Regulation of the tumor suppressor PTEN in triple-negative breast cancer

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

(2021) Monique C. Tavares et al.   BMC CANCER

Functional Proteomic Profiling of Triple-Negative Breast Cancer

(2021) Irina Gromova et al.   Cells

Combined P53/PTEN deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer

(2020) Mari Gasparyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis

(2020) Qinglin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neddylation of PTEN regulates its nuclear import and promotes tumor development

(2020) Ping Xie et al.   CELL RESEARCH

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

(2019) Jessica L. Ritter et al.   CANCER RESEARCH

MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells

(2018) Chengsen Chai et al.   CARCINOGENESIS

EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During Fear Memory Reconsolidation

(2018) Timothy J. Jarome et al.   JOURNAL OF NEUROSCIENCE

PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy

(2018) Nahal Haddadi et al.   Molecular Cancer

Loss of PTEN in high grade advanced stage triple negative breast ductal cancers in African American women

(2018) Farhan Khan et al.   PATHOLOGY RESEARCH AND PRACTICE

Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Sung-Bae Kim et al.   LANCET ONCOLOGY

Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis

(2017) Shuting Li et al.   Oncotarget

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

(2015) Min-Sik Lee et al.   Nature Communications

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

(2015) Makoto Nakakido et al.   NEOPLASIA

Focus on PTEN regulation

(2015) Miriam Bermúdez Brito   Frontiers in Oncology

PTEN: Multiple Functions in Human Malignant Tumors

(2015) Michele Milella et al.   Frontiers in Oncology

Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

(2015) Mark Kriegsmann et al.   Oncotarget

Triple-Negative Breast Carcinoma

(2014) Robert Schmadeka et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β-catenin signaling

(2013) Fei Ma et al.   GENE

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells

(2013) Per Johnsson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PTEN mutation, methylation and expression in breast cancer patients

(2013) HONG-YAN ZHANG et al.   Oncology Letters

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

(2012) D. J. Mulholland et al.   CANCER RESEARCH

Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer

(2012) Jabed Iqbal et al.   HISTOPATHOLOGY

Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities

(2012) D. W. Craig et al.   MOLECULAR CANCER THERAPEUTICS

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

mTOR in breast cancer: Differential expression in triple-negative and non-triple-negative tumors

(2011) S. Walsh et al.   BREAST

MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer

(2011) W. Shi et al.   CANCER RESEARCH

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

(2011) Evelyne Lima-Fernandes et al.   EMBO JOURNAL

miR-29b regulates migration of human breast cancer cells

(2011) Chen Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins

(2011) C Nishioka et al.   Blood Cancer Journal

Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation

(2010) Ke Liang et al.   CANCER CELL

Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

(2010) Lizhi He et al.   JOURNAL OF CLINICAL INVESTIGATION

Deconstructing the molecular portraits of breast cancer

(2010) Aleix Prat et al.   Molecular Oncology

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

Directed Therapy of Subtypes of Triple-Negative Breast Cancer

(2010) L. A. Carey   ONCOLOGIST

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination

(2010) L. Cotter et al.   SCIENCE

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

(2009) Juxiang Cao et al.   EMBO JOURNAL

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

MyosinV controls PTEN function and neuronal cell size

(2009) Michiel T. van Diepen et al.   NATURE CELL BIOLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

How basal are triple-negative breast cancers?

(2008) François Bertucci et al.   INTERNATIONAL JOURNAL OF CANCER

Breast cancer special types: why bother?

(2008) JS Reis-Filho et al.   JOURNAL OF PATHOLOGY

Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis

(2008) M. Escriva et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome

(2008) M S Orloff et al.   ONCOGENE

Id-1 activates Akt-mediated Wnt signaling and p27Kip1 phosphorylation through PTEN inhibition

(2008) J-Y Lee et al.   ONCOGENE

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

(2008) F. Fouladkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA