Review
Biochemistry & Molecular Biology
Michel Y. Braun
Summary: T cells, particularly T lymphocytes of the immune system, exhibit characteristics of proliferation and mobility in tissues and organs, requiring metabolic plasticity to fulfill their immune function. This review focuses on the various mechanisms that allow T cells to adapt their metabolism to different real-life circumstances, such as exiting quiescence, differentiating into effector cells, and participating in immune memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Liang Tan, Yanan Xu, Gongbin Lan, Hongxia Wang, Zhanfeng Liang, Zhaoqi Zhang, Qianchuan Tian, Yangxiao Hou, Yong Zhao, Xubiao Xie
Summary: This study found that deficiency of TSC1 in T cells accelerates acute allograft rejection. TSC1 deficiency leads to increased accumulation of CD8(+) T cells in the allografts and enhances their responsiveness to alloantigens. TSC1-deficient recipients may be more resistant to mTOR inhibitor-mediated immunosuppression during organ transplantation.
Article
Surgery
Marlena V. Habal, April M. I. Miller, Samhita Rao, Sijie Lin, Aleksandar Obradovic, Mohsen Khosravi-Maharlooei, Sarah B. See, Poulomi Roy, Ronzon Shihab, Siu-Hong Ho, Charles C. Marboe, Yoshifumi Naka, Koji Takeda, Susan Restaino, Arnold Han, Donna Mancini, Michael Givertz, Joren C. Madsen, Megan Sykes, Linda J. Addonizio, Maryjane A. Farr, Emmanuel Zorn
Summary: This study investigated the T cell repertoire in CAV patients using TCRB sequencing and high-dimensional flow cytometry, revealing significant overlap between intragraft and blood TCRBs but minimal overlap with IGHV repertoires. T cells in coronary infiltrates expressed inflammatory and profibrotic cytokines and were distinguished from peripheral blood by memory, activation, and tissue residency markers. High-frequency rearrangements were traced back to endomyocardial biopsies, and comparison with HLA-mismatched blood donors revealed shared TCRBs, including cross-reactive sequences, suggesting an active local intragraft T cell response in late-stage CAV.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Immunology
Hua Jiang, Denggang Fu, Alan Bidgoli, Sophie Paczesny
Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) is crucial for treating hematological malignancies, but acute and chronic graft-versus-host disease (aGVHD and cGVHD) are major complications. Understanding the roles of T cell subsets in GVHD pathogenesis is essential for identifying new therapeutic targets and improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juan Fernandez-Garcia, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Ines Vermeire, Tessa Schalley, Melanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt
Summary: The metabolism of T cells undergoes dynamic changes during immune response. Researchers used single-cell RNA sequencing to study the metabolic dynamics of CD8(+) T cells activated and differentiated in vitro. They found that activated T cells have differential reliance on the synthesis and uptake of non-essential amino acids. The expression dynamics of the metabolic gene asparagine synthetase (Asns) was identified as a modulator of CD8(+) T cell differentiation.
Article
Immunology
Aparajita Saha, Jaclyn Escudero, Troy Layouni, Barbra Richardson, Sharon Hou, Nelly Mugo, Andrew Mujugira, Connie Celum, Jared M. Baeten, Jairam Lingappa, Grace C. John-Stewart, Sylvia M. LaCourse, Javeed A. Shah
Summary: This study found that immune activation changes during pregnancy and postpartum may contribute to increased risk for tuberculosis progression. Specifically, pregnant women with latent tuberculosis infection showed diminished M. tuberculosis-specific CD4(+) cytokine responses in the third trimester, while M. tuberculosis-specific CD8(+) cytokines and nonspecifically activated T-cells increased during late pregnancy.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Michael St Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Celine Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi
Summary: Metabolic programming plays a crucial role in the anti-tumor properties of T cells. By utilizing metabolomics, it was found that pantothenate and its metabolite CoA drive T cell polarization, bioenergetics, and anti-tumor immunity, enhancing the efficacy of anti-tumor therapy. Pre-treatment plasma pantothenic acid levels were positively correlated with the response to anti-PD1 therapy in melanoma patients.
Article
Cardiac & Cardiovascular Systems
Sean Agbor-Enoh, Palak Shah, Ilker Tunc, Steven Hsu, Stuart Russell, Erika Feller, Keyur Shah, Maria E. Rodrigo, Samer S. Najjar, Hyesik Kong, Mehdi Pirooznia, Ulgen Fideli, Alfiya Bikineyeva, Argit Marishta, Kenneth Bhatti, Yanqin Yang, Cedric Mutebi, Kai Yu, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Hannah A. Valantine
Summary: This study validated the use of %ddcfDNA as a sensitive blood biomarker for detecting acute rejection in cardiac transplant recipients. It showed excellent performance characteristics in early detection and could potentially reduce the need for invasive endomyocardial biopsies.
Article
Medicine, Research & Experimental
Mengyan Li, Scott J. Garforth, Kaitlyn E. O'Connor, Hang Su, Danica M. Lee, Alev Celikgil, Rodolfo J. Chaparro, Ronald D. Seidel, R. Brad Jones, Ravit Arav-Boger, Steven C. Almo, Harris Goldstein
Summary: In this study, synTacs were used to expand highly functional HIV- and CMV-specific CD8(+) T cells, which showed potent antiviral activities in vivo. The results suggest that synTac-based approaches could be a promising therapeutic strategy for HIV cure and treatment of CMV and other viral infections.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S. Al Dulaijan, Jamil Azzi, Takaharu Ichimura, Xiaofei Li, Petr Jarolim, Paolo Fiorina, Stefan G. Tullius, Joren C. Madsen, Vivek Kasinath, Reza Abdi
Summary: The study reveals that ACTH treatment improves heart transplant outcomes by increasing the formation of Tregs, leading to higher allograft survival rates and reduced chronic rejection.
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Immunology
Yunhan Ma, Guoliang Yan, Junjun Guo, Fujun Li, Haiping Zheng, Chenxi Wang, Yingyu Chen, Yuhan Ye, Helong Dai, Zhongquan Qi, Guohong Zhuang
Summary: Berberine can prolong allograft survival by inducing apoptosis of alloreactive T cells, while also protecting myocardial cells by inhibiting the activation, proliferation, and function of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Eliot G. Peyster, Andrew Janowczyk, Abigail Swamidoss, Samhith Kethireddy, Michael D. Feldman, Kenneth B. Margulies
Summary: This study developed a precision medicine tool for predicting the development of cardiac allograft vasculopathy (CAV) in heart transplant recipients using computational analysis of digital pathology images. The incorporation of computationally extracted histological features greatly improved the prediction of future CAV development, enhancing the precision and personalization of treatment plans.
Editorial Material
Cell Biology
Gregory M. Chen, Jan Joseph Melenhorst, Kai Tan
Summary: CAR T cell therapies targeting CD19 and CD22 have shown success in treating B cell cancers, but not in non-B cell cancers. The interaction between CAR T cells and normal B cells may play a crucial role in determining clinical CAR T cell responses.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Emma T. M. Peereboom, Benedict M. Matern, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Franka E. van Reekum, Marianne C. Verhaar, Elena G. Kamburova, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christien E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Marielle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Azam Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Frederike J. Bemelman, Aiko P. J. de Vries, Johan W. de Fijter, Michiel G. H. Betjes, Dave L. Roelen, Frans H. Claas, Henny G. Otten, Sebastiaan Heidt, Arjan D. van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings
Summary: The presence of pre-transplant donor-reactive CD4(+) memory T-helper cells may increase the risk of graft failure following kidney transplantation, as shown by the significant association between Shared T-cell EPitopes (STEP) score and the 10-year risk of death-censored kidney graft failure.
FRONTIERS IN IMMUNOLOGY
(2021)