Article
Immunology
Fangrui Zhu, Juan Ma, Weitao Li, Qiannv Liu, Xiwen Qin, Yan Qian, Chunlei Wang, Yan Zhang, Yi Li, Dong Jiang, Shuo Wang, Pengyan Xia
Summary: By biochemical screening, we identified the nuclear orphan receptor Nur77 as an intracellular LPS-binding protein, which binds mitochondrial DNA and LPS to activate the non-canonical NLRP3 inflammasome, contributing to the sensing of intracellular LPS and immune response.
Article
Fisheries
Hao Chen, Xiaomin Wu, Zhaoyan Gu, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Zhuang Wang, Dahai Yang
Summary: The study revealed that zebrafish Gsdmea/b can be cleaved by different types of caspases, including inflammatory and apoptotic ones. These findings provide insights into the activation mechanism of pyroptosis in zebrafish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Editorial Material
Immunology
Zhang-Hua Yang, Jiahuai Han
Summary: The activation of the noncanonical NLRP3 inflammasome requires the interaction and interdependent activation of caspase-11 and NLRP3, which occurs when lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria are simultaneously detected.
Article
Multidisciplinary Sciences
Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E. Brodsky, Petr Broz
Summary: Injection of effector proteins by pathogenic organisms to block host innate immune signaling is a common strategy for establishing infection. This study reveals that GSDME is activated in a RIPK1-dependent manner and promotes neutrophil pyroptosis and IL-113 release critical for anti-Yersinia defense, establishing it as an important mediator to counteract pathogen blockade of innate immune signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jonas Moecking, Pawat Laohamonthonkul, Kubilay Mese, Gregor Hagelueken, Annemarie Steiner, Cassandra R. Harapas, Jarrod J. Sandow, Jonathan D. Graves, Seth L. Masters, Matthias Geyer
Summary: This study assessed the impact of the NLRP1 variant M1184V on protein level, revealing that it stabilizes the monomeric conformation of the FIIND domain and indirectly stabilizes the catalytic triad responsible for autocleavage. Additionally, the stabilizing effect of M1184V enhances the binding capacity of FIIND domain and full-length protein to DPP9.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Immunology
Kathy Triantafilou
Summary: This issue introduces a review series on lesser-known enigmatic inflammasomes, including the non-inflammasome role of NLRP7 and the function of extracellular ASC specks, as well as the immunometabolic regulation of these NLRs. The series offers new insights into the complex functions of NLRs, beyond NLRP3, and provides a platform for future discoveries in the field.
Article
Biochemical Research Methods
Lei Jiang, Hao Cai, Weixia Qin, Zijian Li, Liang Zhang, Hong Bi
Summary: In this study, a carbon dots (CDs)-based photosensitizer was prepared through a one-pot method using levofloxacin and neutral red. The CDs showed high reactive oxygen species (ROS) generation efficiency and utilization efficiency for photodynamic therapy. It induced pyroptotic cell death and rapid release of cytokines, making it suitable for photodynamic immunotherapy.
BIOCONJUGATE CHEMISTRY
(2023)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatma A. M. Mohamed, Hesham A. M. Gomaa, O. M. Hendawy, Asmaa T. Ali, Hatem S. Farghaly, Ahmed M. Gouda, Ahmed H. Abdelazeem, Mostafa H. Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif
Summary: The new series of EGFR inhibitors showed promising antiproliferative activity against cancer cell lines, with para-substituted phenethyl derivatives displaying superior activity. Some compounds also exhibited potential EGFR inhibitory activity, modulation of apoptosis-related proteins, and cell cycle arrest effects.
BIOORGANIC CHEMISTRY
(2021)
Review
Cell Biology
Eva Svandova, Herve Lesot, Paul Sharpe, Eva Matalova
Summary: Apoptosis, the programmed cell death, has been extensively studied in various structures, tissues, and cell types of the head. This review provides a comprehensive overview of recent knowledge about apoptosis-related molecules, with a particular focus on caspases. The roles of caspases in non-apoptotic processes are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chenxi Ouyang, Guang Lu, Weifeng He, Boon-Huat Bay, Han-Ming Shen
Summary: The study reveals two forms of post-translational modifications of SIRT1 and their reciprocal effects. The post-translational modifications of SIRT1 play a crucial role in determining cell fate in response to DNA damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, Peter Vandenabeele
Summary: Apoptosis is not essential for turnover of intestinal epithelial cells, maintenance of barrier function, microbiome, and immune cell composition during homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Yi-Fei Zhang, Lu Zhou, Han-Qing Mao, Fu-Hua Yang, Zhi Chen, Lu Zhang
Summary: The study found that cytosolic mtDNA regulates odontoblast inflammation through GSDMD-mediated pyroptosis, while STING-dependent inflammation may serve as a compensatory mechanism to control GSDMD-mediated pyroptosis, promoting the immune inflammatory response. These findings provide important clues to understand the role of mtDNA-GSDMD-STING in regulating odontoblast inflammation.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Ying Li, Debing Pu, Jian Huang, Ying Zhang, Hang Yin
Summary: This study reports a phosphorylation mechanism that inhibits pyroptosis by phosphorylating gasdermin D. Phosphatase 1 is responsible for regulating this phosphorylation process, which affects the ability of gasdermin D to induce cell death. This research is of great importance for understanding the process of pyroptosis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Min Feng, Shaoqiang Wei, Shidong Zhang, Ying Yang
Summary: The study found that mangiferin can regulate inflammation and cell pyroptosis through inhibiting the NF-κ B pathway, suppressing inflammatory caspase-mediated pyroptosis cascades, and reducing GSDMD cleavage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)