk, Melda Celik, Halil Ozdemir, Ayper Somer, Tijen Diri, Ahmet Sami Yazar, Murat Sutcu, Hasan Tezer, Eda Karadag Oncel, Manolya Kara, Solmaz Celebi, Aslinur Ozkaya Parlakay, Sabahat Karakaslilar, Emin Sami Arisoy, Gonul Tanir, Tugce Tural Kara, Ilker Devrim, Tugba Erat, Kubra Aykac, Ozge Kaba, Sirin Guven, Edanur Yesil, Ayse Tekin Yilmaz, Sevgi Yasar Durmus, Ilknur Caglar, Fatih Gunay, Metehan Ozen, Ener Cagri Dinleyici, Ates Kara
Summary: This study assessed the epidemiological data of pediatric patients with antibiotic-associated diarrhea in our region. The results showed that the prevalence of antibiotic-associated diarrhea was 10.4% for amoxicillin-clavulanate and 14.4% for cephalosporins. The occurrence of antibiotic-associated diarrhea differed significantly according to geographical regions in Turkey, particularly higher in The Eastern Anatolia and Southeastern Anatolia. This study provides epidemiological data and geographical differences for pediatric antibiotic-associated diarrhea.
Article
Behavioral Sciences
Tolga Ince, Gulberat Ince, Ozlem Uzum, Adem Aydin
Summary: This study investigated the prevalence and socio-demographic factors affecting the use of complementary and alternative medicine (CAM) in children with epilepsy. The results showed that 30.1% of parents had used some form of CAM for their children in the previous year. Factors such as the child's age, presence of comorbid disorders, duration of antiseizure medication use, and family history of epilepsy were found to be significant predictors of CAM use. However, comorbid disorders were the only significant predictor in logistic regression analysis.
EPILEPSY & BEHAVIOR
(2023)
Article
Environmental Sciences
Aysun Balseven-Odabasi, Mahmut Serif Yildirim, Ramazan Akcan, S. Songul Yalcin, Tolga Ince, Ali Riza Tumer, Kaya Yorganci
Summary: This study aims to investigate the specific etiological factor of child abuse and neglect, specifically related to traditional teapot- and teacup-related scalding burns in our country. Among the scalding burn cases admitted to our Burn Center, 48.6% were found to be related to the use of traditional teapots and teacups. After a detailed assessment, all these cases were considered neglect-related burns. It is important for parents, caregivers, and physicians to be aware of the potential risks associated with traditional teapots and teacups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Pediatrics
Oi Man Chan, Billy Ming-Hei Lai, Agnes Sze-Yin Leung, Ting Fan Leung, Assunta Chi-Hang Ho
Summary: The study aimed to evaluate the clinical characteristics of ERA patients in a tertiary centre in Hong Kong. The results showed a high proportion of ERA patients with sacroiliitis, and a significant number of them had radiological structural changes during early disease. The conclusion of the study highlights the importance of prompt diagnosis and treatment in these children.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Gurkan Bozan, Vicente Perez-Brocal, Kaan Aslan, Eylem Kiral, Esra Sevketoglu, Mutlu Uysal Yazici, Ebru Azapagasi, Tanil Kendirli, Serhat Emeksiz, Oguz Dursun, Dincer Yildizdas, Ayse Berna Anil, Nihal Akcay, Hasan Serdar Kihtir, Merve Havan, Nazan Ulgen Tekerek, Faruk Ekinci, Omer Kilic, Andres Moya, Ener Cagri Dinleyici
Summary: The composition of microbiota in the intestines and nasopharynx of children with invasive meningococcal disease (IMD) was found to be different from that of healthy children. The infection itself or other care interventions led to changes in the microbiota composition. Understanding the interaction of microbiota with pathogens, such as N. meningitidis, could help us understand the dynamics of the disease.
Article
Pediatrics
Ayben Leblebici, Gurkan Bozan, Asli Kavaz Tufan, Eylem Kiral, Ebru Kacmaz, Ener Cagri Dinleyici
Summary: AKI in PICUs is a crucial factor affecting mortality in critically ill pediatric patients. This study compared the AKIN and pRIFLE AKI classifications and PICU scoring modalities, finding a significant correlation between AKI and PRISM III, PELOD-2, and pSOFA scores. However, there were no significant differences in the stages of kidney injury according to the AKIN criteria. Identifying the risk factors for AKI and planning antimicrobial regimens based on PICU admission could decrease mortality rates.
Article
Rheumatology
Samuel Channon-Wells, Ortensia Vito, Andrew J. McArdle, Eleanor G. Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G. Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Oleg Blyuss, Michael Levin
Summary: This study evaluated immunomodulatory treatments for multisystem inflammatory syndrome in children (MIS-C) and found that glucocorticoids or glucocorticoids plus intravenous immunoglobulin were not significantly different from intravenous immunoglobulin alone in terms of clinical efficacy. Initial treatment with glucocorticoids may be a safe alternative to immunoglobulin or combined therapy.
LANCET RHEUMATOLOGY
(2023)
Article
Pediatrics
Irem Ceren Erbas, Begum Nisanci, Berken Gur, Balahan Bora Makay, Osman Tolga Ince, Nursen Belet
CLINICAL PEDIATRICS
(2023)
Article
Microbiology
Gurkan Bozan, Yalcin Kara, Eylem Kiral, Mahmut Can Kizil, Ebru Kacmaz, Tercan Us, Gul Durmaz, Omer Kilic, Ener Cagri Dinleyici
Summary: This study evaluated the use of a rapid molecular diagnostic pneumonia panel in children with lower respiratory tract infections. The results showed that this approach has advantages in diagnosing pneumonia and guiding antibiotic therapy, as it provides results more quickly and enables the identification of resistance profiles.
Article
Microbiology
Pinar Yildiz, Melisa Sahin Tekin, Mucahit Kaya, Ener Cagri Dinleyici
Summary: The prevalence of Neisseria meningitidis carriage and serogroup distribution among older adults in Turkiye was assessed. The study found that 13.9% of participants carried Nm, with MenY being the most common serogroup. Only MenY was detected in patients over 75 years of age. Adequate surveillance and carriage studies can inform vaccination strategies for older adults.
Article
Pediatrics
Dilek Yilmaz, Gulnihan Ustundag, Ayse Buyukcam, Enes Sali, Umit Celik, Gulhadiye Avcu, Nursen Belet, Esra Cakmak Taskin, Sevliya Ocal Demir, Ahmet Ziya Birbilen, Omer Kilic, Ozge Metin Akcan, Ayse Tekin Yilmaz, Bilge Aldemir Kocabas, Nevin Hatipoglu, Adem Karbuz, Deniz Cakir, Murat Sutcu, Fatma Deniz Aygun, Taylan Celik, Semra Bayturan Sen, Nazan Dalgic, Zuhal Umit, Soner Sertan Kara, Eda Karadag Oncel, Ahmet Bolat, Merve Kilic Cil, Caner Turan, Ayse Cakil Guzin, Sevgi Topal, Gulser Esen Besli, Gizem Dogan, Sabiha Sahin, Fatih Akin, Yasar Bildirici, Gulperi Timurtas Dayar, Emine Ergul Sari, Didem Kizmaz Isancli, Manolya Kara, Pinar Onal, Hakan Aylac, Duygu Luleci, Belma Yasar, Elif Dede, Aykut Caglar, Sevgi Akova, Elif Afat Turgut, Pinar Yazici Ozkaya, Tugba Kandemir Gulmez, Emel Ulusoy, Muhterem Duyu, Yalcin Kara, Huseyin Celiktas, Onur Tekeli, Fatma Caglar, Doruk Gul, Sinem Oral Cebeci, Fatih Battal, Alkan Bal, Emre Aygun, Metin Uysalol, Gazi Arslan, Ayberk Ozkavakli, Mahmut Can Kizil, Abdullah Yazar, Fatih Aygun, Ayper Somer, Necdet Kuyucu, Ener Cagri Dinleyici, Ates Kara
Summary: This is a multi-center point prevalence study on children diagnosed with coronavirus disease 2019 (COVID-19). The study included inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 12 cities and 24 centers in Turkey on February 2nd, 2022. Among 8605 patients in participating centers on that day, 706 (8.2%) had COVID-19. The study found that fever, cough, and fatigue were the most common symptoms of COVID-19 in children, and asthma, neurologic disorders, and obesity were the most common underlying chronic diseases. The vaccination rate for COVID-19 was 12.5%.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Mehmet Akif Dundar, Filiz Orak, Can Acipayam, Kubra Aslan, Veysel Gok, Benhur Sirvan Cetin, Ekrem Unal, Christoph Klein, Basak Nur Akyildiz
Summary: This article reports a rare case of primary HLH with fatal Fusarium sepsis. A rare variant of the PRF1 gene was detected in this HLH case. Fusarium species were identified through blood cultures, and hyphal growth was observed on Sabouraud dextrose agar.
ERCIYES MEDICAL JOURNAL
(2023)