Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

(2020) Ting Cai et al.   Cell Death & Disease

Study on the inhibitive effect of Catalpol on diabetic nephropathy

(2020) Jing Chen et al.   LIFE SCIENCES

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism

(2020) Yi Fu et al.   Cell Metabolism

Dianthus superbus Improves Glomerular Fibrosis and Renal Dysfunction in Diabetic Nephropathy Model

(2019) Jung Yoon et al.   Nutrients

The Global Burden of Diabetic Kidney Disease: Time Trends and Gender Gaps

(2019) Bernadette Thomas   Current Diabetes Reports

Obesity, Metabolic Syndrome and the Risk of Microvascular Complications in Patients with Diabetes Mellitus

(2019) Niki Katsiki et al.   CURRENT PHARMACEUTICAL DESIGN

Metabolomic study of the protective effect of Gandi capsule for diabetic nephropathy

(2019) Yue Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Podocyte lipotoxicity in diabetic kidney disease

(2019) Hiroshi Nishi et al.   KIDNEY INTERNATIONAL

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

(2019) Valentina Marchesin et al.   Cell Reports

High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

(2018) Dongsheng Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Update of pathophysiology and management of diabetic kidney disease

(2018) Yi-Chih Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production

(2018) Jingyuan Xu et al.   PHARMACOLOGICAL RESEARCH

Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase

(2017) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

(2017) Eugene J Barrett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fast renal decline to end-stage renal disease: an unrecognized feature of nephropathy in diabetes

(2017) Andrzej S. Krolewski et al.   KIDNEY INTERNATIONAL

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis

(2016) Vivette D. D'Agati et al.   Nature Reviews Nephrology

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

(2015) Milla Kibble et al.   NATURAL PRODUCT REPORTS

HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer

(2014) Hae Ryung Chang et al.   GUT

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE