Review
Clinical Neurology
Silvana Zito, Guido Nosari, Alessandro Pigoni, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review examines the relationship between testosterone levels and mood disorders, specifically major depressive disorder and bipolar disorder. The results from the reviewed studies were conflicting, with some showing low levels of testosterone in both disorders, while others showed a mixed picture of reduced, increased or no difference in testosterone levels. Overall, testosterone may serve as a useful biomarker in mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Review
Psychiatry
Katie Benitah, Ashley N. Siegel, Orly Lipsitz, Nelson B. Rodrigues, Shakila Meshkat, Yena Lee, Rodrigo B. Mansur, Flora Nasri, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: A systematic review of published clinical studies found no significant differences in the antidepressant response, tolerability, or safety of ketamine between males and females in the treatment of mood disorders.
PSYCHIATRY RESEARCH
(2022)
Review
Neurosciences
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d'Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre
Summary: The scoping review synthesized the current literature on the use of ketamine in bipolar depression. The preliminary evidence suggests that ketamine is a promising treatment with minimal risk and some effectiveness. Future studies should focus on ketamine's role in acute and maintenance treatment phases, as well as its effects on recurrence prevention and anti-suicidal measures.
Article
Clinical Neurology
Sara Poletti, Benedetta Vai, Mario Gennaro Mazza, Raffaella Zanardi, Cristina Lorenzi, Federico Calesella, Silvia Cazzetta, Igor Branchi, Cristina Colombo, Roberto Furlan, Francesco Benedetti
Summary: This study successfully predicted the differential diagnosis of MDD and BD by considering plasma levels of cytokines, chemokines, and growth factors, and found that the immune-inflammatory signature is key in distinguishing between the two disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Clinical
David T. Liebers, Mehdi Pirooznia, Andrea Ganna, Fernando S. Goes
Summary: The study demonstrates that psychiatric polygenic risk scores can modestly improve the distinction between BD and MDD cases based on clinical grounds, potentially providing utility for subjects at the extremes of the distribution or those with poorly measured clinical symptoms.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Andrea Escelsior, Samuele Tardito, Bruno Sterlini, Tiziana Altosole, Alice Trabucco, Valentina Marozzi, Gianluca Serafini, Andrea Aguglia, Andrea Amerio, Beatriz Pereira da Silva, Daniela Fenoglio, Gilberto Filaci, Martino Belvederi Murri, Mario Amore
Summary: This study found that CNR1 expression is higher and less variable in mania than in depression, which can help distinguish individuals in different illness phases from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Zainab Nabi, Jacki Stansfeld, Martin Ploderl, Lisa Wood, Joanna Moncrieff
Summary: This study is a systematic review and meta-analysis that includes all eligible data and evaluates the effect of lithium on suicide, non-fatal suicidal behavior, and suicide attempts. The results suggest that evidence from randomized trials is inconclusive and does not support the idea that lithium prevents suicide or suicidal behavior.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Review
Behavioral Sciences
Susana Gomes-da-Costa, Wolfgang Marx, Filippo Corponi, Gerard Anmella, Andrea Murru, Maria Teresa Pons-Cabrera, Anna Gimenez-Palomo, Felipe Gutierrez-Arango, Cristian Daniel Llach, Giovanna Fico, Georgios D. Kotzalidis, Norma Verdolini, Marc Valenti, Michael Berk, Eduard Vieta, Isabella Pacchiarotti
Summary: This study found through a systematic review and meta-analysis that the use of lithium in patients with Bipolar Disorder does not significantly lead to weight gain. Shorter treatment duration is associated with more pronounced weight gain. There were no significant differences in weight gain between lithium and placebo, but weight gain with lithium was lower compared to other active comparators.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Marcin Siwek, Aleksandra Gorostowicz, Magdalena Bosak, Dominika Dudek
Summary: Epilepsy and depression often coexist, and there is a bidirectional relationship between the two disorders. However, current evidence on the effectiveness of antidepressant therapy in patients with epilepsy and comorbid depression is limited. Vortioxetine, a multimodal antidepressant, shows promise as a treatment option for depressed patients with cognitive dysfunctions, anhedonia, and anxiety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Review
Psychiatry
Lindsay M. Melhuish Beaupre, Gregory M. Brown, Nicole A. Braganza, James L. Kennedy, Vanessa F. Goncalves
Summary: The review summarizes the role of mitochondria in sleep based on human and animal studies, showing their involvement in the sleep-wake cycle and briefly discussing the potential clinical implications.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Tuana Kant, Emiko Koyama, Clement C. Zai, Joseph H. Beitchman, James L. Kennedy
Summary: Psychopathic traits may be associated with the gene monoamine oxidase A (MAOA), and developmental factors may play a crucial role in the relationship between MAOA polymorphism and psychopathic traits in males.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Psychiatry
David Eapen-John, Ayeshah G. Mohiuddin, James L. Kennedy
Summary: Pharmacogenetic investigations suggest that genetic variation could be a significant cause of opioid-related morbidity and mortality. Understanding the complex interplay of genetic variations in opioid metabolic and action pathways can shed new light on the addictive and toxic properties of opioids. Personalized treatment plans based on individual genetic makeup could enhance the safety and effectiveness of opioid-based pain management and treatment of opioid use disorder.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Catherine Doust, Pierre Fontanillas, Else Eising, Scott D. Gordon, Zhengjun Wang, Gokberk Alagoz, Barbara Molz, Beate St Pourcain, Clyde Francks, Riccardo E. Marioni, Jingjing Zhao, Silvia Paracchini, Joel B. Talcott, Anthony P. Monaco, John F. Stein, Jeffrey R. Gruen, Richard K. Olson, Erik G. Willcutt, John C. DeFries, Bruce F. Pennington, Shelley D. Smith, Margaret J. Wright, Nicholas G. Martin, Adam Auton, Timothy C. Bates, Simon E. Fisher, Michelle Luciano
Summary: This study conducted a genome-wide association analysis on a large sample size and identified 42 significant loci associated with dyslexia, including 15 loci linked to cognitive ability/educational attainment and 27 newly discovered loci potentially specific to dyslexia. The genetic etiology of dyslexia was found to be similar between sexes, and there were genetic correlations with various traits such as ambidexterity. Dyslexia polygenic scores were able to explain a significant portion of variance in reading traits and could contribute to earlier identification and remediation of dyslexia in the future.
Article
Multidisciplinary Sciences
Else Eising, Nazanin Mirza-Schreiber, Eveline L. de Zeeuw, Carol A. Wang, Dongnhu T. Truong, Andrea G. Allegrini, Chin Yang Shapland, Gu Zhu, Karen G. Wigg, Margot L. Gerritse, Barbara Molz, Gokberk Alagoz, Alessandro Gialluisi, Filippo Abbondanza, Kaili Rimfeld, Marjolein van Donkelaar, Zhijie Liao, Philip R. Jansen, Till F. M. Andlauer, Timothy C. Bates, Manon Bernard, Kirsten Blokland, Milene Bonte, Anders D. Borglum, Thomas Bourgeron, Daniel Brandeis, Fabiola Ceronihh, Valeria Csepe, Philip S. Dale, Peter F. de Jong, John C. DeFries, Jean-Francois Demonet, Ditte Demontis, Yu Feng, Scott D. Gordon, Sharon L. Guger, Marianna E. Hayiou-Thomas, Juan A. Hernandez-Cabrera, Jouke-Jan Hottenga, Charles Hulme, Juha Kere, Elizabeth N. Kerr, Tanner Koomar, Karin Landerl, Gabriel T. Leonard, Maureen W. Lovett, Heikki Lyytinen, Nicholas G. Martin, Angela Martinelli, Urs Maurer, Jacob J. Michaelson, Kristina Moll, Anthony P. Monaco, Angela T. Morgan, Markus M. Nothen, Zdenka Pausova, Craig E. Pennell, Bruce F. Pennington, Kaitlyn M. Price, Veera M. Rajagopal, Franck Ramus, Louis Richer, Nuala H. Simpson, Shelley D. Smith, Margaret J. Snowling, John Stein, Lisa J. Struguuu, Joel B. Talcott, Henning Tiemeier, Marc P. van der Schroeff, Ellen Verhoef, Kate E. Watkins, Margaret Wilkinson, Margaret J. Wright, Cathy L. Barr, Dorret Boomsma, Manuel Carreiras, Marie-Christine J. Franken, Jeffrey R. Gruen, Michelle Luciano, Bertram Muller-Myhsok, Dianne F. Newbury, Richard K. Olson, Silvia Paracchini, Tomas Paus, Robert Plomin, Sheena Reilly, Gerd Schulte-Korn, J. Bruce Tomblin, Elsjevan Bergen, Andrew J. O. Whitehouse, Erik G. Willcutt, Beate St Pourcain, Clyde Francks, Simon E. Fisher
Summary: The use of spoken and written language is a fundamental human capacity. Genetic variation influences individual differences in reading- and language-related skills, with a heritability estimate of 30 to 80%. This study conducted a genome-wide association study on samples of 13,633 to 33,959 participants and identified a significant association between a genetic locus and word reading. All five reading-/language-related traits showed robust SNP heritability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychiatry
Joanna Collaton, Cindy-Lee Dennis, Valerie H. Taylor, Sophie Grigoriadis, Tim F. Oberlander, Benicio N. Frey, Ryan Van Lieshout, Jerry Guintivano, Samantha Meltzer-Brody, James L. Kennedy, Simone N. Vigod
Summary: This study evaluated the feasibility of enrolling Canadian women with postpartum depression and postpartum psychosis using a mobile application for an international psychiatric genetics study and identified clinically distinct subtypes of postpartum depression based on participant responses.
Article
Psychiatry
Yi Zou, Anahit Grigorian, Kody G. G. Kennedy, Clement C. C. Zai, Suyi Shao, James L. L. Kennedy, Ana C. C. Andreazza, Stephanie H. H. Ameis, Chinthaka Heyn, Bradley J. J. Maclntosh, Benjamin I. I. Goldstein
Summary: Oxidative stress is associated with white matter diffusion metrics in adults with bipolar disorder (BD). This study examined the association of single-nucleotide polymorphisms in the oxidative stress system with fractional anisotropy (FA) and radial diffusivity (RD) in youth with BD. The results showed significant diagnosis-by-genotype interaction effects for FA and RD, suggesting that the SOD2 rs4880 GG genotype may attenuate the salutary antioxidant effects on white matter integrity in youth with BD. Future studies are needed to explore other genetic markers and oxidative stress biomarkers.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Kaitlyn M. Price, Karen G. Wigg, Anukrati Nigam, Yu Feng, Kirsten Blokland, Margaret Wilkinson, Elizabeth N. Kerr, Sharon L. Guger, Maureen W. Lovett, Lisa J. Strug, Shreejoy J. Tripathy, Cathy L. Barr
Summary: Neuroimaging studies suggest the involvement of multiple cortical regions in reading ability/disability, but the specific neural cell types responsible for this process remain unknown. This study integrated genetic data and brain gene expression datasets to identify excitatory and inhibitory neurons, as well as fetal cell types, associated with reading ability, attention-deficit/hyperactivity disorder (ADHD), educational attainment, and cognitive ability. The findings contribute to our understanding of the neurobiological basis of reading and related traits.
MOLECULAR PSYCHIATRY
(2023)
Article
Genetics & Heredity
Kazunari Yoshida, Victoria S. Marshe, Samar S. M. Elsheikh, Malgorzata Maciukiewicz, Arun K. Tiwari, Eva J. Brandl, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Mueller
Summary: This study investigated the association between polygenic risk scores (PRS) for various psychiatric and metabolic traits and antipsychotic-induced weight gain (AIWG). The results showed nominal associations between PRSs for BMI, CAD, LDL-C, type 1 diabetes, and SCZ with AIWG. Although these associations became non-significant after multiple testing correction, these preliminary findings suggest that PRS analyses may help identify risk factors for AIWG and elucidate the underlying mechanisms.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W. Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K. Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z. Han, Christopher K. Glass, Cathy L. Barr, Paul S. Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C. Chen
Summary: In 2021, glioblastoma, the most common form of adult brain cancer, was reclassified by the World Health Organization into two subtypes based on genetic characteristics. The study analyzed the chromatin accessibility and transcription profiles of clinical samples from both types of tumors, revealing intratumoral heterogeneity and shared chromatin structure among tumor cells. Silencing specific transcription factors suppressed tumor growth, suggesting a potential therapeutic target for addressing the challenges associated with intratumoral heterogeneity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychiatry
Pritesh Jain, Tyne Miller-Fleming, Apostolia R. Topaloudi, Dongmei K. Yu, Petros Drineas, Marianthi Georgitsi, Zhiyu Yang, Renata Rizzo, Kirsten R. Mueller-Vahl, Zeynep A. Tumer, Nanette Mol Debes, Andreas S. Hartmann, Christel E. Depienne, Yulia S. Worbe, Pablo Mir, Danielle C. Cath, Dorret Boomsma, Veit Roessner, Tomasz Wolanczyk, Piotr Janik, Natalia Szejko, Cezary Zekanowski, Csaba Barta, Zsofia Nemoda, Zsanett Tarnok, Joseph D. Buxbaum, Dorothy Grice, Jeffrey Glennon, Hreinn Stefansson, Bastian Hengerer, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Astrid Morer, Norbert Mueller, Alexander Munchau, Kerstin J. Plessen, Cesare Porcelli, Susanne Walitza, Anette Schrag, Davide Martino, Andrea Dietrich, Carol A. Mathews, Jeremiah M. Scharf, Pieter J. Hoekstra, Lea K. Davis, Peristera Paschou
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Educational
Filippo Abbondanza, Philip S. Dale, Carol A. Wang, Marianna E. Hayiou-Thomas, Umar Toseeb, Tanner S. Koomar, Karen G. Wigg, Yu Feng, Kaitlyn M. Price, Elizabeth N. Kerr, Sharon L. Guger, Maureen W. Lovett, Lisa J. Strug, Elsje van Bergen, Conor V. Dolan, J. Bruce Tomblin, Kristina Moll, Gerd Schulte-Koerne, Nina Neuhoff, Andreas Warnke, Simon E. Fisher, Cathy L. Barr, Jacob J. Michaelson, Dorret I. Boomsma, Margaret J. Snowling, Charles Hulme, Andrew J. O. Whitehouse, Craig E. Pennell, Dianne F. Newbury, John Stein, Joel B. Talcott, Dorothy V. M. Bishop, Silvia Paracchini
Summary: The association between handedness and language-related disorders has been extensively studied. However, the inconsistent findings may be attributed to factors such as small sample sizes, publication bias, and variation in study criteria. This study examined the frequency of non-right-handedness (NRH) in individuals with reading and/or language impairment and found a higher prevalence compared to controls. Meta-analysis results further supported the association between NRH and language/reading impairments, suggesting shared underlying pathways between brain lateralization, handedness, and cognitive functions.
Article
Developmental Biology
Jason Charish, Hidekiyo Harada, Xiaoyan Chen, Thomas Walchli, Cathy L. Barr, Philippe P. Monnier
Summary: Contradictory results were obtained from knockout experiments on the KIAA0319-Like gene, however, this study revealed that knocking down KIAA0319L in chick embryos resulted in abnormal neuronal migration in the optic tectum, highlighting the crucial role of KIAA0319L in this developmental process.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2023)
Article
Psychology, Clinical
Martin Zack, Daniela Lobo, Candice Biback, Tim Fang, Kelly Smart, Daniel Tatone, Aditi Kalia, Daniel Digiacomo, James L. Kennedy
Summary: This study aimed to investigate the effects of gambling-specific priming manipulations and the pharmacological basis on risk-taking in a Game of Dice Task (GDT). The results showed that both gambling and AMPH increased risk-taking, with a stronger effect observed in individuals with gambling disorder. The outcomes varied with pre-treatment, and cognitive inflexibility and symptom severity moderated the effects.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2023)
Article
Education, Special
Kaitlyn M. Price, Karen G. Wigg, Virginia L. Misener, Antoine Clarke, Natalie Yeung, Kirsten Blokland, Margaret Wilkinson, Elizabeth N. Kerr, Sharon L. Guger, Maureen W. Lovett, Cathy L. Barr
Summary: This study examined the relationship between developmental dyslexia (DD), early language delay (ELD), and current language difficulties. The results showed a significant association between DD and ELD, with children in the DD/IR group putting words together later than the SR group. Children with low reading skills were also found to have lower expressive/receptive language abilities, and early language abilities predicted both current language skills and reading abilities.
JOURNAL OF LEARNING DISABILITIES
(2022)
