Highly Conserved Salt Bridge Stabilizes Rigid Signal Patch at Extracellular Loop Critical for Surface Expression of Acid-sensing Ion Channels

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels

(2011) Ye Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A State-Dependent Salt-Bridge Interaction Exists across the  /  Intersubunit Interface of the GABAA Receptor

(2011) K. T. Laha et al.   MOLECULAR PHARMACOLOGY

Stabilizing Salt-Bridge Enhances Protein Thermostability by Reducing the Heat Capacity Change of Unfolding

(2011) Chi-Ho Chan et al.   PLoS One

PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner

(2011) Wenying Jin et al.   Molecular Brain

A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity

(2011) Sonia Y. Lam et al.   PLOS BIOLOGY

The Contact Region between Three Domains of the Extracellular Loop of ASIC1a Is Critical for Channel Function

(2010) Benoîte Bargeton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Putative Extracellular Salt Bridge at the Subunit Interface Contributes to the Ion Channel Function of the ATP-gated P2X2 Receptor

(2010) Ruotian Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

(2010) Ye Yu et al.   NEURON

An Intersubunit Salt Bridge near the Selectivity Filter Stabilizes the Active State of Kir1.1

(2009) Henry Sackin et al.   BIOPHYSICAL JOURNAL

Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins

(2009) Ivet Bahar et al.   CHEMICAL REVIEWS

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

(2009) Huaiyu Yang et al.   PLOS BIOLOGY

Potential Cation and H+ Binding Sites in Acid Sensing Ion Channel-1

(2008) Saher Afshan Shaikh et al.   BIOPHYSICAL JOURNAL

ASIC3, a sensor of acidic and primary inflammatory pain

(2008) Emmanuel Deval et al.   EMBO JOURNAL

Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks

(2008) Koichi Nakajo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Seizure termination by acidosis depends on ASIC1a

(2008) Adam E Ziemann et al.   NATURE NEUROSCIENCE

A conserved salt bridge critical for GABAA receptor function and loop C dynamics

(2008) S. P. Venkatachalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases

(2007) Z XIONG et al.   CURRENT OPINION IN PHARMACOLOGY