Realistic biological approaches for improving thermoradiotherapy

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach

(2015) Jeanette R. McConnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

(2015) Kobe Reynders et al.   CANCER TREATMENT REVIEWS

Therapeutic potential of using the vascular disrupting agent OXi4503 to enhance mild temperature thermoradiation

(2015) Michael R. Horsman   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study

(2015) Katrina S. Pedersen et al.   INVESTIGATIONAL NEW DRUGS

Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

(2015) Mitesh J. Borad et al.   JOURNAL OF CLINICAL ONCOLOGY

Modulation of the tumor vasculature and oxygenation to improve therapy

(2015) Dietmar W. Siemann et al.   PHARMACOLOGY & THERAPEUTICS

Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiation

(2014) Kirtesh Patel et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Alternative approaches to Hsp90 modulation for the treatment of cancer

(2014) Jessica A Hall et al.   Future Medicinal Chemistry

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

(2014) Udo S Gaipl et al.   Immunotherapy

Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair

(2014) Makoto Ihara et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer

(2014) Timothy M. Zagar et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Local tumour hyperthermia as immunotherapy for metastatic cancer

(2014) Seiko Toraya-Brown et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

(2014) Rohit Bhat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unlocking the Combination: Potentiation of Radiation-Induced Antitumor Responses with Immunotherapy

(2014) Max M. Wattenberg et al.   RADIATION RESEARCH

Murine xenograft model demonstrates significant radio-sensitising effect of liposomal doxorubicin in a combination therapy for Feline Injection Site Sarcoma

(2014) H. Petznek et al.   RESEARCH IN VETERINARY SCIENCE

Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?

(2014) C. Tang et al.   Cancer Immunology Research

Combinations of Immunotherapy and Radiation in Cancer Therapy

(2014) Ralph E. Vatner et al.   Frontiers in Oncology

Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy

(2013) Ane B. Iversen et al.   ACTA ONCOLOGICA

Progress in development of biomedical applications of heat shock proteins and thermal stress

(2013) Elizabeth A. Repasky   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Effects of bevacizumab and hyperthermia in a rodent model of hyperthermic intraperitoneal chemotherapy (HIPEC)

(2013) Johanna Verhulst   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia

(2013) Jonathan R. McDaniel et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH

(2013) Ronald Allen Coss et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

In vivoapplications of magnetic nanoparticle hyperthermia

(2013) Ingrid Hilger   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990

(2013) Dušan Milanović et al.   Radiation Oncology

Temperature Matters! And Why It Should Matter to Tumor Immunologists

(2013) E. A. Repasky et al.   Cancer Immunology Research

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules

(2012) Qian Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

(2012) A. A. Manzoor et al.   CANCER RESEARCH

Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy

(2012) Soichiro Yoshida et al.   CELL CYCLE

Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26

(2012) Wen Nie et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Combination of vascular disrupting agents and ionizing radiation

(2012) Céline Clémenson et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Usefulness of combined treatment with continuous administration of tirapazamine and mild temperature hyperthermia inγ-ray irradiation in terms of local tumour response and lung metastatic potential

(2012) Shin-Ichiro Masunaga et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Review of radiotherapy and hyperthermia in primary cervical cancer

(2012) Martine Franckena   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

(2012) Berina Eppink et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial

(2012) Geert O. Janssens et al.   JOURNAL OF CLINICAL ONCOLOGY

Imaging hypoxia to improve radiotherapy outcome

(2012) Michael R. Horsman et al.   Nature Reviews Clinical Oncology

The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

(2012) Shane Zaidi et al.   PLoS One

Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors

(2012) Robert J. Griffin et al.   Journal of Oncology

Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

(2011) J.-T. Chi et al.   CLINICAL CANCER RESEARCH

Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours

(2011) Frank Wolf et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

(2011) P. M. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer

(2010) Zeljko Vujaskovic et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Phase I study of pemetrexed and pegylated liposomal doxorubicin in patients with refractory breast, ovarian, primary peritoneal, or fallopian tube cancer

(2010) Donald A. Richards et al.   INVESTIGATIONAL NEW DRUGS

Radiotherapy With Concurrent Carbogen and Nicotinamide in Bladder Carcinoma

(2010) Peter J. Hoskin et al.   JOURNAL OF CLINICAL ONCOLOGY

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

(2010) E. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phase II Randomized Crossover Study of Liposomal Doxorubicin Versus Weekly Docetaxel in the First-line Treatment of Women With Metastatic Breast Cancer

(2009) Denise A. Yardley et al.   Clinical Breast Cancer

Hsp90 inhibitors as promising agents for radiotherapy

(2009) Alexander E. Kabakov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

(2009) F. A. Dungey et al.   MOLECULAR CANCER THERAPEUTICS

Vascular targeted therapies in oncology

(2008) Dietmar W. Siemann et al.   CELL AND TISSUE RESEARCH

Hyperthermia adds to chemotherapy

(2008) Rolf D. Issels   EUROPEAN JOURNAL OF CANCER

Clinical applications of magnetic nanoparticles for hyperthermia

(2008) Burghard Thiesen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

(2008) T. T. Koll et al.   MOLECULAR CANCER THERAPEUTICS