Article
Immunology
Na Yu, Yiming Weng, Wei Liu, Lixia Chen, Furhan Iqbal, Zhe Yin, Yinyan He, Yanqiu Wang
Summary: The study demonstrates that Toll-like receptor (TLRs) agonists enhance CCL2 production, affecting cytokine secretion by immune cells and potentially promoting Th1/Th2 immune bias.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Yuefang Liu, Shujun Gao, Yangjing Zhao, Hui Wang, Qiong Pan, Qixiang Shao
Summary: This review discusses the important roles of decidual natural killer (dNK) cells in pregnancy, highlighting their generation, subsets, surface or soluble molecules, and functions crucial for maintaining pregnancy. It also explores the new functions of dNK cells, such as controlled cytotoxicity, immunosurveillance, and immunotrophism, and the molecular mechanisms involved in these functions, emphasizing their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Melissa R. Stas, Heinrich Kreutzmann, Julia Stadler, Elena L. Sassu, Kerstin H. Mair, Michaela Koch, Christian Knecht, Maria Stadler, Marlies Dolezal, Gyula Balka, Marianne Zaruba, Marlene Moetz, Armin Saalmueller, Till Ruemenapf, Wilhelm Gerner, Andrea Ladinig
Summary: This study investigated the immune cell phenotypes at the maternal-fetal interface during late gestation in response to PRRSV infection. The results showed that infection led to an expansion of effector lymphocytes, while vaccination improved fetal preservation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Qian Chen, Dan Shan, Yupei Xie, Xingrong Luo, Yuxia Wu, Qiuhe Chen, Ruihong Dong, Yayi Hu
Summary: Single-cell sequencing is a powerful tool to investigate heterogeneity at the maternal-fetal interface. It provides insights into the physiological and pathological changes during pregnancy, and is crucial for understanding and treating various pathological pregnancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Qiwu Bian, Binqing Fu
Summary: This article discusses the immune characteristics at the maternal-fetal interface during pregnancy, focusing on the reshaping of decidual immune cells and the comparison with tumor or transplantation immune microenvironments. It demonstrates the distinctive immune cell niche with activated, tolerant, proangiogenic, and nurturing characteristics at the maternal interface.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Oncology
Yu Tao, Yan-Hong Li, Di Zhang, Ling Xu, Jia-Jia Chen, Yi-Fei Sang, Hai-Lan Piao, Xue-Ling Jing, Min Yu, Qiang Fu, Sheng-Tao Zhou, Da-Jin Li, Mei-Rong Du
Summary: The CXCR4(+)CD56(bright)dNK subset plays an important immunomodulatory role during early pregnancy, promoting Th2 shift and assisting in the establishment of immune-tolerance. This new dNK cell subset may provide important insights into NK cell mechanisms in early pregnancy, and offer potential prognostic factors for the diagnosis and therapy of recurrent miscarriage.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Ling Xu, Yanhong Li, Yifei Sang, Da-Jin Li, Meirong Du
Summary: Successful pregnancy relies on maternal immune tolerance to the fetus, with immunotherapy showing potential for addressing pregnancy complications like recurrent spontaneous abortion. Understanding the mechanisms of maternal-fetal immune tolerance and developing therapeutic strategies can advance reproductive immunology and tumor immunology research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
Summary: A successful human pregnancy requires the maternal immune system to recognize and tolerate the semi-allogeneic fetus. Dysfunctional maternal-fetal interactions might be associated with the development of pregnancy complications. This review elaborates the interactions between trophoblasts and decidual immune cells, and the role of commensal bacteria in promoting pregnancy progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Pilar Flores-Espinosa, Isabel Mendez, Claudine Irles, Andrea Olmos-Ortiz, Cecilia Helguera-Repetto, Ismael Mancilla-Herrera, Daniel Ortuno-Sahagun, Vincent Goffin, Veronica Zaga-Clavellina
Summary: The close interaction between fetal and maternal cells during pregnancy requires various immune-endocrine mechanisms to provide a tolerant environment for the fetus and protect it against infections. Prolactin (PRL), a hormone synthesized by the maternal decidua, is transported through the amnion-chorion and accumulates in the amniotic cavity, creating a hyperprolactinemic environment for the fetus. PRL has multiple immunomodulatory functions, but its precise role at the maternal-fetal interface is still not fully understood. This review summarizes the current knowledge on the immunological effects of PRL and its biological significance for the immune privilege of the maternal-fetal interface.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xue An, Jingkun Qin, Xinyu Hu, Yonggang Zhou, Binqing Fu, Haiming Wei
Summary: Impairment of PBX1 expression in decidual natural killer cells is associated with unexplained recurrent spontaneous abortion and fetal growth restriction. It affects the secretion of downstream growth factors. It is unclear whether other mechanisms limit embryo growth in decidua with PBX1-deficient natural killer cells.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guillaume Fouet, Isabelle Bally, Anne Chouquet, Jean-Baptiste Reiser, Nicole M. Thielens, Christine Gaboriaud, Veronique Rossi
Summary: The immune system relies on a delicate balance of stimulatory and inhibitory signals, with C1q playing a crucial role in immune modulation by interacting with receptors like LAIR-1. The study provides insights into the molecular and structural determinants of C1q/LAIR-1 interaction, contributing to a better understanding of C1q-mediated immune tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Myoungsun Son
Summary: The complement component C1q plays a crucial role in autoimmunity, infection, inflammatory diseases, and tumors. Its tulip-like structure with different binding specificities contributes to the functional complexities in the body. The interaction of C1q with its receptors, especially the inhibitory receptor LAIR-1, is essential for maintaining homeostasis and bridging innate and adaptive immunity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Chuang Guo, Pengfei Cai, Liying Jin, Qing Sha, Qiaoni Yu, Wen Zhang, Chen Jiang, Qian Liu, Dandan Zong, Kun Li, Jingwen Fang, Fangting Lu, Yanshi Wang, Daojing Li, Jun Lin, Lu Li, Zhutian Zeng, Xianhong Tong, Haiming Wei, Kun Qu
Summary: The study revealed significant differences in the distribution of decidual immune cell subsets in patients with recurrent pregnancy loss, as well as a reduced proportion of NK cells supporting embryo growth. Furthermore, alterations in cellular interactions between immune cell subsets within the decidua and those with stromal cells and extravillous trophoblast were observed in the disease state.
Article
Immunology
Kornel F. Lakatos, Kathleen Hasselblatt, Vilmos Fulop, Gyorgy Lajos Vegh, Thomas McElrath, Ross S. Berkowitz, Kevin M. Elias
Summary: dNK cells have unique roles in healthy placental formation and anti-tumor immune response. Investigating the immunological mechanisms of their interaction with target cells can provide insights into immune evasion of tumor cells and immunologic miscarriages. A novel protocol has been developed to isolate and culture dNK cells, which can be sustained in cell culture while preserving their phenotype and functionality.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Cell Biology
S. Adams, P. A. Stapleton
Summary: The increasing accumulation of nanoparticles in the environment poses a concern for fetal development during pregnancy. The placenta, as the interface between the mother and the fetus, plays a crucial role in the translocation and cellular uptake of nanoparticles. However, the mechanisms underlying these processes are poorly understood.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Immunology
Xuebiao Wu, Xiaoli Li, Qiang Fu, Qianhua Cao, Xingyu Chen, Mengjie Wang, Jie Yu, Jingpei Long, Jun Yao, Huixin Liu, Danping Wang, Ruocen Liao, Chenfang Dong
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Multidisciplinary Sciences
Wei Lin, Xuejing Man, Peng Li, Nannan Song, Yingying Yue, Bingqing Li, Yuanbin Li, Yufei Sun, Qiang Fu
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Juanjuan Zhao, Liang Cheng, Hongbo Wang, Haisheng Yu, Bo Tu, Qiang Fu, Guangming Li, Qi Wang, Yanling Sun, Xin Zhang, Zhenwen Liu, Weiwei Chen, Liguo Zhang, Lishan Su, Zheng Zhang
Article
Biochemistry & Molecular Biology
Changxu Wang, Qilai Long, Qiang Fu, Qixia Xu, Da Fu, Yan Li, Libin Gao, Jianming Guo, Xiaoling Zhang, Eric W-F Lam, Judith Campisi, Yu Sun
Summary: The soluble factor EREG, produced by senescent stromal cells, plays a crucial role in the development and malignant progression of cancer cells in the tumor microenvironment. Targeting EREG in treatment-damaged TME significantly improves cancer therapeutic efficacy and shows potential value in translational medicine.
Article
Cell & Tissue Engineering
Yu Tang, Yaru Si, Chengen Liu, Cui Li, Li Qu, Ying Liu, Qiang Fu, Qianqian Luo
Summary: Transplantation of human umbilical cord mesenchymal stem cells (hUMSCs) can improve uterine injury caused by cisplatin. The study found that uterine dysfunction caused by cisplatin is due to endometrial fibrosis, which can be significantly improved by stem cell transplantation.
STEM CELLS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Xuefeng Dou, Qiang Fu, Qilai Long, Shuning Liu, Yejun Zou, Da Fu, Qixia Xu, Zhirui Jiang, Xiaohui Ren, Guilong Zhang, Xiaoling Wei, Qingfeng Li, Judith Campisi, Yuzheng Zhao, Yu Sun
Summary: This study reveals that senescent cells continue to have active metabolism and undergo metabolic reprogramming. Upregulation of PDK4 leads to aerobic glycolysis and increased lactate production, while mitochondrial respiration and redox activity are maintained. Lactate production promotes reactive oxygen species production and drives the senescence-associated secretory phenotype. Inhibition of PDK4 reduces the severity of DNA damage and restrains the senescence-associated secretory phenotype. In preclinical trials, PDK4 inhibition improves physical dysfunction and prevents age-associated frailty.
Article
Public, Environmental & Occupational Health
Kun Wang, Xin Wang, Jiangdong Du, Chunling Liu, Yanan Jiang, Heqiu Zhang, Haiming Jiang, Qiang Fu
Summary: The study found that NLR has predictive value for predicting the severity of COVID-19, and there is a significant positive correlation between NLR and PCT in severe patients.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Immunology
Qiang Fu, Yufei Sun, Yu Tao, Hailan Piao, Xiaoqiu Wang, Xiying Luan, Meirong Du, Dajin Li
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2017)
Article
Oncology
Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu, Tingyan Liu
CANCER CELL INTERNATIONAL
(2017)
