Article
Critical Care Medicine
Deepti Kilaru, Nova Panebianco, Cameron Baston
Summary: A 65-year-old man with septic shock due to pneumonia was admitted to the ICU and required mechanical ventilation. After extubation, he developed increased work of breathing and was eventually reintubated. Diaphragmatic weakness was identified as the likely cause of respiratory failure after thorough evaluation.
Article
Biochemistry & Molecular Biology
Marloes van den Berg, Eva L. Peters, Robbert J. van der Pijl, Shengyi Shen, Leo M. A. Heunks, Henk L. Granzier, Coen A. C. Ottenheijm
Summary: Diaphragm weakness frequently occurs in mechanically ventilated critically ill patients, and this study suggests that modulating titin stiffness may affect its development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Come Bureau, Marine Van Hollebeke, Martin Dres
Summary: Weaning is a critical stage in ICU care and respiratory muscles play a major role. Weakness of respiratory muscles, including diaphragm atrophy and dysfunction, as well as extradiaphragmatic inspiratory and expiratory muscles, is associated with significant morbidity in the ICU. Diagnosis of respiratory muscle weakness can be visually suspected through paradoxical movement of the abdominal compartment or measured using maximal inspiratory pressure. However, ultrasound may be a better option for assessing respiratory muscle function in the ICU. It is important to not let diaphragm dysfunction discourage clinicians from performing spontaneous breathing trials and considering extubation, as recent therapeutic developments show promise in preserving or restoring respiratory muscle function.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Physiology
Shaoping Li, Guanguan Luo, Rong Zeng, Lian Lin, Xingnan Zou, Yu Yan, Haoli Ma, Jian Xia, Yan Zhao, Xianlong Zhou
Summary: ER stress plays a role in VIDD, and its inhibition can alleviate the effects of oxidative stress on the diaphragm.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Luigi Vetrugno, Daniele Orso, Francesco Corradi, Gianluca Zani, Savino Spadaro, Francesco Meroi, Natascia D'Andrea, Tiziana Bove, Gianmaria Cammarota, Edoardo De Robertis, Samuele Ferrari, Marcello Guarnieri, Margherita Ajuti, Maurizio Fusari, Domenico Luca Grieco, Cristian Deana, Enrico Boero, Federico Franchi, Sabino Scolletta, Salvatore Maurizio Maggiore, Francesco Forfori
Summary: This study aimed to evaluate whether ultrasound measured diaphragmatic thickening fraction (DTF) could predict the outcome of weaning COVID-19 patients from mechanical ventilation. The results showed that DTF was correlated with several clinical indicators, but it was not predictive of weaning failure. Further larger studies are needed to validate this conclusion.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Scott K. Powers, Matthew Schrager
Summary: This review examines the role of redox signaling in skeletal muscle adaptation during both exercise and prolonged muscle inactivity. Muscle exercise leads to acute increase in reactive oxygen species (ROS) production in contracting fibers, while prolonged muscle disuse results in chronic elevation in ROS production in inactive fibers. These different patterns of ROS production stimulate divergent cell signaling pathways to promote muscle remodeling.
Article
Medicine, General & Internal
Yuta Takahashi, Tomoyuki Morisawa, Hiroshi Okamoto, Nobuto Nakanishi, Noriko Matsumoto, Masakazu Saitoh, Tetsuya Takahashi, Toshiyuki Fujiwara
Summary: This study compared the incidence of diaphragm dysfunction and ICU-acquired weakness in patients with septic shock, with and without mechanical ventilation. The incidence of diaphragm dysfunction was higher than that of ICU-acquired weakness in patients with septic shock, regardless of the use of mechanical ventilation. Further studies are needed to assess the association between diaphragm dysfunction and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Critical Care Medicine
Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificacion Perez-Teran, Joan R. Masclans
Summary: A systematic review and meta-analysis showed that measurement of diaphragmatic excursion and diaphragmatic thickening fraction can predict the probability of successful weaning from mechanical ventilation with satisfactory diagnostic accuracy. However, significant heterogeneity was evident in the different included studies. High-quality studies in specific subgroups of patients in intensive care units are needed to evaluate the role of diaphragmatic ultrasound as a predictor of weaning from mechanical ventilation.
Article
Critical Care Medicine
Jose Dianti, Samira Fard, Jenna Wong, Timothy C. Y. Chan, Lorenzo Del Sorbo, Eddy Fan, Marcelo B. Passos Amato, John Granton, Lisa Burry, W. Darlene Reid, Binghao Zhang, Damian Ratano, Shaf Keshavjee, Arthur S. Slutsky, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
Summary: This study aimed to optimize respiratory effort in patients with acute hypoxemic respiratory failure (AHRF) to achieve lung- and diaphragm-protective (LDP) targets. Titrating ventilation and sedation could optimize respiratory effort for lung and diaphragm protection in most patients, and the use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) facilitated the delivery of a LDP strategy. Partial neuromuscular blockade (pNMBA) treatment was effective for patients with excessive respiratory effort.
Article
Medicine, General & Internal
Savino Spadaro, Francesca Dalla Corte, Gaetano Scaramuzzo, Salvatore Grasso, Gilda Cinnella, Valentina Rosta, Valentina Chiavieri, Valentina Alvisi, Rosa Di Mussi, Carlo Alberto Volta, Tiziana Bellini, Alessandro Trentini
Summary: Skeletal muscle proteins exhibit distinct patterns of variation during weaning from mechanical ventilation, with fsTnI decreasing significantly over time while ssTnI remains stable. High levels of ssTnI are associated with a greater decrease in diaphragmatic function, whereas high levels of fsTnI are linked to greater displacement at each time point.
FRONTIERS IN MEDICINE
(2021)
Article
Critical Care Medicine
Daniel Oliveira Silva, Patricia Nery de Souza, Mayson Laercio de Araujo Sousa, Caio Cesar Araujo Morais, Juliana Carvalho Ferreira, Marcelo Alcantara Holanda, Wellington Pereira Yamaguti, Laerte Pastore Junior, Eduardo Leite Vieira Costa
Summary: The display of the estimated inspiratory muscle pressure (P-mus) waveform can improve healthcare providers' ability to identify patient-ventilator asynchronies, leading to improved diagnostic accuracy.
Review
Medicine, General & Internal
Marina Saad, Stefano Pini, Fiammetta Danzo, Francesca Mandurino Mirizzi, Carmine Arena, Francesco Tursi, Dejan Radovanovic, Pierachille Santus
Summary: Acute respiratory failure (ARF) is a life-threatening condition with multiple underlying causes. Diaphragmatic dysfunction can be caused by factors such as inflammation, steroid use, and lung abnormalities. Diaphragm function assessment using ultrasound is a noninvasive and repeatable tool that can provide additional information for diagnosing and managing acute respiratory diseases. It can help estimate the need for mechanical ventilation, the risk of weaning failure, and the potential outcomes of mortality and hospital stay.
Article
Medicine, General & Internal
Michele Bertoni, Simone Piva, Alessandra Beretta, Federica Bongiovanni, Riccardo Contarino, Ricard Mellado Artigas, Lucia Ceresoli, Mattia Marchesi, Michele Falappi, Marta Belleri, Alberto Goffi, Matteo Pozzi, Frank Antonio Rasulo, Nicola Latronico
Summary: This study is the first to explore the coexistence of ICUAW and DW in both cooperative and uncooperative patients. A lack of association was found between DW and ICUAW when considering both types of patients. We found a strong correlation between ICUAW and VFDs at 28 days and weaning success.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Civil
Xinmiao Meng, Zhancheng Zhang, Youde Wu, Feiyang Xu, Peng Feng
Summary: This study conducts a comprehensive investigation on the effects of bamboo nodes on the mechanical properties of bamboo culms. Experimental tests and analysis reveal that bamboo nodes have significant effects on the tensile strength and radial compressive modulus of bamboo culms, while the effects are minimal in compressive and shear tests parallel to the grain. A relationship between fiber morphology and mechanical properties is established, highlighting the importance of carefully considering bamboo nodes under tensile conditions.
ENGINEERING STRUCTURES
(2023)
Article
Respiratory System
Shigang Li, Zhe Chen, Weifeng Yan
Summary: This study found that diaphragm thickening fraction (DTF) has higher sensitivity and specificity for predicting successful weaning in elderly patients compared to other parameters. Using a combination of rapid shallow breathing index (RSBI), lung ultrasound score (LUS), diaphragmatic excursion (DE), and DTF performed well in predicting weaning outcome, with high sensitivity and specificity. The clinical utility of these parameters in predicting extubation success may have important implications and should be further evaluated.
BMC PULMONARY MEDICINE
(2021)
Article
Immunology
Arvind Gharbharan, Corine H. GeurtsvanKessel, Carlijn C. E. Jordans, Marc Blaauw, Marjolein van der Klift, Robert-Jan Hassing, Marijn Smits-Zwinkels, Maaike Meertens, Ella C. van den Hout, Anne Marie de Man, Ilse Hageman, Susanne Bogers, C. Ellen van der Schoot, Francis Swaneveld, Adam A. Anas, Casper Rokx, Bart J. A. Rijnders
Summary: In this study, twenty-five B-cell-depleted patients diagnosed with COVID-19, most of whom had received anti-CD19/20 therapy, were treated with convalescent plasma containing high neutralizing antibody titers. 84% of the patients recovered, suggesting the potential therapeutic effects of this treatment in this specific population.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Fieke Hoeijmakers, Koen J. Hartemink, Ad F. Verhagen, Willem H. Steup, Elske Marra, W. F. Boudewijn Roell, David J. Heineman, Wilhelmina H. Schreurs, Rob A. E. M. Tollenaar, Michel W. J. M. Wouters
Summary: In the Netherlands, there is wide variation in the incidence and perioperative (preventive) management of PAL. Using water seal instead of suction drainage and increasing awareness are potential measures to reduce this variation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Hematology
Lisa van Manen, Maike E. van Hezel, Margit Boshuizen, Marleen Straat, Angelique M. E. de Man, Charlotte Dekimpe, Karen Vanhoorelbeke, Robin van Bruggen, Nicole P. Juffermans
Summary: This study found that RBC transfusion in critically ill patients was associated with an increase in circulating vWF levels, indicating further activation of the endothelium, a finding that was independent of the presence of sepsis or organ injury level.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marceline W. Piek, Lisa H. de Vries, Maarten L. Donswijk, Bart de Keizer, Jan Paul de Boer, Lutske Lodewijk, Rachel S. van Leeuwaarde, Menno R. Vriens, Koen J. Hartemink, Iris M. C. van der Ploeg
Summary: The purpose of this study is to examine the incidence and clinical significance of prostate-specific membrane antigen (PSMA) thyroid incidentaloma (PTI) and the associated management strategies. The results show that the incidence of PTI is low and the risk of malignancy is also low. For those cases in which no further thyroid workup was performed, PTI did not have any clinical relevance during follow-up. However, the analysis and treatment of PTI cases should still be considered in the shared decision-making process for cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Pieter J. M. Joosten, Chris Dickhoff, Vincent van der Noort, Maarten Smeekens, Rachel C. Numan, Houke M. Klomp, Judi N. A. van Diessen, Jose S. A. Belderbos, Egbert F. Smit, Kim Monkhorst, Jan W. A. Oosterhuis, Michel M. van den Heuvel, Max Dahele, Koen J. Hartemink
Summary: In patients with Stage IIIA NSCLC, those with a large tumor volume and adenocarcinoma who were selected for trimodality treatment showed better outcomes compared to those receiving chemoradiotherapy.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Medicine, Legal
Romy du Long, Judith Fronczek, Hans W. M. Niessen, Allard C. van der Wal, Hans H. de Boer
Summary: Determining the significance of myocardial inflammation for the cause of death can be challenging. Our study reviewed the histological spectrum of myocardial inflammation between three groups of autopsy cases, defined by their reported cause of death. Only a diffuse increase of inflammatory cells could reliably discriminate between an incidental presence of inflammation or a potentially significant one. Determining the cause of death in case of myocardial inflammation requires a comprehensive approach.
FORENSIC SCIENCES RESEARCH
(2022)
Article
Critical Care Medicine
Heder J. de Vries, Annemijn H. Jonkman, Harm J. de Grooth, Jan Willem Duitman, Armand R. J. Girbes, Coen A. C. Ottenheijm, Marcus J. Schultz, Peter M. van de Ven, Yingrui Zhang, Angelique M. E. de Man, Pieter R. Tuinman, Leo M. A. Heunks
Summary: This study aimed to assess the impact of adjusting inspiratory support based on patient breathing effort on lung-protective ventilation. The results showed that adjusting inspiratory support greatly increased the time that patients had diaphragm effort in the predefined diaphragm-protective range, without compromising tidal volumes and transpulmonary pressures.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Julianne Cynthia de Ruiter, Judi Nani Annet van Diessen, Egbert Frederik Smit, Vincent van der Noort, Ronald Alphons Maria Damhuis, Koen Johan Hartemink
Summary: This study aimed to compare outcomes between minimally invasive lobectomy (MIL) and stereotactic ablative radiotherapy (SABR) for stage I non-small cell lung cancer (NSCLC) patients. The results showed differences in survival rates and progression-free survival rates between MIL and SABR.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Letter
Cardiac & Cardiovascular Systems
Julianne Cynthia de Ruiter, Egbert Frederik Smit, Vincent van der Noort, Koen Johan Hartemink
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Harri Hemila, Elizabeth Chalker, Angelique M. E. de Man
Summary: This meta-analysis study found that vitamin C can increase left ventricular ejection fraction (LVEF), and it is effective for both heart failure and non-heart failure patients. The effect of vitamin C is negatively correlated with baseline LVEF level.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Daan C. L. Vessies, Milou M. F. Schuurbiers, Vincent van der Noort, Irene Schouten, Theodora C. Linders, Mirthe Lanfermeijer, Kalpana L. Ramkisoensing, Koen J. Hartemink, Kim Monkhorst, Michel M. van den Heuvel, Daan van den Broek
Summary: A study developed a method combining variant calling and ctDNA fragment length analysis to identify patients with disease recurrence or no recurrence in stage II-IIIA NSCLC patients, providing useful information for postoperative treatment.
MOLECULAR ONCOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Article
Oncology
Stijn J. C. van der Burg, Deborah van de Wal, Evelyne Roets, Neeltje Steeghs, Johanna W. van Sandick, Martijn Kerst, Frits van Coevorden, Koen J. Hartemink, Xander A. A. F. A. Veenhof, Anne Miek Koenen, Nikki Ijzerman, Winette T. A. van der Graaf, Yvonne M. Schrage, Winan J. van Houdt
Summary: This study demonstrates the effectiveness and safety of neoadjuvant imatinib for patients with large or locally advanced GIST.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Elise Beijer, Stefan F. van Wonderen, Wietse P. Zuidema, Marieke C. Visser, Michael J. R. Edwards, Michael H. J. Verhofstad, Tjarda N. Tromp, Charissa E. van den Brom, Esther M. M. van Lieshout, Frank W. Bloemers, Leo M. G. Geeraedts Jr
Summary: This study identified an association between sex and outcomes in severe traumatic brain injury (TBI) patients, particularly favoring older females by indicating shorter hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Sander Ubels, Moniek Verstegen, Bastiaan Klarenbeek, Stefan Bouwense, Mark van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan W. Haveman, Joos Heisterkamp, Renol Koshy, Grard Nieuwenhuijzen, Fatih Polat, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: The Severity of oEsophageal Anastomotic Leak (SEAL) score was developed using data from the TENTACLE-Esophagus study, an international, multicentre retrospective cohort study including 1509 patients with anastomotic leak after oesophagectomy. The SEAL score was developed to determine anastomotic leak severity at diagnosis, and combines 12 leak-related parameters at diagnosis. The score may be useful in clinical practice and could improve future research.
BRITISH JOURNAL OF SURGERY
(2022)