Review
Biochemistry & Molecular Biology
Kazuaki Yoshioka
Summary: PI3Ks are lipid kinases involved in regulating various cellular processes. Recent studies suggest that class II PI3K isoforms play important roles in clathrin-mediated endocytosis and endosomal signaling.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: The study identified BMI1 as a positive regulator of testosterone production, with the mechanism involving BMI1-mediated gene silencing to inhibit the p38 MAPK pathway and promote steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Ebru Aydin, Sebastian Faehling, Mariam Saleh, Laura Llao Cid, Martina Seiffert, Philipp M. Roessner
Summary: PI3K pathway plays a crucial role in cell growth and malignant transformation, with its hyperactivation being a hallmark of cancer. Inhibiting PI3K not only affects cancer cells but also impacts the tumor microenvironment and immune cell function. Understanding the effects of PI3K inhibition on the tumor microenvironment in CLL can lead to improved drug development and novel combinatory treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Takuya Nagai, Tomohisa Sekimoto, Syuji Kurogi, Tomomi Ohta, Shihoko Miyazaki, Yoichiro Yamaguchi, Takuya Tajima, Etsuo Chosa, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Narantsog Choijookhuu, Katsuaki Sato, Yoshitaka Hishikawa, Taro Funamoto
Summary: This study reveals that Tmem161a is a crucial regulator in bone structure and function. Depletion of Tmem161a leads to thicker and stronger bones in mice.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Jian Sun, Jie Zhou, Jianhui Zhou, Wenxin Xu, Yali Du, Zhenyu Jia, Yingjie Shen, Xiaohua Lin, Xulan Wang, Yuxuan Bao, Zhiheng Rao, Siyang Dong, Yongde Luo, Weitao Cong, Litai Jin, Xiaokun Li
Summary: Cutaneous wound healing is a complex process, and FGF4 has been identified as an important regulator of wound repair by promoting re-epithelialization through the migration and proliferation of keratinocytes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Natasha M. Setiabakti, Pia Larsson, Justin R. Hamilton
Summary: Understanding the role of phosphoinositide 3-kinases (PI3Ks) in platelet function and thrombus formation is crucial for the development of therapeutic drugs for thrombotic cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sarah M. Ryan, Michael Almassey, Amelia M. Burch, Gia Ngo, Julia M. Martin, David Myers, Devin Compton, Shira Archie, Megan Cross, Lauren Naeger, Ashley Salzman, Alyssa Virola-Iarussi, Scott A. Barbee, Nathan T. Mortimer, Subhabrata Sanyal, Alysia D. Vrailas-Mortimer
Summary: As organisms age, protein aggregates accumulate and may lead to age-related diseases. While genetic factors play a role in longevity, their impact on protein homeostasis is not fully understood. Research shows that the gene p38Kb regulates age-dependent protein aggregation and interacts with the regulator starvin to maintain muscle protein homeostasis.
Article
Allergy
Jessica Oh, Elizabeth Garabedian, Ramsay Fuleihan, Charlotte Cunningham-Rundles
Summary: Activated phosphoinositide 3-kinase delta syndrome is a combined primary immunodeficiency characterized by various manifestations such as respiratory infections, lymphadenopathy, and developmental delay. Clinical features differ between PIK3CD and PIK3R1 patients, with a higher frequency of asthma observed in the PIK3CD cohort.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Biochemical Research Methods
Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett
Summary: The functional differences between the two isoforms of glycogen synthase kinase-3 (GSK-3), a protein-serine/threonine kinase, are still not fully understood. While the isoforms are structurally similar and redundant, there is evidence for specific roles. This study aimed to identify novel GSK-3 interaction partners and compare the interactomes of the two isoforms using affinity purification and proximity-dependent biotinylation mass spectrometry methods. The results showed that the interactomes of the isoforms were highly similar in HEK293 cells, but there were differences in HeLa cells, suggesting isoform-specific associations with certain proteins.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemical Research Methods
Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett
Summary: This study investigates the functional differentiation of two isoforms of GSK-3 and identifies novel interaction partners using affinity purification and proximity-dependent biotinylation mass spectrometry methods. The interactomes of the two isoforms are highly similar in HEK293 cells, but there are isoform-specific interactions in HeLa cells. Understanding the differences in interactions between the isoforms may provide insights into their distinct functions and regulation, and open up possibilities for isoform-specific strategies.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olivia Molinar-Inglis, Jacob M. Wozniak, Neil J. Grimsey, Lennis B. Orduna-Castillo, Norton Cheng, Ying Lin, Monica L. Gonzalez Ramirez, Cierra A. Birch, John D. Lapek, David J. Gonzalez, JoAnn Trejo
Summary: This study identified candidate proteins regulated by PAR1-p38 signaling that may play important roles in endothelial dysfunction, by analyzing the global phosphoproteome in human cultured endothelial cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Thuy Phan, Xu Hannah Zhang, Steven Rosen, Laleh G. Melstrom
Summary: Gastrointestinal cancers are a major cause of cancer-related morbidity and mortality worldwide. The p38 signaling pathway, particularly p38 gamma, plays a crucial role in cancer development and metastasis. This article provides an overview of p38 and p38 gamma in gastrointestinal cancers, as well as discusses the potential of targeting p38 gamma as a therapy.
CANCER GENE THERAPY
(2023)