Review
Cell Biology
Caojie Liu, Ning Kang, Yuchen Guo, Ping Gong
Summary: CHD proteins play a crucial role in stem cell differentiation and human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Audiology & Speech-Language Pathology
Alejandra Laureano, Jihyun Kim, Edward Martinez, Kelvin Y. Kwan
Summary: Loss of spiral ganglion neurons (SGNs) in the cochlea causes hearing loss. Understanding the mechanisms of cell fate transition accelerates efforts to repopulate lost SGNs. CHD4 may play a role in suppressing alternative cell fates to promote inner ear regeneration.
Article
Surgery
Emma S. Hogg, Nesrettin F. Turgut, Emma McCann, Shivaram Avula, Sujata De, Sunil D. Sharma
Summary: This study retrospectively reviewed CT images of patients with Apert syndrome and found anatomical variations in the inner ear structures, which were correlated with audiological testing.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Biophysics
Mingyue Ai, Chuanjia Guo, Liwei Wang, Ming Hu, Kaixu Xu, Chen Li, Zhimin Zhou
Summary: Achieving precise surface charge manipulation of non-spherical drug microcrystals is essential for local drug delivery. In this study, silk-coated dexamethasone microcrystals were synthesized and modified with positive or negative charge using facile methods, showing improved inner ear delivery outcomes in guinea pigs. These findings suggest a potential strategy for developing surface charge-tunable drug delivery vehicles for crossing biological barriers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Clinical Neurology
Martin A. A. Lewis, Amy Juliano, Caroline Robson, Emma Clement, Robert Nash, Kaukab Rajput, Felice D'Arco
Summary: This study reviewed the genotypes and imaging appearances of cochleae in CHARGE patients, providing a detailed anatomical description and grading system of cochlear anomalies. The goal was to gain insight into the spectrum of cochlear anomalies in CHARGE syndrome and the role of the CHD7 gene in otic vesicle development.
Article
Otorhinolaryngology
Aysun Parlak Kocabay, Betul Cicek Cinar, Merve Ozbal Batuk, Mehmet Yarali, Gonca Sennaroglu
Summary: The aim of this study was to evaluate the mapping parameters of cochlear implant users with inner ear malformation (IEM) and to examine the changes over time. The results showed significant differences in impedance measurements at several time points. There were also noticeable differences in threshold levels, most comfortable levels, and pulse width values between the IEM and control groups at all time points. Threshold levels, most comfortable levels, and pulse width values significantly increased over time in both groups, with higher values observed in the IEM group. Significant differences in rates were only observed at the initial activation, both within and between groups.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2022)
Review
Oncology
Chengsen Chai, H. Helena Wu, Yasser Abuetabh, Consolato Sergi, Roger Leng
Summary: This review focuses on the role and regulation of PTEN in triple-negative breast cancer (TNBC). PTEN inactivation is associated with aggressive tumor phenotype and plays a crucial role in negatively regulating cell proliferation and migration. The review provides a summary of genomic alterations of PTEN, discusses the transcriptional regulation and posttranslational modifications of PTEN, and explores the prospects of PTEN protein in TNBC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert C. Power, Amanda G. Henry, Julian Moosmann, Felix Beckmann, Heiko Temming, Anthony Roberts, Adeline Le Cabec
Summary: Research on dental calculus can provide insights into diet, health, and environmental pollution. The use of PPC-SR-mu CT technique allows for non-destructive examination of its internal organization, revealing important features and the high heterogeneity and variability within calculus.
JOURNAL OF MEDICAL IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Jong Hoon Lee, Badar Kanwar, Asif Khattak, Jenny Balentine, Ngoc Huy Nguyen, Richard E. Kast, Chul Joong Lee, Jean Bourbeau, Eric L. Altschuler, Consolato M. Sergi, Tuan Ngoc Minh Nguyen, Sangsuk Oh, Mun-Gi Sohn, Michael Coleman
Summary: SARS-CoV-2 induces immune-mediated type 1 interferon production, which leads to exacerbated interferonopathies. Aspirin inhibits cGAS-mediated signaling to regulate immune response. Additionally, aspirin and dapsone inhibit the activation of IFN-1 and NF-kappa B by targeting cGAS. Timely alleviation of the pathologic course is necessary for immune cell reactions and viral clearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Irene Donato, Kiran K. Velpula, Andrew J. Tsung, Jack A. Tuszynski, Consolato M. Sergi
Summary: This study proposes a mathematical and computational approach to diagnose neuroblastoma by calculating image entropy, fractal dimension, and lacunarity. The method is able to automatically predict tumor malignancy and may challenge the current classification of neuroblastoma.
Article
Genetics & Heredity
Julia Vodopiutz, Lisa-Maria Steurer, Florentina Haufler, Franco Laccone, Dorota Garczarczyk-Asim, Matthias Hilkenmeier, Philipp Steinbauer, Andreas R. Janecke
Summary: SHOX deficiency is a common genetic cause of short stature. It can lead to Leri-Weill dyschondrosteosis and nonspecific short stature. This study reports the pseudo-autosomal recessive inheritance of Leri-Weill dyschondrosteosis in two siblings caused by a novel homozygous non-canonical splice-site variant in the SHOX gene. This study expands the understanding of the molecular and inheritance spectrum of SHOX deficiency.
Review
Medicine, General & Internal
Josef Hager, Consolato M. Sergi
Summary: Factors such as population migration, tourism, dog translocations, and poor hygiene practices contribute to the spread of echinococcosis. Prompt diagnosis of cystic echinococcosis (CE) should be considered when a cyst-like mass is found in the liver or lung of individuals with a history of exposure to sheepdogs in endemic areas. Routine imaging techniques and serologic investigations are used for detection and confirmation. Treatment options for pediatric echinococcosis include drug therapy and surgical interventions.
Editorial Material
Medicine, General & Internal
Consolato M. Sergi
Summary: Road accidents involving dangerous chemical compounds pose a hazard to public health worldwide. This commentary briefly reviews a recent event in East Palestine, Ohio and discusses one of the chemicals involved, which has a predisposition to initiate a carcinogenic process. The author, as a consultant for the International Agency for Research on Cancer, has reviewed numerous chemical compounds.
Review
Medicine, General & Internal
Consolato M. Sergi, Deborah Spencer, Taher Al-Jishi
Summary: This article summarizes the most frequent findings discussed at multidisciplinary team (MDT) meetings, including pathological findings of stillbirth and the importance of the placenta.
JOURNAL OF LABORATORY PHYSICIANS
(2023)
Article
Otorhinolaryngology
Daniel Dejaco, David Riedl, Timo Maria Gottfried, Matthias Santer, Annette Runge, Josef Seebacher, Philipp Zelger, Bicego Lia, Schmutzhard Joachim
Summary: This study investigates the influence of intraoperative ABR measurements and various fixation methods on postoperative coupling quality in Vibroplasty surgery, and finds that intraoperative ABR measurement can significantly improve the coupling quality after the surgery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Luisa-Marie Heine, Andreas Heider, Roland Gauch, Mathias Schlett, Marc Hummel, Christoph Spurk, Felix Beckmann, Julian Moosmann
Summary: Laser beam welding is an important joining process for copper components in the electrical powertrain. However, welding copper with laser beams is challenging due to its high heat conductivity and low absorptivity. Recent research has shown that using blue lasers with a wavelength of 450 nm can improve the welding process and reduce weld defects. Additionally, investigations using a blue diode laser have provided insights into the material behavior during welding, particularly in relation to melt pool dynamics and capillary dynamics.
JOURNAL OF LASER APPLICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Griffin Rodgers, Christos Bikis, Philipp Janz, Christine Tanner, Georg Schulz, Peter Thalmann, Carola A. Haas, Bert Mueller
Summary: The most common form of epilepsy in adults is mesial temporal lobe epilepsy (mTLE), which is characterized by seizures originating in the hippocampus due to abnormal electrical activity. This study proposes a complementary three-dimensional (3D) X-ray histology technique to analyze the histopathology of mTLE. By using synchrotron radiation-based phase-contrast microtomography, the authors were able to visualize tissue microstructure in postmortem brain hemispheres and identify hippocampal sclerosis. Morphological and density changes during epileptogenesis were quantified using a deep convolutional neural network. The results suggest that 3D X-ray histology can serve as a valuable tool for cellular-resolution histopathological analysis of mTLE.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Genetics & Heredity
Ferda O. Hosnut, Andreas R. Janecke, Gulseren Sahin, Georg F. Vogel, Naz G. Lafci, Paul Bichler, Thomas Mueller, Lukas A. Huber, Taras Valovka, Aysel U. Aksu
Summary: Congenital glucose-galactose malabsorption is a rare autosomal recessive disorder caused by mutations in SLC5A1 gene. Our study reports clinical and molecular data from 11 affected individuals in four unrelated Turkish families. Two novel SLC5A1 missense variants, p.Gly43Arg and p.Ala92Val, were identified in two families and linked to the disease. Our findings expand the mutational spectrum of this rare disorder.
Article
Multidisciplinary Sciences
Willy Kuo, Diego Rossinelli, Georg Schulz, Roland H. Wenger, Simone Hieber, Bert Muller, Vartan Kurtcuoglu
Summary: The performance of machine learning algorithms in segmenting 3D biomedical images falls short of expectations compared to 2D photos. This is due to the lack of large, high-quality training datasets. The HR-Kidney dataset presented in this work provides a solution by offering a significantly larger dataset and can be used to further advance image processing, data augmentation, and machine learning research.
Letter
Obstetrics & Gynecology
Consolato M. Sergi, Tomy Mullur
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Proceedings Paper
Optics
Adriana A. Velasco, Christine Tanner, Georg Schulz, Griffin Rodgers, Jeannette von Jackowski, Mattia Humbel, Timm Weitkamp, Henry T. Bunn, Bert Mueller
Summary: This study utilized microtomography to analyze the teeth of African bovids, discovering that this technique could replace the traditional sectioning method, which is significant for archaeologists and museum curators.
DEVELOPMENTS IN X-RAY TOMOGRAPHY XIV
(2022)