Article
Surgery
Giuseppe Zambito, Robert Roether, Brittany Kern, Ryan Conway, David Scheeres, Amy Banks-Venegoni
Summary: This study found that BE has lower concordance with HRM in diagnosing esophageal dysmotility, and therefore should not be used as a substitute for HRM in assessing pre-operative motility in patients undergoing anti-reflux surgery.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Gastroenterology & Hepatology
Katelyn E. Madigan, J. Shawn Smith, Joni K. Evans, Steven B. Clayton
Summary: This study found that an elevated average maximum intrabolus pressure (AM-IBP) is associated with abnormal findings of esophageal tablet retention and/or bolus stasis. An abnormal AM-IBP was also found to be associated with a higher probability of retaining liquid bolus or barium tablet arrest, as well as esophageal dysmotility.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexandra J. Baumann, Erica N. Donnan, Joseph R. Triggs, Wenjun Kou, Jacqueline Prescott, Alex Decorrevont, Emily Dorian, Peter J. Kahrilas, John E. Pandolfino, Dustin A. Carlson
Summary: This study found that patients with normal FLIP panometry results generally did not exhibit major esophageal motor disorders, and HRM results that were abnormal were often considered false positives. In some cases, normal FLIP panometry results could potentially eliminate the need for HRM to diagnose esophageal motility disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J. Kahrilas, Isis K. Araujo, Mira Yang, Marie-Pier Tetreault, John E. Pandolfino
Summary: Classifying the physiological and mechanical esophageal function in EoE based on FLIP panometry features may help define the severity of the disease and guide its management.
Article
Medicine, General & Internal
Akshat Ritesh Shah, Maaz S. Arif, We'am Hussain, Sangeeta Agrawal
Summary: This report presents a case of an unusual complication during high-resolution manometry testing, emphasizing the importance of caution for clinicians during the procedure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Giulini, Sumeet K. Mittal, Takahiro Masuda, Deepika Razia, Mate Csucska, Rajat Walia, Michael A. Smith, Ross M. Bremner
Summary: Esophageal peristalsis can improve after lung transplant, especially in patients with obstructive lung disease or pulmonary arterial hypertension. However, patients with restrictive lung disease and scleroderma are unlikely to experience peristalsis improvement. Subjective esophagram assessment may help predict peristalsis improvement in patients with restrictive lung disease without scleroderma.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Chloe W. Caudell, Ethan P. Covil, John W. Gilpin, Brian Hodgens, Alex Ewing, Shanu N. Kothari
Summary: The study evaluates the use of Minimally Invasive Marshmallow Swallow Study (MSS) as a screening technique and its correlation with High Resolution Manometry (HRM) results and post-operative dysphagia. The results suggest that MSS is effective in ruling out major esophageal motility disorders and reducing the need for invasive HRM.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Wei-Yi Lei
Summary: The study investigated the effects of acute administration of codeine on primary and secondary peristalsis in healthy adults. Results showed that codeine increased the relaxation pressure and frequency of secondary peristalsis, while also affecting primary peristalsis by increasing relaxation pressure and shortening distal latency. This suggests that opioids like codeine can impact both primary and secondary peristalsis in the esophagus.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Shu-Wei Liang, Jui-Sheng Hung, Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Chien-Lin Chen
Summary: Intraluminal infusion of menthol reduces upper esophageal sphincter basal pressure and inhibits the frequency of secondary peristalsis. Although menthol modulates esophageal peristalsis, it does not alter other esophageal motility characteristics significantly.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Wenjun Kou, Katharine P. Rooney, Alexandra J. Baumann, Erica Donnan, Joseph R. Triggs, Ezra N. Teitelbaum, Amy Holmstrom, Eric Hungness, Sajiv Sethi, Peter J. Kahrilas, John E. Pandolfino
Summary: Using FLIP panometry and machine learning, a model was developed to predict and classify achalasia subtypes on HRM. The model can differentiate type III achalasia from non-spastic achalasia, with potential for clinical application.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Boram Cha, Kyungmin Choi, Kee Wook Jung, Hwa Jung Kim, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Segyeong Joo
Summary: This study compared two diagnostic tools for non-obstructive dysphagia (NOD) and found that the volume of inverted impedance (VII) ratio is more reliable than the esophageal impedance integral (EII) ratio.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Health Care Sciences & Services
Monica M. Vasquez, Chengcheng Hu, Denise J. Roe, Marilyn Halonen, Stefano Guerra
STATISTICAL METHODS IN MEDICAL RESEARCH
(2019)
Article
Obstetrics & Gynecology
Rachael B. Smith, Janel Brink, Chengcheng Hu, Richard Gerkin, Jordan H. Perlow, Jamal Mourad
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2020)
Article
Health Care Sciences & Services
Mary L. Miller, Denise J. Roe, Chengcheng Hu, Melanie L. Bell
BMC MEDICAL RESEARCH METHODOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Monal Sharma, Muthukumar Gunasekaran, Ranjithkumar Ravichandran, Cynthia E. Fisher, Ajit P. Limaye, Chengcheng Hu, John McDyer, Vaidehi Kaza, Ankit Bharat, Sofya Tokman, Ashraf Omar, Ashwini Arjuna, Rajat Walia, Ross M. Bremner, Michael A. Smith, Ramsey R. Hachem, Thalachallour Mohanakumar
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Article
Mathematical & Computational Biology
Chiu-Hsieh Hsu, Yulei He, Chengcheng Hu, Wei Zhou
STATISTICS IN MEDICINE
(2020)
Article
Clinical Neurology
Gokul Krishna, Caitlin Bromberg, Emily Charlotte Connell, Erum Mian, Chengcheng Hu, Jonathan Lifshitz, P. David Adelson, Theresa Currier Thomas
FRONTIERS IN NEUROLOGY
(2020)
Article
Emergency Medicine
Joshua B. Gaither, Daniel W. Spaite, Bentley J. Bobrow, Samuel M. Keim, Bruce J. Barnhart, Vatsal Chikani, Duane Sherrill, Kurt R. Denninghoff, Terry Mullins, P. David Adelson, Amber D. Rice, Chad Viscusi, Chengcheng Hu
Summary: The study evaluated the impact of implementing pediatric traumatic brain injury guidelines on outcomes in children with severe traumatic brain injuries. While overall survival rates did not improve, children with severe traumatic brain injuries showed significant improvement in survival rates, suggesting a potential for guidelines to be effective in severe cases.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Shawna Follis, Yann C. Klimentidis, Jennifer Bea, Chengcheng Hu, David Garcia, Jean Wactawski-Wende, Lindsay Kohler, Aladdin H. Shadyab, Melissa Flores, Hilary A. Tindle, Zhao Chen
Summary: This study found that social stress is prospectively associated with fracture incidence among postmenopausal women, with age and race/ethnicity modifying these associations. Higher social support was associated with lower total fracture incidence, while higher social strain was associated with greater hip fracture incidence among specific racial/ethnic groups.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Xiuli Zhao, Annika B. Ozols, Kimberly T. Meyers, Janet Campbell, Andrew McBride, Ketan K. Marballi, Amanda M. Maple, Carren Raskin, Abhinav Mishra, Serena M. Noss, Kelsey L. Beck, Rami Khoshaba, Amulya Bhaskara, Meghna N. Godbole, James R. Lish, Paul Kang, Chengcheng Hu, Mikael Palner, Agnete Overgaard, Gitte M. Knudsen, Amelia L. Gallitano
Summary: Sleep deprivation upregulates 5-HT2A receptor levels in the mouse frontal cortex, and this induction requires the activity-dependent immediate early gene transcription factor early growth response 3 (Egr3). EGR3 directly regulates Htr2a expression, and both EGR3 and HTR2A mRNA are reduced in the prefrontal cortex of schizophrenia patients compared to controls.
MOLECULAR PSYCHIATRY
(2022)
Article
Oncology
Clara Curiel-Lewandrowski, Caitlyn N. Myrdal, Kathylynn Saboda, Chengcheng Hu, Edith Arzberger, Giovanni Pellacani, Franz Josef Legat, Martina Ulrich, Petra Hochfellner, Margaret C. Oliviero, Paola Pasquali, Melissa Gill, Rainer Hofmann-Wellenhof
Summary: Non-invasive imaging technology, such as reflectance confocal microscopy, has the potential to enhance the evaluation of actinic keratoses (AKs) and monitor treatment responses over time. Standardized RCM protocols may enable better comparison across clinical trials and early detection of relapses.
Article
Emergency Medicine
Daniel W. Spaite, Chengcheng Hu, Bentley J. Bobrow, Bruce Barnhart, Vatsal Chikani, Joshua B. Gaither, Kurt R. Denninghoff, Gail H. Bradley, Amber D. Rice, Jeffrey T. Howard, Samuel M. Keim
Summary: This study aimed to evaluate the associations between out-of-hospital systolic blood pressure (SBP) and multiple hospital outcomes in traumatic brain injury (TBI) patients. The findings suggest that optimal adjusted mortality is associated with a surprisingly high SBP range (130 to 180 mmHg). The study also highlights that the definition of hypotension in TBI is likely too low.
ANNALS OF EMERGENCY MEDICINE
(2022)
Article
Surgery
Daiji Kano, Chengcheng Hu, Caitlin J. Thornley, Cecilia Y. Cruz, Nathaniel J. Soper, Jennifer F. Preston
Summary: The positioning during surgery can affect the risk of venous thromboembolism (VTE), with the reverse-Trendelenburg position potentially increasing the risk of postoperative VTE. Therefore, appropriate positioning choice in laparoscopic surgery can help decrease the risk of VTE.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Public, Environmental & Occupational Health
Naila Khalil, Alan M. Ducatman, Shripad Sinari, Dean Billheimer, Chengcheng Hu, Sally Littau, Jefferey L. Burgess
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Article
Ergonomics
David P. Bui, Stephanie C. Griffin, Dustin D. French, Chengcheng Hu, Keshia Pollack Porter, Alesia M. Jung, Steve Crothers, Jefferey L. Burgess
JOURNAL OF SAFETY RESEARCH
(2019)