Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Takazumi Yasui, Hiroki Nagamine, Kenta Tanaka, Moemi Kimura, Takeshi Karube, Hiromasa Kawana, Katsuhiro Onizawa
Summary: This study aimed to evaluate the prognostic treatment outcome of non-operative management of medication-related osteonecrosis of the jaw (MRONJ), particularly regarding the relationship between image findings and treatment outcomes. The study found that sequestrum formation on the internal texture and chemotherapy were significantly associated with treatment outcome. Sequestrum formation on the internal texture was associated with shorter time to healing and better outcomes, while sclerosis and normal findings were associated with longer healing times.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Article
Orthopedics
Wang-yong Zhu, Wei-fa Yang, Leilei Wang, Xinmiao Lan, Zhuo-ying Tao, Jiaxin Guo, Jiankun Xu, Ling Qin, Yu-xiong Su
Summary: This animal study found that an 8-week drug holiday prior to dental extractions can partially recover osteoclastic activity in osteoporosis rats, but does not alleviate the development of MRONJ-like lesion or exacerbate the osteoporotic condition in the femur. Longer-term drug holiday, or combination of drug holiday and other prophylaxes, could be explored in future studies for prevention of MRONJ in patients with osteoporosis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Lum Han
Summary: The study found that Korean dentists have insufficient awareness of medication-related osteonecrosis of the jaw and lack consistency in responding to patients' drug history prior to dental procedures. There is a need for increased cooperation between dentists and physicians, as well as targeted educational interventions for the dental profession, to reduce the risk of medication-related osteonecrosis of the jaw.
Article
Dentistry, Oral Surgery & Medicine
Jae-In Ryu, Ha-Young Kim, Yong-Dae Kwon
Summary: This study found that dental implantation was not a risk factor for osteonecrosis in older osteoporotic Korean patients, while patients who had undergone tooth extraction may face higher risks of ONJ. The presence of rheumatoid arthritis (RA) and the use of bisphosphonates (BPs) were also associated with an increased risk of ONJ.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sung-Woon On, Seoung-Won Cho, Soo-Hwan Byun, Byoung-Eun Yang
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is an interesting disease in the field of maxillofacial surgery. While the exact pathogenesis and definitive treatment protocol have not been established, various therapeutic approaches and research are being conducted to address this condition.
Review
Dentistry, Oral Surgery & Medicine
Ole Kristian Lobekk, Ward Dijkstra, Torbjorn O. Pedersen
Summary: The study compared the outcomes of surgical and conservative treatment for medication-related osteonecrosis of the jaw, with slightly better results reported after surgical treatment. However, there are issues with poor quality of evidence and high risk of bias in the research.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Ran Yan, Ruixue Jiang, Longwei Hu, Yuwei Deng, Jin Wen, Xinquan Jiang
Summary: This review provides an overview of medication-related osteonecrosis of the jaw (MRONJ), emphasizing the significance of animal models and discussing classical and modified rodent models for studying MRONJ. It also highlights the lack of a unified assessment system for these models and presents different approaches for evaluating MRONJ-like lesions in rodents.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Se Hwa Kim, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Summary: The study aimed to estimate the incidence of osteonecrosis of the jaw (ONJ) in Korean osteoporosis patients treated with bisphosphonates (BPs) and identified clinical risk factors such as advanced age, diabetes, and rheumatoid arthritis that increase the risk for ONJ.