Article
Computer Science, Information Systems
Sudha R. Raman, Emily C. O'Brien, Bradley G. Hammill, Adam J. Nelson, Laura J. Fish, Lesley H. Curtis, Keith Marsolo
Summary: The study aimed to explore how pragmatic clinical trials using real-world data assessed study-specific fitness-for-use. Concerns about EHR data included reliability, missingness, variation in data quality, and incorrect values. Most PCTs conducted fitness-for-use activities, but less than a quarter did so before choosing a data source. Overall costs and personnel costs were barriers to fitness-for-use assessments.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Rachel Boykan, Julie Gorzkowski, Robert J. Wellman, Brian P. Jenssen, Jonathan D. Klein, Jessica Krugman, Lori Pbert, Ramzi G. Salloum
Summary: Based on the survey, although pediatricians should address tobacco use and exposure, many medical residents do not receive education on this topic. The electronic health records have not been effectively utilized to help doctors address tobacco issues.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Alast Ahmadi, Andrea Sorensen, Chad Wes A. Villaflores, John N. Mafi, Sitaram S. Vangala, Ira S. Hofer, John D. Bartlett, Eric M. Cheng, Victor F. Duval, Cheryl Damberg, David Elashoff, Noah J. Goldstein, Joseph A. Ladapo, James M. Moore, Antonio M. Pessegueiro, Suzanne B. Shu, Samuel A. Skootsky, Ashley Turner, Catherine A. Sarkisian
Summary: A pragmatic randomised trial is being conducted to evaluate the impact of an interdisciplinary electronic health record intervention on preoperative testing rates for cataract surgery patients.
Article
Substance Abuse
Stanislav Spivak, Eric C. Strain, Bernadette Cullen, An Anne E. Ruble, Denis G. Antoine, Ramin Mojtabai
Summary: This study found that EHR adoption lags behind in US SUD facilities compared to MH facilities. Exclusive EHR use for clinical purposes remains limited in both facility types, with wide variability among states. Factors such as Joint Commission accreditation may help expedite EHR adoption in SUD treatment facilities.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Computer Science, Information Systems
Andrew D. Boyd, Rosa Gonzalez-Guarda, Katharine Lawrence, Crystal L. Patil, Miriam O. Ezenwa, Emily C. O'Brien, Hyung Paek, Jordan M. Braciszewski, Oluwaseun Adeyemi, Allison M. Cuthel, Juanita E. Darby, Christina K. Zigler, P. Michael Ho, Keturah R. Faurot, Karen L. Staman, Jonathan W. Leigh, Dana L. Dailey, Andrea Cheville, Guilherme Del Fiol, Mitchell R. Knisely, Corita R. Grudzen, Keith Marsolo, Rachel L. Richesson, Judith M. Schlaeger
Summary: Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing population health problems by utilizing electronic health record (EHR) systems to increase the speed and volume of relevant research. However, the growing number of ePCTs using EHR-derived data increases the risk of biases due to differences in data capture and access to care, perpetuating health inequalities. This article identifies 3 challenges - incomplete data on social determinants of health, lack of representation of vulnerable populations, and data loss due to variable technology use - that exacerbate bias when working with EHR data and provides recommendations and examples to actively mitigate bias.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Computer Science, Information Systems
Sally L. Baxter, Nate C. Apathy, Dori A. Cross, Christine Sinsky, Michelle R. Hribar
Summary: Variation in how EHRs are used can impact clinical and operational outcomes, including measures of provider well-being and burnout. Standardized measures for EHR use can facilitate cross-institution, cross-vendor research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Review
Computer Science, Information Systems
Oliver T. Nguyen, Shivani Shah, Alexander J. Gartland, Arpan Parekh, Kea Turner, Sue S. Feldman, Lisa J. Merlo
Summary: This systematic review examines the multivariable factors associated with EHR-related nurse well-being, highlighting the importance of personal digital literacy and integrated displays in improving nurse well-being. Recommendations for improving EHRs include IT-, organization-, and policy-level solutions to address EHR-related burden.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Computer Science, Interdisciplinary Applications
Mark S. Pfaff, Ozgur Eris, Charlene Weir, Amanda Anganes, Tina Crotty, Mohammad Rahman, Merry Ward, Jonathan R. Nebeker
Summary: This study aimed to understand the cognitive demands clinicians face when using an EHR system and identify expert clinicians' cues and strategies for managing those demands. Through cognitive task analysis, 145 unique cognitive demands of using an EHR were revealed and categorized into 22 themes across seven categories. The study found that EHR systems may not support clinicians in developing overall awareness, reasoning about patients' states and potential treatments, and working collaboratively.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Computer Science, Information Systems
Rachel L. Richesson, Keith S. Marsolo, Brian J. Douthit, Karen Staman, P. Michael Ho, Dana Dailey, Andrew D. Boyd, Kathleen M. McTigue, Miriam O. Ezenwa, Judith M. Schlaeger, Crystal L. Patil, Keturah R. Faurot, Leah Tuzzio, Eric B. Larson, Emily C. O'Brien, Christina K. Zigler, Joshua R. Lakin, Alice R. Pressman, Jordan M. Braciszewski, Corita Grudzen, Guilherme Del Fiol
Summary: The study identified 21 challenges related to EHR systems in pragmatic research, falling into 6 broad themes, and formulated 6 prerequisites for conducting pragmatic clinical trials.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Awatif M. Alrasheeday, Bushra Alshammari, Sameer A. Alkubati, Eddieson Pasay-an, Monirah Albloushi, Awayed M. Alshammari
Summary: This study aimed to assess nurses' attitudes toward electronic health records (EHRs) and factors affecting EHR implementation in different hospitals in Saudi Arabia. The majority of participants had positive attitudes towards EHRs. Male, Saudi nurses, younger nurses, nurses with previous computer experience, and nurses with less than five years of experience had more positive attitudes towards EHRs. Sex, education level, and previous computer experience were independent factors of nurses' knowledge of EHRs.
Article
Medicine, Research & Experimental
Emily C. O'Brien, Sudha R. Raman, Alicia Ellis, Bradley G. Hammill, Lisa G. Berdan, Tyrus Rorick, Salim Janmohamed, Zachary Lampron, Adrian F. Hernandez, Lesley H. Curtis
Summary: Although electronic health record screening is commonly used for recruitment in a cardiovascular outcomes trial, there are important technical, governance, and regulatory barriers that need to be addressed to support optimal use of EHR for trial participant identification.
Review
Oncology
Yash S. Huilgol, Julia Adler-Milstein, Susan L. Ivey, Julian C. Hong
Summary: The rapid adoption of electronic health records has created a wealth of digitized data that can be used to improve care delivery and patient outcomes. In addition to clinical data, electronic health records also capture audit log data, which provide insights into user behavior and decision-making processes. This data can be utilized to enhance oncology care and outcomes.
Article
Computer Science, Information Systems
A. Jay Holmgren, N. Lance Downing, Mitchell Tang, Christopher Sharp, Christopher Longhurst, Robert S. Huckman
Summary: The study found that during the COVID-19 pandemic, clinicians spent less time on EHR per day at first, but had recovered to higher levels by July 2020. Time spent actively working on EHR after hours showed similar trends. Additionally, the number of In-Basket messages received also increased compared to before the pandemic.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Substance Abuse
Scott Veldhuizen, Laurie Zawertailo, Aliya Noormohamed, Sarwar Hussain, Peter Selby
Summary: The study analyzed 38,094 treatment episodes from a smoking cessation program in Ontario, Canada, finding that time in treatment, number of visits, and weeks of NRT used were below maximum levels. The results suggest that extending treatment programs may have relatively low marginal costs, with age and use of nicotine patches being strongly associated with care utilization.
Review
Oncology
Joanna M. Streck, Angela W. Walter, Jennifer S. Temel, Areej El-Jawahri, Hyo Jin Shin, Susan Regan, Alona Muzikansky, Colin J. Ponzani, Jamie S. Ostroff, Elyse R. Park
Summary: Little is known about the assessment and treatment of non-tobacco substance use in cancer patients. This study found that about one-third of oncology patients did not have substance use assessment documented. Many clinicians documented use but did not specify the substance type, and few clinicians documented a follow-up plan for problematic substance use. Standardized assessment and referral methods should be used in oncology settings.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Elisabeth F. Beaber, Aruna Kamineni, Andrea N. Burnett-Hartman, Brian Hixon, Sarah C. Kobrin, Christopher I. Li, Malia Oliver, Katharine A. Rendle, Celette Sugg Skinner, Kaitlin Todd, Yingye Zheng, Rebecca A. Ziebell, Erica S. Breslau, Jessica Chubak, Douglas A. Corley, Robert T. Greenlee, Jennifer S. Haas, Ethan A. Halm, Stacey Honda, Christine Neslund-Dudas, Debra P. Ritzwoller, Joanne E. Schottinger, Jasmin A. Tiro, Anil Vachani, V. Paul Doria-Rose
Summary: PROSPR II consortium aims to improve cancer screening processes and reduce disparities by investigating factors affecting cervical, colorectal, and lung cancer screening. They collected screening data from over 9 million racially and ethnically diverse individuals and identified variations in patient, provider, and facility characteristics across different communities.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Immunology
Rebecca Neergaard, Nora L. Jones, Christopher Roebuck, Katharine A. Rendle, Zoe Barbati, Beth Peterson, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dube, Frances K. Barg
Summary: Analytical treatment interruption (ATI), a clinical pause in antiretroviral therapy (ART) monitored closely, is an important component of HIV cure-directed clinical studies. This study aimed to understand the motivations and decision-making processes of participants enrolling in the BEAT-2 cure-directed trial, as well as their perceptions of ATI. The majority of participants were driven by a desire to find a cure for HIV and help others in the HIV community. While altruism was a primary motivation, participants also expressed interest in learning about HIV science and research. They displayed a strong understanding of trial procedures and trust in the study team, but also expressed anxiety about the potential ineffectiveness of their previous ART regimen after resuming ART.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Letter
Critical Care Medicine
Roger Y. Kim, Katharine A. Rendle, Nandita Mitra, Chelsea A. Saia, Christine Neslund-Dudas, Robert T. Greenlee, Andrea N. Burnett-Hartman, Stacey A. Honda, Michael J. Simoff, Marilyn M. Schapira, Jennifer M. Croswell, Rafael Meza, Debra P. Ritzwoller, Anil Vachani
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Oncology
Stephanie Markovina, Katharine A. Rendle, Alexander C. Cohen, Lindsay M. Kuroki, Surbhi Grover, Julie K. Schwarz
Summary: Cervical cancer is characterized by significant socioeconomic and racial disparities in various aspects including incidence, mortality, morbidity, and years of life lost. The standard-of-care treatment for locally advanced cervical cancer has not seen significant innovation since 1999, and current chemoradiation therapy has a failure rate of 30%-50% with no cure for recurrent or metastatic disease. The National Institutes of Health recognizes the urgent need to address the global clinical problem of cervical cancer morbidity and mortality, and efforts are being made to advance research in this area. This review discusses the state of the science and opportunities for improving cervical cancer survival, with a focus on improving access, utilizing technology in innovative ways, and enhancing the current understanding of cervical cancer biology.
Article
Medicine, General & Internal
Patrick Gould, Tasnim Salam, Laura Kimberly, Alison Bateman-House, Holly Fernandez Lynch
Summary: This qualitative study examines how oncologists at academic medical centers perceive expanded access (EA) to investigational medical products. The results show that oncologists view EA as an important tool to secure the best treatment options for their patients and are willing to pursue EA as part of their obligation. They also express confidence in evaluating investigational treatments and do not necessarily view EA as a last resort.
Article
Public, Environmental & Occupational Health
Andrea N. Burnett-Hartman, Nikki M. Carroll, Jennifer M. Croswell, Robert T. Greenlee, Stacey A. Honda, Christine M. Neslund-Dudas, Roger Y. Kim, Katharine A. Rendle, Anil Vachani, Debra P. Ritzwoller
Summary: The authors aimed to determine the percentage of individuals up-to-date with lung cancer screening testing and evaluate differences based on patient and health system characteristics. The study found that only 28.3% of eligible individuals were up-to-date with testing. Factors associated with being up-to-date included age, chronic obstructive pulmonary disease, socioeconomic status, while factors inversely associated included smoking, BMI, ethnicity, and the type of lung cancer screening program.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Letter
Critical Care Medicine
David P. L. Sachs, Palo Alto, Frank T. Leone, Brendan T. Heiden, Li-Shiun Chen, Varun Puri
Article
Public, Environmental & Occupational Health
Patricia A. Cioe, Robert Schnoll, Bettina B. Hoeppner, Robert Gross, Brian L. Hitsman, Frank T. Leone, Rebecca Ashare, Roger Vilardaga, Karen Tashima, Megan Pinkston, Christopher W. Kahler
Summary: People with HIV have higher smoking rates and the COVID-19 pandemic has impacted their smoking behaviors, with some reporting increased smoking. Worrying about food and greater COVID-related worry were significantly associated with increased smoking.
Editorial Material
Critical Care Medicine
Katharine A. Rendle, Anil Vachani
Review
Oncology
Kevin Selby, Mai Sedki, Emma Levine, Aruna Kamineni, Beverly B. Green, Anil Vachani, Jennifer S. Haas, Debra P. Ritzwoller, Jennifer M. Croswell, Kabiru Ohikere, V. Paul Doria-Rose, Katharine A. Rendle, Jessica Chubak, Jennifer Elston Lafata, John Inadomi, Douglas A. Corley
Summary: This study reviewed guidelines for breast, cervical, colorectal, and lung cancer screening and summarized the relevant quality assessment metrics. The results showed that there are more metrics and supporting evidence in the guidelines for breast and colorectal cancer screening, while fewer metrics and no supporting evidence were found for cervical and lung cancer screening.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Letter
Medicine, General & Internal
Holly Fernandez Lynch, Tasnim Salam, Patrick Gould, Alison Bateman-House, Laura Kimberly
Article
Medicine, Research & Experimental
Julie S. Steiner, Erica Blum-Barnett, Betsy Rolland, Courtney R. Kraus, Jocelyn V. Wainwright, Ruth Bedoy, Yannica Theda Martinez, Elizabeth R. Alleman, Roxy Eibergen, Lisa E. Pieper, Nikki M. Carroll, Brian Hixon, Andrew Sterrett, Katharine A. Rendle, Chelsea Saia, Anil Vachani, Debra P. Ritzwoller, Andrea Burnett-Hartman
Summary: This manuscript describes how the PROSPR-Lung consortium utilized evidence-based SciTS best practices to establish infrastructure and processes for translational research in lung cancer screening. Specific examples are provided for developing a shared mission, transparent leadership, research support systems, efficient data management, interdisciplinary conversations, and a culture of trust. Guidance is offered for managing a multi-site research center and data repository, along with project management tools and processes to drive collaboration, efficiency, and scientific productivity.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Pediatrics
Charlotte Z. Woods-Hill, Maria N. Nelson, Whitney Eriksen, Katharine A. Rendle, Rinad S. Beidas, Christopher P. Bonafide, Michelle R. Brajcich, Aaron M. Milstone, Judy A. Shea
Summary: Blood cultures are crucial for diagnosing and treating sepsis in the pediatric intensive care unit, but there is significant variation in practices. Understanding the reasons behind blood culture use and overuse is important to optimize patient care. This study identified various factors influencing blood culture use, including clinician characteristics and behavioral economics concepts.
PEDIATRIC QUALITY & SAFETY
(2023)
Article
Psychology, Clinical
Robert Schnoll, Gabrielle M. Barrila, ShelDan Dalsimer, Mackenzie Hosie Quinn, Anna-Marika Bauer, Erica Fox, Matthew Olonoff, Nancy C. Jao, Frank Leone, Mark D. Huffman, Sadiya S. Khan, Jacqueline K. Gollan, George D. Papandonatos, Brian Hitsman
Summary: People with major depressive disorder (MDD) have high rates of tobacco use and lower responsiveness to tobacco cessation treatments. Treatment adherence plays a significant role in treatment outcomes, but its impact on smokers with MDD has not been evaluated. Factors such as demographic characteristics, smoking and psychiatric characteristics, withdrawal symptoms, and treatment-related side effects are associated with treatment adherence. Improving rates of treatment adherence can enhance cessation outcomes.
ADDICTIVE BEHAVIORS
(2023)
Article
Public, Environmental & Occupational Health
Erica T. Warner, Nathalie Huguet, Michelle Fredericks, Daniel Gundersen, Andrea Nederveld, Meagan C. Brown, Thomas K. Houston, Kia L. Davis, Stephanie Mazzucca, Katharine A. Rendle, Karen M. Emmons
Summary: This study developed a data resource to assess the outer setting across seven center funded by the National Cancer Institute's IS Centers in Cancer Control (ISC3) Network program. The results showed that the outer setting varies across these centers and often differs from the national level.
SOCIAL SCIENCE & MEDICINE
(2023)