Article
Psychiatry
Mai Uchida, Qasim Bukhari, Maura DiSalvo, Allison Green, Giulia Serra, Chloe Hutt Vater, Satrajit S. Ghosh, Stephen V. Faraone, John D. E. Gabrieli, Joseph Biederman
Summary: This study developed a quantitative predictive model for bipolar disorder using machine learning algorithms and clinical data. The predictors included behavioral problems, school functioning, and anxiety/depression and aggression scales. The results have important clinical and scientific implications for assessing the risk of bipolar disorder in children.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Clinical Neurology
Silvana Zito, Guido Nosari, Alessandro Pigoni, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review examines the relationship between testosterone levels and mood disorders, specifically major depressive disorder and bipolar disorder. The results from the reviewed studies were conflicting, with some showing low levels of testosterone in both disorders, while others showed a mixed picture of reduced, increased or no difference in testosterone levels. Overall, testosterone may serve as a useful biomarker in mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Galecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Summary: This study examines the association between the reoccurrence of illness (ROI), the phenome of depression, and major dysmood disorder (MDMD) features and immune response in major depressive disorder and a major depressive episode (MDD/MDE). The results show that MDMD is characterized by heightened immune responses, which are a consequence of ROI-associated sensitization combined with immunostimulatory triggers.
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Article
Behavioral Sciences
Adam J. Walker, Yesul Kim, Igor Borissiouk, Rodolfo Rehder, Seetal Dodd, Gerwyn Morris, Andrew A. Nierenberg, Michael Maes, Brisa S. Fernandes, Olivia M. Dean, Lana J. Williams, Harris A. Eyre, Sung-Wan Kim, Sophia Zoungas, Andre F. Carvalho, Michael Berk
Summary: Statins, known for their lipid-lowering and cardiovascular benefits, may also have therapeutic potential in mood disorders due to their anti-inflammatory properties. However, the specific mechanisms of action in mood disorders and optimal dosing remain unclear, highlighting the need for further research and clinical trials.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Psychiatry
Katie Benitah, Ashley N. Siegel, Orly Lipsitz, Nelson B. Rodrigues, Shakila Meshkat, Yena Lee, Rodrigo B. Mansur, Flora Nasri, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: A systematic review of published clinical studies found no significant differences in the antidepressant response, tolerability, or safety of ketamine between males and females in the treatment of mood disorders.
PSYCHIATRY RESEARCH
(2022)
Review
Neurosciences
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d'Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre
Summary: The scoping review synthesized the current literature on the use of ketamine in bipolar depression. The preliminary evidence suggests that ketamine is a promising treatment with minimal risk and some effectiveness. Future studies should focus on ketamine's role in acute and maintenance treatment phases, as well as its effects on recurrence prevention and anti-suicidal measures.
Review
Psychiatry
Redwan Maatoug, Antoine Oudin, Vladimir Adrien, Bertrand Saudreau, Olivier Bonnot, Bruno Millet, Florian Ferreri, Stephane Mouchabac, Alexis Bourla
Summary: This article provides a conceptual and critical review of the theoretical and technical principles of digital phenotyping applied to mood disorders. The use of real-time markers to determine the digital signature of a pathology shows potential in computerizing the clinical characteristics of mood disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Chemistry, Medicinal
Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Atapol Sughondhabirom, Kitiporn Plaimas, Apichat Suratanee, Michael Maes
Summary: This study examines the effects of cannabidiol (CBD) on the immune-inflammatory response and immune-regulatory system in patients with depression and healthy controls. The results suggest that higher concentrations of CBD may worsen inflammatory processes.
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Health Care Sciences & Services
Sunhae Kim, Hye-Kyung Lee, Kounseok Lee
Summary: Using machine learning analysis, participants' mood symptoms can be classified and predicted more accurately. The prediction results for depressive symptoms and hypomanic symptoms vary across different methods used.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychiatry
Serena Borroni, Linda Franchini, Silvia Brioschi, Giulia Vassena, Elisabetta Masci, Chiara Franzoni, Giulia Ruotolo, Cristina Colombo, Andrea Fossati
Summary: This study examines the role of sociodemographic and clinical variables as well as personality pathological features in predicting high lethality suicide attempts. The results indicate that previous suicide attempts and current suicide ideation play a role in predicting serious suicide attempts. Specifically, the Detachment domain is associated with high lethality suicide attempts and remains a significant predictor even when considering the effects of previous attempts and ideation.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Elena Mazza, Federico Calesella, Marco Paolini, Camilla di Pasquasio, Sara Poletti, Cristina Lorenzi, Andrea Falini, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: Our study investigated the effects of insulin and its derived measures on white matter microstructure and neural functional connectivity in patients with bipolar disorder (BD). The results showed that insulin was negatively associated with fractional anisotropy and positively influenced radial diffusivity and mean diffusivity. Additionally, insulin resistance had a significant effect on radial diffusivity, while insulin sensitivity was positively associated with fractional anisotropy and negatively associated with radial diffusivity and mean diffusivity. These findings suggest that insulin may play a role in the pathophysiology of BD by affecting white matter microstructure and functional connectivity.
Article
Biochemistry & Molecular Biology
Angela Genchi, Elena Brambilla, Francesca Sangalli, Marta Radaelli, Marco Bacigaluppi, Roberto Furlan, Annapaola Andolfo, Denise Drago, Cinzia Magagnotti, Giulia Maria Scotti, Raffaella Greco, Paolo Vezzulli, Linda Ottoboni, Marco Bonopane, Daniela Capilupo, Francesca Ruffini, Daniela Belotti, Benedetta Cabiati, Stefania Cesana, Giada Matera, Letizia Leocani, Vittorio Martinelli, Lucia Moiola, Luca Vago, Paola Panina-Bordignon, Andrea Falini, Fabio Ciceri, Anna Uglietti, Maria Pia Sormani, Giancarlo Comi, Mario Alberto Battaglia, Maria A. A. Rocca, Loredana Storelli, Elisabetta Pagani, Giuseppe Gaipa, Gianvito Martino
Summary: This study conducted a phase 1 clinical trial evaluating the feasibility, safety and tolerability of intrathecally transplanted human fetal neural precursor cells (hfNPCs) in patients with progressive multiple sclerosis (PMS). The results demonstrated that hfNPC therapy is feasible, safe and tolerable in PMS patients.
Article
Clinical Neurology
Marco Paolini, Mariagrazia Palladini, Mario Gennaro Mazza, Federica Colombo, Benedetta Vai, Patrizia Rovere-Querini, Andrea Falini, Sara Poletti, Francesco Benedetti
Summary: Cognitive impairment is a common residual symptom in COVID-19 survivors and is associated with various brain changes. This study investigated the neural correlates of subjective cognitive decline using multimodal imaging in a sample of 58 COVID-19 survivors. The findings revealed widespread white matter disruption and abnormal functional connectivity in the brains of individuals with cognitive complaints. These results suggest a potential brain signature of cognitive decline in COVID-19 survivors and may aid in the identification of therapeutic targets for mitigating long-term cognitive dysfunction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
David Leppert, Mitsuru Watanabe, Sabine Schaedelin, Fredrik Piehl, Roberto Furlan, Matteo Gastaldi, Jeremy Lambert, Bjorn Evertsson, Katharina Fink, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Jun-ichi Kira, Pascal Benkert, Aleksandra Maceski, Eline Willemse, Johanna Oechtering, Annette Orleth, Stephanie Meier, Jens Kuhle
Summary: This study aimed to determine the differences in granulocyte activation markers (GAM) between neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS), and whether they are associated with neurological impairment. The results showed that GAM and adhesion molecules were higher in acute NMOSD compared to RRMS and correlated with clinical disability scores. The composite of GAM can be used as a reliable biomarker to differentiate NMOSD from MS, including aAQP4(-) NMOSD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychiatry
Sigrid Breit, Elena Mazza, Sara Poletti, Francesco Benedetti
Summary: Major depressive disorder (MDD) is a complex and serious mental disorder that can result in chronic recurrent symptoms, treatment resistance, and suicidal behavior. Immune dysregulation and brain volume changes, particularly in white matter (WM), are associated with MDD. Neuroimaging markers and blood markers, such as inflammation-related cytokines, may serve as predictors of treatment response in MDD, but the relationship between peripheral inflammation, WM integrity, and antidepressant response is still not clearly understood. This review aims to explore the association between inflammation and WM integrity, and their impact on MDD pathophysiology and progression, as well as the potential role of novel biomarkers in improving MDD prevention and treatment strategies.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Paride Schito, Tommaso Russo, Teuta Domi, Alessandra Mandelli, Laura Pozzi, Ubaldo Del Carro, Paola Carrera, Federica Agosta, Angelo Quattrini, Roberto Furlan, Massimo Filippi, Nilo Riva
Summary: The study aims to determine the features at onset that can differentiate between primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS), evaluate the diagnostic performance of a serum biomarker panel, and identify prognostic factors for patients with upper motor neuron syndrome.
Article
Medicine, General & Internal
Mariagrazia Palladini, Mario Gennaro Mazza, Andrea Scalabrini, Patrizia Rovere Querini, Sara Poletti, Francesco Benedetti
Summary: COVID-19 survivors experience intense depressive and post-traumatic symptoms in the sub-acute stages. Survivor guilt may contribute to the development of post-COVID psychiatric implications. This study aims to uncover the affective mechanism behind these implications by examining the association between survivor guilt, psychopathology, and maladaptive attributional style. The study evaluated symptoms of depression, post-traumatic distress, and sleep disturbances in 195 COVID-19 survivors one month after discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Laura Raffaelli, Sara Poletti, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: This study investigated the impact of Neutrophil-to-lymphocyte ratio (NLR) on treatment response in Major Depressive Disorder (MDD) patients, and the influence of sex and hippocampal volume on this relationship. The results showed that NLR had a different effect on treatment response in females compared to males. Additionally, NLR negatively affected hippocampal volume in females, and hippocampal volume partially mediated the effect of NLR on treatment response in females.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Federica Colombo, Valentina Bettonagli, Sara Poletti, Matteo Carminati, Cristina Colombo, Francesco Benedetti, Raffaella Zanardi
Summary: A study found that there is a correlation between MRI imaging and treatment response in patients with major depressive disorder (MDD). The study analyzed MRI scans of 100 patients and found that lower grey matter volumes, particularly in the hippocampus and temporal lobe-related areas, were associated with worse treatment outcomes. Functional connectivity patterns were also found to be related to treatment response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Igor Branchi
Summary: Plasticity is recognized as a key concept in psychiatry and mental health, allowing for the reorganization of neural circuits and behavior. Individual differences in plasticity may explain why therapies are effective in some patients but not others. A mathematical formula is proposed to assess plasticity, which can identify individuals or populations more likely to modify their behavior based on therapies or contextual factors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Nicolas Fissolo, Pascal Benkert, Jaume Sastre-Garriga, Neus Mongay-Ochoa, Andreu Vilaseca-Jolonch, Sara Llufriu, Yolanda Blanco, Harald Hegen, Klaus Berek, Francisco Perez-Miralles, Konrad Rejdak, Luisa M. Villar, Enric Monreal, Roberto Alvarez-Lafuente, Onder K. Soylu, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Sergio Martinez-Yelamos, Antonio J. Sanchez-Lopez, Antonio Garcia-Merino, Lucia Gutierrez, Tamara Castillo-Trivino, Jan Lycke, Igal Rosenstein, Roberto Furlan, Massimo Filippi, Nieves Tellez, Lluis Ramio-Torrenta, Jan D. Lunemann, Heinz Wiendl, Sara Eichau, Michael Khalil, Jens Kuhle, Xavier Montalban, Manuel Comabella
Summary: This study aimed to investigate the potential of serum biomarker levels in predicting disability progression in patients with primary progressive multiple sclerosis (PPMS). The study found that levels of neurofilament light chain (sNfL), glial fibrillar acidic protein (sGFAP), and chitinase 3-like 1 (sCHI3L1) were associated with changes in the Expanded Disability Status Scale (EDSS) over different time periods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)