Article
Biochemistry & Molecular Biology
Chantelle Thimm, Lars Erichsen, Wasco Wruck, James Adjaye
Summary: Podocytes, specialized cells in the kidney, play a crucial role in blood filtration and dysfunction of these cells can lead to renal diseases. Studying and utilizing podocytes is important in the field of regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Qiang Wei, Li Zhang, Mei-fan Duan, Yue-mei Wang, Nan Huang, Chun-rong Song
Summary: This case study highlights the potential fetal toxicity associated with the use of losartan in pregnant women with nephrotic syndrome. Discontinuation of losartan and replacement with nifedipine led to the normalization of amniotic fluid levels, successful delivery of a healthy infant, and overall positive outcomes. Pregnant women should be informed about the risks and carefully monitored if using ARBs, with treatment adjustments made as needed to optimize maternal and infant health.
Article
Peripheral Vascular Disease
Lenka Rezacova, Ivana Vaneckova, Silvie Hojna, Anna Vavrinova, Pavol Valovic, Hana Rauchova, Michal Behuliak, Josef Zicha
Summary: In immature TGR, chronic administration of the AT(1) receptor inhibitor losartan reduced blood pressure by lowering both sympathetic and angiotensin II-dependent blood pressure components. Central and peripheral mechanisms of the renin-angiotensin system were found to play important roles in the development of hypertension, with central sympathoexcitation being more susceptible to inhibition by low doses of RAS-blocking agents.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas D. Fried, Tamara M. Morris, Anna Whitehead, Eric Lazartigues, Xinping Yue, Jason D. Gardner
Summary: Chronic nicotine exposure induces pulmonary hypertension and right ventricular remodeling in mice, while treatment with losartan, an angiotensin II type 1 receptor antagonist, can ameliorate these effects. This provides preclinical evidence for using renin-angiotensin system-based therapies in treating pulmonary hypertension, particularly in patients with a history of tobacco-product use.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Orthopedics
K. Yamaura, A. L. Nelson, H. Nishimura, J. C. Rutledge, S. K. Ravuri, C. Bahney, M. J. Philippon, J. Huard
Summary: The objective of this study was to analyze the latest evidence on the effects of losartan or Ang II receptor antagonists on cartilage repair, with a focus on their clinical relevance. The effects of losartan or Ang II receptor antagonists on cartilage repair in in vitro and in vivo animal studies were evaluated. A total of 12 studies were included in this systematic review, and qualitative evaluation was conducted for each study due to the difficulty of meta-analysis. Both in vitro and in vivo studies provide evidence to demonstrate the beneficial effects of Ang II receptor antagonists on osteoarthritis and cartilage defect models across animal species.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Peripheral Vascular Disease
Marcos Vinicius Fernandes, Mariana Rosso Melo, Francesca Elisabeth Mowry, Gabriela Maria Lucera, Mariana Ruiz Lauar, Gustavo Frigieri, Vinicia Campana Biancardi, Jose Menani, Debora Simoes Almeida Colombari, Eduardo Colombari
Summary: The mechanisms of intracranial pressure changes during hypertension remain unclear, especially in the 2K1C hypertensive model. This study found that as mean arterial pressure increased in 2K1C hypertensive rats, intracranial pressure also significantly increased with changes in pulse waveforms. Additionally, blood-brain barrier disruption in key central cardioregulatory nuclei was observed during the development of 2K1C hypertension. Losartan, an AT1R antagonist, partially reduced the increase in intracranial pressure in hypertensive rats, indicating that AT1R activation may play a role in elevated intracranial pressure during hypertension.
Article
Pharmacology & Pharmacy
Tabata de Paula Facioli, Stella Vieira Philbois, Bruno Augusto Aguilar, Ana Catarine Veiga, Hugo Celso Dutra de Souza
Summary: Pharmacological and non-pharmacological treatments are important strategies to control arterial hypertension. However, the combined effects of angiotensin II receptor type 1 receptor blocker use and physical aerobic exercise on autonomic cardiovascular control have been rarely evaluated. This study found that the combination intervention of losartan administration and physical aerobic training improved cardiac autonomic modulation in hypertensive patients, but did not fully normalize the analyzed autonomic parameters.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Oncology
Salvatore Panza, Rocco Malivindi, Amanda Caruso, Umberto Russo, Francesca Giordano, Balazs Gyorffy, Luca Gelsomino, Francesca De Amicis, Ines Barone, Francesca Luisa Conforti, Cinzia Giordano, Daniela Bonofiglio, Stefania Catalano, Sebastiano Ando
Summary: Losartan, as an adjuvant pharmacological tool, may represent a potential treatment for GBM by inhibiting local estrogen production and halting cell growth. The limited mortality benefit of current treatments underscores the importance of exploring new therapeutic avenues.
Article
Biochemistry & Molecular Biology
Takashi Nishida, Sho Akashi, Masaharu Takigawa, Satoshi Kubota
Summary: This study revealed that angiotensin II has negative effects on chondrocyte metabolism, while AT(1)R blockade can mitigate these effects, potentially reducing chondrocyte degeneration. Additionally, ANG II regulates age-related cartilage degeneration through the ANG II-AT(1)R axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Michael A. Puskarich, Nathan W. Cummins, Nicholas E. Ingraham, David A. Wacker, Ronald A. Reilkoff, Brian E. Driver, Michelle H. Biros, Fernanda Bellolio, Jeffrey G. Chipman, Andrew C. Nelson, Kenneth Beckman, Ryan Langlois, Tyler Bold, Matthew T. Aliota, Timothy W. Schacker, Helen T. Voelker, Thomas A. Murray, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: The study found that losartan did not reduce hospitalizations in low-risk outpatients with mild symptomatic COVID-19, and viral load was not affected by the treatment. This suggests that initiation of losartan treatment for this group is not supported.
Article
Biochemistry & Molecular Biology
Dinesh Aryal, Tithi Roy, Jean Christopher Chamcheu, Keith E. Jackson
Summary: This study found that chronic metabolic acidosis induced in Sprague Dawley rats led to sustained elevation in blood pressure and significant decrease in blood pH. Treatment with captopril/tempol resulted in a significant decrease in blood pressure, while spironolactone did not show the same effect. Induction of chronic acidosis may potentially be causative of hypertension, possibly through activation of intrarenal angiotensin II and induction of oxidative stress.
Article
Peripheral Vascular Disease
Xiao Chun Li, Ana Paula Oliveira Leite, Xiaowen Zheng, Chunling Zhao, Xu Chen, Liang Zhang, Xinchun Zhou, Isabelle Rubera, Michel Tauc, Jia Long Zhuo
Summary: The study reveals the critical role of intratubular Ang II/AT(1) (AT(1a))/NHE3 pathways in the proximal tubules in normal blood pressure control and the development of Ang II-induced hypertension.
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Imane Bensaada, Blaise Robin, Joelle Perez, Yann Salemkour, Anna Chipont, Marine Camus, Mathilde Lemoine, Lea Guyonnet, Helene Lazareth, Emmanuel Letavernier, Carole Henique, Pierre-Louis Tharaux, Olivia Lenoir
Summary: The study revealed that chronic angiotensin II-induced hypertension inhibits autophagy in mouse glomeruli, leading to accelerated podocyte injury when autophagy-related gene Atg5 is deleted. However, transgenic mice expressing the endogenous calpain inhibitor calpastatin showed higher podocyte autophagy and resistance to angiotensin II-induced inhibition, demonstrating a potential protective effect against podocyte damage and albuminuria. These findings suggest that preventing calpain-mediated inhibition of autophagy may offer a new therapeutic strategy for nephropathies associated with high renin-angiotensin system activity.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Giovanna Castoldi, Raffaella Carletti, Silvia Ippolito, Isabella Villa, Biagio Palmisano, Simona Bolamperti, Alessandro Rubinacci, Gianpaolo Zerbini, Michela Meani, Giovanni Zatti, Cira R. T. di Gioia
Summary: The study found that angiotensin II-dependent hypertension led to increased urinary excretion of calcium and phosphate, without significantly affecting bone density.
Article
Neurosciences
S. Gasparini, M. R. Melo, G. M. F. Andrade-Franze, J. C. Geerling, J. V. Menani, E. Colombari
Article
Neurosciences
Lisandra B. De Oliveira, Carina A. F. Andrade, Laurival A. De Luca, Debora S. A. Colombari, Jose V. Menani
BRAIN RESEARCH BULLETIN
(2018)
Article
Biochemistry & Molecular Biology
Camila F. Roncari, Rafaela M. Barbosa, Regina C. Vendramini, Laurival A. De Luca, Jose V. Menani, Eduardo Colombari, Debora S. A. Colombari
Article
Neurosciences
Augusto Anesio, Silas Pereira Barbosa, Laurival A. De Luca, Patricia Maria de Paula, Debora S. A. Colombari, Eduardo Colombari, Carina A. F. Andrade, Jose V. Menani
BRAIN RESEARCH BULLETIN
(2019)
Article
Physiology
Elaine Fernanda da Silva, Mirian Bassi, Jose Vanderlei Menani, Debora Simoes Almeida Colombari, Daniel Breseghello Zoccal, Gustavo Rodrigues Pedrino, Eduardo Colombari
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Peripheral Vascular Disease
Mariana Rosso Melo, Silvia Gasparini, Guilherme F. Speretta, Elaine Fernanda Silva, Gustavo Rodrigues Pedrino, Jose Menani, Daniel B. Zoccal, Debora Simoes Almeida Colombari, Eduardo Colombari
HYPERTENSION RESEARCH
(2019)
Article
Peripheral Vascular Disease
Guilherme F. Speretta, Prashant J. Ruchaya, Maria A. Delbin, Mariana R. Melo, Hongwei Li, Jose Menani, Colin Sumners, Eduardo Colombari, Mirian Bass, Debora S. A. Colombari
HYPERTENSION RESEARCH
(2019)
Article
Behavioral Sciences
E. D. Pereira, R. M. Dantas, G. M. F. Andrade-Franze, L. A. De Luca, J. V. Menani, C. A. F. Andrade
Article
Endocrinology & Metabolism
Cintia Yamila Porcari, Iracema Gomes Araujo, Lilia Urzedo-Rodrigues, Laurival Antonio De Luca, Jose Vanderlei Menani, Ximena Elizabeth Caeiro, Hans Imboden, Jose Antunes-Rodrigues, Luis Carlos Reis, Laura Vivas, Andrea Godino, Andre Souza Mecawi
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Jessica Matheus Sa, Milena Cassolatti Barros, Mariana Rosso Melo, Eduardo Colombari, Jose Vanderlei Menani, Debora Simoes Almeida Colombari
NEUROSCIENCE LETTERS
(2019)
Article
Behavioral Sciences
Jessica Matheus Sa, Rafaela Moreira Barbosa, Jose V. Menani, Laurival Antonio De Luca, Eduardo Colombari, Debora Simoes Almeida Colombari
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Neurosciences
S. Gasparini, M. R. Melo, P. A. Nascimento, G. M. F. Andrade-Franze, J. Antunes-Rodrigues, G. L. C. Yosten, J. V. Menani, W. K. Samson, E. Colombari
Article
Neurosciences
Mariana R. Lauar, Debora S. A. Colombari, Eduardo Colombari, Patricia M. De Paula, Laurival A. De Luca Jr, Jose Menani
BRAIN RESEARCH BULLETIN
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Marlusa Karlen-Amarante, Daniel B. Zoccal, Jose V. Menani, Eduardo Colombari, Debora S. A. Colombari
Meeting Abstract
Biochemistry & Molecular Biology
Mirian Bassi, Rafaela Moreira Barbosa, Jessica M. de Sa, Jose Vanderlei Menani, Eduardo Colombari, Debora Simoes de Almeida Colombari