Editorial Material
Multidisciplinary Sciences
Aksim Mamonkin, Malcolm K. Brenner
Summary: Exhausted engineered T cells show improved antitumor activity with pulsatile signaling.
Article
Anesthesiology
Pieter H. Sloos, M. Adrie W. Maas, Joost C. M. Meijers, Rienk Nieuwland, Joris J. T. H. Roelofs, Nicole P. Juffermans, Derek J. B. Kleinveld
Summary: Inhibition of HMGB-1 improves trauma-induced coagulopathy by enhancing clot formation and strength, preserving platelet count, and reducing bleeding time in a mouse model.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Hematology
Andrea Rossetto, Jared M. Wohlgemut, Karim Brohi, Ross Davenport
Summary: This study compared the performance of Quantra and ROTEM in rapidly diagnosing trauma-induced coagulopathy (TIC) and predicting transfusion requirements and mortality. The results showed that both Quantra and ROTEM had similar diagnostic performances in evaluating TIC and predicting clinically relevant outcomes.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Critical Care Medicine
Ander Dorken Gallastegi, Leon Naar, Apostolos Gaitanidis, Anthony Gebran, Charlie J. Nederpelt, Jonathan J. Parks, John O. Hwabejire, Jason Fawley, April E. Mendoza, Noelle N. Saillant, Peter J. Fagenholz, George C. Velmahos, Haytham M. A. Kaafarani
Summary: The study found that trauma patients receiving massive transfusion more often have unbalanced platelet (PLT) transfusion than unbalanced fresh frozen plasma (FFP) transfusion. As the RBC:PLT ratio increased, there was a gradual increase in 24-hour mortality, while balanced platelet and fresh frozen plasma transfusion lowered the risk of death.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Hematology
Zachary A. Matthay, Alexander T. Fields, Brenda Nunez-Garcia, John J. Park, Chayse Jones, Aleksandra Leligdowicz, Carolyn M. Hendrickson, Rachael A. Callcut, Michael A. Matthay, Lucy Z. Kornblith
Summary: This study aimed to determine the relationship between catecholamines and platelet-dependent hemostasis after injury, as well as to model catecholamine-induced functional platelet exhaustion in healthy donor platelets. The study found that epinephrine and norepinephrine were associated with impaired platelet aggregation in trauma patients. In healthy donors, short incubation with epinephrine enhanced platelet aggregation, platelet adhesion, and glycoprotein IIb/IIIa activation, while longer incubation resulted in decreased platelet adhesion, aggregation, and surface expression of glycoprotein IIb/IIIa.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Han Qi (Wayne) Zhao, Katherine Serrano, Brankica Culibrk, Zhongming Chen, Dana V. Devine
Summary: This study investigated the effectiveness of using cold-stored platelets (CPs) compared to room temperature stored platelets (RPs) in treating actively bleeding patients. The results showed that transfusion packages containing CPs could restore the blood hemostatic profile of bleeding patients and provide additional benefit in resisting hyperfibrinolysis.
Article
Hematology
Ian S. LaCroix, Mitchell Cohen, Ernest E. Moore, Monika Dzieciatkowska, Christopher C. Silliman, Kirk C. Hansen, Angelo D'Alessandro
Summary: This study characterized the multi-omics features of platelet transfusion efficacy in a clinically relevant cohort of trauma patients using metabolomics and proteomics approaches. The results showed higher levels of tranexamic acid, inflammatory proteins, carnitines, and polyamines in patients requiring platelet transfusion. The study also identified increased platelet activation in the most severely injured patients. This study provides the first multi-omics characterization of platelet transfusion efficacy.
Editorial Material
Hematology
Francesca Bonifazi
Summary: This study demonstrates that higher exposure to abatacept can reduce the occurrence of acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) from unrelated donors (URDs), without increasing the risk of relapse.
Editorial Material
Hematology
Shawn M. Jobe, Renren Wen
Summary: The study identifies circulating procoagulant platelets as a novel biomarker of COVID-19 disease severity and demonstrates that antibodies induced in response to SARS-CoV-2 can initiate procoagulant platelet formation.
Article
Oncology
Claire Battin, Annika De Sousa Linhares, Judith Leitner, Anna Grossmann, Daniela Lupinek, Shiva Izadi, Alexandra Castilho, Petra Waidhofer-Soellner, Katharina Grabmeier-Pfistershammer, Jochen Stritzker, Peter Steinberger
Summary: Targeting co-stimulatory receptors enhances the functions of anti-tumor lymphocytes. The use of a secreted 4-1BBL ectodomain with a trimerization domain derived from human collagen as a payload in therapeutic viral vectors has been shown to be effective in reducing tumor burden in a CD34(+) humanized mouse model.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Moritz Muckenhuber, Thomas Wekerle, Christoph Schwarz
Summary: Regulatory T cells (Tregs) play a critical role in transplantation, and the use of pharmaceutical costimulation blockers may have an impact on these cells. This review provides an overview of the effects of costimulation therapy on Treg function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Frederik Greve, Olivia Mair, Ina Aulbach, Peter Biberthaler, Marc Hanschen
Summary: This study found a correlation between platelet counts and lung dysfunction in severely injured patients, especially in those with severe injuries. An increase in platelet counts was positively associated with improvement in lung function indicators.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Muataz Ali Hamad, Krystin Krauel, Nancy Schanze, Nadine Gauchel, Peter Stachon, Thomas Nuehrenberg, Mark Zurek, Daniel Duerschmied
Summary: In addition to their role in hemostasis and thrombosis, platelets also play a role in modulating inflammatory reactions and immune responses. Circulating platelets can differ within an individual due to their different physical properties and can be categorized into distinct subtypes based on their function or age. Understanding platelet phenotypic variation is important in various physiological and pathological circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Manuel Reithofer, Sandra Rosskopf, Judith Leitner, Claire Battin, Barbara Bohle, Peter Steinberger, Beatrice Jahn-Schmid
Summary: The translation highlights the different effects of costimulatory signals on human CD8 T-cell responses, with CD28 costimulation enhancing antigen-reactive CD8 T cells, 4-1BB costimulation inducing bystander proliferation, and CD27 signals enhancing antigen-specific CD8 T cell responses.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Alexander I. Lebedev
Summary: In this study, the microscopic mechanisms of spontaneous strain and folding in Janus CdSe nanoplatelets are investigated using first-principles calculations. Three mechanisms are identified, including two bulk mechanisms related to the electric field created by the difference in electronegativities of ligands and the depolarizing field resulting from potential jumps in electrical double layers, and a predominant mechanism associated with surface strain of nanoplatelets through bridging bonds.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Surgery
Christine Park, Tyler Schappe, Sarah Peskoe, Dinushika Mohottige, Norine W. Chan, Nrupen A. Bhavsar, Jane Pendergast, Allan D. Kirk, Lisa M. McElroy
Summary: The choice of deprivation index has an impact on conclusions about deprivation extent and identifying the most deprived communities. This study aimed to determine correlations among commonly used deprivation indices for transplant populations. Different deprivation indices were compared using a retrospective cohort of liver or kidney transplant patients. The choice of deprivation index affects the applicability of research findings on social risk and clinical outcomes. Careful selection of indices based on intended use and variable relevance is necessary for transplant populations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Mary E. Knatterud, Richard L. Simmons, William Payne, Peter Stock, Blanche Chavers, Nancy Ascher, Dixon Kaufman, Alan Kirk, Shafique Keshavjee, Abhinav Humar, Swaytha Ganesh, Christopher Hughes, Raja Kandaswamy, Arthur J. Matas
Summary: Dr. John S Najarian (1927-2020), the chairman of the University of Minnesota's Department of Surgery, was a trailblazer in surgery, clinical immunology, and transplantation. A delayed Festschrift was held on May 20, 2022, to honor his achievements. During the event, speakers discussed his numerous contributions to surgery, transplantation, and resident/fellow training, as well as ongoing research efforts to improve clinical outcomes. It is worth mentioning that Dr. Najarian was the founder of the journal Clinical Transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Shu Li, Imran J. Anwar, Aidan J. Canning, Tuan Vo-Dinh, Allan D. Kirk, He Xu
Summary: Porcine vascular endothelial cells release extracellular vesicles expressing SLA-I, which can directly initiate T cell-mediated immune responses through xenorecognition and costimulation, suggesting a potential role in xenograft rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Surgery
Flavio Vincenti, Klemens Budde, Josep Grinyo, Lionel Rostaing, Allan D. Kirk, Christian P. Larsen
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Andrew Adams, Linda C. Cendales, David K. C. Cooper, Emanuele Cozzi, John Gill, Eric Judd, Eliezer Katz, Allan D. Kirk, Jay A. Fishman, Peter P. Reese, Anji Wall, James F. Markmann
Summary: The US FDA held a meeting to discuss regulatory expectations for xenotransplantation products, and a summary was compiled by a committee, focusing on 7 key topics including preclinical evidence, porcine kidney function, ethical aspects, clinical trial design, infectious disease issues, industry perspectives, and regulatory oversight.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Rondi B. Gelbard, Hannah Hensman, Seth Schobel, Linda Stempora, Eric Gann, Dimitrios Moris, Christopher J. Dente, Timothy G. Buchman, Allan D. Kirk, Eric Elster
Summary: This study aimed to explore whether assessment of cell phenotypes using flow cytometry (FCM) could be used to identify pulmonary infection after thoracic trauma. The results showed that Acute Physiology and Chronic Health Evaluation score, highest pulse rate in first 24 hours, and frequency of CD4(+) central memory cells were the three key variables for identifying pulmonary infection after thoracic trauma. The study suggests that clinical and FCM data have diagnostic utility in the early identification of patients at risk of nosocomial pneumonia (PNA) following thoracic injury.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Cell Biology
Imran J. Anwar, Dora M. Berman, Isabel Delaura, Qimeng Gao, Melissa A. Willman, Allison Miller, Alan Gill, Cindy Gill, Steve Perrin, Camillo Ricordi, Philip Ruiz, Mingqing Song, Joseph M. Ladowski, Allan D. Kirk, Norma S. Kenyon
Summary: This study investigated the anti-CD40 ligand (CD40L) immunosuppressant AT-1501 and found that it can enhance the survival and function of both islet and kidney allografts in nonhuman primate models, with better outcomes compared to conventional immunosuppression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Surgery
M. Song, K. Samy, B. M. Martin, Q. Gao, B. Collins, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
A. D. Kirk, J. Shoji, D. Wojciechowski, J. Kim, W. Xu, T. M. Wilson, F. Vincenti
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, I. J. Anwar, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, C. Z. Jordan, B. I. Shaw, Q. Gao, I. DeLaura, A. Dangi, I. Husain, M. Ribeiro, J. M. Ladowski, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, M. S. Mulvihill, R. Schmitz, B. I. Shaw, Z. W. Fitch, T. How, S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, Q. Gao, I. DeLaura, A. Miller, B. I. Shaw, K. Krynychka, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)