Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: Cattle have a unique mechanism for efficient hepatic gluconeogenesis, involving the high expression of specific genes and the activation of the mTORC1 signaling pathway. These findings are important for understanding the mechanism underlying the quantitative differences in hepatic gluconeogenesis efficiency between cattle and non-ruminant animals.
Review
Pharmacology & Pharmacy
Ya-Na Yang, Mao-Qing Zhang, Feng-Lin Yu, Bing Han, Ming-Yue Bao, Xing Li, Yuan Zhang
Summary: Neurodegenerative disorders (NDDs) are characterized by progressive loss of vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive dysfunction. Peroxisome proliferator-activated receptor-? coactivator-1a (PGC-1a) has shown a strong connection with NDDs and its understanding is important for the development of therapeutic strategies. This review provides an overview of PGC-1a, its role in various NDDs, and the mechanisms through which it exerts neuroprotective effects.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhijun He, Xiaoqian Li, Zi Wang, Yingqi Cao, Shuangxue Han, Nan Li, Jie Cai, Shuiyuan Cheng, Qiong Liu
Summary: This study revealed the beneficial effects of luteolin on Alzheimer's disease through inhibiting Aβ generation, repairing mitochondrial damage, and reducing neuronal apoptosis. The mechanism involved the binding of luteolin to PPARγ to promote its expression and function.
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu Yang, Yan Li, Yongying Zhou, Daoquan Liu, Jianmin Liu, Michael E. DiSanto, Xinhua Zhang
Summary: BPH is a common disease in elderly men and is closely related to MetS. This study demonstrates that SV can modulate cell proliferation, apoptosis, tissue fibrosis, and the EMT process in the prostate through crosstalk between PPAR gamma and WNT/beta-catenin pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lei Wang, Mengmeng Yang, Huihan Jin
Summary: The study demonstrated that PI3K/AKT phosphorylation enhances ERR alpha activity in NOZ cells by upregulating the expression levels of PGC-1 alpha and PGC-1 beta, promoting the invasion and proliferation of gallbladder cancer cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: This study uncovered the mechanisms of high-efficiency hepatic gluconeogenesis in cattle, involving gene expression and regulation by mTORC1 activation. This provides important insights into understanding the differences in this process between cattle and non-ruminant animals.
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: Qiliqiangxin (QLQX) is a traditional Chinese medicine consisting of 11 plant ingredients that exert cardiovascular effects by regulating nutrient surplus and nutrient deprivation pathways. Experimental studies and clinical trials have shown its beneficial effects in improving cardiac injuries.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mahesha Gangadhariah, Triveni Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh
Summary: PPAR gamma agonists are effective in treating type 2 diabetes but have severe side effects. Lemon contains eriocitrin, which may have potential as a PPAR gamma agonist.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Nuno M. S. Almeida, Yigitcan Eken, Angela K. Wilson
Summary: This study investigates the impact of PFASs on PPAR gamma and their molecular interactions, identifying two binding sites on PPAR gamma and studying the influence of acidic and basic residues on binding. Furthermore, a comparison of the binding patterns of L-carnitine and PFASs provides insights into mitigation strategies for PFASs.