Review
Health Care Sciences & Services
Samim Azizi, Yousif Subhi, Marie Louise Roed Rasmussen
Summary: This systematic review examined the surgical treatment methods and effects of shield ulcers in VKC. The results showed that almost all patients experienced resolution or improvement of their ulcers regardless of the surgical approach. However, there is a risk of recurrence and potential side effects, highlighting the importance of careful post-operative treatment and follow-ups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Giuseppe Giannaccare, Costanza Rossi, Massimiliano Borselli, Chiara Bonzano, Giovanna Carnovale Scalzo, Massimo Nicolo, Vincenzo Scorcia, Carlo Enrico Traverso, Aldo Vagge
Summary: This study aimed to report the clinical outcomes of using topical 0.1% ciclosporin cationic emulsion (CsA-CE) on label in children with vernal keratoconjunctivitis (VKC). The findings showed that this drug effectively reduced symptoms and improved clinical scores, and it was well tolerated by almost all patients.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Minjie Chen, Bilian Ke, Jun Zou, Lan Gong, Yan Wang, Chaoran Zhang, Jianjiang Xu, Anji Wei, Jiaxu Hong
Summary: Both the isolated use of fluorometholone and combined use of azelastine and fluorometholone are effective in alleviating the signs and symptoms of severe ACD, but optimal response can be achieved with adjunctive treatment including azelastine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Dilek Ozkaya, Gulsah Usta, Umut Karaca
Summary: This case highlights the role of the anti-inflammatory effect of CsA in preventing the recurrence of shield ulcers.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Allergy
Serge Doan, Nikolaos G. Papadopoulos, Jason K. Lee, Salvatore Leonardi, Sara Manti, Susanne Lau, Carmen Rondon, Vibha Sharma, Uwe Pleyer, Xavier Jaumont, Slawomir B. Lazarewicz
Summary: Vernal keratoconjunctivitis (VKC) is a severe ocular allergic disease that mainly affects children and is more common in warm and humid regions. Inadequately treated VKC can lead to severe complications and corneal damage. Studies have shown that IgE-mediated and non-IgE-mediated mechanisms are involved in the pathophysiology of VKC.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Ophthalmology
Ishin Ninomiya, Kenji Yamatoya, Keitaro Mashimo, Akira Matsuda, Ayumi Usui-Ouchi, Yoshihiko Araki, Nobuyuki Ebihara
Summary: This study investigated the role of oncostatin M (OSM) in vernal keratoconjunctivitis (VKC). The results showed that OSM induced epithelial barrier dysfunction and IL-33 production in VKC, playing important roles in severe and prolonged allergic inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Allergy
Angela Messina, Angelo Palmigiano, Claudia Tosto, Donata Agata Romeo, Luisa Sturiale, Domenico Garozzo, Andrea Leonardi
Summary: The study aimed to investigate tear fluid N-Glycome from patients with VKC and AKC to identify specific changes and potential glyco-biomarkers. Three distinct patterns for CTRL, VKC, and AKC patients were identified in terms of relative intensities for some N-glycans structures, with major variations involving bisecting and hyperfucosylated glycoforms. The tear MS profiles showed rich specific glycoforms, particularly with high fucosylation degree, providing important information for a better understanding of VKC and AKC alterations at the molecular level.
Article
Ophthalmology
Akira Hirota, Jun Shoji, Noriko Inada, Yukiko Shiraki, Satoru Yamagami
Summary: Treatment with topical tacrolimus ophthalmic suspension for VKC and AKC leads to clinical improvement and stable stages of the diseases. The remission rates increase over time and the need for concomitant administration of steroid eye drops decreases with age. Cluster analysis helps to categorize patients into different subgroups for better understanding of disease characteristics.
Review
Ophthalmology
Sepehr Feizi, Mohammad Ali Javadi, Mohammadhasan Alemzadeh-Ansari, Amir Arabi, Toktam Shahraki, Ahmad Kheirkhah
Summary: Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctivitis that can lead to long-term visual impairment due to corneal complications. Management includes medical treatment and prevention of recurrences, with surgical intervention if necessary for corneal involvement.
Review
Chemistry, Medicinal
DeGaulle Chigbu, Bisant A. Labib
Summary: Vernal keratoconjunctivitis (VKC) is a complex chronic ocular surface inflammatory condition primarily affecting male children in hot climates, characterized by intense ocular pruritus and a risk of vision loss. Current treatment options are not effective, highlighting the importance of identifying future therapeutic targets.
Article
Ophthalmology
Anuradha Pradhan, Sabyasachi Pattanayak, Jayashree Dora, Praveen Subudhi
Summary: This study evaluated the effectiveness of a modified therapeutic protocol for VKC based on Bonini grading system. The results showed significant improvement in symptoms and reduced recurrence rates after following the treatment protocol.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Letter
Dermatology
C. Zengarini, M. Roda, C. Schiavi, F. Bruni, F. Bardazzi, C. Bellusci, B. Raone
Summary: A clinical case of an atopic patient with severe manifestations impacting quality of life at the cutaneous and ocular site is reported. Conventional treatments were ineffective and omalizumab had to be used to successfully treat the disease.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Ophthalmology
Roberta Jansen de Mello Farias, Monica Elinor Alves Gama, Ronney Mendes, Nyla Tyara Melo Lobao, Luciene Barbosa de Sousa
Summary: This case report highlights the importance of investigating HIV infection in patients with refractory allergic conjunctivitis, as it may reveal potential co-infections that could be contributing to treatment resistance.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Jilu Jaffet, Vivek Singh, Sunita Chaurasia, Saumya Jakati, Ajit Hazari, Virender Sangwan
Summary: The study reports the clinical outcomes and histopathological and immunohistochemistry features in eyes with the sequelae stage of vernal keratoconjunctivitis (VKC). The results suggest that keratoplasty and amniotic membrane transplantation can effectively manage these eyes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Ophthalmology
Swati Singh, Gorrepati C. Naidu, Geeta Vemuganti, Sayan Basu
Summary: This study describes the histopathological features of different morphological variants of human meibomian glands seen on infrared imaging. The results show that glands with short, hooked, tortuous, and overlapping morphologies had similar histology to normal glands, while glands with thick and fluffy morphologies showed increased acinar diameter. Severely short glands showed atrophic changes with loss of meibocyte differentiation and cellular proliferation. Dropout areas showed total loss of glandular elements.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Materials Science, Multidisciplinary
H. Gururani, S. N. S. H. Chittajallu, M. Ramji, S. Basu, V Chinthapenta
Summary: This study investigates the birefringence behavior of the human cornea using digital photoelasticity and finite element method. The results show that there is inter-individual variability in corneal birefringence, which is related to the microstructure, curvature, and stress distribution of the cornea. The study suggests that digital photoelasticity has potential clinical applications for diagnosis and monitoring.
EXPERIMENTAL MECHANICS
(2023)
Article
Ophthalmology
Swati Singh, Saumya Srivastav, Zarin Modiwala, Mohammed Hasnat Ali, Sayan Basu
Summary: This study assessed the repeatability and reliability of different commercially available diagnostic platforms in the objective assessment of tear film parameters and found that they cannot be used interchangeably. There were significant differences in the measurement values of tear film parameters between different instruments, and patients with dry eye disease had higher variability in tear film parameters.
Article
Ophthalmology
Vineet Pramod Joshi, Subhajit Chatterjee, Sayan Basu
Summary: The purpose of this study was to explore the relationship between the density, depth, and surface irregularity of superficial corneal opacities and vision. The results showed that the surface irregularity, specifically higher-order aberrations, has a greater impact on vision than the depth or density of the opacity.
CURRENT EYE RESEARCH
(2023)
Review
Ophthalmology
Minal Thacker, Vivek Singh, Sayan Basu, Swati Singh
Summary: Dry eye disease (DED) is a common health problem that affects millions of people. Current treatments include eye drops and anti-inflammatory agents, but they have limitations. This review discusses the potential of biomaterials such as nanosystems, hydrogels, and contact lenses as drug delivery systems for DED. Animal studies have shown promising results, but human trials are still needed. Long-term studies evaluating their safety and effectiveness would help in their transition to clinical use.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Ophthalmology
Ashok Sharma, Namrata Sharma, Sayan Basu, Rajan Sharma, Shruti Aggarwal, Parul Chawla Gupta, Jagat Ram, Verinder S. Nirankari
Summary: Corneal perforations are serious emergencies in ophthalmology that can lead to vision loss and even loss of the eye if not promptly and appropriately managed. Tissue adhesives, such as cyanoacrylate glue and fibrin glue, offer effective treatment options for corneal perforations with advantages including reduced surgical time, inflammation, and improved postoperative comfort. However, each type of adhesive has its own benefits and limitations, and there is a need for newer adhesives in this field. This review explores the applications, complications, safety, and efficacy data of tissue adhesives in managing corneal perforations.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Swati Singh, Saumya Srivastav, Minal Thacker, Kiran K. Bokara, Vivek Singh, Sayan Basu
Summary: The current study examined the normative data values and repeatability of non-invasive tear film tests using Oculus Keratograph 5M in rabbit eyes. The results showed that the non-invasive tear film parameters measured with K5M have good repeatability and can be used as an objective parameter for rabbit ocular surface experiments.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Swati Singh, Simmy Chaudhary, Anthony Vipin Das, Sayan Basu
Summary: This study aims to report the clinical course of corneal ulceration/perforation in patients with Sjogren's syndrome. The majority of the corneal ulceration/perforation in these patients is sterile and can be a presenting sign of undiagnosed Sjogren's syndrome. Intensive medical therapy, as well as interventions such as bandage contact lens and isobutylcyanoacrylate patch, can effectively manage these ulcers with a mean healing time of 49 days.
Editorial Material
Ophthalmology
Swati Singh, Saumya Srivastav, Sayan Basu
Article
Ophthalmology
A. Tarakeswara Rao, Amit Gupta, Tulika Chauhan, Sayan Basu, Nitin Batra, Namrata Sharma, Virender S. Sangwan, Vinay Gupta, Shoibal Mukherjee
Summary: This study compared the efficacy of two MNP cyclosporine formulations with Restasis (TM) in the management of DED. The results suggest that a higher dose of MNP cyclosporine administered twice daily is more effective than Restasis (TM) in treating DED.
Article
Ophthalmology
Anthony Vipin Das, Sayan Basu
Summary: This hospital-based study found that irreversible blindness with no light perception is present in a significant number of patients, with glaucoma, trauma, and phthisis bulbi being the major causes. Most affected individuals are adults, predominantly male, and from lower socio-economic strata and rural areas. The study highlights the need for further development of regenerative therapies and sight restorative procedures, as many blind patients cannot currently be restored to vision.
SEMINARS IN OPHTHALMOLOGY
(2023)
Article
Cell & Tissue Engineering
Abhishek Sahoo, Mukesh Damala, Jilu Jaffet, Deeksha Prasad, Sayan Basu, Vivek Singh
Summary: This study successfully optimized the growth and expansion of human limbus-derived stromal/mesenchymal stem cells (hLMSCs) in a serum-free environment using commercially available SM medium. The hLMSCs cultured in SM showed superior characteristics compared to the control medium, including lower population doubling time, higher colony-forming ability, and retention of tri-lineage differentiation potential and expression of MSC markers. This study provides important insights for the future use of hLMSCs in translational research.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Mukesh Damala, Abhishek Sahoo, Naveen Pakalapati, Vivek Singh, Sayan Basu
Summary: Corneal opacification or scarring is a major cause of blindness worldwide. Human limbus-derived stromal/mesenchymal stem cells (hLMSCs) have the potential to clear corneal scarring. The results of the study show that En+ and En- hLMSCs are not harmful to the recipient and potentially restore the transparency of debrided or scarred corneas, suggesting that hLMSCs could be clinically useful.
Editorial Material
Medicine, General & Internal
Sayan Basu
FRONTIERS IN MEDICINE
(2023)
Article
Engineering, Biomedical
Shibu Chameettachal, Animith Venuganti, Yash Parekh, Deeksha Prasad, Vineet P. Joshi, Anviti Vashishtha, Sayan Basu, Vivek Singh, Kiran Kumar Bokara, Falguni Pati
Summary: Corneal scarring and opacification are a major cause of blindness worldwide. This study demonstrates the potential clinical application of a human corneal extracellular matrix hydrogel in preventing scar formation and opacification after corneal injury.
ACTA BIOMATERIALIA
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
