Article
Urology & Nephrology
Usman J. Wudil, Muktar H. Aliyu, Heather L. Prigmore, Donna J. Ingles, Aima A. Ahonkhai, Baba M. Musa, Hamza Muhammad, Mahmoud U. Sani, Aisha M. Nalado, Aliyu Abdu, Kabiru Abdussalam, Bryan E. Shepherd, Faisal S. Dankishiya, Anna M. Burgner, T. Alp Ikizler, Christina M. Wyatt, Jeffrey B. Kopp, Paul L. Kimmel, Cheryl A. Winkler, C. William Wester
Summary: The study found that among HIV-positive Nigerian adults, the prevalence of APOL1 high-risk genotype was 6.2%, with significant differences among ethnic groups. The APOL1 high-risk genotype was strongly associated with albuminuria and estimated glomerular filtration rate.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad
Summary: After feeding, the activity of lipid-metabolizing enzyme lipoprotein lipase (LPL) in adipose tissue needs to be maximized, which is inhibited by angiopoietin-like protein 4 (ANGPTL4). However, this inhibition is blocked by ANGPTL8 through the formation of ANGPTL4/8 complexes. Recent research has shown that ANGPTL4/8 not only protects LPL but also interacts with tissue plasminogen activator (tPA) and plasminogen to generate plasmin, which cleaves ANGPTL4/8 and restores LPL activity. These findings shed light on the intricate regulation of LPL activity in response to feeding.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Clinical Neurology
Kaori Miwa, Masatoshi Koga, Marit Jensen, Manabu Inoue, Sohei Yoshimura, Mayumi Fukuda-Doi, Florent Boutitie, Henry Ma, Peter A. Ringleb, Ona Wu, Lee H. Schwamm, Steven Warach, Werner Hacke, Stephen M. Davis, Geoffrey A. Donnan, Christian Gerloff, Gotz Thomalla, Kazunori Toyoda
Summary: This study aimed to evaluate the efficacy and safety of intravenous thrombolysis for acute ischemic stroke with unknown onset time in patients with chronic kidney disease (CKD). The results showed that CKD did not modify the treatment effect of thrombolysis and was associated with a slightly increased risk of bleeding.
Article
Cardiac & Cardiovascular Systems
Bowen Lin, Ying Shen, Pengfei Zhang, Yunli Shen, Yuying Gu, Xiaoyan He, Jimin Li, Ke Yang, Weifeng Shen, Qi Zhang, Yuanfeng Xin, Yehong Liu
Summary: This study investigated the relationship between circulating tissue plasminogen activator (t-PA) level and long-term outcomes in stable coronary artery disease patients with or without aortic valve sclerosis (AVSc). The results showed that patients with AVSc had significantly higher levels of t-PA, and this high level was associated with poor outcomes such as heart failure and cardiovascular death. However, for patients without AVSc, t-PA levels were not associated with outcomes.
Article
Urology & Nephrology
Salam Bennouar, Abdelghani Bachir Cherif, Mohamed Temmar, Jean-Pierre Fauvel, Mohamed Tahar Bouafia, Samia Abdi
Summary: The combination of obesity and metabolic disorders significantly worsens the decline of glomerular function in hypertensive subjects, with 51% to 53% of the risk of microalbuminuria and low eGFR being explained by this interaction. Management of high-risk subjects requires not only therapeutic regimen but also adequate dietary and physical program to preserve glomerular function.
Article
Urology & Nephrology
Esben Iversen, Thomas Kallemose, Mads Hornum, Anne Kathrine Bengaard, Jan Olof Nehlin, Line Jee Hartmann Rasmussen, Haakon Sandholdt, Juliette Tavenier, Bo Feldt-Rasmussen, Ove Andersen, Jesper Eugen-Olsen, Morten Baltzer Houlind
Summary: The study shows that elevated suPAR levels during hospitalization are associated with a decline in eGFR after discharge. Measurement of suPAR may be useful for early detection of kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Bettina Mittendorfer, Brandon D. Kayser, Mihoko Yoshino, Jun Yoshino, Jeramie D. Watrous, Mohit Jain, J. Christopher Eagon, Bruce W. Patterson, Samuel Klein
Summary: This study evaluated the metabolic effects of weight loss in women with obesity and found that the heterogeneity in the effect of weight loss on muscle and hepatic insulin sensitivity is determined by baseline insulin action.
Article
Multidisciplinary Sciences
Alkebaier Aobulikasimu, Tao Liu, Jinying Piao, Shingo Sato, Hiroki Ochi, Atsushi Okawa, Kunikazu Tsuji, Yoshinori Asou
Summary: The role of SIRT6 in osteocytes was investigated in this study, using mice lacking Sirt6 and an osteocyte-like cell line. The results showed that Sirt6 deficiency led to increased expression of senescence-associated genes and decreased serum phosphate levels, resulting in low-turnover osteopenia. However, the effects were reversed in mice lacking PAI-1 gene. Further experiments revealed that senescence induction increased the expression of Fgf23 and Sost genes, and Sirt6 knockout and senescence induction enhanced the binding of HIF-1 alpha to Fgf23 enhancer sequence. These findings suggest that SIRT6 agonists or PAI-1 inhibitors may be potential therapeutic options for aging-related bone metabolism disruptions.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shuai Li, Haibo Jia, Zhihang Liu, Nan Wang, Xiaochen Guo, Muhua Cao, Fang Fang, Jiarui Yang, Junyan Li, Qi He, Rui Guo, Teng Zhang, Kai Kang, Zongbao Wang, Shijie Liu, Yukai Cao, Xinghao Jiang, Guiping Ren, Kai Wang, Bo Yu, Wei Xiao, Deshan Li
Summary: FGF-21 functions as an antithrombotic agent by inhibiting blood clot formation and promoting fibrinolysis. It exhibits anticoagulant and antiplatelet effects, and regulates the expression of inflammatory factors involved in thrombosis.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Shailza Sharma, Tomoya Watanabe, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Xinh-Xinh Nguyen, Matthew Sanderson, Yunyun Su, Roger A. Chambers, Carol Feghali-Bostwick
Summary: The fibroproliferative disorders like systemic sclerosis have no effective therapies till now, but the C-terminal domain of endostatin called E4 has shown promising results in preventing and reversing dermal and pulmonary fibrosis. This study found that E4 works by regulating the urokinase pathway, increasing MMP-1 and MMP-3 levels, and binding to proteins like enolase-1 and uPA receptor to promote extracellular matrix degradation. Furthermore, the glycolytic enzyme enolase-1 plays a moonlighting function in fibrosis by mediating the effects of TGF-beta 1 and exerting TGF-beta 1-independent fibrotic effects.
Article
Cardiac & Cardiovascular Systems
Albe C. Swanepoel, Mari van Reenen, Zelda de Lange-Loots, Marlien Pieters
Summary: The study found that there is an association between Metabolic syndrome (MetS) and plasminogen activator inhibitor-1 (PAI-1), with increased PAI-1 activity and longer clot lysis time (CLT) in individuals with MetS. However, this condition did not worsen over a 10-year period compared to controls. Waist circumference, triglycerides, and HDL-C were the main predictors of PAI-1 activity and CLT.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Pediatrics
Riko Sato, Tomomi Aizawa, Tadaatsu Imaizumi, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, Hiroshi Tanaka
Summary: This study found that serum from patients with SLE may activate the fibrinolysis system in glomerulus, which may be involved in the pathogenesis of lupus nephritis.
PEDIATRICS INTERNATIONAL
(2022)
Article
Integrative & Complementary Medicine
Zhuo Yu, Wei Dong, Lianhua Li, Yan Jiao, Ming Chen, Xicheng Jiang, Peiqing Zhang
Summary: CD146 could be an early indicator in clinical monitoring and is associated with the NF-.B1 and TGF-beta 1/SMAD2 pathways under Shendibushen treatment.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Rowan Pentz, M. Florencia Iulita, Adriana Ducatenzeiler, David A. Bennett, A. Claudio Cuello
Summary: The study revealed that in Alzheimer's disease, there are changes in the metabolism of NGF, leading to disease progression. Mature NGF degradation is enhanced while proNGF maturation is impaired, with these changes correlating with cognition, pathology, and cholinergic tone.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Wen Dai, Heng Zhang, Hayley Lund, Ziyu Zhang, Mark Castleberry, Maya Rodriguez, George Kuriakose, Sweta Gupta, Magdalena Lewandowska, Hayley R. Powers, Swati Valmiki, Jieqing Zhu, Amy D. Shapiro, M. Mahmood Hussain, Jose A. Lopez, Mary G. Sorci-Thomas, Roy L. Silverstein, Henry N. Ginsberg, Daisy Sahoo, Ira Tabas, Ze Zheng
Summary: This study found that low apoB-lipoprotein cholesterol levels may be associated with the absence of tPA in hepatocytes, and tPA may affect lipoprotein synthesis and secretion by interacting with apoB.
Article
Endocrinology & Metabolism
M. Kupreeva, A. Diane, R. Lehner, R. Watts, M. Ghosh, S. Proctor, D. Vine
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Melanie A. Fontaine, Abdoulaye Diane, Vijay P. Singh, Rabban Mangat, Jacqueline A. Krysa, Randy Nelson, Benjamin P. Willing, Spencer D. Proctor
Article
Cardiac & Cardiovascular Systems
Jacqueline A. Krysa, Donna F. Vine, Lawrence J. Beilin, Sally Burrows, Rae-Chi Huang, Trevor A. Mori, Spencer D. Proctor
Review
Food Science & Technology
Payam Vahmani, Eric N. Ponnampalam, Jana Kraft, Cletos Mapiye, Emma N. Bermingham, Peter J. Watkins, Spencer D. Proctor, Michael E. R. Dugan
Article
Endocrinology & Metabolism
Jesus M. Pradillo, Macarena Hernandez-Jimenez, Maria E. Fernandez-Valle, Violeta Medina, Juan E. Ortuno, Stuart M. Allan, Spencer D. Proctor, Juan M. Garcia-Segura, Maria J. Ledesma-Carbayo, Andres Santos, Maria A. Moro, Ignacio Lizasoain
Summary: The study found that stroke outcomes and angiogenesis/vasculogenesis in old rats are negatively affected by the co-morbidities present in the corpulent genotype. DCE-MRI may be a useful technique for non-invasive evaluation of vascular function and angiogenesis processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Microbiology
Craig Resch, Mihir Parikh, J. Alejandro Austria, Spencer D. Proctor, Thomas Netticadan, Heather Blewett, Grant N. Pierce
Summary: Research indicates that an HFHS diet leads to dysbiosis in the gut microbiota, and gender, diet, and flaxseed supplementation all play a role in influencing the composition and diversity of the microbiota.
Article
Biochemistry & Molecular Biology
Mihir Parikh, Branislav Kura, Bhavana Garg, J. Alejandro Austria, Liping Yu, Thane G. Maddaford, Spencer D. Proctor, Thomas Netticadan, Grant N. Pierce
Summary: The research indicates that dietary flaxseed can protect obese rats from myocardial ischemic lesions and reduce the occurrence of cardiac lesions; a high-fat, high-sucrose diet increases the frequency of myocardial ischemic lesions, but dietary flaxseed can lower the frequency of cardiac lesions and improve heart function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Microbiology
Vijay P. Singh, Melanie A. Fontaine, Rabban Mangat, Janelle M. Fouhse, Abdoulaye Diane, Benjamin P. Willing, Spencer D. Proctor
Summary: High-fat diets can influence gut microbial composition, while beef fat rich in vaccenic acid may have insulin-sensitizing effects, increase HDL cholesterol, reduce postprandial plasma TG, and protect against high-fat diet-induced changes in gut microbial composition in low birth weight pigs. Further research is needed to understand the mechanisms behind natural trans fats' effects on gut dysbiosis.
Review
Nutrition & Dietetics
Yongbo She, Rabban Mangat, Sue Tsai, Spencer D. Proctor, Caroline Richard
Summary: Obesity is strongly linked to inflammation, impaired insulin signaling, lipid metabolism, and immune function. Recent research has provided insights into the mechanisms of immune dysfunction in obesity, using various animal and clinical models. Nutritional strategies, particularly those involving choline-rich foods, are emerging as potential ways to improve immune function in the context of obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Edward C. Deehan, Zhengxiao Zhang, Alessandra Riva, Anissa M. Armet, Maria Elisa Perez-Munoz, Nguyen K. Nguyen, Jacqueline A. Krysa, Benjamin Seethaler, Yuan-Yuan Zhao, Janis Cole, Fuyong Li, Bela Hausmann, Andreas Spittler, Julie-Anne Nazare, Nathalie M. Delzenne, Jonathan M. Curtis, Wendy Wismer, Spencer D. Proctor, Jeffrey A. Bakal, Stephan C. Bischoff, Dan Knights, Catherine J. Field, David Berry, Carla M. Prado, Jens Walter
Summary: This study demonstrates the efficacy of purified dietary fibers when used as supplements and suggests that the satiating effects of AX may be linked to bacterial taxa that ferment the fiber or utilize breakdown products.
Article
Nutrition & Dietetics
Yongbo She, Kun Wang, Alexander Makarowski, Rabban Mangat, Sue Tsai, Benjamin P. Willing, Spencer D. Proctor, Caroline Richard
Summary: This study investigated the impact of dairy and dairy fat on cardiometabolic risk factors and immune function using a low birthweight swine model. The results showed that consuming high-fat dairy products improved fasting plasma glucose concentrations compared to low-fat dairy, while dairy consumption had a neutral effect on fasting lipid profile. Furthermore, consuming low-fat dairy significantly improved the production of certain cytokines, indicating enhanced immune function.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yongbo She, Kun Wang, Alexander Makarowski, Rabban Mangat, Sue Tsai, Benjamin P. Willing, Spencer D. Proctor, Caroline Richard
Summary: This study investigated the effects of consuming high-fat and low-fat dairy products on postprandial cardiometabolic risk factors and intestinal immune function using a low birthweight swine model. The results showed that dairy consumption, regardless of fat content, did not have an impact on postprandial cardiometabolic risk factors. However, low-fat dairy products were found to significantly improve intestinal T cell function compared to high-fat dairy products in this model of obesity and insulin resistance.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Kun Wang, Yongbo She, Rabban Mangat, Alexander Makarowski, Bimol C. Roy, Heather L. Bruce, Michael K. Dyck, Caroline Richard, Spencer D. Proctor
Summary: Increasing dairy intake can enhance the absorption of fatty acids into pork. Low-birth weight (LBW) swine fed a high-fat diet are susceptible to insulin resistance and excessive lipid absorption, but increasing dairy intake can alleviate these issues. Additionally, increasing dairy intake can increase the healthy fatty acid content in pork and improve carcass lean yield.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Pediatrics
Jacqueline A. Krysa, Geoff D. C. Ball, Donna F. Vine, Mary Jetha, Spencer D. Proctor
Summary: This study examined the association between obesity and cardiovascular risk factors in youth, finding that obesity was linked to higher levels of fasting and non-fasting apoB48-remnants compared to non-obese individuals. Additionally, fasting apoB48-remnants were positively correlated with non-fasting apoB48 response as well as other cardiometabolic risk factors, suggesting that they may serve as potential biomarkers for cardiovascular disease risk in youth.
Article
Endocrinology & Metabolism
Donna F. Vine, Lawrence J. Beilin, Sally Burrows, Rae-Chi Huang, Martha Hickey, Roger Hart, Spencer D. Proctor, Trevor A. Mori
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)