Article
Gastroenterology & Hepatology
Deepika Razia, Amy Trahan, Chengcheng Hu, Luca Giulini, Ross M. Bremner, Sumeet K. Mittal
Summary: The study aimed to investigate the correlation between upright and prone bolus transit time (BTT) on barium esophagography (BE), esophageal peristalsis on high-resolution manometry (HRM), and self-reported dysphagia in patients. The results showed that prone BTT correlated with the proportion of normal esophageal swallows and dysphagia.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zuzana Vackova, Jan Mares, Jana Krajciova, Zuzana Rabekova, Lucie Zdrhova, Pavla Loudova, Julius Spicak, Petr Stirand, Tomas Hucl, Jan Martinek
Summary: More than 20% of achalasia patients show signs of partial recovery of esophageal peristalsis after POEM treatment. This recovery is mainly seen in patients with type II achalasia, but the clinical impact appears to be minimal.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Wei-Yi Lei
Summary: The study investigated the effects of acute administration of codeine on primary and secondary peristalsis in healthy adults. Results showed that codeine increased the relaxation pressure and frequency of secondary peristalsis, while also affecting primary peristalsis by increasing relaxation pressure and shortening distal latency. This suggests that opioids like codeine can impact both primary and secondary peristalsis in the esophagus.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Shu-Wei Liang, Jui-Sheng Hung, Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Chien-Lin Chen
Summary: Intraluminal infusion of menthol reduces upper esophageal sphincter basal pressure and inhibits the frequency of secondary peristalsis. Although menthol modulates esophageal peristalsis, it does not alter other esophageal motility characteristics significantly.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Gastroenterology & Hepatology
Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study evaluated the utility of barium esophagography (BE) screening using two novel findings to diagnose esophageal motility disorders (EMDs). The results showed that BE screening using these two additional novel findings, along with conventional findings, had higher sensitivity and specificity in diagnosing EMDs, and could be useful in general clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Ali Zifan, Vignesh Gandu, Melissa Ledgerwood, Ravinder Mittal
Summary: Intraluminal impedance recordings can measure luminal distension in the esophagus. Factors such as posture and bolus viscosity affect bolus flow rate, esophageal wall tension, and esophageal wall distensibility during swallow-induced primary peristalsis.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Wenjun Kou, Galal Osama Galal, Matthew William Klug, Vladislav Mukhin, Dustin A. Carlson, Mozziyar Etemadi, Peter J. Kahrilas, John E. Pandolfino
Summary: This study developed and evaluated a deep learning AI model for automatic classification of swallow types based on raw HRM data. The model achieved high accuracies in training/validation/test datasets and accurately classified peristalsis at study level. The misclassifications were mainly adjacent categories, indicating the need for further refinement and incorporation of overall manometric diagnoses in future work.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Ming-Wun Wong, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Shu-Wei Liang, William C. Orr, Chien-Lin Chen
Summary: In patients with normal endoscopy, those with absent primary peristalsis and lacking a secondary peristaltic response to esophageal air distension have a more significant acid reflux burden.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Tso-Tsai Liu, Jen-Hung Wang, Chih-Hsun Yi, Jui-Sheng Hung, Ming-Wun Wong, Chandra Prakash Gyawali, Chien-Lin Chen
Summary: The study found significant defects in the triggering of secondary peristalsis in GERD patients, particularly those with IEM. This can be characterized by HRM to show differences in esophageal secondary peristalsis between patients with and without IEM.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Surgery
Yazmin Johari, Anagi Wickremasinghe, Pradipta Kiswandono, Helen Yue, Geraldine Ooi, Cheryl Laurie, Geoffrey Hebbard, Paul Beech, Kenneth Yap, Wendy Brown, Paul Burton
Summary: Following sleeve gastrectomy, esophago-gastric transit is primarily driven by isobaric pressurization of the stomach induced by repeated esophageal peristaltic contractions, with a strong association with reflux. Transit of food from the esophagus to the small bowel post-operatively is rapid and substantial.
Article
Medicine, General & Internal
Chul-Hyun Park, Kunwoo Kim, Jin-Tae Hwang, Jae-Hyung Choi, Yong-Taek Lee, Young Sook Park, Jung Ho Park, Kyung Jae Yoon
Summary: This study compared two methods of measuring upper esophageal sphincter (UES) relaxation and determined their diagnostic value in UES relaxation impairment. The results showed that VFSS and HRM have complementary ability in evaluating UES relaxation duration in patients with oropharyngeal dysphagia.