Article
Public, Environmental & Occupational Health
Michael B. Steinberg, William J. Young, Erin J. Miller Lo, Michelle T. Bover-Manderski, Heather M. Jordan, Zibran Hafiz, Karthik J. Kota, Rohit Mukherjee, Nicolette E. Garthe, Frank A. Sonnenberg, Mary O'Dowd, Cristine D. Delnevo
Summary: Lung cancer is the leading cause of cancer death in the U.S., primarily caused by combustible tobacco use. This study demonstrates the effectiveness of electronic health record prompts in increasing identification of lung cancer screening eligibility and ordering of low-dose computed tomography.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Review
Medicine, General & Internal
Harriet L. Lancaster, Marjolein A. Heuvelmans, Matthijs Oudkerk
Summary: Lung cancer causes more deaths than breast, cervical, and colorectal cancer combined. Despite the proven benefits of early detection through LDCT lung cancer screening, it is not widely practiced globally. The focus is now on implementation research to successfully introduce standardized, effective, and accessible screening programs.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Oncology
Rayjean J. Hung
Summary: This commentary outlines key considerations for biomarker implementations in LDCT eligibility assessment and possible mitigation strategies.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Health Care Sciences & Services
Brian P. Jenssen, Robert Schnoll, Rinad Beidas, Justin Bekelman, Anna-Marika Bauer, Callie Scott, Sarah Evers-Casey, Jody Nicoloso, Peter Gabriel, David A. Asch, Alison Buttenheim, Jessica Chen, Julissa Melo, Lawrence N. Shulman, Alicia B. W. Clifton, Adina Lieberman, Tasnim Salam, Kelly Zentgraf, Katharine A. Rendle, Krisda Chaiyachati, Rachel Shelton, E. Paul Wileyto, Sue Ware, Frank Leone
Summary: This study aims to compare the effectiveness of nudges in promoting patient engagement with tobacco use treatment services among cancer patients. Data will be collected through electronic medical records, clinician surveys, and semi-structured interviews to assess the impact of nudges on referral rates and patient engagement. Results will provide insights into improving uptake of evidence-based tobacco use treatment and understanding contextual factors influencing response to implementation strategies.
IMPLEMENTATION SCIENCE
(2021)
Review
Oncology
Katharina Martini, Guillaume Chassagnon, Thomas Frauenfelder, Marie-Pierre Revel
Summary: Lung cancer is the leading cause of cancer deaths in Europe and globally, with a low five-year survival rate. Screening for lung cancer can improve outcomes, but challenges such as high-risk individual selection and nodule classification standardization need to be addressed to successfully implement screening programs.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jorge Diaz-Alvarez, Patricia Roiz, Luis Gorospe, Ana Ayala, Sergio Perez-Pinto, Javier Martinez-Sanz, Matilde Sanchez-Conde, Jose L. Casado, Maria J. Perez-Elias, Ana Moreno, Raquel Ron, Maria J. Vivancos, Pilar Vizcarra, Santiago Moreno, Sergio Serrano-Villar
Summary: In this pilot program, the prevalence of lung cancer among people with HIV screened using LDCT was 3.6%, and the number needed to screen to detect one case of lung cancer was 28. While data from additional cohorts with longitudinal measurements are needed, people with HIV are a target population for lung cancer screening with LDCT.
Article
Respiratory System
Stephen Lam, Martin Tammemagi
Summary: Lung cancer screening with low-dose CT can reduce death rates in high-risk smokers, but it requires an organized approach to replicate clinical trial results, consider cost-effectiveness, and manage lung nodules effectively.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tri Le, Stacie Miller, Emily Berry, Sarah Zamarripa, Aurelio Rodriguez, Benjamin Barkley, Asha Kandathil, Cecelia Brewington, Keith E. Argenbright, David E. Gerber
Summary: By collaborating with community leaders and stakeholders, a community-based lung cancer screening program with telephone-based navigation and tobacco cessation counseling support was successfully implemented in rural areas. The program demonstrated feasibility and effectiveness in promoting awareness, increasing referrals, and completing LDCTs for eligible individuals.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2022)
Article
Critical Care Medicine
Polina Kukhareva, Haojia Li, Tanner J. Caverly, Guilherme Del Fiol, Angela Fagerlin, Jorie M. Butler, Rachel Hess, Yue Zhang, Teresa Taft, Michael C. Flynn, Chakravarthy Reddy, Douglas K. Martin, Isaac A. Warner, Salvador Rodriguez-Loya, Phillip B. Warner, Kensaku Kawamoto
Summary: The study found that the use of clinician-facing EHR prompts and an EHR-integrated everyday SDM tool significantly increased LDCT scan imaging ordering and completion rates in primary care settings, with potential for further improvement.
Review
Oncology
Carlijn M. van der Aalst, Kevin ten Haaf, Harry J. de Koning
Summary: The efficacy of CT lung cancer screening in reducing lung cancer mortality has been shown in large-scale RCTs, but personalized and risk-based approaches present remaining uncertainties. The ongoing implementation trial on volume CT lung cancer screening aims to provide answers to remaining questions and potentially benefit EU citizens with high-quality screening technology while decreasing healthcare costs significantly. Implementing a new cancer screening programme involves multiple stakeholders, facilitators, barriers, and obstacles.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander T. Sandhu, Fatima Rodriguez, Summer Ngo, Bhavik N. Patel, Domenico Mastrodicasa, David Eng, Nishith Khandwala, Sujana Balla, Doug Sousa, David J. Maron
Summary: This study evaluated the impact of notifying clinicians and patients about incidental coronary artery calcium (CAC) on statin initiation. The results showed that notifying patients and clinicians about incidental CAC significantly increased the prescription rate of statin medication.
Article
Oncology
Adriana A. Rodriguez Alvarez, Sun Yuming, Jui Kothari, Subba R. Digumarthy, Nicole M. Byrne, Yi Li, David C. Christiani
Summary: This study aimed to evaluate the impact of lung cancer screening on survival rates between females and males. The study found that unscreened females had a lower risk of mortality and better survival than unscreened males, while there was no significant difference in overall survival between sexes among the screened population.
Article
Critical Care Medicine
Anton Manyak, Luke Seaburg, Kristin Bohreer, Steve H. Kirtland, Michal Hubka, Anthony J. Gerbino
Summary: This retrospective study analyzed a lung cancer screening program conducted at a nonuniversity teaching hospital and found that invasive procedures to resolve false-positive findings were uncommon. While there were some invasive procedures performed to evaluate incidental findings considered benign but clinically important, these procedures often had clinical value.
Review
Public, Environmental & Occupational Health
Shristi Bhochhibhoya, Page D. Dobbs, Sarah B. Maness
Summary: This scoping review examines the effectiveness of MHealth interventions in increasing cervical cancer screening uptake, finding that text messages and phone calls are commonly used strategies. It is important to ensure privacy and confidentiality when utilizing these interventions. The findings suggest that MHealth interventions may be effective, but barriers such as transportation cost and accessibility need to be addressed for improving screening rates.
PREVENTIVE MEDICINE
(2021)
