Structure and activity of the acid-sensing ion channels

Highly Conserved Salt Bridge Stabilizes Rigid Signal Patch at Extracellular Loop Critical for Surface Expression of Acid-sensing Ion Channels

(2012) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Glycosylation of Acid-Sensing Ion Channel 1a Regulates Its Trafficking and Acidosis-Induced Spine Remodeling

(2012) L. Jing et al.   JOURNAL OF NEUROSCIENCE

Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

(2012) Roger J.P. Dawson et al.   Nature Communications

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

On the Putative Binding Site of RFamide-Family Neuropeptides from the Western Atlantic Clam Sunray Venus and Cephalopods on Acid-Sensing Ion Channels. An Automated Docking and Molecular-Dynamics Study with hASIC1a Homology Model

(2011) Francesco Pietra   CHEMISTRY & BIODIVERSITY

Nonproton Ligand Sensing Domain Is Required for Paradoxical Stimulation of Acid-sensing Ion Channel 3 (ASIC3) Channels by Amiloride

(2011) Wei-Guang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Mechanism of Pore Opening of Acid-sensing Ion Channel 1A

(2011) Lindsey A. Tolino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels

(2011) Ye Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between Two Extracellular Linker Regions Controls Sustained Opening of Acid-sensing Ion Channel 1

(2011) Andreas Springauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asp433in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+block

(2011) Tianbo Li et al.   JOURNAL OF GENERAL PHYSIOLOGY

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

(2011) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Acid-Sensing Ion Channels in Postoperative Pain

(2011) E. Deval et al.   JOURNAL OF NEUROSCIENCE

Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis

(2011) B. Duan et al.   JOURNAL OF NEUROSCIENCE

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

(2011) Christopher J. Bohlen et al.   NATURE

Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition

(2011) Q. Jiang et al.   NEUROSCIENCE

Proton-Binding Sites of Acid-Sensing Ion Channel 1

(2011) Hiroshi Ishikita   PLoS One

The Interaction between the First Transmembrane Domain and the Thumb of ASIC1a Is Critical for Its N-Glycosylation and Trafficking

(2011) Lan Jing et al.   PLoS One

Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1

(2011) Tianbo Li et al.   Nature Communications

Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel

(2010) Tianbo Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cells

(2010) Wen-Shuo Chung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification

(2010) Masatoshi Yokokawa et al.   FEBS LETTERS

A Combined Computational and Functional Approach Identifies New Residues Involved in pH-dependent Gating of ASIC1a

(2010) Luz Angélica Liechti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Contact Region between Three Domains of the Extracellular Loop of ASIC1a Is Critical for Channel Function

(2010) Benoîte Bargeton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Cleavage of Human Acid-sensing Ion Channel 1 by the Serine Protease Matriptase

(2010) Edlira B. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asn415in the β11-β12 Linker Decreases Proton-dependent Desensitization of ASIC1

(2010) Tianbo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Calcium Permeable Human Acid-sensing Ion Channel 1 Transcript Variant

(2010) Erin N. Hoagland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leu85in the β1-β2 Linker of ASIC1 Slows Activation and Decreases the Apparent Proton Affinity by Stabilizing a Closed Conformation

(2010) Tianbo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Chloride Modulates the Desensitization Kinetics of Acid-sensing Ion Channel 1a (ASIC1a)

(2010) Nobuyoshi Kusama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride Docking to Acid-sensing Ion Channel-1

(2010) Yawar J. Qadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

(2010) Ye Yu et al.   NEURON

Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain

(2010) Emmanuel Deval et al.   PHARMACOLOGY & THERAPEUTICS

High-Density Expression of Ca2+-Permeable ASIC1a Channels in NG2 Glia of Rat Hippocampus

(2010) Yen-Chu Lin et al.   PLoS One

Pore-opening mechanism in trimeric P2X receptor channels

(2010) Mufeng Li et al.   Nature Communications

The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior

(2009) Adam E. Ziemann et al.   CELL

Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation

(2009) Huaiyu Yang et al.   CELL RESEARCH

Acid Sensing Ion Channels and Acid Nociception

(2009) G. Dube et al.   CURRENT PHARMACEUTICAL DESIGN

Conformational Changes Associated with Proton-dependent Gating of ASIC1a

(2009) Christopher J. Passero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Protein Domains That Control Proton and Calcium Sensitivity of ASIC1a

(2009) Thomas Sherwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Psalmotoxin-1 Docking to Human Acid-sensing Ion Channel-1

(2009) Yawar J. Qadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Elements for the Generation of Sustained Currents by the Acid Pain Sensor ASIC3

(2009) Miguel Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death

(2009) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior

(2009) M. W. Coryell et al.   JOURNAL OF NEUROSCIENCE

Acid-sensing ion channels in neurones of the rat suprachiasmatic nucleus

(2009) Chun-Hao Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

(2009) Huaiyu Yang et al.   PLOS BIOLOGY

Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function

(2008) Edlira Bashari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b

(2008) Ivan Kadurin et al.   BIOCHEMICAL JOURNAL

Potential Cation and H+ Binding Sites in Acid Sensing Ion Channel-1

(2008) Saher Afshan Shaikh et al.   BIOPHYSICAL JOURNAL

Interaction of the Aromatics Tyr-72/Trp-288 in the Interface of the Extracellular and Transmembrane Domains Is Essential for Proton Gating of Acid-sensing Ion Channels

(2008) Tianbo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating the pore of P2X receptor channels

(2008) Mufeng Li et al.   NATURE NEUROSCIENCE

Seizure termination by acidosis depends on ASIC1a

(2008) Adam E Ziemann et al.   NATURE NEUROSCIENCE

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases

(2007) Z XIONG et al.   CURRENT OPINION IN PHARMACOLOGY