Article
Medical Laboratory Technology
Yevgen Chornenkyy, Xiaoqi Lin
Summary: This case presents a rare instance of a lymphoma showing characteristics of carcinoma and highlights the challenges it brings in diagnosis.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Y. Kurasawa, H. Sato, Y. Saito, T. Moriya, S. Egawa, H. Katsuta, T. Shimane
Summary: This study aimed to evaluate the accuracy of fine needle aspiration cytology (FNAC) and biopsy for clinical diagnosis of minor salivary gland tumors (MSGTs). Results showed that biopsy was more accurate than FNAC in diagnosing MSGTs, with mucoepidermoid carcinoma being the most common malignant tumor and pleomorphic adenomas being the most common benign tumor.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Kotaro Matsumoto, Shinpei Doi, Ayako Watanabe, Nobuhiro Katsukura, Takayuki Tsujikawa, Mikiko Takahashi, Kentaro Kikuchi
Summary: This retrospective study compared the efficacy and safety of endoscopic ultrasound-guided liver biopsy (EUS-LB) with percutaneous liver biopsy (PLB). The results showed no statistical difference in terms of hepatic tissue surface area and portal tracts between the two methods. EUS-LB had a higher success rate and a lower adverse event rate, suggesting it is a new alternative to PLB.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Rheumatology
M. Lorenzon, F. Tulipano Di Franco, A. Zabotti, E. Pegolo, I Giovannini, V Manfre, E. Mansutti, S. De Vita, C. Zuiani, R. Girometti
Summary: The study aimed to identify ultrasound features of lymphomas in primary Sjogren's syndrome patients, with L-pSS patients showing more suspicious features in focal lesions.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Omer Ozan Yildizli, Ibrahim Untan, Deniz Demirci
Summary: The study found that needle biopsies' Gleason scores do not perfectly predict the Gleason scores of prostatectomy specimens, with around 39% of tumors being undergraded, 7% being overgraded, and 54% having matching scores. After grouping patients based on the ISUP 2014 prostate cancer grading system, 64% of results stayed in the same category post-surgery, but the correlation was still weak.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pathology
Manish Rohilla, Sumit Garg, Amanjit Bal, Ashim Das, Nalini Gupta, Pranab Dey, Radhika Srinivasan
Summary: This study subclassified DLBCL using IHC, finding that FNABC cell blocks are an acceptable alternative to biopsy for a complete diagnosis of DLBCL with a high concordance with histopathology results.
Article
Clinical Neurology
Julian S. Rechberger, Liang Zhang, Jizhi Ge, Cody L. Nesvick, Kai J. Miller, David J. Daniels
Summary: This study reports a feasible technique for creating DMG cell lines and patient-derived xenografts (PDXs) without the need for additional biopsy specimens. Viable tumor cells were obtained and expanded in vitro through probe washing immediately after biopsy. The technique is important for understanding disease biology and preclinical testing of novel therapeutics.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Oncology
Makoto Matsushita, Kazutoshi Fujita, Koji Hatano, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Akinaru Yamamoto, Toshihiko Uemura, Gaku Yamamichi, Eisuke Tomiyama, Yoko Koh, Taigo Kato, Atsunari Kawashima, Motohide Uemura, Satoshi Nojima, Ryoichi Imamura, Aysha Mubeen, George J. Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda, Eiichi Morii, Norio Nonomura
Summary: The consumption of Western high-fat diets is considered a major risk factor for prostate cancer. A study found that these diets can lead to dysbiosis in the gut microbiota, contributing to the growth of inflammatory prostate cancer. It was also discovered that histamine signaling plays a role in this process.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Pathology
Haider A. Mejbel, Shuko Harada, Todd M. Stevens, Xiao Huang, George J. Netto, Alexander C. Mackinnon, Sameer Al Diffalha
Summary: MEIS1::NCOA1/2 sarcomas are rare low-grade tumors that often affect the genitourinary and gynecologic tracts. They can be diagnostically challenging due to their similarity to other entities, but molecular pathology plays a crucial role in arriving at an accurate diagnosis.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Chandrakumar Shanmugam, Michael Behring, Vishwas Luthra, Sixto M. Leal, Sooryanarayana Varambally, George J. Netto, Upender Manne
Summary: Accurate detection of SARS-CoV-2 is necessary to control the COVID-19 pandemic. The study reviewed 85 studies from five regions and identified issues in the early-phase diagnosis of COVID-19. Serological testing can complement and reduce false negative results from RT-PCR.
Article
Oncology
Darshan Shimoga Chandrashekar, Santhosh Kumar Karthikeyan, Praveen Kumar Korla, Henalben Patel, Ahmedur Rahman Shovon, Mohammad Athar, George J. Netto, Zhaohui S. Qin, Sidharth Kumar, Upender Manne, Chad J. Creighton, Sooryanarayana Varambally
Summary: UALCAN is a web portal for exploring, analyzing, and visualizing cancer genomic, transcriptomic, and proteomic data, providing researchers with valuable insights into gene, protein, and pathway alterations in cancer, as well as evaluating patient survival data.
Review
Urology & Nephrology
Holger Moch, Mahul B. Amin, Daniel M. Berney, Eva M. Comperat, Anthony J. Gill, Arndt Hartmann, Santosh Menon, Maria R. Raspollini, Mark A. Rubin, John R. Srigley, Puay Hoon Tan, Satish K. Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, George J. Netto
Summary: The fifth edition of the WHO classification of urogenital tumours has made significant revisions, including the introduction of molecular-driven renal tumour classification and simplification of the morphologic classification of penile squamous cell carcinomas. A new chapter has also been added for tumours of the scrotum. The main nomenclature for testicular tumours remains the same, but there have been changes in some terms.
Article
Medical Laboratory Technology
Jaylou M. Velez Torres, Manuel Lora Gonzalez, Ernesto Martinez Duarte, Bassel Zein-Sabatto, Manju Aron, Nilesh S. Gupta, Darcy A. Kerr, George J. Netto, Merce Jorda, Oleksandr N. Kryvenko
Summary: In this study, the features of pseudocarcinomatous urothelial hyperplasia (PCUH) in urine cytology were described. The results showed that PCUH features in urine cytology can overlap with nonurothelial malignancies and lead to misdiagnosis initially.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Editorial Material
Urology & Nephrology
George J. Netto, Mahul B. Amin, Eva M. Comperat, Anthony J. Gill, Arndt Hartmann, Holger Moch, Santosh Menon, Maria R. Raspollini, Mark A. Rubin, John R. Srigley, Puay Hoon Tan, Satish K. Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, Daniel M. Berney
Letter
Urology & Nephrology
Mark A. Rubin, Mahul B. Amin, Eva Comperat, Anthony Gill, Arndt Hartman, Santosh Menon, Maria Raspollini, John Srigley, Puay Hoon Tan, Satish Ticktoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, Daniel Berney, Holger Moch, George J. Netto
Article
Cell Biology
S. Menon, H. Moch, D. M. Berney, I. A. Cree, J. R. Srigley, T. Tsuzuki, E. Comperat, A. Hartmann, G. Netto, M. A. Rubin, A. J. Gill, S. Turajlic, P. H. Tan, M. R. Raspollini, S. K. Tickoo, M. B. Amin
Summary: Squamous cell carcinoma (SCC) is the most common malignant tumor of the penis. The 2022 WHO classification reinforces the 2016 classification and subclassifies precursor lesions and tumors into human papillomavirus (HPV)-associated and HPV-independent types. The use of p16 immunohistochemistry is practical for differentiating HPV-associated from HPV-independent penile SCC. The classification and reporting of scrotal tumors is provided for the first time in the fifth edition of the WHO Blue book, following the schema of penile cancer classification.
Article
Endocrinology & Metabolism
Santhosh Kumar Karthikeyan, Nuo Xu, James E. Ferguson III, Soroush Rais-Bahrami, Zhaohui S. Qin, Upender Manne, George J. Netto, Darshan S. Chandrashekar, Sooryanarayana Varambally
Summary: In this study, publicly available RNA-sequencing and ChIP-seq data were used to identify 15 lncRNAs that are highly correlated with androgen response genes in prostate cancer. AR binding was observed in the promoter regions of 5 lncRNAs, indicating their direct influence by androgen/AR axis and their association with the androgen response pathway.
Article
Oncology
Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Daniel Barocas, Rhonda Bitting, Alan Bryce, Brian Chapin, Heather H. Cheng, Anthony Victor D'Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. Mckay, Todd Morgan, George Netto, Julio M. Pow-Sang, Robert Reiter, Mack Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Dorothy A. Shead, Jenna Snedeker, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Prostate Cancer provide a comprehensive framework for decision-making and management of prostate cancer patients in various disease settings. The guidelines emphasize the importance of individualized treatment plans based on patient preferences and clinical factors.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Review
Pathology
Joa Lobo, Andres M. Acosta, George J. Netto
Summary: This review provides an overview of the progress in molecular biomarkers of testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs), focusing on those with greatest potential for clinical application. The diagnosis and treatment selection of testicular tumors pose a challenge for pathologists, and the advancements in molecular biomarker research in this field provide important support for precision medicine.
Article
Oncology
Yuri Tolkach, Vlado Ovtcharov, Alexey Pryalukhin, Marie-Lisa Eich, Nadine Therese Gaisa, Martin Braun, Abdukhamid Radzhabov, Alexander Quaas, Peter Hammerer, Ansgar Dellmann, Wolfgang Hulla, Michael C. Haffner, Henning Reis, Ibrahim Fahoum, Iryna Samarska, Artem Borbat, Hoa Pham, Axel Heidenreich, Sebastian Klein, George Netto, Peter Caie, Reinhard Buettner
Summary: This retrospective study validates a deep learning-based classifier for prostate cancer (PCA) detection and Gleason grading (AI tool) in biopsy samples. The AI tool showed high accuracy in tumor detection and had similar accuracy in Gleason grading compared to experienced pathologists.
NPJ PRECISION ONCOLOGY
(2023)
Review
Pathology
Maria Rosaria Raspollini, Eva M. Comperat, Antonio Lopez-Beltran, Rodolfo Montironi, Alessia Cimadamore, Toyonori Tsuzuki, George J. Netto
Summary: The fifth edition of WHO Classification of Tumors series for urinary and male genital tract tumors has been published after six years of the fourth edition. New treatment approaches and molecular data on urological cancers have been implemented during these years. Although morphology remains the basis for taxonomy, a molecular approach and new therapeutic modalities like immunotherapy are emerging. More data is required for the application of these advances in routine pathology practice and patient management.
Article
Pathology
Manju Arona, Darshan S. Chandrashekarc, Sofia Canete-Portilloc, Fadi Brimod, Sean R. Williamsone, Adeboye O. Osunkoyaf, Maria Rosaria Raspollinih, Lakshmi P. Kunjui, Sooryanarayana Varamballyc, Alexander C. Mackinnonc, Shuko Haradac, George J. Nettoc
Summary: Nested urothelial carcinoma (NUC) and large nested urothelial carcinoma (LNUC) of the upper urinary tract are rare tumors. This study provides insights into their clinicopathological and molecular characteristics, revealing better clinical outcomes for LNUC and a higher prevalence of pathogenic mutations in FGFR3 and PIK3CA in LNUC.